CA2351720C - Taste masking rapid release coating system - Google Patents

Taste masking rapid release coating system Download PDF

Info

Publication number
CA2351720C
CA2351720C CA002351720A CA2351720A CA2351720C CA 2351720 C CA2351720 C CA 2351720C CA 002351720 A CA002351720 A CA 002351720A CA 2351720 A CA2351720 A CA 2351720A CA 2351720 C CA2351720 C CA 2351720C
Authority
CA
Canada
Prior art keywords
weight
core
drug
taste masking
microns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002351720A
Other languages
English (en)
French (fr)
Other versions
CA2351720A1 (en
Inventor
Kris E. Holt
Rajendra K. Khankari
John Hontz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of CA2351720A1 publication Critical patent/CA2351720A1/en
Application granted granted Critical
Publication of CA2351720C publication Critical patent/CA2351720C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002351720A 1998-11-25 1999-11-24 Taste masking rapid release coating system Expired - Fee Related CA2351720C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11003298P 1998-11-25 1998-11-25
US60/110,032 1998-11-25
PCT/US1999/027981 WO2000030617A1 (en) 1998-11-25 1999-11-24 Taste masking rapid release coating system

Publications (2)

Publication Number Publication Date
CA2351720A1 CA2351720A1 (en) 2000-06-02
CA2351720C true CA2351720C (en) 2006-11-21

Family

ID=22330879

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002351720A Expired - Fee Related CA2351720C (en) 1998-11-25 1999-11-24 Taste masking rapid release coating system

Country Status (6)

Country Link
EP (2) EP2260836B1 (enExample)
JP (1) JP2002530322A (enExample)
AU (1) AU753476B2 (enExample)
CA (1) CA2351720C (enExample)
ES (1) ES2601855T3 (enExample)
WO (1) WO2000030617A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AR034813A1 (es) * 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US6753009B2 (en) 2002-03-13 2004-06-22 Mcneil-Ppc, Inc. Soft tablet containing high molecular weight polyethylene oxide
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
AU2002368090A1 (en) * 2002-07-17 2004-02-09 Eurand Pharmaceuticals Ltd Process for the preparation of pharmaceutical microcapsules with enhanced tastemasking and high dissolution rate
US20040258752A1 (en) * 2003-01-31 2004-12-23 Paruthi Manoj Kumar Taste masking pharmaceutical composition and process for its preparation
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
US20040265372A1 (en) 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
MX2007008320A (es) * 2005-01-06 2007-09-07 Cima Labs Inc Sistema enmascarador de sabor para farmacos no plastificantes.
US20070098746A1 (en) * 2005-11-02 2007-05-03 Nichols William M Multi-layered coating technology for taste masking
WO2007143131A2 (en) * 2006-06-01 2007-12-13 Cima Labs, Inc. Prednisolone sodium phosphate formulations
US8637076B2 (en) 2006-06-01 2014-01-28 Cima Labs Inc. Prednisolone salt formulations
EA017832B1 (ru) * 2006-08-04 2013-03-29 Этифарм Гранулы и орально дезинтегрируемые таблетки, содержащие оксикодон
KR101408315B1 (ko) * 2006-08-04 2014-06-20 에씨팜 다층 경구 붕해 정제
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
KR20120056824A (ko) 2009-08-19 2012-06-04 바이엘 파마 악티엔게젤샤프트 소아과 용도를 위한 약물 전달 시스템 (웨이퍼)
WO2011042897A1 (en) * 2009-10-05 2011-04-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd Liquid precursor compositions and uses thereof for a ph-dependant sustained release treatment of oral disorders
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
FR3078630B1 (fr) 2018-03-08 2021-05-14 Karim Ioualalen Mode de formulation sous forme de solide divise hydrophobe
FR3079146B1 (fr) 2018-03-23 2020-04-17 Karim Ioualalen Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive.
CN110755404B (zh) * 2019-12-04 2022-03-08 长春雷允上药业有限公司 一种阿奇霉素药物组合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8623557D0 (en) * 1986-10-01 1986-11-05 Boots Co Plc Therapeutic agents
SE8605515D0 (sv) * 1986-12-22 1986-12-22 Astra Laekemedel Ab A liquid dosage form for oral administration of a pharmaceutically active substance
US5004595A (en) * 1986-12-23 1991-04-02 Warner-Lambert Company Multiple encapsulated flavor delivery system and method of preparation
US4874613A (en) * 1987-03-06 1989-10-17 Baker Cummins Pharmaceuticals, Inc. Taste concealing pharmaceutical dosage unit
US5234957A (en) 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5026559A (en) * 1989-04-03 1991-06-25 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
US4966770A (en) * 1989-07-26 1990-10-30 Himedics, Inc. Prednisone microencapsulated granules
US5527545A (en) * 1989-09-18 1996-06-18 Recordati S.A. Chemical And Pharmaceutical Company Liquid-suspension controlled-release pharmaceutical composition
US5516524A (en) * 1993-12-20 1996-05-14 The Procter & Gamble Company Laxative compositions containing bulk fiber
US5614222A (en) * 1994-10-25 1997-03-25 Kaplan; Milton R. Stable aqueous drug suspensions and methods for preparation thereof
US5529783A (en) * 1994-12-19 1996-06-25 Mcneil-Ppc, Inc. Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan
CN1244119A (zh) * 1997-01-06 2000-02-09 辉瑞大药厂 迅速释放和掩蔽味觉的药物剂型
US6289180B1 (en) * 1997-12-08 2001-09-11 Intel Corporation Photoflash charging circuit with current and voltage monitor

Also Published As

Publication number Publication date
HK1146901A1 (en) 2011-07-22
CA2351720A1 (en) 2000-06-02
EP1133282A4 (en) 2006-03-29
EP2260836B1 (en) 2016-08-10
EP2260836A3 (en) 2012-02-01
EP1133282A1 (en) 2001-09-19
JP2002530322A (ja) 2002-09-17
AU1922000A (en) 2000-06-13
AU753476B2 (en) 2002-10-17
ES2601855T3 (es) 2017-02-16
EP2260836A2 (en) 2010-12-15
WO2000030617A9 (en) 2000-11-23
WO2000030617A1 (en) 2000-06-02

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20181126