CA2373497A1 - Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands - Google Patents
Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands Download PDFInfo
- Publication number
- CA2373497A1 CA2373497A1 CA002373497A CA2373497A CA2373497A1 CA 2373497 A1 CA2373497 A1 CA 2373497A1 CA 002373497 A CA002373497 A CA 002373497A CA 2373497 A CA2373497 A CA 2373497A CA 2373497 A1 CA2373497 A1 CA 2373497A1
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- Prior art keywords
- hydrogen
- group
- alkyl
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000015554 Dopamine receptor Human genes 0.000 title claims abstract description 18
- 239000003446 ligand Substances 0.000 title abstract description 9
- 230000003389 potentiating effect Effects 0.000 title description 2
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- 150000001875 compounds Chemical class 0.000 claims abstract description 54
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract description 30
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14016699P | 1999-06-21 | 1999-06-21 | |
| US60/140,166 | 1999-06-21 | ||
| PCT/US2000/016857 WO2000078765A2 (en) | 1999-06-21 | 2000-06-20 | CHROMENO[4,3,2-de]ISOQUINOLINES AS POTENT DOPAMINE RECEPTOR LIGANDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2373497A1 true CA2373497A1 (en) | 2000-12-28 |
Family
ID=22490027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002373497A Abandoned CA2373497A1 (en) | 1999-06-21 | 2000-06-20 | Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands |
Country Status (16)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082567A2 (en) * | 2003-03-17 | 2004-09-30 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dopamine receptor d1a (drd1) |
| AU2004308413A1 (en) * | 2003-12-23 | 2005-07-14 | Darpharma, Inc. | Co-administration of dopamine-receptor binding compounds |
| CA2643300C (en) * | 2006-02-21 | 2011-11-08 | Purdue Research Foundation | Trans-fused chromenoisoquinolines, synthesis and methods for use |
| WO2010124005A1 (en) | 2009-04-21 | 2010-10-28 | Purdue Research Foundation | Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK297275A (da) * | 1974-08-07 | 1976-02-08 | Aspro Nicholas Ltd | Isoquinolinderivater |
| DK272182A (da) * | 1981-06-18 | 1982-12-19 | Univ Northeastern | Fremgangsmaade til fremstilling af oralt effektive aporphin-forbindelser eller dopamin-agonist-forbindelser med ikke aporphinstruktur eller farmaceutisk acceptable syreadditionssalte deraf |
| US5635506A (en) * | 1990-06-26 | 1997-06-03 | Research Corporation Technologies, Inc. | 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents |
| US6635642B1 (en) * | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
-
1999
- 1999-06-21 AU AU45365/99A patent/AU4536599A/en not_active Abandoned
-
2000
- 2000-06-20 EP EP00942943A patent/EP1192161B1/en not_active Expired - Lifetime
- 2000-06-20 WO PCT/US2000/016857 patent/WO2000078765A2/en active IP Right Grant
- 2000-06-20 KR KR1020017016235A patent/KR20020010716A/ko active IP Right Grant
- 2000-06-20 BR BR0011711-0A patent/BR0011711A/pt not_active IP Right Cessation
- 2000-06-20 ES ES00942943T patent/ES2199837T3/es not_active Expired - Lifetime
- 2000-06-20 DE DE60002867T patent/DE60002867T2/de not_active Expired - Fee Related
- 2000-06-20 DK DK00942943T patent/DK1192161T3/da active
- 2000-06-20 CA CA002373497A patent/CA2373497A1/en not_active Abandoned
- 2000-06-20 JP JP2001504931A patent/JP2003502428A/ja not_active Withdrawn
- 2000-06-20 MX MXPA01013229A patent/MXPA01013229A/es active IP Right Grant
- 2000-06-20 NZ NZ515613A patent/NZ515613A/xx unknown
- 2000-06-20 AU AU57492/00A patent/AU777522C/en not_active Ceased
- 2000-06-20 AT AT00942943T patent/ATE240959T1/de not_active IP Right Cessation
- 2000-06-20 PT PT00942943T patent/PT1192161E/pt unknown
- 2000-06-21 US US09/598,127 patent/US6413977B1/en not_active Expired - Lifetime
-
2001
- 2001-12-20 NO NO20016255A patent/NO20016255L/no not_active Application Discontinuation
-
2002
- 2002-07-02 US US10/188,579 patent/US6916832B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1192161B1 (en) | 2003-05-21 |
| US6916832B2 (en) | 2005-07-12 |
| WO2000078765A2 (en) | 2000-12-28 |
| AU777522B2 (en) | 2004-10-21 |
| DE60002867T2 (de) | 2004-02-26 |
| AU777522C (en) | 2005-07-28 |
| NZ515613A (en) | 2004-03-26 |
| MXPA01013229A (es) | 2002-11-04 |
| WO2000078765A3 (en) | 2001-06-28 |
| US20050080266A1 (en) | 2005-04-14 |
| EP1192161A2 (en) | 2002-04-03 |
| NO20016255D0 (no) | 2001-12-20 |
| US6413977B1 (en) | 2002-07-02 |
| JP2003502428A (ja) | 2003-01-21 |
| DK1192161T3 (da) | 2003-08-25 |
| AU5749200A (en) | 2001-01-09 |
| ES2199837T3 (es) | 2004-03-01 |
| ATE240959T1 (de) | 2003-06-15 |
| NO20016255L (no) | 2001-12-20 |
| DE60002867D1 (de) | 2003-06-26 |
| BR0011711A (pt) | 2002-03-26 |
| PT1192161E (pt) | 2003-09-30 |
| KR20020010716A (ko) | 2002-02-04 |
| AU4536599A (en) | 2001-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |