CA2352592A1 - Composes quinazolinone - Google Patents
Composes quinazolinone Download PDFInfo
- Publication number
- CA2352592A1 CA2352592A1 CA002352592A CA2352592A CA2352592A1 CA 2352592 A1 CA2352592 A1 CA 2352592A1 CA 002352592 A CA002352592 A CA 002352592A CA 2352592 A CA2352592 A CA 2352592A CA 2352592 A1 CA2352592 A1 CA 2352592A1
- Authority
- CA
- Canada
- Prior art keywords
- compounds
- aralkyl
- benzyl
- phenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title abstract 3
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 abstract 2
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 102000011724 DNA Repair Enzymes Human genes 0.000 abstract 1
- 108010076525 DNA Repair Enzymes Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 abstract 1
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 abstract 1
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9404485A GB9404485D0 (en) | 1994-03-09 | 1994-03-09 | Benzamide analogues |
| GB9404485.6 | 1994-03-09 | ||
| CA002184747A CA2184747C (fr) | 1994-03-09 | 1995-03-09 | Analogues de benzamide, utiles comme inhibiteurs de l'enzyme parp (adp-ribosyltransferase, adprt), reparatrice de l'adn |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002184747A Division CA2184747C (fr) | 1994-03-09 | 1995-03-09 | Analogues de benzamide, utiles comme inhibiteurs de l'enzyme parp (adp-ribosyltransferase, adprt), reparatrice de l'adn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2352592A1 true CA2352592A1 (fr) | 1995-09-14 |
| CA2352592C CA2352592C (fr) | 2006-06-06 |
Family
ID=25678653
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002352592A Expired - Fee Related CA2352592C (fr) | 1994-03-09 | 1995-03-09 | Composes quinazolinone |
| CA002350941A Abandoned CA2350941A1 (fr) | 1994-03-09 | 1995-03-09 | Analogues de benzamide comme inhibiteurs de l'enzyme parp reparatrice de l'adn |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002350941A Abandoned CA2350941A1 (fr) | 1994-03-09 | 1995-03-09 | Analogues de benzamide comme inhibiteurs de l'enzyme parp reparatrice de l'adn |
Country Status (1)
| Country | Link |
|---|---|
| CA (2) | CA2352592C (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012151701A1 (fr) * | 2011-05-10 | 2012-11-15 | Université Laval / Vice-Rectorat À La Recherche Et À La Création | Procédés pour le traitement et le diagnostic de l'hypertension artérielle pulmonaire |
-
1995
- 1995-03-09 CA CA002352592A patent/CA2352592C/fr not_active Expired - Fee Related
- 1995-03-09 CA CA002350941A patent/CA2350941A1/fr not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012151701A1 (fr) * | 2011-05-10 | 2012-11-15 | Université Laval / Vice-Rectorat À La Recherche Et À La Création | Procédés pour le traitement et le diagnostic de l'hypertension artérielle pulmonaire |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2350941A1 (fr) | 1995-09-14 |
| CA2352592C (fr) | 2006-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |