CA2360585A1 - Protease - Google Patents

Protease Download PDF

Info

Publication number
CA2360585A1
CA2360585A1 CA002360585A CA2360585A CA2360585A1 CA 2360585 A1 CA2360585 A1 CA 2360585A1 CA 002360585 A CA002360585 A CA 002360585A CA 2360585 A CA2360585 A CA 2360585A CA 2360585 A1 CA2360585 A1 CA 2360585A1
Authority
CA
Canada
Prior art keywords
leu
ser
ala
val
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002360585A
Other languages
English (en)
Inventor
Kay Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorec Biotec GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19902550A external-priority patent/DE19902550A1/de
Application filed by Individual filed Critical Individual
Publication of CA2360585A1 publication Critical patent/CA2360585A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

L'invention concerne une protéase comportant deux restes aspartate dans une structure catalytiquement active, un premier reste aspartate se situant dans un motif X¿1?GX¿2?GD et un deuxième reste aspartate se situant dans un motif X¿3?X¿4?DX¿5?. La protéase selon l'invention est caractérisée en ce que X¿1?, X¿2?, X¿3? et X¿5? pouvent être choisis indépendamment les uns des autres parmi Ala, Val, Leu, Met et Ile, en ce que X¿4? est un acide aminé aromatique et en ce que les motifs X¿1?GX¿2?GD et X¿3?X¿4?DX¿5? se situent dans une région transmembranaire.
CA002360585A 1999-01-22 2000-01-19 Protease Abandoned CA2360585A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19902550A DE19902550A1 (de) 1999-01-22 1999-01-22 Aspartatprotease
DE19902550.9 1999-01-22
DE19925946.1 1999-06-08
DE19925946 1999-06-08
DE19929115.2 1999-06-24
DE19929115 1999-06-24
PCT/EP2000/000390 WO2000043505A2 (fr) 1999-01-22 2000-01-19 Protease

Publications (1)

Publication Number Publication Date
CA2360585A1 true CA2360585A1 (fr) 2000-07-27

Family

ID=27218935

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360585A Abandoned CA2360585A1 (fr) 1999-01-22 2000-01-19 Protease

Country Status (4)

Country Link
EP (1) EP1144603A3 (fr)
AU (1) AU2542100A (fr)
CA (1) CA2360585A1 (fr)
WO (1) WO2000043505A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887677B1 (en) 1999-07-12 2005-05-03 Trustees Of Dartmouth College Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases
US8609087B2 (en) 1999-07-12 2013-12-17 Trustees Of Dartmouth College Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases
GB0126782D0 (en) * 2001-11-07 2002-01-02 Medical Res Council Assay

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965397A (en) * 1997-01-31 1999-10-12 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998040404A2 (fr) * 1997-03-11 1998-09-17 Genetics Institute, Inc. Proteines secretees et polynucleotides codant ces dernieres
CA2296815A1 (fr) * 1997-07-16 1999-01-28 Human Genome Sciences, Inc. Serie de 64 proteines humaines secretees
JPH11187882A (ja) * 1997-12-26 1999-07-13 Ono Pharmaceut Co Ltd 新規なポリペプチド、その製造方法、そのポリペプチドをコードするｃＤＮＡ、そのｃＤＮＡからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物
AU2783899A (en) * 1998-02-26 1999-09-15 Human Genome Sciences, Inc. 36 human secreted proteins
AU5928899A (en) * 1998-09-23 2000-04-10 Human Genome Sciences, Inc. 31 human secreted proteins

Also Published As

Publication number Publication date
EP1144603A2 (fr) 2001-10-17
EP1144603A3 (fr) 2002-02-06
WO2000043505A2 (fr) 2000-07-27
AU2542100A (en) 2000-08-07
WO2000043505A3 (fr) 2001-11-29

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Legal Events

Date Code Title Description
FZDE Discontinued