CA2374000A1 - Utilisation de molecules proteiniques solubles exprimees par le pancreas et le glomerule de malpighi - Google Patents

Utilisation de molecules proteiniques solubles exprimees par le pancreas et le glomerule de malpighi Download PDF

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Publication number
CA2374000A1
CA2374000A1 CA002374000A CA2374000A CA2374000A1 CA 2374000 A1 CA2374000 A1 CA 2374000A1 CA 002374000 A CA002374000 A CA 002374000A CA 2374000 A CA2374000 A CA 2374000A CA 2374000 A1 CA2374000 A1 CA 2374000A1
Authority
CA
Canada
Prior art keywords
nephrin
molecules
soluble
leu
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002374000A
Other languages
English (en)
Inventor
Harry Holthofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GLOMEGA Inc Oy
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2374000A1 publication Critical patent/CA2374000A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

L'invention concerne des molécules de type néphrine solubles exprimées par le pancréas et les reins et des séquences d'acides nucléiques codant pour ces molécules de type néphrine, comprenant un ADNc codant pour une néphrine humaine ainsi que des substances de liaison capables de reconnaître et de lier de manière spécifique ces molécules de type néphrine. Ces molécules sont utiles pour fabriquer des moyens de détermination diagnostique, de susceptibilité au criblage, de traitements préventif et thérapeutique du diabète et d'autre néphropathies, du diabète sucré ainsi que d'autres maladies pancréatiques inflammatoires et néoplasiques. L'invention est caractérisée en ce que les molécules de type néphrine solubles et les subsistances de liaison permettant de reconnaître ces molécules de type néphrine solubles peuvent être utilisées lors de l'évaluation diagnostique à partir d'un prélèvement de sang, de sérum et/ou d'urine.
CA002374000A 1999-06-15 2000-06-15 Utilisation de molecules proteiniques solubles exprimees par le pancreas et le glomerule de malpighi Abandoned CA2374000A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI991369A FI991369A0 (fi) 1999-06-15 1999-06-15 Haiman ja munuaiskeräsen ilmentäminen liukoisten proteiinimolekyylien käyttö
FI991369 1999-06-15
PCT/FI2000/000540 WO2000077044A1 (fr) 1999-06-15 2000-06-15 Utilisation de molecules proteiniques solubles exprimees par le pancreas et le glomerule de malpighi

Publications (1)

Publication Number Publication Date
CA2374000A1 true CA2374000A1 (fr) 2000-12-21

Family

ID=8554889

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002374000A Abandoned CA2374000A1 (fr) 1999-06-15 2000-06-15 Utilisation de molecules proteiniques solubles exprimees par le pancreas et le glomerule de malpighi

Country Status (6)

Country Link
EP (1) EP1185556A1 (fr)
AU (1) AU5225300A (fr)
CA (1) CA2374000A1 (fr)
FI (1) FI991369A0 (fr)
HK (1) HK1044781A1 (fr)
WO (1) WO2000077044A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198959A1 (en) * 2002-03-28 2003-10-23 Kurnit David M. Methods and compositions for analysis of urine samples in the diagnosis and treatment of kidney diseases
FI20021406A0 (fi) * 2002-07-24 2002-07-24 Glomega Inc Oy Densiinitapaisten yhdisteiden käyttö
WO2011129768A1 (fr) * 2010-04-12 2011-10-20 National University Of Singapore Marqueur biologique de la fonction rénale de patients atteints de diabète de type 2
CA3199237A1 (fr) * 2020-10-22 2022-04-28 The Brigham And Women's Hospital, Inc. Procedes d'identification et methodes de traitement du syndrome nephrotique idiopathique primaire ou recurrent acquis a mediation par des anticorps

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207811B1 (en) * 1998-03-18 2001-03-27 Karl Tryggvason Nephrin gene and protein

Also Published As

Publication number Publication date
FI991369A0 (fi) 1999-06-15
AU5225300A (en) 2001-01-02
WO2000077044A1 (fr) 2000-12-21
HK1044781A1 (zh) 2002-11-01
EP1185556A1 (fr) 2002-03-13

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