CA2374482A1 - Methods and materials for the synthesis of organic products - Google Patents

Methods and materials for the synthesis of organic products Download PDF

Info

Publication number
CA2374482A1
CA2374482A1 CA002374482A CA2374482A CA2374482A1 CA 2374482 A1 CA2374482 A1 CA 2374482A1 CA 002374482 A CA002374482 A CA 002374482A CA 2374482 A CA2374482 A CA 2374482A CA 2374482 A1 CA2374482 A1 CA 2374482A1
Authority
CA
Canada
Prior art keywords
microorganism
culturing
culture conditions
under
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002374482A
Other languages
French (fr)
Other versions
CA2374482C (en
Inventor
Vineet Rajgarhia
Vassily Hatzimanikatis
Stacey Olson
Ting Liu Carlson
John N. Starr
Jeffrey J. Kolstad
Aharon M. Eyal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cargill Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2374482A1 publication Critical patent/CA2374482A1/en
Application granted granted Critical
Publication of CA2374482C publication Critical patent/CA2374482C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/48—Tricarboxylic acids, e.g. citric acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention provides methods and materials related to the production of organic products. Specifically, the invention provides various recombinant yeast cells, methods for culturing yeast cells, methods for making yeast cells, nucleic acid constructs, and methods and materials for producing various organic products.

Claims (33)

1. A method for making a selected organic product, said method comprising:

a) providing a microorganism exhibiting a crabtree-negative phenotype;

b) culturing the crabtree-negative microorganism in a first culture medium which includes a carbon source under a first set of culture conditions which promote cellular respiration; and c) culturing the crabtree-negative microorganisms in a second culture medium which includes a carbon source under a second set of culture conditions which promote production of the selected organic product.
2. A method according to claim 1, wherein the selected organic product comprises a pyruvate-derived product.
3. A method according to claim 2, wherein the pyruvate-derived product comprises lactate.
4. A method according to claim 1, wherein the first culture medium is different from the second culture medium.
5. A method according to claim 1, wherein the first set of culture conditions comprise aerobic conditions.
6. A method according to claim 1, wherein the first culture medium comprises a dissolved oxygen content of at least 2 %.
7. A method according to claim 1, wherein the first set of culture conditions comprise maintaining a culture medium under an air flow of at least 0.1 VVM.
8. A method according to claim 1, wherein the microorganism has a doubling time of less than 10 hours under the first set of culture conditions.
9. A method according to claim 1, wherein at least about 0.3 grams biomass is produced per gram carbon source consumed under the first set of culture conditions.
10. A method according to claim 1, wherein the first set of culture conditions comprise a culture medium having a pH of less than 3.0, a temperature of greater than 35°C and a dissolved oxygen content of at least about 2 %.
11. A method according to claim 1, wherein the second set of culture conditions comprise anaerobic conditions.
12. A method according to claim 1, wherein the second culture medium comprises a dissolved oxygen content of no greater than 2 %.
13. A method according to claim 1, wherein the second set of culture conditions comprise maintaining a culture medium under an air flow of less than 0.1 VVM.
14. A method according to claim 1, wherein no more than about 0.3 grams biomass is produced per gram carbon source consumed under the second set of culture conditions.
15. A method according to claim 1, wherein the second set of culture conditions comprises a culture medium having a pH of less than 3.0, a temperature greater than 35°C, and a dissolved oxygen content of less than 2 %.
16. A method according to claim 1, wherein the second culture medium comprises an inhibitor of cellular respiration.
17. A method according to claim 1, wherein at least one of the first culture media and the second culture media comprise pentose carbons.
18. A method according to claim 1, wherein the crabtree-negative microorganism comprises yeast.
19. A method according to claim 18, wherein in the yeast is selected from the group consisting of Kluyveromyces, Pichia, Hansenula, Candida, Trichsporon, and Yamadazyma.
20. A method according to claim 1, wherein the crabtree-negative microorganism is genetically modified.
21. A method according to claim 20, wherein the crabtree-negative microorganism is genetically modified to include an exogenous lactate dehydrogenase gene.
22. A method according to claim 21, wherein the crabtree-negative microorganism is genetically modified to include a lactate dehydrogenase gene selected from the group consisting of bovine lactate dehydrogenase, bacterial lactate dehydrogenase and fungal lactate dehydrogenase.
23. A method according to claim 1, further comprising a step of adding a terminal electron acceptor to the second culture medium.
24. A method for producing a selected pyruvate-derived product, comprising:
a. providing a microorganism;
b. culturing the microorganism under a first set of culture conditions which promote cellular respiration;
c. culturing the microorganism under a second set of culture conditions which promote production of the selected pyruvate-derived product;
d. culturing the microorganism under a third set of culture conditions which comprise a culture medium which includes an agent which increases metabolic energy of the mircoorganism.
25. A method according to claim 24, wherein the step of culturing the microorganism under a first set of culture conditions comprises culturing the microorganism in a culture media which includes a carbon source, wherein said culturing yields greater than 0.4 g microorganism (dry wt) per gram of carbon source.
26. A method according to claim 24, wherein the step of culturing the microorganism under a first set of culture conditions yields a microorganism having a growth rate greater than 0.2 hr-1.
27. A method according to 24 wherein the step of culturing the microorganism under a first set of culture conditions comprises culturing the microorganism under aerobic conditions.
28. A method according to 24 wherein the step of culturing the microorganism under a second set of culture conditions comprises culturing the microorganism under anaerobic conditions.
29. A method according to claim 24 wherein the pyruvate-derived product is produced at a rate of at least 0.1 grams of product per gram microorganism per hour during said step of culturing the microorganism under a second set of culture conditions.
30. A method according to claim 24 wherein the agent which increases metabolic energy of the microorganism comprises oxygen.
31. Use of a genetically modified microorganism, exhibiting a crabtree-negative phenotype, in a process for the production of lactic acid, wherein said process comprises an aerobic phase and an anaerobic phase.
32. A yeast strain lacking ethanol production ability or having reduced ethanol production ability with respect to wild-type yeast of the same strains and having an endogenous lactate dehydrogenase gene.
33. A yeast strain according to claim 32, wherein the yeast strain is K.
thermotolerans.
CA2374482A 1999-05-21 2000-05-19 Methods and materials for the synthesis of organic products Expired - Lifetime CA2374482C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31649099A 1999-05-21 1999-05-21
US09/316,490 1999-05-21
PCT/US2000/013907 WO2000071738A1 (en) 1999-05-21 2000-05-19 Methods and materials for the synthesis of organic products

