CA2372796A1 - Reaction vessel containing a siphon tube - Google Patents
Reaction vessel containing a siphon tube Download PDFInfo
- Publication number
- CA2372796A1 CA2372796A1 CA002372796A CA2372796A CA2372796A1 CA 2372796 A1 CA2372796 A1 CA 2372796A1 CA 002372796 A CA002372796 A CA 002372796A CA 2372796 A CA2372796 A CA 2372796A CA 2372796 A1 CA2372796 A1 CA 2372796A1
- Authority
- CA
- Canada
- Prior art keywords
- reaction vessel
- riser
- reaction
- housing
- vessel according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Abstract
The invention relates to a reaction vessel (1) which can be used in a reaction block to perform solid phase syntheses, wherein the reaction fluid (2) can be fed to a micro-titration plate using a siphon outlet. A siphon pipe (16) is located at the outlet (15) of the reaction vessel and an ascending pipe (21) is arranged at a radial distance to said siphon pipe. The ascending pipe (21) is closed in the upper region and is connected to the siphon pipe (16). The lower region of said siphon is interconnected with the receiving chamber (12) of the reaction vessel. This configuration prevents any additional forming when a siphon outlet is constructed and practically eliminates leakages in the area of the siphon outlet.
Description
~fA. ".; ~, r.SP '~ a~,j ~ ~C~ r a "' ,-~ ~ i ~ i r, ~ ~ f X
~ fn n t~ ~A 01 Reaction vessel containing a syphon tube The invention relates to a reaction vessel for accepting a reaction fluid which, together with other reaction vessels, can be placed in a reaction vessel holder for carrying out solid phase synthesis, the reaction fluid of which can be supplied to a micro-titre plate via a syphon outlet.
Such a reaction vessel is known from US-5 770 157 A. A tube piece is utilised in the outlet opening of this reaction vessel to implement a syphon outlet, one end of which is fixed to the base of the reaction vessel by melting and the other end of which is to be hung in a discharge pipe in order that the reaction fluid can be conveyed into this.
In each case, the discharge pipes are disposed adjacent to a reaction vessel at a lateral distance from one another in a reaction vessel holder, so that in each case, the tube piece is to be bent through 180° both in the melted area and in its other end area. The syphon outlet formed by the tube piece is therefore disposed outside the reaction vessel, laterally adjacent thereto.
Manual bending of the occasionally-brittle tube piece which is connected to the reaction vessel and its introduction into the discharge pipe, especially since space is limited in a reaction vessel holder, does not just require dexterity, these work processes are also extremely time-consuming. Above all, however, it is disadvantageous that the melt connection between the tube piece and the base of the reaction vessel is loaded to such a high degree by bending and/or displacing so that damage is often unavoidable. This can lead to leakage, as a result of which the solid phase synthesis may be questioned, leading to high expenditure in time and money.
In addition, considerable space is required as a result of the arrangement of the tube piece which forms the syphon outlet in each case adjacent to the reaction vessel in the reaction vessel holder, hence the reaction vessel holder is almost completely filled by the reaction vessels and tube pieces so that uniform heating or cooling of the reaction vessels by flushing is practically excluded. Therefore the known reaction vessels are only unsatisfactorily suitable for use in a reaction vessel holder.
Hence the invention is tasked to produce a reaction vessel to accept a reaction fluid of the type mentioned above which is not only configured in a constructionally-simple manner and is thus economical to produce but wherein it is practically out of the question that leakage can occur. Rather it is to be avoided that additional processing for formation of a syphon outlet is necessary and that substantial amounts of space can be saved with the same vessel capacity, so that greater amounts of free space can be used in a reaction vessel holder for the supply of fluids and gases to uniformly heat or cool reaction vessels placed in a reaction vessel holder. Furthermore, versatility with a low failure rate and simple manipulation should also be guaranteed.
