CA2371758A1 - 2,1-benzisothiazoline 2,2-dioxydes - Google Patents

2,1-benzisothiazoline 2,2-dioxydes Download PDF

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Publication number
CA2371758A1
CA2371758A1 CA002371758A CA2371758A CA2371758A1 CA 2371758 A1 CA2371758 A1 CA 2371758A1 CA 002371758 A CA002371758 A CA 002371758A CA 2371758 A CA2371758 A CA 2371758A CA 2371758 A1 CA2371758 A1 CA 2371758A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
alkoxy
hydrogen
aminoalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002371758A
Other languages
English (en)
Inventor
Lin Zhi
Todd K. Jones
Christopher M. Tegley
Jay E. Wrobel
Valerie A. Mackner
Mark A. Collins
James P. Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Ligand Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,630 external-priority patent/US6339098B1/en
Application filed by Individual filed Critical Individual
Publication of CA2371758A1 publication Critical patent/CA2371758A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La présente invention concerne un antagoniste du récepteur de progestérone de formule (1) dans laquelle R¿1?, et R¿2? représentent individuellement hydrogène, alky, alkyle substitué, hydroxy, alcoxy, alcoxy substitué, aryle, aryle substitué, hétéroaryle, hétéroaryle substitué, arylalkyle, hétéroarylalkyle, et alcynyle; ou R¿1? et R¿2? pris ensemble contiennent -CH¿2?(CH¿2?)¿n?CH¿2?-, -CH¿2?CH¿2?CMe¿2?CH¿2?-CH¿2?-, -O(CH¿2?)¿p?CH¿2?-, O(CH¿2?)¿q?O-, -CH¿2?CH¿2?OCH¿2?CH¿2?-, -CH¿2?CH¿2?NR¿7?CH¿2?CH¿2?-; ou R¿1? et R¿2? représentent une double liaison, cette double liaison ayant deux groupes méthyle liés à l'extrémité terminale, un groupe cycloalkyle lié à l'extrémité terminale, un oxygène lié à l'extrémité terminale, ou un cycloéther lié à l'extrémité terminale; R?5¿ représente un cycle phénylique trisubstitué de structure (2), ou R?5¿ représente un cycle hétéroaryle à 5 ou 6 éléments contenant 1, 2, ou 3 hétéroatomes sélectionnés dans le groupe constitué par O, S, SO¿2? et NR?6¿, ou un sel de celui-ci acceptable sur le plan pharmaceutique.
CA002371758A 1999-05-04 2000-05-01 2,1-benzisothiazoline 2,2-dioxydes Abandoned CA2371758A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18303999P 1999-05-04 1999-05-04
US60/183,039 1999-05-04
US09/552,630 US6339098B1 (en) 1999-05-04 2000-04-19 2,1-benzisothiazoline 2,2-dioxides
US09/552,630 2000-04-19
PCT/US2000/011823 WO2000066574A1 (fr) 1999-05-04 2000-05-01 2,1-benzisothiazoline 2,2-dioxydes

Publications (1)

Publication Number Publication Date
CA2371758A1 true CA2371758A1 (fr) 2000-11-09

Family

ID=26878685

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002371758A Abandoned CA2371758A1 (fr) 1999-05-04 2000-05-01 2,1-benzisothiazoline 2,2-dioxydes

Country Status (6)

Country Link
EP (1) EP1175413A1 (fr)
JP (1) JP2002543195A (fr)
CN (1) CN1349518A (fr)
AU (1) AU4813800A (fr)
CA (1) CA2371758A1 (fr)
MX (1) MXPA01011292A (fr)

Also Published As

Publication number Publication date
CN1349518A (zh) 2002-05-15
JP2002543195A (ja) 2002-12-17
EP1175413A1 (fr) 2002-01-30
AU4813800A (en) 2000-11-17
MXPA01011292A (es) 2003-07-14

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Legal Events

Date Code Title Description
FZDE Discontinued