CA2358891A1 - Thienylbenzoylbenzazepines utilisees en tant qu'agonistes de la vasopressine - Google Patents

Thienylbenzoylbenzazepines utilisees en tant qu'agonistes de la vasopressine Download PDF

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Publication number
CA2358891A1
CA2358891A1 CA002358891A CA2358891A CA2358891A1 CA 2358891 A1 CA2358891 A1 CA 2358891A1 CA 002358891 A CA002358891 A CA 002358891A CA 2358891 A CA2358891 A CA 2358891A CA 2358891 A1 CA2358891 A1 CA 2358891A1
Authority
CA
Canada
Prior art keywords
chloro
methanone
benzodiazepin
phenyl
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002358891A
Other languages
English (en)
Inventor
Amedeo Arturo Failli
David Kent Williams
Thomas Joseph Caggiano
Mark Anthony Ashwell
Jay Scott Shumsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2358891A1 publication Critical patent/CA2358891A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention se rapporte à des composés représentés par la formule générale (I) dans laquelle Y est une fraction sélectionnée indépendamment parmi NH ou (CH¿2?)¿n?, où n est égal à 1; m est un entier égal à 1 ou 2 et la fraction (a) représente (1) un noyau hétérocyclique aromatique (insaturé) à 5 éléments comportant un atome d'azote (dans lequel A est azote, et B et C sont CH), (2) un noyau hétérocyclique aromatique (insaturé) à 6 éléments comportant un atome d'azote (dans lequel A est carbone, B est azote, et C est CH-CH-), (3) un noyau aromatique (insaturé) à 6 éléments (dans lequel A est carbone, B est CH et C est CH-CH-). L'invention se rapporte également à des méthodes et à des compositions pharmaceutiques utilisant ces composés pour le traitement des troubles qui peuvent être soignés ou soulagés par une activité agoniste de la vasopressine, notamment le diabète insipide, l'énurésie nocturne, la polyurie nocturne, l'incontinence urinaire, les troubles de saignement et de coagulation ou le retard temporaire de la miction.
CA002358891A 1999-02-04 2000-01-07 Thienylbenzoylbenzazepines utilisees en tant qu'agonistes de la vasopressine Abandoned CA2358891A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24417999A 1999-02-04 1999-02-04
US09/244,179 1999-02-04
PCT/US2000/000358 WO2000046227A1 (fr) 1999-02-04 2000-01-07 Thienylbenzoylbenzazepines utilisees en tant qu'agonistes de la vasopressine

Publications (1)

Publication Number Publication Date
CA2358891A1 true CA2358891A1 (fr) 2000-08-10

Family

ID=22921681

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002358891A Abandoned CA2358891A1 (fr) 1999-02-04 2000-01-07 Thienylbenzoylbenzazepines utilisees en tant qu'agonistes de la vasopressine

Country Status (7)

Country Link
EP (1) EP1149103A1 (fr)
JP (1) JP2002536377A (fr)
CN (1) CN1339036A (fr)
AR (1) AR028470A1 (fr)
AU (1) AU2603000A (fr)
CA (1) CA2358891A1 (fr)
WO (1) WO2000046227A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391476A (zh) * 1999-09-27 2003-01-15 美国氰胺公司 血管升压素激动剂制剂和方法
MXPA03009158A (es) * 2001-04-12 2004-02-12 Wyeth Corp Azepinas y diazepinas bi y triciclicas substituidas de n-bifenilcarbonil y n-fenilpiridilcarbonil como agonistas de la vasopresion.
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US5849735A (en) * 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
CN1339036A (zh) 2002-03-06
EP1149103A1 (fr) 2001-10-31
JP2002536377A (ja) 2002-10-29
WO2000046227A1 (fr) 2000-08-10
AU2603000A (en) 2000-08-25
AR028470A1 (es) 2003-05-14

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Legal Events

Date Code Title Description
FZDE Dead