CA2364914A1 - N-substituted benzoyl indoles as estrogenic agents - Google Patents

N-substituted benzoyl indoles as estrogenic agents Download PDF

Info

Publication number
CA2364914A1
CA2364914A1 CA002364914A CA2364914A CA2364914A1 CA 2364914 A1 CA2364914 A1 CA 2364914A1 CA 002364914 A CA002364914 A CA 002364914A CA 2364914 A CA2364914 A CA 2364914A CA 2364914 A1 CA2364914 A1 CA 2364914A1
Authority
CA
Canada
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002364914A
Other languages
English (en)
French (fr)
Inventor
Marci Catherine Koko
John William Ullrich
Arthur Attilio Santilli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2364914A1 publication Critical patent/CA2364914A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CA002364914A 1999-03-04 2000-02-22 N-substituted benzoyl indoles as estrogenic agents Abandoned CA2364914A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26241399A 1999-03-04 1999-03-04
US09/262,413 1999-03-04
PCT/US2000/004386 WO2000051983A1 (en) 1999-03-04 2000-02-22 N-SUBSTITUTED BENzOYL INDOLES AS ESTROGENIC AGENTS

Publications (1)

Publication Number Publication Date
CA2364914A1 true CA2364914A1 (en) 2000-09-08

Family

ID=22997395

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002364914A Abandoned CA2364914A1 (en) 1999-03-04 2000-02-22 N-substituted benzoyl indoles as estrogenic agents

Country Status (8)

Country Link
EP (1) EP1159268A1 (de)
JP (1) JP2002538141A (de)
CN (1) CN1342144A (de)
AR (1) AR022797A1 (de)
AU (1) AU3859400A (de)
CA (1) CA2364914A1 (de)
MX (1) MXPA01008911A (de)
WO (1) WO2000051983A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998402A (en) 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
BR0314126A (pt) 2002-09-20 2005-06-28 Pfizer Prod Inc Ligandos de amida acìclica e sulfonamida para o receptor de estrogênio
CN100506795C (zh) * 2003-06-18 2009-07-01 中国科学院上海药物研究所 茚酮并吲哚类化合物、制备方法及它的医学用途
US7250440B2 (en) * 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
US8367665B2 (en) 2008-04-16 2013-02-05 Karo Bio Ab Estrogen receptor ligands

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
NZ314601A (en) * 1996-04-19 1999-09-29 American Home Prod 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole derivatives as estrogenic agents and pharmaceutical compositions

Also Published As

Publication number Publication date
AU3859400A (en) 2000-09-21
EP1159268A1 (de) 2001-12-05
JP2002538141A (ja) 2002-11-12
CN1342144A (zh) 2002-03-27
MXPA01008911A (es) 2002-10-23
AR022797A1 (es) 2002-09-04
WO2000051983A1 (en) 2000-09-08

Similar Documents

Publication Publication Date Title
US5880137A (en) 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US5780497A (en) 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US6232307B1 (en) Tissue selective compounds in the treatment of ovarian cancer
EP0802184B1 (de) N-Benzyl-2-phenylindole als östrogene Mittel
HU227077B1 (en) Estrogenical 2-phenyl-1-benzyl-indole derivatives, preparation and use thereof and pharmaceutical compositions containing these compounds
US5985910A (en) 3- [4- (2- Phenyl-Indole-1-ylmethyl) Phenyl]- Acrylamides as estrogenic agents
JPH0623197B2 (ja) インドール誘導体
HU198014B (en) Process for producing antiarithmic sulfonamides and pharmaceutical compositions containing them
CA2364914A1 (en) N-substituted benzoyl indoles as estrogenic agents
US6069153A (en) Indenoindoles and benzocarbazoles as estrogenic agents
US6380185B1 (en) N-substituted benzoyl indoles as estrogenic agents
EP1159267B1 (de) N-substituierte indoline als östrogene mittel
US6358943B1 (en) N-substituted indolines as estrogenic agents
MXPA01008912A (en) N-substituted indolines as estrogenic agents
CA2203073A1 (en) Estrogenic agents
MXPA97002866A (en) Estrogeni agents

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead