CA2366615A1 - Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine - Google Patents

Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine Download PDF

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Publication number
CA2366615A1
CA2366615A1 CA002366615A CA2366615A CA2366615A1 CA 2366615 A1 CA2366615 A1 CA 2366615A1 CA 002366615 A CA002366615 A CA 002366615A CA 2366615 A CA2366615 A CA 2366615A CA 2366615 A1 CA2366615 A1 CA 2366615A1
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CA
Canada
Prior art keywords
substituted
alkyl
aryl
compound
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002366615A
Other languages
English (en)
Inventor
Thomas F. Walsh
Feroze Ujjainwalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2366615A1 publication Critical patent/CA2366615A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Cette invention concerne des composés de formule (I) et des sels de ces composés acceptables au plan pharmaceutiques qui jouent un rôle utile en tant qu'antagonistes de GnRH et qui, en tant que tels, peuvent convenir pour le traitement de diverses pathologies en rapport avec diverses hormones sexuelles et autres pathologies connexes, tant chez l'homme que chez la femme.
CA002366615A 1999-03-10 2000-03-06 Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine Abandoned CA2366615A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12362099P 1999-03-10 1999-03-10
US60/123,620 1999-03-10
PCT/US2000/005799 WO2000053602A1 (fr) 1999-03-10 2000-03-06 Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine

Publications (1)

Publication Number Publication Date
CA2366615A1 true CA2366615A1 (fr) 2000-09-14

Family

ID=22409767

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002366615A Abandoned CA2366615A1 (fr) 1999-03-10 2000-03-06 Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine

Country Status (5)

Country Link
EP (1) EP1161431A4 (fr)
JP (1) JP2002539124A (fr)
AU (1) AU3868500A (fr)
CA (1) CA2366615A1 (fr)
WO (1) WO2000053602A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3514200A (en) * 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
TWI262920B (en) * 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
DE60314158T2 (de) 2002-08-21 2008-01-31 Astrazeneca Ab Pyrazolderivate als gnrh-inhibitoren
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
WO2004018479A1 (fr) 2002-08-21 2004-03-04 Astrazeneca Ab Composes de thieno-pyrrole utilises comme antagonistes de l'hormone de liberation de gonadotrophine
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
EP1730155A1 (fr) * 2004-02-20 2006-12-13 AstraZeneca AB Thiénopyrroles comme antagonistes de gnrh
PT1753764E (pt) 2004-06-09 2009-01-28 Glaxo Group Ltd Derivados de pirrolopiridina
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
WO2006036266A1 (fr) 2004-07-16 2006-04-06 Sunesis Pharmaceuticals, Inc. Thienopyrimidines utiles en tant qu'inhibiteurs des kinases aurora
US7932257B2 (en) 2005-07-22 2011-04-26 Sunesis Pharmaceuticals, Inc. Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
CL2008001933A1 (es) 2007-06-29 2009-09-25 Millennium Pharm Inc Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
US7968536B2 (en) 2007-06-29 2011-06-28 Millennium Pharmaceuticals, Inc. Heterocyclic compounds useful as RAF kinase inhibitors
EP2095818A1 (fr) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
US11767321B2 (en) 2020-10-05 2023-09-26 Enliven Inc. 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
AU707277B2 (en) * 1995-12-14 1999-07-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
KR19990072124A (ko) * 1995-12-14 1999-09-27 애쉬톤 왈레이스 티 고나도트로핀 방출 호르몬의 길항제
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP0997465B1 (fr) * 1998-10-30 2004-02-04 Eli Lilly And Company Dérivés de l'azaindole et leur utilisation comme agents antithrombotiques

Also Published As

Publication number Publication date
EP1161431A1 (fr) 2001-12-12
AU3868500A (en) 2000-09-28
EP1161431A4 (fr) 2002-04-24
JP2002539124A (ja) 2002-11-19
WO2000053602A1 (fr) 2000-09-14

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FZDE Dead