CA2362520A1 - Nouveau compose de complexe suppresseur de tumeur de von hippel-lindau et scf ubiquitine ligase - Google Patents

Nouveau compose de complexe suppresseur de tumeur de von hippel-lindau et scf ubiquitine ligase Download PDF

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Publication number
CA2362520A1
CA2362520A1 CA002362520A CA2362520A CA2362520A1 CA 2362520 A1 CA2362520 A1 CA 2362520A1 CA 002362520 A CA002362520 A CA 002362520A CA 2362520 A CA2362520 A CA 2362520A CA 2362520 A1 CA2362520 A1 CA 2362520A1
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CA
Canada
Prior art keywords
protein
complex
ring box
rbxl
cullin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002362520A
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English (en)
Inventor
Joan W. Conaway
Ronald C. Conaway
Takumi Kamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2362520A1 publication Critical patent/CA2362520A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne Rbx1, une protéine à doigt RING-H2 conservée au cours de l'évolution, interagissant avec Cullin. Rbx1 de mammifère à été découverte en tant que composant du complexe VHL contenant CUL2. Un homologue de Rbx1, obtenu à partir de S. cerevisiae a également été identifié en tant que sous-unité et activateur de SCF?Cdc4¿ ubiquitine ligase contenant Cdc53, nécessaire à l'ubiquitination de l'inhibiteur Sic1 de cdk ainsi qu'à la transition du cycle cellulaire G1/S des levures, assurant une liaison entre le complexe suppresseur de tumeur VHL multiprotéique et l'ubiquitination cellulaire. La protéine Rbx1 agit en tant que marqueur cellulaire, utile (1) afin de détecter une éventuelle prédisposition à certains carcinomes, (2) en tant que cible moléculaire en vue de traiter ces carcinomes de manière thérapeutique, (3) en tant que cible pour l'inhibition par des médicaments agissant sur la croissance cellulaire, et (4) en tant qu'outil de recherche permettant de mieux comprendre les différents mécanismes complexes de l'ubiquitinaion cellulaire, la liaison de certaines protéines activatrices, le dépôt de fibronectine et d'autres aspects du processus de division cellulaire.
CA002362520A 1999-02-26 2000-02-25 Nouveau compose de complexe suppresseur de tumeur de von hippel-lindau et scf ubiquitine ligase Abandoned CA2362520A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12178799P 1999-02-26 1999-02-26
US60/121,787 1999-02-26
PCT/US2000/004838 WO2000050445A1 (fr) 1999-02-26 2000-02-25 Nouveau compose de complexe suppresseur de tumeur de von hippel-lindau et scf ubiquitine ligase

Publications (1)

Publication Number Publication Date
CA2362520A1 true CA2362520A1 (fr) 2000-08-31

Family

ID=22398786

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002362520A Abandoned CA2362520A1 (fr) 1999-02-26 2000-02-25 Nouveau compose de complexe suppresseur de tumeur de von hippel-lindau et scf ubiquitine ligase

Country Status (5)

Country Link
EP (1) EP1155030A4 (fr)
JP (1) JP2002541775A (fr)
AU (1) AU769012B2 (fr)
CA (1) CA2362520A1 (fr)
WO (1) WO2000050445A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078203B1 (en) 1999-03-31 2006-07-18 The University Of North Carolina At Chapel Hill Isolated DNA encoding cullin regulators ROC1 and ROC2, isolated proteins encoded by the same, and methods utilizing the same
WO2000058472A2 (fr) * 1999-03-31 2000-10-05 The University Of North Carolina At Chapel Hill Adn isole codant pour des regulateurs cullin roc1 et roc2, proteines isolees codees par ledit adn. procedes d'utilisation associes
US6740495B1 (en) 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay
US6979551B2 (en) 2000-04-03 2005-12-27 Rigel Pharmaceuticals, Inc. Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
US20030194725A1 (en) * 2001-11-19 2003-10-16 Tsvika Greener Methods for identifying and validating potential drug targets
MX358660B (es) * 2012-01-12 2018-08-30 Univ Yale Compuestos y metodos para degradacion mejorada de proteinas y otros polipeptidos elegidos como blanco mediante una ubiquitina ligasa e3.
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
US10730870B2 (en) 2015-03-18 2020-08-04 Arvinas Operations, Inc. Compounds and methods for the enhanced degradation of targeted proteins
KR20180097530A (ko) 2015-11-02 2018-08-31 예일 유니버시티 단백질분해 표적화 키메라 화합물(Proteolysis Targeting Chimera compound) 및 그의 제조 및 사용 방법

Also Published As

Publication number Publication date
EP1155030A1 (fr) 2001-11-21
AU769012B2 (en) 2004-01-15
JP2002541775A (ja) 2002-12-10
WO2000050445A1 (fr) 2000-08-31
EP1155030A4 (fr) 2005-12-14
AU3378700A (en) 2000-09-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20100225