Publications (2)

Publication Number Publication Date
CA2374482A1 true CA2374482A1 (en) 2000-11-30
CA2374482C CA2374482C (en) 2012-09-18

Family

ID=23229271

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2374482A Expired - Lifetime CA2374482C (en) 1999-05-21 2000-05-19 Methods and materials for the synthesis of organic products

Country Status (19)

Country Link
US (3) US6485947B1 (en)
EP (1) EP1183385B1 (en)
JP (1) JP4637372B2 (en)
KR (1) KR20020048910A (en)
CN (1) CN100347308C (en)
AT (1) ATE333509T1 (en)
AU (1) AU780135B2 (en)
BR (1) BR0010806B1 (en)
CA (1) CA2374482C (en)
CZ (1) CZ299320B6 (en)
DE (1) DE60029440T2 (en)
HK (1) HK1045174A1 (en)
HU (1) HUP0201204A3 (en)
NO (1) NO326775B1 (en)
PL (1) PL352434A1 (en)
PT (1) PT1183385E (en)
RS (1) RS49895B (en)
UA (1) UA77386C2 (en)
WO (1) WO2000071738A1 (en)

Families Citing this family (213)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (en) * 1997-09-12 1999-04-12 Biopolo S C A R L YEAST STRAWS FOR THE REPRODUCTION OF LACTIC ACID
US20070031950A1 (en) * 1998-09-11 2007-02-08 Winkler Aaron A Production of D-lactic acid with yeast
EP1183385B1 (en) * 1999-05-21 2006-07-19 Cargill Dow LLC Methods and materials for the synthesis of organic products
US7374905B2 (en) * 2000-11-08 2008-05-20 Oxyrase, Inc. Medium composition, method and device for selectively enhancing the isolation of anaerobic microorganisms contained in a mixed sample with facultative microorganisms
WO2002042471A2 (en) * 2000-11-22 2002-05-30 Cargill Dow Polymers Llc Methods and materials for the synthesis of organic products
US7141410B2 (en) * 2000-11-22 2006-11-28 Natureworks Llc Methods and materials for the production of organic products in cells of Candida species
US7140438B2 (en) 2003-08-14 2006-11-28 Halliburton Energy Services, Inc. Orthoester compositions and methods of use in subterranean applications
US7080688B2 (en) 2003-08-14 2006-07-25 Halliburton Energy Services, Inc. Compositions and methods for degrading filter cake
US7276466B2 (en) 2001-06-11 2007-10-02 Halliburton Energy Services, Inc. Compositions and methods for reducing the viscosity of a fluid
US7168489B2 (en) 2001-06-11 2007-01-30 Halliburton Energy Services, Inc. Orthoester compositions and methods for reducing the viscosified treatment fluids
EP1281766B1 (en) 2001-07-16 2008-06-04 Canon Kabushiki Kaisha Process for producing polyester, process for producing substituted alpha-hydroxy acid, and Clostridium beijerinckii strain HICA432
GB0117551D0 (en) * 2001-07-18 2001-09-12 Elsworth Biotech Ltd Lastic acid production
JP2003093060A (en) * 2001-09-20 2003-04-02 Toyota Motor Corp Method for producing organic acids and alcohols using acid-resistant microorganisms
BRPI0214366B1 (en) * 2001-11-23 2016-03-22 Cargill Dow Llc Candida cell and methods for producing one or more isocitrate, alpha-ketoglutarate, lactate, succinate, malate, fumarate, oxaloacetate, citrate and acrylate, and for producing a cell
US7216711B2 (en) 2002-01-08 2007-05-15 Halliburton Eenrgy Services, Inc. Methods of coating resin and blending resin-coated proppant
US7267171B2 (en) 2002-01-08 2007-09-11 Halliburton Energy Services, Inc. Methods and compositions for stabilizing the surface of a subterranean formation
US7343973B2 (en) 2002-01-08 2008-03-18 Halliburton Energy Services, Inc. Methods of stabilizing surfaces of subterranean formations
US6691780B2 (en) 2002-04-18 2004-02-17 Halliburton Energy Services, Inc. Tracking of particulate flowback in subterranean wells
US8507253B2 (en) 2002-05-13 2013-08-13 Algae Systems, LLC Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby
CN1735691B (en) 2002-05-30 2010-05-26 卡吉尔道有限责任公司 Fermentation method using specific oxygen absorption rate as process control
GB0222846D0 (en) 2002-10-03 2002-11-06 Choo Yen Cell culture
US20040211561A1 (en) 2003-03-06 2004-10-28 Nguyen Philip D. Methods and compositions for consolidating proppant in fractures
US7114570B2 (en) 2003-04-07 2006-10-03 Halliburton Energy Services, Inc. Methods and compositions for stabilizing unconsolidated subterranean formations
PL2338895T3 (en) 2003-05-02 2013-11-29 Cargill Inc Genetically modified yeast species and fermentation processes using genetically modified yeast
US7405068B2 (en) 2003-05-02 2008-07-29 Tate & Lyle Ingredients Americas, Inc. Pyruvate producing yeast strain
AU2004241394B2 (en) * 2003-05-22 2008-05-22 Teijin Limited DNA coding for protein having D-lactic acid dehydrogenase activity and use thereof
US6978836B2 (en) 2003-05-23 2005-12-27 Halliburton Energy Services, Inc. Methods for controlling water and particulate production
US7413010B2 (en) 2003-06-23 2008-08-19 Halliburton Energy Services, Inc. Remediation of subterranean formations using vibrational waves and consolidating agents
US7114560B2 (en) 2003-06-23 2006-10-03 Halliburton Energy Services, Inc. Methods for enhancing treatment fluid placement in a subterranean formation
US7013976B2 (en) 2003-06-25 2006-03-21 Halliburton Energy Services, Inc. Compositions and methods for consolidating unconsolidated subterranean formations
US7178596B2 (en) * 2003-06-27 2007-02-20 Halliburton Energy Services, Inc. Methods for improving proppant pack permeability and fracture conductivity in a subterranean well
US7036587B2 (en) 2003-06-27 2006-05-02 Halliburton Energy Services, Inc. Methods of diverting treating fluids in subterranean zones and degradable diverting materials
US7228904B2 (en) 2003-06-27 2007-06-12 Halliburton Energy Services, Inc. Compositions and methods for improving fracture conductivity in a subterranean well
US7044224B2 (en) 2003-06-27 2006-05-16 Halliburton Energy Services, Inc. Permeable cement and methods of fracturing utilizing permeable cement in subterranean well bores
US7044220B2 (en) * 2003-06-27 2006-05-16 Halliburton Energy Services, Inc. Compositions and methods for improving proppant pack permeability and fracture conductivity in a subterranean well
US7032663B2 (en) 2003-06-27 2006-04-25 Halliburton Energy Services, Inc. Permeable cement and sand control methods utilizing permeable cement in subterranean well bores
US7021379B2 (en) 2003-07-07 2006-04-04 Halliburton Energy Services, Inc. Methods and compositions for enhancing consolidation strength of proppant in subterranean fractures
US7066258B2 (en) 2003-07-08 2006-06-27 Halliburton Energy Services, Inc. Reduced-density proppants and methods of using reduced-density proppants to enhance their transport in well bores and fractures
US7497278B2 (en) 2003-08-14 2009-03-03 Halliburton Energy Services, Inc. Methods of degrading filter cakes in a subterranean formation
US8541051B2 (en) 2003-08-14 2013-09-24 Halliburton Energy Services, Inc. On-the fly coating of acid-releasing degradable material onto a particulate
US7156194B2 (en) 2003-08-26 2007-01-02 Halliburton Energy Services, Inc. Methods of drilling and consolidating subterranean formation particulate
US7017665B2 (en) 2003-08-26 2006-03-28 Halliburton Energy Services, Inc. Strengthening near well bore subterranean formations
US7237609B2 (en) 2003-08-26 2007-07-03 Halliburton Energy Services, Inc. Methods for producing fluids from acidized and consolidated portions of subterranean formations
US7059406B2 (en) 2003-08-26 2006-06-13 Halliburton Energy Services, Inc. Production-enhancing completion methods
US6997259B2 (en) 2003-09-05 2006-02-14 Halliburton Energy Services, Inc. Methods for forming a permeable and stable mass in a subterranean formation
US7032667B2 (en) 2003-09-10 2006-04-25 Halliburtonn Energy Services, Inc. Methods for enhancing the consolidation strength of resin coated particulates
US7021377B2 (en) 2003-09-11 2006-04-04 Halliburton Energy Services, Inc. Methods of removing filter cake from well producing zones
US7829507B2 (en) 2003-09-17 2010-11-09 Halliburton Energy Services Inc. Subterranean treatment fluids comprising a degradable bridging agent and methods of treating subterranean formations
US7833944B2 (en) 2003-09-17 2010-11-16 Halliburton Energy Services, Inc. Methods and compositions using crosslinked aliphatic polyesters in well bore applications
US7674753B2 (en) 2003-09-17 2010-03-09 Halliburton Energy Services, Inc. Treatment fluids and methods of forming degradable filter cakes comprising aliphatic polyester and their use in subterranean formations
CN101654666B (en) * 2003-09-30 2012-11-14 三井化学株式会社 Biocatalyst for production of d-lactic acid
US7345011B2 (en) 2003-10-14 2008-03-18 Halliburton Energy Services, Inc. Methods for mitigating the production of water from subterranean formations
US20050112737A1 (en) * 2003-11-20 2005-05-26 A. E. Staley Manufacturing Co. Lactic acid producing yeast
US7063150B2 (en) 2003-11-25 2006-06-20 Halliburton Energy Services, Inc. Methods for preparing slurries of coated particulates
US7195068B2 (en) 2003-12-15 2007-03-27 Halliburton Energy Services, Inc. Filter cake degradation compositions and methods of use in subterranean operations
US7131493B2 (en) 2004-01-16 2006-11-07 Halliburton Energy Services, Inc. Methods of using sealants in multilateral junctions
US7096947B2 (en) 2004-01-27 2006-08-29 Halliburton Energy Services, Inc. Fluid loss control additives for use in fracturing subterranean formations
US7036586B2 (en) 2004-01-30 2006-05-02 Halliburton Energy Services, Inc. Methods of cementing in subterranean formations using crack resistant cement compositions
US7156174B2 (en) 2004-01-30 2007-01-02 Halliburton Energy Services, Inc. Contained micro-particles for use in well bore operations
US7204312B2 (en) 2004-01-30 2007-04-17 Halliburton Energy Services, Inc. Compositions and methods for the delivery of chemical components in subterranean well bores
US20050173116A1 (en) 2004-02-10 2005-08-11 Nguyen Philip D. Resin compositions and methods of using resin compositions to control proppant flow-back
US7211547B2 (en) 2004-03-03 2007-05-01 Halliburton Energy Services, Inc. Resin compositions and methods of using such resin compositions in subterranean applications
US7063151B2 (en) 2004-03-05 2006-06-20 Halliburton Energy Services, Inc. Methods of preparing and using coated particulates
US7172022B2 (en) 2004-03-17 2007-02-06 Halliburton Energy Services, Inc. Cement compositions containing degradable materials and methods of cementing in subterranean formations
DK1756292T3 (en) 2004-03-31 2014-10-27 Cargill Inc PROCEDURE FOR FERMENTING SUGAR CONTAINING OLIGOMERIC SUCCHARIDES
US7541318B2 (en) 2004-05-26 2009-06-02 Halliburton Energy Services, Inc. On-the-fly preparation of proppant and its use in subterranean operations
AU2005250074B2 (en) * 2004-06-04 2011-04-14 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
US7299875B2 (en) 2004-06-08 2007-11-27 Halliburton Energy Services, Inc. Methods for controlling particulate migration
US7073581B2 (en) 2004-06-15 2006-07-11 Halliburton Energy Services, Inc. Electroconductive proppant compositions and related methods
JP2006006271A (en) * 2004-06-29 2006-01-12 Toyota Central Res & Dev Lab Inc Lactic acid producing yeast and lactic acid producing method
US7547665B2 (en) 2005-04-29 2009-06-16 Halliburton Energy Services, Inc. Acidic treatment fluids comprising scleroglucan and/or diutan and associated methods
US7621334B2 (en) 2005-04-29 2009-11-24 Halliburton Energy Services, Inc. Acidic treatment fluids comprising scleroglucan and/or diutan and associated methods
US7475728B2 (en) 2004-07-23 2009-01-13 Halliburton Energy Services, Inc. Treatment fluids and methods of use in subterranean formations
US7299869B2 (en) 2004-09-03 2007-11-27 Halliburton Energy Services, Inc. Carbon foam particulates and methods of using carbon foam particulates in subterranean applications
US7281580B2 (en) 2004-09-09 2007-10-16 Halliburton Energy Services, Inc. High porosity fractures and methods of creating high porosity fractures
US7255169B2 (en) 2004-09-09 2007-08-14 Halliburton Energy Services, Inc. Methods of creating high porosity propped fractures
US7413017B2 (en) 2004-09-24 2008-08-19 Halliburton Energy Services, Inc. Methods and compositions for inducing tip screenouts in frac-packing operations
US7757768B2 (en) 2004-10-08 2010-07-20 Halliburton Energy Services, Inc. Method and composition for enhancing coverage and displacement of treatment fluids into subterranean formations
US7648946B2 (en) 2004-11-17 2010-01-19 Halliburton Energy Services, Inc. Methods of degrading filter cakes in subterranean formations
US7553800B2 (en) 2004-11-17 2009-06-30 Halliburton Energy Services, Inc. In-situ filter cake degradation compositions and methods of use in subterranean formations
US7281581B2 (en) 2004-12-01 2007-10-16 Halliburton Energy Services, Inc. Methods of hydraulic fracturing and of propping fractures in subterranean formations
US7273099B2 (en) 2004-12-03 2007-09-25 Halliburton Energy Services, Inc. Methods of stimulating a subterranean formation comprising multiple production intervals
US7398825B2 (en) 2004-12-03 2008-07-15 Halliburton Energy Services, Inc. Methods of controlling sand and water production in subterranean zones
US7883740B2 (en) 2004-12-12 2011-02-08 Halliburton Energy Services, Inc. Low-quality particulates and methods of making and using improved low-quality particulates
US7334635B2 (en) 2005-01-14 2008-02-26 Halliburton Energy Services, Inc. Methods for fracturing subterranean wells
US20060169182A1 (en) 2005-01-28 2006-08-03 Halliburton Energy Services, Inc. Methods and compositions relating to the hydrolysis of water-hydrolysable materials
US8030249B2 (en) 2005-01-28 2011-10-04 Halliburton Energy Services, Inc. Methods and compositions relating to the hydrolysis of water-hydrolysable materials
US20080009423A1 (en) 2005-01-31 2008-01-10 Halliburton Energy Services, Inc. Self-degrading fibers and associated methods of use and manufacture
US7267170B2 (en) 2005-01-31 2007-09-11 Halliburton Energy Services, Inc. Self-degrading fibers and associated methods of use and manufacture
US7497258B2 (en) 2005-02-01 2009-03-03 Halliburton Energy Services, Inc. Methods of isolating zones in subterranean formations using self-degrading cement compositions
US7353876B2 (en) 2005-02-01 2008-04-08 Halliburton Energy Services, Inc. Self-degrading cement compositions and methods of using self-degrading cement compositions in subterranean formations
US8598092B2 (en) 2005-02-02 2013-12-03 Halliburton Energy Services, Inc. Methods of preparing degradable materials and methods of use in subterranean formations
US7334636B2 (en) 2005-02-08 2008-02-26 Halliburton Energy Services, Inc. Methods of creating high-porosity propped fractures using reticulated foam
US7506689B2 (en) 2005-02-22 2009-03-24 Halliburton Energy Services, Inc. Fracturing fluids comprising degradable diverting agents and methods of use in subterranean formations
US7216705B2 (en) 2005-02-22 2007-05-15 Halliburton Energy Services, Inc. Methods of placing treatment chemicals
US7318473B2 (en) 2005-03-07 2008-01-15 Halliburton Energy Services, Inc. Methods relating to maintaining the structural integrity of deviated well bores
US7448451B2 (en) 2005-03-29 2008-11-11 Halliburton Energy Services, Inc. Methods for controlling migration of particulates in a subterranean formation
US7673686B2 (en) 2005-03-29 2010-03-09 Halliburton Energy Services, Inc. Method of stabilizing unconsolidated formation for sand control
US7608567B2 (en) 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7677315B2 (en) 2005-05-12 2010-03-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7662753B2 (en) 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
BRPI0610951A2 (en) 2005-06-02 2010-08-03 Cargill Inc genetically modified yeast of issatchenkia orientalis and closely related species and fermentation processes using them
US7318474B2 (en) 2005-07-11 2008-01-15 Halliburton Energy Services, Inc. Methods and compositions for controlling formation fines and reducing proppant flow-back
US7484564B2 (en) 2005-08-16 2009-02-03 Halliburton Energy Services, Inc. Delayed tackifying compositions and associated methods involving controlling particulate migration
US7595280B2 (en) 2005-08-16 2009-09-29 Halliburton Energy Services, Inc. Delayed tackifying compositions and associated methods involving controlling particulate migration
