CA2361601A1 - Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo - Google Patents
Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo Download PDFInfo
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- CA2361601A1 CA2361601A1 CA002361601A CA2361601A CA2361601A1 CA 2361601 A1 CA2361601 A1 CA 2361601A1 CA 002361601 A CA002361601 A CA 002361601A CA 2361601 A CA2361601 A CA 2361601A CA 2361601 A1 CA2361601 A1 CA 2361601A1
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- A61N1/00—Electrotherapy; Circuits therefor
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
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- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/0424—Shape of the electrode
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
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- A—HUMAN NECESSITIES
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- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
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- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11899699P | 1999-02-08 | 1999-02-08 | |
| US60/118,996 | 1999-02-08 | ||
| US12918999P | 1999-04-14 | 1999-04-14 | |
| US60/129,189 | 1999-04-14 | ||
| PCT/US2000/002831 WO2000045823A1 (en) | 1999-02-08 | 2000-02-07 | Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2361601A1 true CA2361601A1 (en) | 2000-08-10 |
Family
ID=26816956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002361601A Abandoned CA2361601A1 (en) | 1999-02-08 | 2000-02-07 | Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1148885A4 (de) |
| AU (1) | AU2868200A (de) |
| CA (1) | CA2361601A1 (de) |
| WO (1) | WO2000045823A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| AU1236801A (en) | 1999-10-27 | 2001-05-08 | Chiron Corporation | Activation of hcv-specific t cells |
| US20050054594A1 (en) * | 2001-12-14 | 2005-03-10 | Lei Zhang | Methods for particle-assisted polynucleotide immunization using a pulsed electric field |
| WO2003076006A2 (en) * | 2002-03-07 | 2003-09-18 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US7245963B2 (en) | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| WO2006055729A1 (en) * | 2004-11-16 | 2006-05-26 | Transcutaneous Technologies Inc. | Iontophoretic device and method for administering immune response-enhancing agents and compositions |
| SI2816118T1 (sl) | 2005-05-31 | 2019-01-31 | The Regents Of The University Of Colorado, A Body Corporate | Metode za dostavo genov |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| WO2008063555A2 (en) * | 2006-11-17 | 2008-05-29 | Genetronics, Inc. | Methods of enhancing immune response using electroporation-assisted vaccination and boosting |
| US8586055B2 (en) | 2007-01-12 | 2013-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | DNA immunization protocols |
| EP2185195A2 (de) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen-plattform |
| MX2010007461A (es) * | 2008-01-11 | 2010-10-20 | VGX Pharmaceuticals LLC | Nuevas vacunas contra multiples subtipos del virus del dengue. |
| US9428565B2 (en) | 2011-01-31 | 2016-08-30 | The General Hospital Corporation | Treatment and bioluminescent visualization using multimodal TRAIL molecules |
| WO2014035474A1 (en) | 2012-08-30 | 2014-03-06 | The General Hospital Corporation | Compositions and methods for treating cancer |
| WO2014145042A1 (en) | 2013-03-15 | 2014-09-18 | Loma Linda University | Treatment of autoimmune diseases |
| EP3848044A1 (de) | 2013-05-21 | 2021-07-14 | President and Fellows of Harvard College | Manipulierte heme-bindende zusammensetzungen und verwendungen davon |
| WO2016168601A1 (en) | 2015-04-17 | 2016-10-20 | Khalid Shah | Agents, systems and methods for treating cancer |
| CN113423461A (zh) | 2018-12-13 | 2021-09-21 | 新南创新私人有限公司 | 控制分子电转移的方法和系统 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5749847A (en) * | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| ES2087166T3 (es) * | 1990-01-15 | 1996-07-16 | Cino Rossi | Dispositivo de iontoforesis. |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5830877A (en) * | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
| US5786464C1 (en) * | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| EA002087B1 (ru) * | 1997-04-03 | 2001-12-24 | Электрофект Ас | Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу |
| IL133709A0 (en) * | 1997-06-30 | 2001-04-30 | Rhone Poulence Rorer S A | Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo |
| EP0991425B1 (de) * | 1997-06-30 | 2005-03-09 | Institut Gustave Roussy | Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens |
| AU8577098A (en) * | 1997-07-22 | 1999-02-16 | Emed Corporation | Needle for iontophoretic delivery of agent |
| WO1999036563A1 (en) * | 1998-01-14 | 1999-07-22 | Emed Corporation | Electrically mediated cellular expression |
-
2000
- 2000-02-07 EP EP00907132A patent/EP1148885A4/de not_active Withdrawn
- 2000-02-07 WO PCT/US2000/002831 patent/WO2000045823A1/en not_active Application Discontinuation
- 2000-02-07 CA CA002361601A patent/CA2361601A1/en not_active Abandoned
- 2000-02-07 AU AU28682/00A patent/AU2868200A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1148885A4 (de) | 2002-05-08 |
| WO2000045823A9 (en) | 2001-10-11 |
| WO2000045823A1 (en) | 2000-08-10 |
| EP1148885A1 (de) | 2001-10-31 |
| AU2868200A (en) | 2000-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |