CA2365460A1 - Copolymeres fluores pour revetement de dispositifs biomedicaux et procede de fabrication correspondant - Google Patents

Copolymeres fluores pour revetement de dispositifs biomedicaux et procede de fabrication correspondant Download PDF

Info

Publication number
CA2365460A1
CA2365460A1 CA002365460A CA2365460A CA2365460A1 CA 2365460 A1 CA2365460 A1 CA 2365460A1 CA 002365460 A CA002365460 A CA 002365460A CA 2365460 A CA2365460 A CA 2365460A CA 2365460 A1 CA2365460 A1 CA 2365460A1
Authority
CA
Canada
Prior art keywords
comonomer
fluorinated
copolymer
formula
moieties derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002365460A
Other languages
English (en)
Inventor
Ineke Verweire
Etienne Honore Schacht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Universiteit Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Gent filed Critical Universiteit Gent
Publication of CA2365460A1 publication Critical patent/CA2365460A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D153/00—Coating compositions based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/22—Esters containing halogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C08F297/02—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
    • C08F297/026—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type polymerising acrylic acid, methacrylic acid or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne des copolymères dont des premiers fragments sont dérivés d'au moins un premier comonomère fluoré représenté par la formule générale (I). Dans cette formule, X est hydrogène ou méthyle, Y est une liaison simple ou un radical représenté par la formule CH¿2?NRSO¿2? ou NRSO¿2?, dans laquelle R est un groupe alkyle en C¿1?-C¿6?, Z est hydrogène ou fluor, et n vaut de 0 à 12. D'autres fragments de ces copolymères sont dérivés d'au moins un second copolymère non fluoré. En l'occurrence, la température de transition vitreuse de l'homopolymère du second comonomère est inférieure à la température de tansition vitreuse de l'homopolymère du premier comonomère. Une couche d'un tel copolymère, comprenant en outre éventuellement une quantité biologiquement efficace d'au moins un ingrédient biologiquement actif, convient particulièrement au revêtement d'un dispositif biomédical tel qu'un cathéter ou un stent.
CA002365460A 1999-03-31 2000-03-29 Copolymeres fluores pour revetement de dispositifs biomedicaux et procede de fabrication correspondant Abandoned CA2365460A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99870063 1999-03-31
EP99870063.7 1999-03-31
PCT/EP2000/002733 WO2000059963A1 (fr) 1999-03-31 2000-03-29 Copolymeres fluores pour revetement de dispositifs biomedicaux et procede de fabrication correspondant

Publications (1)

Publication Number Publication Date
CA2365460A1 true CA2365460A1 (fr) 2000-10-12

Family

ID=8243815

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002365460A Abandoned CA2365460A1 (fr) 1999-03-31 2000-03-29 Copolymeres fluores pour revetement de dispositifs biomedicaux et procede de fabrication correspondant

Country Status (4)

Country Link
EP (1) EP1171490A1 (fr)
AU (1) AU4112600A (fr)
CA (1) CA2365460A1 (fr)
WO (1) WO2000059963A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009043174A1 (fr) * 2007-10-05 2009-04-09 Interface Biologics Inc. Polymères réticulés oligofluorés et leurs utilisations

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030195610A1 (en) * 2002-04-04 2003-10-16 Herrmann Robert A. Processes for producing polymer coatings through surface polymerization
US7041308B2 (en) * 2002-04-18 2006-05-09 Poly-Med, Inc. Drug-polymer coated stents with segmented homochain copolyesters
US7261946B2 (en) 2003-11-14 2007-08-28 Advanced Cardiovascular Systems, Inc. Block copolymers of acrylates and methacrylates with fluoroalkenes
DE102004025130A1 (de) * 2004-05-18 2005-12-08 Universitätsklinikum Hamburg-Eppendorf Körperschaft des Öffentlichen Rechts Verfahren und Vorrichtung zur Untersuchung von Sludgeablagerungen auf Materialien für Endoprothesen sowie Endoprothese
US8034874B2 (en) 2005-11-23 2011-10-11 Boston Scientific Scimed, Inc. Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers
EP2468305B1 (fr) * 2010-12-03 2016-06-15 Xeltis B.V. Utilisation d'un polymère fluoré en tant qu'agent de contraste dans une imagerie à résonnance magnétique (IRM) 19F à l'état solide, support comprenant ce polymère et utilisation associée
US10238776B2 (en) 2010-12-29 2019-03-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Hydrophobic catheter and composition
US9913933B2 (en) 2013-03-15 2018-03-13 St. Jude Medical, Cardiology Division, Inc. Multilayered catheter shaft containing polyvinylidene fluoride polymers
KR102128282B1 (ko) * 2014-01-09 2020-06-30 삼성전자주식회사 항균방오 코팅 조성물, 그 피막, 그 제조 방법 및 그 코팅이 적용된 제품
EP3357946A1 (fr) * 2017-02-07 2018-08-08 Daikin Industries, Ltd. Composition de résine hydrofuge et oléofuge

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663409A (en) * 1984-12-24 1987-05-05 Bausch & Lomb Incorporated Alpha, beta-unsaturated carbonyl modified amino acid monomer and polymers for biomedical uses
US4931279A (en) * 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
JPH0539444A (ja) * 1990-11-30 1993-02-19 Hitachi Chem Co Ltd ポジ型感光性アニオン電着塗料樹脂組成物、これを用いた電着塗装浴、電着塗装法及びプリント回路板の製造方法
US5212229A (en) * 1991-03-28 1993-05-18 Union Carbide Chemicals & Plastics Technology Corporation Monodispersed acrylic polymers in supercritical, near supercritical and subcritical fluids
FR2725721B1 (fr) * 1994-10-18 1998-12-04 Atochem Elf Sa Latex et melanges de latex acryliques et methacyliques fluores, leurs procedes de fabrication et leurs applications dans le domaine des revetements hydrophobes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009043174A1 (fr) * 2007-10-05 2009-04-09 Interface Biologics Inc. Polymères réticulés oligofluorés et leurs utilisations
US10039864B2 (en) 2007-10-05 2018-08-07 Interface Biologics, Inc. Oligofluorinated cross-linked polymers and uses thereof

Also Published As

Publication number Publication date
EP1171490A1 (fr) 2002-01-16
WO2000059963A1 (fr) 2000-10-12
AU4112600A (en) 2000-10-23

Similar Documents

Publication Publication Date Title
US8088404B2 (en) Biocompatible controlled release coatings for medical devices and related methods
US9687368B2 (en) Biocompatible controlled release coatings for medical devices and related methods
US7442721B2 (en) Durable biocompatible controlled drug release polymeric coatings for medical devices
EP1732621B1 (fr) Compositions de revetement de phospholipide et resistant a l'encrassement
US8063151B2 (en) Methods for manufacturing copolymers having 1-methyl-2-methoxyethyl moieties and use of same
US7544673B2 (en) Coating compositions for bioactive agents
CA2572257C (fr) Copolymeres avec blocs bio-actifs
US20090043378A1 (en) Biocompatible Polymer System for Extended Drug Release
JP5138208B2 (ja) 両親媒性コポリマー組成物
US8722826B2 (en) Zwitterionic terpolymers, method of making and use on medical devices
EP2265293B1 (fr) Systèmes d'enrobage pour l'administration contrôlée d'agents bioactifs hydrophiles
JP2007514808A (ja) アクリレート及びメタクリレートのフルオロアルケンとのブロックコポリマー
US7041308B2 (en) Drug-polymer coated stents with segmented homochain copolyesters
CA2365460A1 (fr) Copolymeres fluores pour revetement de dispositifs biomedicaux et procede de fabrication correspondant
US9056153B2 (en) Biocompatible polymers for coating or fabricating implantable medical devices
CN102091355A (zh) 一种复合涂层冠脉药物洗脱支架及其制备方法
US20090299464A1 (en) Reducing Bioabsorbtion Time of Polymer Coated Implantable Medical Devices Using Polymer Blends
Rodriguez et al. Bioactive polymeric systems with platelet antiaggregating activity for the coating of vascular devices

Legal Events

Date Code Title Description
FZDE Discontinued