JP2007061024A (en) * 2005-08-31 2007-03-15 Neo-Morgan Laboratory Inc Organism excellent in resistance to lactic acid and method for preparing organism excellent in resistance to lactic acid
ATE472606T1 (en) 2005-09-19 2010-07-15 Basf Se BIOCATALYTIC PRODUCTION OF (METH-)ACRYLIC ACID ESTERS
US7713916B2 (en) 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
WO2007038130A2 (en) 2005-09-22 2007-04-05 Tate & Lyle Ingredients Americas, Inc. Improved strains for the production of organic acids
EP1975232A4 (en) * 2005-10-14 2009-07-29 Toray Industries Yeast and method of producing l-lactic acid
US7461697B2 (en) 2005-11-21 2008-12-09 Halliburton Energy Services, Inc. Methods of modifying particulate surfaces to affect acidic sites thereon
US8137953B2 (en) * 2005-11-23 2012-03-20 Cargill Inc. Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells
US7431088B2 (en) 2006-01-20 2008-10-07 Halliburton Energy Services, Inc. Methods of controlled acidization in a wellbore
US8613320B2 (en) 2006-02-10 2013-12-24 Halliburton Energy Services, Inc. Compositions and applications of resins in treating subterranean formations
US7926591B2 (en) 2006-02-10 2011-04-19 Halliburton Energy Services, Inc. Aqueous-based emulsified consolidating agents suitable for use in drill-in applications
US7819192B2 (en) 2006-02-10 2010-10-26 Halliburton Energy Services, Inc. Consolidating agent emulsions and associated methods
US7665517B2 (en) 2006-02-15 2010-02-23 Halliburton Energy Services, Inc. Methods of cleaning sand control screens and gravel packs
KR100725021B1 (en) * 2006-02-16 2007-06-07 주식회사 마크로젠 Mass production methods, mass production strains and methods for their production of primary metabolites
EP2586313B1 (en) 2006-03-13 2017-02-22 Cargill, Incorporated Fermentation process using yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol
US7407010B2 (en) 2006-03-16 2008-08-05 Halliburton Energy Services, Inc. Methods of coating particulates
US7237610B1 (en) 2006-03-30 2007-07-03 Halliburton Energy Services, Inc. Degradable particulates as friction reducers for the flow of solid particulates and associated methods of use
US7608566B2 (en) 2006-03-30 2009-10-27 Halliburton Energy Services, Inc. Degradable particulates as friction reducers for the flow of solid particulates and associated methods of use
JP5410089B2 (en) * 2006-05-29 2014-02-05 株式会社カネカ A method for producing an optically active amine compound, a recombinant vector, and a transformant containing the vector.
US7500521B2 (en) 2006-07-06 2009-03-10 Halliburton Energy Services, Inc. Methods of enhancing uniform placement of a resin in a subterranean formation
US8110395B2 (en) 2006-07-10 2012-02-07 Algae Systems, LLC Photobioreactor systems and methods for treating CO2-enriched gas and producing biomass
CN104962586A (en) 2006-07-21 2015-10-07 希乐克公司 Biomass conversion system
US8329621B2 (en) 2006-07-25 2012-12-11 Halliburton Energy Services, Inc. Degradable particulates and associated methods
US7678743B2 (en) 2006-09-20 2010-03-16 Halliburton Energy Services, Inc. Drill-in fluids and associated methods
US7687438B2 (en) 2006-09-20 2010-03-30 Halliburton Energy Services, Inc. Drill-in fluids and associated methods
US7678742B2 (en) 2006-09-20 2010-03-16 Halliburton Energy Services, Inc. Drill-in fluids and associated methods
US7455112B2 (en) 2006-09-29 2008-11-25 Halliburton Energy Services, Inc. Methods and compositions relating to the control of the rates of acid-generating compounds in acidizing operations
WO2008054609A2 (en) * 2006-10-04 2008-05-08 The Regents Of The University Of Michigan Dissolution and precipitation of cocrystals with ionizable components
US7686080B2 (en) 2006-11-09 2010-03-30 Halliburton Energy Services, Inc. Acid-generating fluid loss control additives and associated methods
WO2008133665A2 (en) 2006-12-07 2008-11-06 Massachusetts Institute Of Technology Global transcription machinery engineering
CA2715092A1 (en) * 2006-12-21 2008-07-03 Gevo, Inc. Butanol production by metabolically engineered yeast
US8220548B2 (en) 2007-01-12 2012-07-17 Halliburton Energy Services Inc. Surfactant wash treatment fluids and associated methods
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
AP2009005054A0 (en) 2007-04-27 2009-12-31 Greenfuel Technologies Corp Photobioreactor systems positioned on bodies of water
CA2696018A1 (en) * 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of olefins and derivatives
JP2011509691A (en) 2008-01-22 2011-03-31 ジェノマティカ， インコーポレイテッド Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CN106119112B (en) 2008-03-27 2021-07-13 基因组股份公司 Microorganisms for the production of adipic acid and other compounds
US8006760B2 (en) 2008-04-10 2011-08-30 Halliburton Energy Services, Inc. Clean fluid systems for partial monolayer fracturing
JP4963488B2 (en) 2008-04-23 2012-06-27 トヨタ自動車株式会社 Mutant yeast and substance production method using the same
AU2009242615A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
US7906464B2 (en) 2008-05-13 2011-03-15 Halliburton Energy Services, Inc. Compositions and methods for the removal of oil-based filtercakes
JP2011522543A (en) * 2008-06-04 2011-08-04 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー Method for producing butanol using two-phase extractive fermentation
EP2304039B1 (en) 2008-06-17 2019-08-21 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
