CA2370884A1 - Polymorphismes de nucleotides simples dans des genes mitochondriaux qui segregent avec la maladie d'alzheimer - Google Patents

Polymorphismes de nucleotides simples dans des genes mitochondriaux qui segregent avec la maladie d'alzheimer Download PDF

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Publication number
CA2370884A1
CA2370884A1 CA002370884A CA2370884A CA2370884A1 CA 2370884 A1 CA2370884 A1 CA 2370884A1 CA 002370884 A CA002370884 A CA 002370884A CA 2370884 A CA2370884 A CA 2370884A CA 2370884 A1 CA2370884 A1 CA 2370884A1
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Canada
Prior art keywords
mitochondrial
disease
single nucleotide
alzheimer
gene
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Abandoned
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CA002370884A
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English (en)
Inventor
Corinna Herrnstadt
Robert E. Davis
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Migenix Corp
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Individual
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Publication of CA2370884A1 publication Critical patent/CA2370884A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention porte sur des compositions et des méthodes fondées sur la détermination de polymorphismes de nucléotides simples dans l'ADN mt ou dans des mutations homoplasmiques d'ADN mt, utilisées pour détecter la présence de la maladie d'Alzheimer (AD) ou le risque de l'avoir, et pour identifier des agents appropriés pour traiter cette maladie.
CA002370884A 1999-04-20 2000-04-19 Polymorphismes de nucleotides simples dans des genes mitochondriaux qui segregent avec la maladie d'alzheimer Abandoned CA2370884A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13044799P 1999-04-20 1999-04-20
US60/130,447 1999-04-20
US16090199P 1999-10-22 1999-10-22
US60/160,901 1999-10-22
PCT/US2000/010906 WO2000063441A2 (fr) 1999-04-20 2000-04-19 Polymorphismes de nucleotides simples dans des genes mitochondriaux qui segregent avec la maladie d'alzheimer

Publications (1)

Publication Number Publication Date
CA2370884A1 true CA2370884A1 (fr) 2000-10-26

Family

ID=26828492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002370884A Abandoned CA2370884A1 (fr) 1999-04-20 2000-04-19 Polymorphismes de nucleotides simples dans des genes mitochondriaux qui segregent avec la maladie d'alzheimer

Country Status (5)

Country Link
EP (1) EP1208225A2 (fr)
JP (1) JP2003521879A (fr)
AU (1) AU4368300A (fr)
CA (1) CA2370884A1 (fr)
WO (1) WO2000063441A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1229130T3 (en) * 2000-12-04 2014-02-24 Primagen B V TEST BASED ON nucleic acids OF ENDOSYMBIONTISKE, cellular organelles
GB2380194B (en) * 2001-10-01 2005-06-22 Roger Michael Marchbanks A mitochondrial mutation associated with schizophrenia and increased oxidative stress
US6897025B2 (en) * 2002-01-07 2005-05-24 Perlegen Sciences, Inc. Genetic analysis systems and methods
US20080187911A1 (en) * 2003-01-30 2008-08-07 Research Development Foundation Methods and compositions for analysis of mitochondrial-related gene expression
PL2270159T3 (pl) 2003-05-21 2015-08-31 Andes Biotechnologies Global Inc Markery dla komórek przedrakowych i rakowych oraz sposób zakłócania proliferacji tych komórek
EP1694695A4 (fr) * 2003-12-11 2007-10-31 1304854 Ontario Ltd Sequences completes du genome mitochondrial utilisees comme outil de diagnostic pour des sciences de la sante
CA2792443A1 (fr) 2005-04-18 2006-10-26 Ryan Parr Rearrangements et mutations mitochondriales utilises en tant qu'outil de diagnostic pour la detection de l'exposition au soleil, le cancer de la prostate et d'autres cancers
US20130022979A1 (en) 2005-04-18 2013-01-24 Genesis Genomics Inc. 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
EP2142923A2 (fr) * 2007-03-23 2010-01-13 King's College London Procédé
WO2012008839A2 (fr) * 2010-07-16 2012-01-19 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Procédé d'analyse d'un échantillon de sang d'un sujet dans le but de détecter la présence d'un marqueur d'une maladie
AU2012231884B2 (en) 2011-03-18 2017-03-09 Stichting Vumc A method of analysing a blood sample of a subject for the presence of a disease marker
ES2482866B1 (es) * 2012-11-22 2015-05-12 Consejo Superior De Investigaciones Científicas (Csic) Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.
ES2546743B1 (es) * 2014-03-28 2016-07-07 Institut D'investigació Biomèdica De Bellvitge (Idibell) Marcadores mitocondriales de enfermedades neurodegenerativas
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
TW202033760A (zh) * 2018-11-28 2020-09-16 國立大學法人千葉大學 多因素遺傳疾病的基因檢測法、及檢測套件
CN113862346B (zh) * 2021-09-26 2023-07-07 北京大学 长链非编码rna在治疗阿尔茨海默病中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494794A (en) * 1992-10-20 1996-02-27 Emory University Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease
US6027883A (en) * 1994-03-30 2000-02-22 Mitokor Optimal procedure for isolation of mutant mitochondrial alleles
US5976798A (en) * 1994-03-30 1999-11-02 Mitokor Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid
US5565323A (en) * 1994-03-30 1996-10-15 Mitokor Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease
EP0812922A3 (fr) * 1996-05-16 2002-08-21 Affymetrix, Inc. (a California Corporation) Polymorphismes dans l'acide nucléique mitochondrial humain

Also Published As

Publication number Publication date
EP1208225A2 (fr) 2002-05-29
AU4368300A (en) 2000-11-02
JP2003521879A (ja) 2003-07-22
WO2000063441A3 (fr) 2002-03-14
WO2000063441A2 (fr) 2000-10-26

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