CA2371632A1 - Cyclocarbamate et derives d'amides cycliques - Google Patents

Cyclocarbamate et derives d'amides cycliques Download PDF

Info

Publication number
CA2371632A1
CA2371632A1 CA002371632A CA2371632A CA2371632A1 CA 2371632 A1 CA2371632 A1 CA 2371632A1 CA 002371632 A CA002371632 A CA 002371632A CA 2371632 A CA2371632 A CA 2371632A CA 2371632 A1 CA2371632 A1 CA 2371632A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
aryl
alkoxy
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002371632A
Other languages
English (en)
Inventor
Lin Zhi
Andrew Fensome
Todd K. Jones
Puwen Zhang
Andrew Q. Viet
James P. Edwards
Christopher M. Tegley
Jay E. Wrobel
Arthur A. Santilli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Ligand Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,036 external-priority patent/US6306851B1/en
Application filed by Individual filed Critical Individual
Publication of CA2371632A1 publication Critical patent/CA2371632A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés représentés par la formule (I), dans laquelle A et B représentent des substituants indépendants choisis parmi S, CH ou N ; étant entendu que lorsque A désigne S, B désigne CH ou N ; que lorsque B désigne S, A désigne CH ou N ; que A et B ne peuvent pas désigner tous deux CH; et que lorsque A et B représentent tous deux N, un N peut être éventuellement substitué par un groupe alkyle en C¿1?-C¿6? ; R¿1? et R¿2? représentent des substituants indépendants sélectionnés dans le groupe constitué de H, alkyle en C¿1?-C¿6?, alkyle en C¿1?-C¿6? substitué, alcényle en C¿2?-C¿6?, alcényle en C¿2?-C¿6? substitué, alkynyle en C¿2?-C¿6?, alkynyle en C¿2?-C¿6? substitué, cycloalkyle en C¿3?-C¿8?, cycloalkyle en C¿3?-C¿8? substitué, aryle, aryle substitué, hétérocyclique, hétérocyclique substitué, COR?A¿, ou NR?B¿COR?A¿ ; ou R?1¿ et R?2¿ sont condensés pour former un alkyle, un alcényle ou un noyau hétérocyclique spirocyclique éventuellement substitué à 3-8 chaînons, le noyau hétérocyclique renfermant de un à trois hétéroatomes sélectionnés dans le groupe constitué de O, S et N. L'invention concerne également des sels pharmaceutiquement utiles de ces composés. Les composés selon la présente invention sont utilisés comme agonistes et antagonistes du récepteur de la progestérone, ainsi que dans des méthodes d'induction de contraception et dans le traitement ou la prévention des maladies néoplasiques bénignes ou malignes.
CA002371632A 1999-05-04 2000-05-01 Cyclocarbamate et derives d'amides cycliques Abandoned CA2371632A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18301599P 1999-05-04 1999-05-04
US60/183,015 1999-05-04
US09/552,036 2000-04-19
US09/552,036 US6306851B1 (en) 1999-05-04 2000-04-19 Cyclocarbamate and cyclic amide derivatives
PCT/US2000/011825 WO2000066591A1 (fr) 1999-05-04 2000-05-01 Cyclocarbamate et derives d'amides cycliques

Publications (1)

Publication Number Publication Date
CA2371632A1 true CA2371632A1 (fr) 2000-11-09

Family

ID=26878651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002371632A Abandoned CA2371632A1 (fr) 1999-05-04 2000-05-01 Cyclocarbamate et derives d'amides cycliques

Country Status (6)

Country Link
EP (1) EP1185535A1 (fr)
JP (1) JP2002543205A (fr)
CN (1) CN1349538A (fr)
AU (1) AU4688800A (fr)
CA (1) CA2371632A1 (fr)
MX (1) MXPA01011288A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638525B2 (en) * 2004-10-27 2009-12-29 Janssen Pharmaceutica N.V. Trisubstituted thiophenes as progesterone receptor modulators

Also Published As

Publication number Publication date
EP1185535A1 (fr) 2002-03-13
JP2002543205A (ja) 2002-12-17
AU4688800A (en) 2000-11-17
MXPA01011288A (es) 2003-07-14
CN1349538A (zh) 2002-05-15

Similar Documents

Publication Publication Date Title
US6306851B1 (en) Cyclocarbamate and cyclic amide derivatives
US6509334B1 (en) Cyclocarbamate derivatives as progesterone receptor modulators
US7649007B2 (en) Oxazolidine derivatives as PR modulators
US7319152B2 (en) 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
US6339098B1 (en) 2,1-benzisothiazoline 2,2-dioxides
US20080045578A1 (en) Tricyclic oxazolidone derivatives useful as PR modulators
US6369056B1 (en) Cyclic urea and cyclic amide derivatives
KR20070039567A (ko) 피롤-옥신돌 유도체를 포함하는 프로게스테론 수용체조절제 및 그의 용도
US20080045560A1 (en) Pyrrolidine and related derivatives useful as PR modulators
WO2000066554A1 (fr) Derives de l'indoline a substitution 3,3
US6380178B1 (en) Cyclic regimens using cyclocarbamate and cyclic amide derivatives
ES2341268T3 (es) Tiofenos trisubstituidos utilizados como antagonistas del receptor de la progesterona.
DE60013798T2 (de) Empfängnisverhütende zusammensetzungen die progestagen und progesteronantagonisten enthalten
CA2371632A1 (fr) Cyclocarbamate et derives d'amides cycliques
JP5190268B2 (ja) プロゲステロン受容体モジュレーターとして有用なインドール誘導体
US7652018B2 (en) Imidazolidin-2-one derivatives useful as PR modulators
EP1175397B1 (fr) Derives de l'indoline a substitution 3,3
WO2000066592A1 (fr) Derives d'uree et d'amide cycliques
CA2371642A1 (fr) Derives d'uree et d'amide cycliques
CA2371758A1 (fr) 2,1-benzisothiazoline 2,2-dioxydes

Legal Events

Date Code Title Description
FZDE Discontinued