DE102008029302B4 (en) * 2008-06-19 2016-08-11 Insilico Biotechnology Ag Biotechnological production of acrylic acid
US20110151528A1 (en) * 2008-06-30 2011-06-23 Toyota Jidosha Kabushiki Kaisha Process for producing organic acid
CA2730595C (en) * 2008-07-08 2014-12-16 Dsm Ip Assets B.V. Low ph dicarboxylic acid production
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
US7833943B2 (en) 2008-09-26 2010-11-16 Halliburton Energy Services Inc. Microemulsifiers and methods of making and using same
CA2746952A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
US7998910B2 (en) 2009-02-24 2011-08-16 Halliburton Energy Services, Inc. Treatment fluids comprising relative permeability modifiers and methods of use
CA2754470A1 (en) * 2009-03-13 2010-09-16 Mascoma Corporation Mesophilic and thermophilic organisms modified to produce acrylate, and methods of use thereof
EP2233562A1 (en) 2009-03-24 2010-09-29 Metabolic Explorer Method for producing high amount of glycolic acid by fermentation
KR20120068763A (en) 2009-04-30 2012-06-27 게노마티카 인코포레이티드 Organisms for the production of isopropanol, n-butanol, and isobutanol
JP5876822B2 (en) 2009-04-30 2016-03-02 ゲノマチカ， インク． Organisms for the production of 1,3-butanediol
AU2010245687A1 (en) 2009-05-07 2011-11-24 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
WO2010132845A1 (en) * 2009-05-15 2010-11-18 Genomatica, Inc. Organisms for the production of cyclohexanone
EP2440669A4 (en) 2009-06-10 2013-08-28 Genomatica Inc Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
US8082992B2 (en) 2009-07-13 2011-12-27 Halliburton Energy Services, Inc. Methods of fluid-controlled geometry stimulation
EP2462221B1 (en) 2009-08-05 2017-02-22 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
WO2011031897A1 (en) 2009-09-09 2011-03-17 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
DE102009029651A1 (en) * 2009-09-22 2011-03-24 Evonik Röhm Gmbh Process for the preparation of free carboxylic acids
MX2012004291A (en) 2009-10-13 2012-08-17 Genomatica Inc Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto.
WO2011050326A1 (en) * 2009-10-23 2011-04-28 Genomatica, Inc. Microorganisms for the production of aniline
US20110183389A1 (en) * 2009-10-26 2011-07-28 Van Walsum G Peter Production of lactic acid from hemicellulose extracts
SG181607A1 (en) 2009-12-10 2012-07-30 Genomatica Inc Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
US20110183382A1 (en) * 2009-12-15 2011-07-28 Qteros, Inc. Methods and compositions for producing chemical products from c. phytofermentans
AU2011209862A1 (en) 2010-01-29 2012-07-26 Genomatica, Inc. Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR20190006103A (en) 2010-05-05 2019-01-16 게노마티카 인코포레이티드 Microorganisms and methods for the biosynthsis of butadiene
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
CN103025877A (en) 2010-07-26 2013-04-03 基因组股份公司 Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
KR20130119945A (en) 2010-11-22 2013-11-01 노보자임스 인코포레이티드 Compositions and methods for 3-hydroxypropionic acid production
ES2645680T3 (en) 2010-11-22 2017-12-07 Cargill, Incorporated Yeast cells and process to convert acetaldehyde into ethanol
WO2012103261A2 (en) 2011-01-25 2012-08-02 Finley Kenneth R Compositions and methods for succinate production
EP2697252B1 (en) 2011-04-11 2016-08-10 Cargill, Incorporated Compositions and methods for increased ethanol production from biomass
EP2877568B1 (en) 2012-07-25 2021-04-28 Cargill, Incorporated Yeast cells having reductive tca pathway from pyruvate to succinate and overexpressing an exogenous nad(p)+ transhydrogenase enzyme
CA2884266C (en) 2012-09-14 2022-05-24 Myriant Corporation Production of organic acids by fermentation at low ph
WO2014076232A2 (en) 2012-11-19 2014-05-22 Novozymes A/S Isopropanol production by recombinant hosts using an hmg-coa intermediate
CA2891130A1 (en) 2012-11-30 2014-06-05 Novozymes, Inc. 3-hydroxypropionic acid production by recombinant yeasts
CA2893940C (en) 2012-12-10 2021-11-02 Cargill, Incorporated Batch feed process for fermenting sugars
TW201437367A (en) 2013-03-29 2014-10-01 Far Eastern New Century Corp Yeast strain for lactic acid production by using pentose and hexose
CN103194496A (en) * 2013-04-09 2013-07-10 天津科技大学 Residual sugar control method for producing alpha-ketoglutaric acid by fermentation method
EP3011017B1 (en) * 2013-06-18 2019-09-11 Calysta, Inc. Compositions and methods for biological production of lactate from c1 compounds using lactate dehydrogenase transformants
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN105431520A (en) 2013-07-31 2016-03-23 诺维信公司 3-Hydroxypropionate Production Using Recombinant Yeast Expressing Insect Aspartate 1-Decarboxylase
KR102208959B1 (en) * 2013-08-09 2021-01-28 삼성전자주식회사 Yeast cell with activated lactate dehydrogenase and method for producing lactate using the same
KR101577134B1 (en) * 2014-05-09 2015-12-14 씨제이제일제당 (주) A microorganism having enhanced productivity of lactic acid and a process for producing lactic acid using the same
KR101689004B1 (en) * 2014-06-20 2016-12-23 한국생명공학연구원 Kluyveromyces marxianus deficient in the lactic acid utilization pathway and use thereof
KR102277898B1 (en) 2014-07-03 2021-07-15 삼성전자주식회사 Yeast having a improved product productivity and method of producint the product
