CA2350759A1 - Benzylmaltotriosides inhibiteurs de la proliferation des cellules des muscles lisses - Google Patents

Benzylmaltotriosides inhibiteurs de la proliferation des cellules des muscles lisses Download PDF

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Publication number
CA2350759A1
CA2350759A1 CA002350759A CA2350759A CA2350759A1 CA 2350759 A1 CA2350759 A1 CA 2350759A1 CA 002350759 A CA002350759 A CA 002350759A CA 2350759 A CA2350759 A CA 2350759A CA 2350759 A1 CA2350759 A1 CA 2350759A1
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Canada
Prior art keywords
carbon atoms
hydrogen
independently
alkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA002350759A
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English (en)
Inventor
Paul Jeffrey Dollings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
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Individual
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Publication of CA2350759A1 publication Critical patent/CA2350759A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des inhibiteurs de la prolifération des cellules des muscles lisses représentés par la formule générale (I), ou certains de leurs sels pharmaceutiquement admis. Dans cette formule générale (I), X est tel que représenté par la formule (A). R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿ et R?10¿ sont chacun indépendamment C¿2?-C¿7? acyle, C¿2?-C¿10? perfluoroacyle, C¿1?-C¿6? alkyle, C¿1?-C¿6? perfluoroalkyle, benzoyle, benzyle ou -SO¿3?M; M est hydrogène, lithium, sodium, potassium ou ammonium; R?11¿ est hydrogène, C¿1?-C¿6? alkyle; R?12¿ est hydrogène, nitro, amino, C¿2?-C¿7? acylamino, C¿2?-C¿7? perfluoroacylamino, C¿1?-C¿6? alkylamino, C¿1?-C¿6? perfluoroalkylamino, dialklylamino où chaque chaîne alkyle est indépendamment C¿1?-C¿6? alkyle, perfluorodialklylamino où chaque chaîne alkyle est indépendamment C¿1?-C¿6? alkyle, C¿1?-C¿6? alkylsulfonylamino, C¿1?-C¿6? perfluoroalkylsulfonylamino, C¿1?-C¿6? arylsulfonylamino ou arylsulfonylamino substitué par C¿6?-C¿10? halo.
CA002350759A 1998-11-24 1999-11-23 Benzylmaltotriosides inhibiteurs de la proliferation des cellules des muscles lisses Abandoned CA2350759A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19880598A 1998-11-24 1998-11-24
US09/198,805 1998-11-24
PCT/US1999/027775 WO2000031095A2 (fr) 1998-11-24 1999-11-23 Benzylmaltotriosides inhibiteurs de la prolifération des cellules des muscles lisses

Publications (1)

Publication Number Publication Date
CA2350759A1 true CA2350759A1 (fr) 2000-06-02

Family

ID=22734935

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002350759A Abandoned CA2350759A1 (fr) 1998-11-24 1999-11-23 Benzylmaltotriosides inhibiteurs de la proliferation des cellules des muscles lisses

Country Status (7)

Country Link
EP (1) EP1133506A2 (fr)
JP (1) JP2002530420A (fr)
CN (1) CN1333778A (fr)
AU (1) AU1919800A (fr)
BR (1) BR9915643A (fr)
CA (1) CA2350759A1 (fr)
WO (1) WO2000031095A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115745A (en) * 1994-11-07 2000-11-21 American Home Prod Acylated benzylglycosides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP1133506A2 (fr) 2001-09-19
CN1333778A (zh) 2002-01-30
AU1919800A (en) 2000-06-13
JP2002530420A (ja) 2002-09-17
BR9915643A (pt) 2001-08-07
WO2000031095A2 (fr) 2000-06-02
WO2000031095A3 (fr) 2001-01-04

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