CA2361534C - Peptides d'alpha-conotoxine - Google Patents

Peptides d'alpha-conotoxine Download PDF

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Publication number
CA2361534C
CA2361534C CA2361534A CA2361534A CA2361534C CA 2361534 C CA2361534 C CA 2361534C CA 2361534 A CA2361534 A CA 2361534A CA 2361534 A CA2361534 A CA 2361534A CA 2361534 C CA2361534 C CA 2361534C
Authority
CA
Canada
Prior art keywords
cys
ala
arg
ser
xaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2361534A
Other languages
English (en)
Other versions
CA2361534A1 (fr
Inventor
Maren Watkins
Baldomero M. Olivera
David R. Hillyard
J. Michael Mcintosh
Robert M. Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Cognetix Inc
Original Assignee
University of Utah Research Foundation UURF
Cognetix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation UURF, Cognetix Inc filed Critical University of Utah Research Foundation UURF
Priority to CA2743116A priority Critical patent/CA2743116C/fr
Publication of CA2361534A1 publication Critical patent/CA2361534A1/fr
Application granted granted Critical
Publication of CA2361534C publication Critical patent/CA2361534C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne des peptides relativement courts et dénommés .alpha.-conotoxines qui possèdent une longueur d'environ 10 à 30 radicaux, qui sont naturellement disponibles en quantités minuscules dans le venin de cônes ou qui sont analogues aux peptides naturellement disponibles, et qui comprennent de préférence deux liaisons disulfure.
CA2361534A 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine Expired - Fee Related CA2361534C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2743116A CA2743116C (fr) 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11838199P 1999-01-29 1999-01-29
US60/118,381 1999-01-29
PCT/US2000/001979 WO2000044776A1 (fr) 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2743116A Division CA2743116C (fr) 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine

Publications (2)

Publication Number Publication Date
CA2361534A1 CA2361534A1 (fr) 2000-08-03
CA2361534C true CA2361534C (fr) 2011-08-30

Family

ID=22378229

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2361534A Expired - Fee Related CA2361534C (fr) 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine
CA2743116A Expired - Fee Related CA2743116C (fr) 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2743116A Expired - Fee Related CA2743116C (fr) 1999-01-29 2000-01-28 Peptides d'alpha-conotoxine

Country Status (5)

Country Link
EP (1) EP1147130A4 (fr)
JP (1) JP2002534996A (fr)
AU (1) AU770076B2 (fr)
CA (2) CA2361534C (fr)
WO (1) WO2000044776A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002245934B2 (en) * 2001-03-29 2008-05-01 John Down Alpha conotoxin peptides with analgesic properties
AUPR409401A0 (en) * 2001-03-29 2001-04-26 University Of Melbourne, The Analgesic compound
US9284358B2 (en) 2006-07-18 2016-03-15 University Of Utah Research Foundation Conotoxin peptides
US9717775B2 (en) 2006-07-18 2017-08-01 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds
DK2051991T3 (da) * 2006-08-17 2012-01-30 Eribis Pharmaceuticals Ab Cardiobeskyttende forbindelser
CN103483439B (zh) * 2012-06-15 2015-09-16 海南大学 αO-超家族芋螺毒素肽、其药物组合物及用途
JP6336979B2 (ja) * 2012-08-07 2018-06-06 ハイナン ユニバーシティ α−コノトキシンペプチド、その医薬組成物及びそれらの使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514774A (en) * 1993-06-29 1996-05-07 University Of Utah Research Foundation Conotoxin peptides
US5595972A (en) * 1993-06-29 1997-01-21 University Of Utah Research Foundation Conotoxin peptides
US5432155A (en) * 1993-06-29 1995-07-11 The Salk Institute For Biological Studies Conotoxins I
US5739276A (en) * 1994-10-07 1998-04-14 University Of Utah Research Foundation Conotoxin peptides
US5719264A (en) * 1994-10-07 1998-02-17 Univ. Of Utah Research Foundation Conotoxin peptides
US5670622A (en) * 1996-02-15 1997-09-23 University Of Utah Research Foundation Conotoxin peptide PIIIA
US5672682A (en) * 1996-03-18 1997-09-30 University Of Utah Research Foundation Conotoxin peptide PVIIA
JP2001505878A (ja) * 1996-11-18 2001-05-08 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 心臓血管剤としてのコノトキシンペプチドＩｍＩおよびＭＩＩの使用
US5780433A (en) * 1996-12-06 1998-07-14 University Of Utah Research Foundation Use of α-conotoxin MII to treat disorders resulting from nicotine stimulated dopamine release
US5889147A (en) * 1997-01-17 1999-03-30 University Of Utah Research Foundation Bromo-tryptophan conopeptides
US5866682A (en) * 1997-05-15 1999-02-02 University Of Utah Research Foundation Conopeptides AuIA, AuIB and AuIC
US5969096A (en) * 1998-06-26 1999-10-19 The Salk Institute For Biological Studies Conotoxin peptides

Also Published As

Publication number Publication date
AU770076B2 (en) 2004-02-12
JP2002534996A (ja) 2002-10-22
CA2361534A1 (fr) 2000-08-03
CA2743116A1 (fr) 2000-08-03
WO2000044776A1 (fr) 2000-08-03
EP1147130A1 (fr) 2001-10-24
CA2743116C (fr) 2016-06-21
EP1147130A4 (fr) 2004-09-29
AU2973500A (en) 2000-08-18

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City et al. Walker et al.(45) Date of Patent: Oct. 7, 2003

Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20180129