KR20160046615A (en) 2014-10-21 2016-04-29 삼성전자주식회사 Polyurethane elastomer, thermoplastic resin composition comprising polyurethane elastomer, molding made of thermoplastic resin composition and preparation method of polyurethane elastomer
EP3274461A1 (en) 2015-03-27 2018-01-31 Cargill, Incorporated Glucoamylase-modified yeast strains and methods for bioproduct production
US20180179499A1 (en) 2015-06-04 2018-06-28 Bioamber Inc. Biobased production of functionalized alpha-substituted acrylates and c4-dicarboxylates
KR101704212B1 (en) 2015-06-12 2017-02-08 씨제이제일제당 (주) A microorganism producing lactic acid and method for producing lactic acid using the same
WO2017003387A2 (en) * 2015-06-29 2017-01-05 Ptt Global Chemical Public Company Limited Process for producing lactic acid or its salts from fermentation using thermotolerance bacillus bacteria
BR112018002284A2 (en) 2015-08-05 2018-12-11 Cargill Inc fermentation method to produce a bioproduct, genetically engineered negative crabtree yeast and method to reduce glycerol production by an engineered yeast
US20180265902A1 (en) 2015-08-24 2018-09-20 Novozymes A/S Beta-Alanine Aminotransferases For The Production of 3-Hydroxypropionic Acid
CN105177065B (en) * 2015-09-11 2019-07-23 浙江树人大学 A kind of method of biotransformation method synthesis α-ketoglutaric acid
BR112018010384A2 (en) 2015-11-24 2018-12-04 Cargill Inc genetically modified yeast and process for making a fermentation product
CN108431229A (en) 2015-12-17 2018-08-21 嘉吉公司 The yeast strain of saccharide transporter modification and the method produced for biological products
EP3485004B1 (en) 2016-07-13 2021-09-22 DSM IP Assets B.V. Malate dehyrogenases
JP6994821B2 (en) * 2016-08-02 2022-01-14 三菱商事ライフサイエンス株式会社 Reduction of ethanol production in continuous culture of Saccharomyces cerevisiae
CN109661403A (en) 2016-08-05 2019-04-19 嘉吉公司 The yeast strain for the engineering that the glucoamylase polypeptide of leader sequence modification and the biologic with enhancing generate
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
US11718820B2 (en) 2017-08-17 2023-08-08 Cargill, Incorporated Genetically modified haploid Issatchenkia orientalis
KR102691949B1 (en) * 2018-02-16 2024-08-06 피티티 글로벌 케미칼 피씨엘 Microorganisms and methods for producing lactic acid
CN109280652A (en) * 2018-09-13 2019-01-29 四川自豪时代药业有限公司 A kind of fermentation process in high density of external source height expression lactic dehydrogenase enzyme mutant
CN114009751B (en) * 2021-11-16 2024-03-26 上海昌进生物科技有限公司 Composition, preparation method and application thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39710A (en) 1972-06-19 1975-04-25 Imi Inst For Res & Dev Recovery of acids from aqueous solutions by solvent extraction
US4943529A (en) 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
JP2608540B2 (en) 1982-05-19 1997-05-07 ギスト ブロカデス ナ−ムロ−ゼ フエンノ−トチヤツプ Cloning system for Kluyveromyces species
FR2532656B2 (en) 1982-06-02 1985-10-18 Elf Bio Rech NEW CLONING AND EXPRESSION VECTOR, YEAST AND BACTERIA TRANSFORMED BY THIS VECTOR
US5882884A (en) 1987-06-19 1999-03-16 Lucky Biotech Corporation Expression of proteinaceous sweeteners in yeast
JPH0650979B2 (en) * 1988-11-24 1994-07-06 農林水産省食品総合研究所長 Method for producing baker's yeast
US5866382A (en) 1990-04-06 1999-02-02 Xyrofin Oy Xylose utilization by recombinant yeasts
US5639949A (en) 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
FR2692591B1 (en) * 1992-06-23 1995-06-09 Agronomique Inst Nat Rech YEAST STRAINS EXPRESSING THE GENE OF LACTIC LDH, AND VECTORS FOR USE IN OBTAINING SAID STRAINS.
FR2693463B1 (en) * 1992-07-08 1994-09-02 Rhone Poulenc Rorer Sa Yeast promoter and its use.
AT398982B (en) 1993-02-18 1995-02-27 Vogelbusch Gmbh METHOD FOR SEPARATING AND PURIFYING LACTIC ACID
US5876951A (en) 1993-03-31 1999-03-02 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates and uses therefor
US5789184A (en) 1993-03-31 1998-08-04 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
IL109003A (en) 1994-03-16 1999-09-22 Yissum Res Dev Co Process and extractant composition for extracting water-soluble carboxylic and mineral acids
US5843760A (en) 1994-04-15 1998-12-01 Midwest Research Institute Single zymomonas mobilis strain for xylose and arabinose fermentation
GB9411356D0 (en) 1994-06-07 1994-07-27 Delta Biotechnology Ltd Yeast strains
US5770435A (en) * 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
DE19544233A1 (en) 1995-11-28 1997-06-05 Hoechst Ag Process for using the yeast ADH II promoter system for the biotechnological production of heterologous proteins in high yields
JPH09262089A (en) * 1996-03-28 1997-10-07 Oriental Yeast Co Ltd DNA encoding the B-type subunit of chicken lactate dehydrogenase
CA2274150A1 (en) * 1996-12-12 1998-06-18 Universiteit Van Amsterdam Methods for modulating metabolic pathways of micro-organisms and micro-organisms obtainable by said methods
ES2357027T3 (en) * 1997-05-30 2011-04-15 Chr. Hansen A/S METHOD THAT USES A BACTERIAL LACTIC ACID CEPA.
IT1294728B1 (en) * 1997-09-12 1999-04-12 Biopolo S C A R L YEAST STRAWS FOR THE REPRODUCTION OF LACTIC ACID
WO2000014258A1 (en) * 1998-09-09 2000-03-16 Novo Nordisk A/S Method for the production of heterologous polypeptides in transformed yeast cells
EP1183385B1 (en) * 1999-05-21 2006-07-19 Cargill Dow LLC Methods and materials for the synthesis of organic products
WO2002042471A2 (en) * 2000-11-22 2002-05-30 Cargill Dow Polymers Llc Methods and materials for the synthesis of organic products

