CA2372742A1 - Animaux transgeniques doubles utilises comme modeles dans les maladies neurodegenaratives - Google Patents
Animaux transgeniques doubles utilises comme modeles dans les maladies neurodegenaratives Download PDFInfo
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- CA2372742A1 CA2372742A1 CA002372742A CA2372742A CA2372742A1 CA 2372742 A1 CA2372742 A1 CA 2372742A1 CA 002372742 A CA002372742 A CA 002372742A CA 2372742 A CA2372742 A CA 2372742A CA 2372742 A1 CA2372742 A1 CA 2372742A1
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Abstract
La présente invention concerne un acide nucléique vecteur comprenant : (a) une séquence nucléotidique codant une protéine Tau humaine ; (b) une séquence capable de diriger l'expression de la protéine Tau humaine dans le système nerveux d'un animal non humain ; et (c) une séquence de ciblage qui facilite l'intégration dudit vecteur dans le génome de l'animal afin d'empêcher l'expression de la protéine Tau équivalente ou d'une protéine liée ou équivalente de l'animal en faveur de la protéine Tau humaine. Dans un autre aspect, l'invention concerne un acide nucléique vecteur comprenant : (a) une séquence nucléotidique codant une protéine humaine capable de moduler la protéine Tau humaine ; (b) une séquence capable de diriger l'expression de la protéine précitée dans le système nerveux de l'animal ; et (c) une séquence de ciblage capable de faciliter l'intégration dudit vecteur dans le génome de l'animal facultativement en une position correspondant à une séquence dans l'animal codant un équivalent de la protéine humaine précitée, de façon à empêcher l'expression de la séquence équivalente en faveur de la protéine humaine capable de moduler la protéine Tau humaine. On utilise les vecteurs de l'invention pour fabriquer un animal transgénique non humain en (a) introduisant dans une cellule embryonnaire de l'animal un ou plusieurs acides nucléiques vecteurs décrits ci-dessus ; (b) en introduisant l'embryon de l'étape (a) précitée dans un animal femelle ; (c) en maintenant la femelle dans l'étape (b) jusqu'à ce que l'embryon se soit suffisamment développé et naisse ; et (d) en maintenant en vie l'animal transgénique obtenu.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9915574.9 | 1999-07-02 | ||
GBGB9915574.9A GB9915574D0 (en) | 1999-07-02 | 1999-07-02 | Transgenic animals as models for neurodegenerative disease |
GBGB0002674.0A GB0002674D0 (en) | 1999-07-02 | 2000-02-04 | Transgenic animals as models for neurodegenerative disease |
GB0002674.0 | 2000-02-04 | ||
PCT/EP2000/006171 WO2001002552A2 (fr) | 1999-07-02 | 2000-06-30 | Animaux transgeniques utilises comme modeles dans les maladies neurodegeneratives |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2372742A1 true CA2372742A1 (fr) | 2001-01-11 |
Family
ID=26243577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002372742A Abandoned CA2372742A1 (fr) | 1999-07-02 | 2000-06-30 | Animaux transgeniques doubles utilises comme modeles dans les maladies neurodegenaratives |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1216297A2 (fr) |
JP (1) | JP2003504015A (fr) |
AU (1) | AU782281B2 (fr) |
CA (1) | CA2372742A1 (fr) |
IL (1) | IL147406A0 (fr) |
NO (1) | NO20020010L (fr) |
NZ (1) | NZ515956A (fr) |
WO (1) | WO2001002552A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799535B1 (en) | 1997-12-09 | 2010-09-21 | Arch Development Corporation | Methods for identifying factors that control the folding of amyloid proteins of diverse origin |
GB0012056D0 (en) * | 2000-05-18 | 2000-07-12 | Consejo Superior Investigacion | Model for neurodegenerative disease |
US7098374B2 (en) * | 2001-02-09 | 2006-08-29 | University Of Florida Research Foundation, Inc. | Human disease modeling using somatic gene transfer |
ATE382704T1 (de) | 2001-02-15 | 2008-01-15 | Univ Chicago | Verfahren zum nachweis in hefe für mittels die proteinfaltung beeinflussen |
GB0104685D0 (en) * | 2001-02-26 | 2001-04-11 | Leuven K U Res & Dev | Tau-opathy model |
GB0126988D0 (en) * | 2001-11-09 | 2002-01-02 | Univ London | Disease model |
AU2003246664B2 (en) * | 2002-07-12 | 2007-06-14 | Axon Neuroscience Se | Transgenic animal expressing Alzheimer's tau protein |
JP5558049B2 (ja) * | 2009-08-21 | 2014-07-23 | 泰造 谷口 | 非ヒトモデル動物を用いたパーキンソン症候群の検査方法 |
KR101890978B1 (ko) | 2014-06-17 | 2018-08-24 | 서울대학교산학협력단 | 알츠하이머 질환 모델용 형질전환 돼지 및 이의 용도 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9316727D0 (en) * | 1993-08-12 | 1993-09-29 | Inst Of Psychiatry | Models of alzheimers's disease |
-
2000
- 2000-06-30 EP EP00949241A patent/EP1216297A2/fr not_active Ceased
- 2000-06-30 CA CA002372742A patent/CA2372742A1/fr not_active Abandoned
- 2000-06-30 JP JP2001508325A patent/JP2003504015A/ja not_active Withdrawn
- 2000-06-30 NZ NZ515956A patent/NZ515956A/en unknown
- 2000-06-30 IL IL14740600A patent/IL147406A0/xx unknown
- 2000-06-30 AU AU62673/00A patent/AU782281B2/en not_active Ceased
- 2000-06-30 WO PCT/EP2000/006171 patent/WO2001002552A2/fr active IP Right Grant
-
2002
- 2002-01-02 NO NO20020010A patent/NO20020010L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20020010D0 (no) | 2002-01-02 |
NO20020010L (no) | 2002-01-02 |
NZ515956A (en) | 2004-04-30 |
JP2003504015A (ja) | 2003-02-04 |
WO2001002552A3 (fr) | 2001-12-20 |
EP1216297A2 (fr) | 2002-06-26 |
AU782281B2 (en) | 2005-07-14 |
WO2001002552A2 (fr) | 2001-01-11 |
IL147406A0 (en) | 2002-08-14 |
AU6267300A (en) | 2001-01-22 |
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