According to the invention, this is attained with a reaction vessel for accepting a reaction fluid of the type mentioned above in that a syphon tube is disposed preferably centrically in the reaction vessel, connected to its outlet, that a riser, which is closed at its upper end, is attached at a radial distance thereto in the lower portion of the reaction vessel, and that the riser is in communication with its acceptance space and is linked in the upper portion with the syphon tube.
Here, it is expedient to configure the syphon tube as one piece with a housing which forms the acceptance space of the reaction vessel and preferably to injection mould it on the base thereof, and to place the riser therein at an axial distance to the base of the housing, wherein in order to hold the riser in the housing, the base of this housing can be provided with a shoulder piece in its edge area, preferably disposed about its periphery, which is especially configured as a step, on which the riser is supported with a moulded-on collar, and the collar should preferably have symmetrically-disposed penetration openings. Furthermore, it is indicated that an outlet nozzle is to be moulded onto the outside of the base of the housing, preferably injection moulded centrically thereon.
It is also very advantageous to dispose a filter insert, especially in the form of a frit, in the transitional area between the acceptance space of the housing and the riser, which can be supported on the collar of the riser, and to provide the riser in its upper edge area with a penetration opening which opens into the acceptance space of the housing, to which a restrictor is to be assigned, e.g. in the form of a frit placed in the interior of the riser.
Furthermore, it is appropriate to provide the housing of the reaction vessel with an inlet opening in its upper portion for the introduction of a pressurised gas.
If a plurality of such reaction vessels are to be placed in a reaction vessel holder, it is expedient to seal the reaction vessels together in an airtight manner with the help of a plate.
If a reaction vessel for accepting a reaction fluid is configured according to the invention, not only it is possible in the easiest manner to assemble this but it is also practically out of the question that the individual components of the reaction vessel will be damaged. During assembly, the riser must merely be placed over the syphon tube which is moulded onto the housing of the reaction vessel in order to provide a reaction vessel which can be used in a very versatile manner over an extended time period, wherein there is no danger of operational failure.
Furthermore, it is substantially advantageous, since the syphon tube is disposed within the housing of the reaction vessel, hence saving space, that large amounts of free space are provided when the reaction vessel is placed in a reaction vessel holder, these spaces being useful for cooling and heating the reaction fluids disposed in the reaction vessels in that the free spaces are rinsed through with fluids or gases.
Uniform influencing of the individual reaction vessels is consequently guaranteed, which means that versatility is provided along with simple manipulation.
An embodiment example of the reaction vessel for acceptance of a reaction fluid, configured according to the invention, is shown in the drawing and is explained in greater detail in the following text.
The reaction vessel, designated as 1 and shown in axial cross-section, serves to accept reaction fluids 2 in order to carry out solid phase synthesis in a reaction vessel holder, and substantially comprises a housing 11 which is configured like a beaker, a syphon tube 16, centrically moulded onto the base 13 thereof, projecting into the acceptance space 12 of the housing 11 and a riser 21 placed over this and disposed laterally thereto, supported on the base 13 of the housing 11 and in communication with the interior 12 thereof. In order to effect this, an annular-configured flange 23 is moulded onto the riser 21 and a peripherally-projecting shoulder 14 is provided in the edge area of the base 13 of the housing 11, on which the flange 23 rests. The riser 21, or its flange 23, is thus supported at a distance from the base 13. And since the flange 23 is provided with uniformly-distributed penetrations 24, the reaction fluid 2 can flow out from the interior of the housing 11 into the annular space 22 between the syphon tube 16 and the riser 21. Furthermore, a filter insert 25 in the form of an annular frit is placed on the flange 23, hence particles disposed in the reaction fluid are held back and do not gain access to the annular space 22.