Also Published As

Publication number Publication date
DE60029440D1 (en) 2006-08-31
UA77386C2 (en) 2006-12-15
US7700332B1 (en) 2010-04-20
JP2003500062A (en) 2003-01-07
AU5034400A (en) 2000-12-12
US6485947B1 (en) 2002-11-26
CN100347308C (en) 2007-11-07
BR0010806A (en) 2002-06-04
HUP0201204A2 (en) 2002-08-28
AU780135B2 (en) 2005-03-03
PT1183385E (en) 2006-11-30
WO2000071738A1 (en) 2000-11-30
NO20015688L (en) 2002-01-21
CZ299320B6 (en) 2008-06-18
YU83101A (en) 2004-07-15
CN1367841A (en) 2002-09-04
EP1183385B1 (en) 2006-07-19
DE60029440T2 (en) 2007-02-08
EP1183385A1 (en) 2002-03-06
BR0010806B1 (en) 2014-02-18
KR20020048910A (en) 2002-06-24
HUP0201204A3 (en) 2004-07-28
ATE333509T1 (en) 2006-08-15
US7229805B2 (en) 2007-06-12
RS49895B (en) 2008-08-07
US20040029238A1 (en) 2004-02-12
NO326775B1 (en) 2009-02-16
PL352434A1 (en) 2003-08-25
NO20015688D0 (en) 2001-11-21
CA2374482C (en) 2012-09-18
JP4637372B2 (en) 2011-02-23
CZ20014090A3 (en) 2002-06-12
HK1045174A1 (en) 2002-11-15

Similar Documents

Publication Publication Date Title
CA2374482A1 (en) Methods and materials for the synthesis of organic products
AU724822B2 (en) A mutant E.coli strain with increased succinic acid production
EP2878675B1 (en) Fermentation process using specific oxygen uptake rates as a process control
EP1012323B1 (en) A method for the production of dicarboxylic acids
Lee et al. Isolation and characterization of mutant strains of Escherichia coli altered in H2 metabolism
JP2005528111A5 (en)
JP2012506716A (en) Microaerobic culture for converting glycerol to chemicals
Kim et al. Deletion of glycerol-3-phosphate dehydrogenase genes improved 2, 3-butanediol production by reducing glycerol production in pyruvate decarboxylase-deficient Saccharomyces cerevisiae
Kapat et al. Improvement of extracellular recombinant glucose oxidase production in fed-batch culture of Saccharomyces cerevisiae: Effect of different feeding strategies
CN102618478B (en) Strain producing dynamic controlling recombinant strain and method for preparing D-lactic acid with recombinant strain
CN117402803A (en) Bacillus subtilis genetically engineered bacterium for high yield of D-pantothenic acid, construction method and application
Hahn-Hägerdal et al. Azide sterilization of fermentation media: ethanol production from glucose using immobilized Saccharomyces cerevisiae
Lee et al. Production of poly (β-hydroxybutyrate-co-β-hydroxyvalerate) from glucose and valerate in Alcaligenes eutrophus
CN118620969A (en) A two-stage biological method for producing xylitol using hemicellulose hydrolysate
JP2005102625A (en) Method for producing d-lactic acid
Berrı́os-Rivera et al. Effect of glucose analog supplementation on metabolic flux distribution in anaerobic chemostat cultures of Escherichia coli
CN120536333A (en) A ferulic acid-tolerant Corynebacterium glutamicum genetically engineered bacterium and its construction and application
JP2000060548A (en) Method of controlling metabolism by electrochemical method

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200519