After placing a plurality of reaction vessels 1 in a reaction vessel holder, not illustrated, and filling with reaction fluid 2, these are sealed together in an airtight manner with the help of a plate 20. If required, the reaction vessel 1 is then heated or cooled to influence solid phase synthesis. When this process is completed, the reaction fluid is transferred to a micro-titre plate. This takes place in that the reaction fluid 2 disposed in the acceptance space 12 of the housing 11 is acted upon by a pressurised gas which can be supplied by means of a bore 18 introduced into an upper portion of the housing 12. As a result, since the riser 21 is closed at its upper end portion the reaction fluid 102 rises into the annular space 22 and flows into the interior 17 of the syphon tube 16 which is connected with an outlet nozzle 15 centrically moulded onto the outside of the base 13. With the help of the outlet nozzle 15, the reaction fluid 2 can then be poured into the respective acceptance space of a micro-titre plate. Naturally it is also possible to empty the reaction vessels 1 by syphoning off, in that a vacuum is applied to the outlet nozzle 15.
Since an overpressure is formed in that part of the interior 12 of the housing 11 which is not filled with reaction fluid 2 when the reaction vessels are heated, which can lead to the reaction fluid 2 being forced into the syphon tube 16, causing the housing 11 to undesirably run dry, a penetration bore 26 is introduced into the upper end of the riser 21 to prevent this. With the help of the penetration bore 26, pressure is equalised in the two spaces which are connected thereto so that even the reaction fluid 2 disposed in the annular space 22 is acted upon and hence no rise occurs. And in order to prevent the fluid stream from being interrupted by the air sucked through the penetration bore 26 when the reaction fluid 102 is drawn off, a frit 27 is also disposed in front of the penetration bore 26 which works as a restrictor, only allowing a small quantity of air to be drawn off. Despite its simple construction, the reaction vessel 1 can be used over extended periods of time, in particular for testing solid phase synthesis, without operational failure.
~ fn n t~ ~A 01 Reaction vessel containing a syphon tube The invention relates to a reaction vessel for accepting a reaction fluid which, together with other reaction vessels, can be placed in a reaction vessel holder for carrying out solid phase synthesis, the reaction fluid of which can be supplied to a micro-titre plate via a syphon outlet.
Such a reaction vessel is known from US-5 770 157 A. A tube piece is utilised in the outlet opening of this reaction vessel to implement a syphon outlet, one end of which is fixed to the base of the reaction vessel by melting and the other end of which is to be hung in a discharge pipe in order that the reaction fluid can be conveyed into this.
In each case, the discharge pipes are disposed adjacent to a reaction vessel at a lateral distance from one another in a reaction vessel holder, so that in each case, the tube piece is to be bent through 180° both in the melted area and in its other end area. The syphon outlet formed by the tube piece is therefore disposed outside the reaction vessel, laterally adjacent thereto.
Manual bending of the occasionally-brittle tube piece which is connected to the reaction vessel and its introduction into the discharge pipe, especially since space is limited in a reaction vessel holder, does not just require dexterity, these work processes are also extremely time-consuming. Above all, however, it is disadvantageous that the melt connection between the tube piece and the base of the reaction vessel is loaded to such a high degree by bending and/or displacing so that damage is often unavoidable. This can lead to leakage, as a result of which the solid phase synthesis may be questioned, leading to high expenditure in time and money.
In addition, considerable space is required as a result of the arrangement of the tube piece which forms the syphon outlet in each case adjacent to the reaction vessel in the reaction vessel holder, hence the reaction vessel holder is almost completely filled by the reaction vessels and tube pieces so that uniform heating or cooling of the reaction vessels by flushing is practically excluded. Therefore the known reaction vessels are only unsatisfactorily suitable for use in a reaction vessel holder.
Hence the invention is tasked to produce a reaction vessel to accept a reaction fluid of the type mentioned above which is not only configured in a constructionally-simple manner and is thus economical to produce but wherein it is practically out of the question that leakage can occur. Rather it is to be avoided that additional processing for formation of a syphon outlet is necessary and that substantial amounts of space can be saved with the same vessel capacity, so that greater amounts of free space can be used in a reaction vessel holder for the supply of fluids and gases to uniformly heat or cool reaction vessels placed in a reaction vessel holder. Furthermore, versatility with a low failure rate and simple manipulation should also be guaranteed.
According to the invention, this is attained with a reaction vessel for accepting a reaction fluid of the type mentioned above in that a syphon tube is disposed preferably centrically in the reaction vessel, connected to its outlet, that a riser, which is closed at its upper end, is attached at a radial distance thereto in the lower portion of the reaction vessel, and that the riser is in communication with its acceptance space and is linked in the upper portion with the syphon tube.
Here, it is expedient to configure the syphon tube as one piece with a housing which forms the acceptance space of the reaction vessel and preferably to injection mould it on the base thereof, and to place the riser therein at an axial distance to the base of the housing, wherein in order to hold the riser in the housing, the base of this housing can be provided with a shoulder piece in its edge area, preferably disposed about its periphery, which is especially configured as a step, on which the riser is supported with a moulded-on collar, and the collar should preferably have symmetrically-disposed penetration openings. Furthermore, it is indicated that an outlet nozzle is to be moulded onto the outside of the base of the housing, preferably injection moulded centrically thereon.
It is also very advantageous to dispose a filter insert, especially in the form of a frit, in the transitional area between the acceptance space of the housing and the riser, which can be supported on the collar of the riser, and to provide the riser in its upper edge area with a penetration opening which opens into the acceptance space of the housing, to which a restrictor is to be assigned, e.g. in the form of a frit placed in the interior of the riser.
Furthermore, it is appropriate to provide the housing of the reaction vessel with an inlet opening in its upper portion for the introduction of a pressurised gas.
If a plurality of such reaction vessels are to be placed in a reaction vessel holder, it is expedient to seal the reaction vessels together in an airtight manner with the help of a plate.
If a reaction vessel for accepting a reaction fluid is configured according to the invention, not only it is possible in the easiest manner to assemble this but it is also practically out of the question that the individual components of the reaction vessel will be damaged. During assembly, the riser must merely be placed over the syphon tube which is moulded onto the housing of the reaction vessel in order to provide a reaction vessel which can be used in a very versatile manner over an extended time period, wherein there is no danger of operational failure.
Furthermore, it is substantially advantageous, since the syphon tube is disposed within the housing of the reaction vessel, hence saving space, that large amounts of free space are provided when the reaction vessel is placed in a reaction vessel holder, these spaces being useful for cooling and heating the reaction fluids disposed in the reaction vessels in that the free spaces are rinsed through with fluids or gases.
Uniform influencing of the individual reaction vessels is consequently guaranteed, which means that versatility is provided along with simple manipulation.
An embodiment example of the reaction vessel for acceptance of a reaction fluid, configured according to the invention, is shown in the drawing and is explained in greater detail in the following text.
The reaction vessel, designated as 1 and shown in axial cross-section, serves to accept reaction fluids 2 in order to carry out solid phase synthesis in a reaction vessel holder, and substantially comprises a housing 11 which is configured like a beaker, a syphon tube 16, centrically moulded onto the base 13 thereof, projecting into the acceptance space 12 of the housing 11 and a riser 21 placed over this and disposed laterally thereto, supported on the base 13 of the housing 11 and in communication with the interior 12 thereof. In order to effect this, an annular-configured flange 23 is moulded onto the riser 21 and a peripherally-projecting shoulder 14 is provided in the edge area of the base 13 of the housing 11, on which the flange 23 rests. The riser 21, or its flange 23, is thus supported at a distance from the base 13. And since the flange 23 is provided with uniformly-distributed penetrations 24, the reaction fluid 2 can flow out from the interior of the housing 11 into the annular space 22 between the syphon tube 16 and the riser 21. Furthermore, a filter insert 25 in the form of an annular frit is placed on the flange 23, hence particles disposed in the reaction fluid are held back and do not gain access to the annular space 22.
After placing a plurality of reaction vessels 1 in a reaction vessel holder, not illustrated, and filling with reaction fluid 2, these are sealed together in an airtight manner with the help of a plate 20. If required, the reaction vessel 1 is then heated or cooled to influence solid phase synthesis. When this process is completed, the reaction fluid is transferred to a micro-titre plate. This takes place in that the reaction fluid 2 disposed in the acceptance space 12 of the housing 11 is acted upon by a pressurised gas which can be supplied by means of a bore 18 introduced into an upper portion of the housing 12. As a result, since the riser 21 is closed at its upper end portion the reaction fluid 102 rises into the annular space 22 and flows into the interior 17 of the syphon tube 16 which is connected with an outlet nozzle 15 centrically moulded onto the outside of the base 13. With the help of the outlet nozzle 15, the reaction fluid 2 can then be poured into the respective acceptance space of a micro-titre plate. Naturally it is also possible to empty the reaction vessels 1 by syphoning off, in that a vacuum is applied to the outlet nozzle 15.
Since an overpressure is formed in that part of the interior 12 of the housing 11 which is not filled with reaction fluid 2 when the reaction vessels are heated, which can lead to the reaction fluid 2 being forced into the syphon tube 16, causing the housing 11 to undesirably run dry, a penetration bore 26 is introduced into the upper end of the riser 21 to prevent this. With the help of the penetration bore 26, pressure is equalised in the two spaces which are connected thereto so that even the reaction fluid 2 disposed in the annular space 22 is acted upon and hence no rise occurs. And in order to prevent the fluid stream from being interrupted by the air sucked through the penetration bore 26 when the reaction fluid 102 is drawn off, a frit 27 is also disposed in front of the penetration bore 26 which works as a restrictor, only allowing a small quantity of air to be drawn off. Despite its simple construction, the reaction vessel 1 can be used over extended periods of time, in particular for testing solid phase synthesis, without operational failure.
Claims (12)
1. A reaction vessel (1) for accepting a reaction fluid (2) which, for the purpose of carrying out solid phase synthesis, can be placed in a reaction vessel holder together with other reaction vessels, the reaction fluid (2) of which can be supplied to a micro-titre plate via a syphon outlet, characterised in that a syphon tube (16) is disposed preferably centrically in the reaction vessel (1), connected to its outlet (15), that a riser (21), which is closed at its upper end, is attached at a radial distance thereto in the lower portion of the reaction vessel, and that the riser (21) is in communication with its acceptance space (12) and is linked in the upper portion with the syphon tube (16).
2. A reaction vessel according to claim 1, characterised in that the syphon tube (16) is formed as one piece with a housing (11) which forms the acceptance space (12) of the reaction vessel (1) and is preferably formed by injection moulding on the base (13) thereof.
3. A reaction vessel according to claim 1 or 2, characterised in that the riser (21) is placed therein at an axial distance to the base (13) of the housing (11).
4. A reaction vessel according to claim 3, characterised in that in order to hold the riser (16) in the housing (12), the base (13) of this housing can be provided with a shoulder piece (14) in its edge area, preferably disposed about its periphery, which is especially configured as a step, on which the riser (16) is supported with a moulded-on collar (23).
5. A reaction vessel according to claim 4, characterised in that the collar (23) is provided with penetration openings (24) which are preferably disposed symmetrically.
6. A reaction vessel according to one or more of claims 1 to 5, characterised in that an outlet nozzle (15) is moulded onto the outside of the base (13) of the housing (11), preferably injection moulded centrically thereon.
7. A reaction vessel according to one or more of claims 1 to 6, characterised in that a filter insert (25), especially in the form of a frit, is disposed in the transitional area between the acceptance space (12) of the housing (11) and the riser (21).
8. A reaction vessel according to claim 7, characterised in that the filter insert (25) is supported on the collar (23) of the riser (21).
9. A reaction vessel according to one or more of claims 1 to 8, characterised in that riser (21) is provided in its upper edge area with a penetration opening (26) which opens into the acceptance space (12) of the housing (11).
10. A reaction vessel according to claim 9, characterised in that the penetration opening (26) has a restrictor (27), especially in the form of a frit placed in the interior (22) of the riser (21).
11. A reaction vessel according to one or more of claims 1 to 10, characterised in that the housing (11) of the reaction vessel (1) is provided with an inlet opening (18) in its upper portion for the introduction of a pressurised gas.
12. A reaction vessel holder with a plurality of reaction vessels configured according to one or more of claims 1 to 11, characterised in that the reaction vessels (1) are sealed together in an airtight manner with the help of a plate (20).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1999115811 DE19915811C2 (en) | 1999-04-08 | 1999-04-08 | Reaction vessel |
| DE19915811.8 | 1999-04-08 | ||
| PCT/EP2000/002988 WO2000061279A1 (en) | 1999-04-08 | 2000-04-04 | Reaction vessel containing a siphon pipe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2372796A1 true CA2372796A1 (en) | 2000-10-19 |
Family
ID=7903862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002372796A Abandoned CA2372796A1 (en) | 1999-04-08 | 2000-04-04 | Reaction vessel containing a siphon tube |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1183098A1 (en) |
| JP (1) | JP2002540931A (en) |
| AU (1) | AU3558800A (en) |
| CA (1) | CA2372796A1 (en) |
| DE (1) | DE19915811C2 (en) |
| MX (1) | MXPA01010014A (en) |
| WO (1) | WO2000061279A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10057195A1 (en) * | 2000-11-17 | 2002-05-23 | Robert Loesel | Reaction vessel, used for carrying out chemical reactions, comprises base formed by membrane having liquid permeability that can be controlled using pressures |
| EP1291074A1 (en) | 2001-09-07 | 2003-03-12 | F. Hoffmann-La Roche Ag | Reaction block for parallel synthetic chemistry and vessel therefor |
| EP1291075B1 (en) * | 2001-09-07 | 2007-04-11 | F. Hoffmann-La Roche Ag | Reaction block for parallel synthetic chemistry and vessel therefor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE940110L (en) * | 1989-03-23 | 1990-09-23 | Bunce Roger A | Liquid transfer devices |
| US5516491A (en) * | 1994-07-28 | 1996-05-14 | Merck & Co., Inc. | Disposable reactor vessel |
| SE503529C2 (en) * | 1994-10-17 | 1996-07-01 | System Teeg Ab | Basin valve with integrated water trap |
| US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
| US5746982A (en) * | 1996-02-29 | 1998-05-05 | Advanced Chemtech, Inc. | Apparatus for automated synthesis of chemical compounds |
| AU2939497A (en) * | 1996-05-10 | 1998-01-05 | Alanex Corporation | Simultaneous chemical reaction apparatus |
-
1999
- 1999-04-08 DE DE1999115811 patent/DE19915811C2/en not_active Expired - Fee Related
-
2000
- 2000-04-04 WO PCT/EP2000/002988 patent/WO2000061279A1/en not_active Application Discontinuation
- 2000-04-04 EP EP00914180A patent/EP1183098A1/en not_active Withdrawn
- 2000-04-04 MX MXPA01010014A patent/MXPA01010014A/en not_active Application Discontinuation
- 2000-04-04 CA CA002372796A patent/CA2372796A1/en not_active Abandoned
- 2000-04-04 JP JP2000610604A patent/JP2002540931A/en active Pending
- 2000-04-04 AU AU35588/00A patent/AU3558800A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU3558800A (en) | 2000-11-14 |
| MXPA01010014A (en) | 2002-04-24 |
| JP2002540931A (en) | 2002-12-03 |
| EP1183098A1 (en) | 2002-03-06 |
| WO2000061279A1 (en) | 2000-10-19 |
| DE19915811A1 (en) | 2000-10-19 |
| DE19915811C2 (en) | 2001-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |