CA2347247A1 - Genes d'evaluation d'etat cardio-vasculaire et compositions d'utilisations associees - Google Patents

Genes d'evaluation d'etat cardio-vasculaire et compositions d'utilisations associees Download PDF

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Publication number
CA2347247A1
CA2347247A1 CA002347247A CA2347247A CA2347247A1 CA 2347247 A1 CA2347247 A1 CA 2347247A1 CA 002347247 A CA002347247 A CA 002347247A CA 2347247 A CA2347247 A CA 2347247A CA 2347247 A1 CA2347247 A1 CA 2347247A1
Authority
CA
Canada
Prior art keywords
polymorphic
numbered
positions
receptor
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002347247A
Other languages
English (en)
Inventor
Leif Torbjorn Norberg
Maria Kristina Andersson
Per Harry Rutger Lindstrom
Lena Jonsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pyrosequencing AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2347247A1 publication Critical patent/CA2347247A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C12N9/0079—Steroid 11 beta monooxygenase (P-450 protein)(1.14.15.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6486—Renin (3.4.23.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23015—Renin (3.4.23.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des méthodes d'évaluation d'état cardio-vasculaire chez un sujet, comprenant une détermination de la séquence à une ou plusieurs positions polymorphes dans les gènes humains qui codent pour l'ACE, l'AT1, l'AGT, la rénine, l'aldostérone synthase, le récepteur d'angiotensine II de type 2, le récepteur d'endothéline, et le .beta.-adrénocepteur. L'invention concerne aussi des acides nucléiques isolés qui codent des polymorphismes dans des gènes qui codent pour l'ACE, l'AT1, l'AGT, la rénine, l'aldostérone synthase, le récepteur d'angiotensine II de type 2, le récepteur d'endothéline et le .beta.-adrénocepteur, des sondes d'acides nucléiques qui s'hybrident sur des positions polymorphes, des nécessaires de prédiction d'état cardio-vasculaire, et des cibles d'acides nucléiques et de peptides destinées à l'identification de substances cardio-vasculaires candidates.
CA002347247A 1998-10-14 1999-10-13 Genes d'evaluation d'etat cardio-vasculaire et compositions d'utilisations associees Abandoned CA2347247A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10430298P 1998-10-14 1998-10-14
US10428698P 1998-10-14 1998-10-14
US60/104,286 1998-10-14
US60/104,302 1998-10-14
PCT/IB1999/001678 WO2000022166A2 (fr) 1998-10-14 1999-10-13 Genes d'evaluation d'etat cardio-vasculaire et compositions d'utilisations associees

Publications (1)

Publication Number Publication Date
CA2347247A1 true CA2347247A1 (fr) 2000-04-20

Family

ID=26801367

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002347247A Abandoned CA2347247A1 (fr) 1998-10-14 1999-10-13 Genes d'evaluation d'etat cardio-vasculaire et compositions d'utilisations associees

Country Status (7)

Country Link
EP (1) EP1121462A2 (fr)
JP (1) JP2002527079A (fr)
AU (1) AU6116399A (fr)
CA (1) CA2347247A1 (fr)
IL (1) IL142548A0 (fr)
NO (1) NO20011847L (fr)
WO (1) WO2000022166A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19938390A1 (de) * 1999-08-05 2001-03-08 Max Delbrueck Centrum Neue Sequenzvarianten des menschlichen ßl-Adrenozeptorgens und ihre Verwendung
US20030124524A1 (en) * 2000-06-23 2003-07-03 Kenneth Kornman Screening assays for identifying modulators of the inflammatory or immune response
US20030113726A1 (en) * 2000-12-04 2003-06-19 Zenta Tsuchihashi Human single nucleotide polymorphisms
DE10065666B4 (de) * 2000-12-29 2008-10-02 Wiesner, Rudolf, Prof. Dr. DNA-Chip zur kausalen Diagnose von Bluthochdruck
WO2002063045A1 (fr) * 2001-02-02 2002-08-15 Genaissance Pharmaceuticals, Inc. Isogenes cibles de medicament: polymorphismes dans le gene du recepteur 2 de l'angiotensine
EP1394267A1 (fr) * 2002-08-19 2004-03-03 Bayer HealthCare AG Polymorphismes à nucléotide unique permettant de pronostiquer les maladies cardio-vasculaires, les effets secondaires et l'efficacité des medicaments
JP4502570B2 (ja) * 2002-09-24 2010-07-14 株式会社東洋紡ジーンアナリシス 遺伝子多型解析を用いたＩｇＡ腎症診断およびＩｇＡ腎症診断用キット
ATE469245T1 (de) 2004-09-14 2010-06-15 Univ Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
EP1851329B1 (fr) 2005-02-02 2012-06-20 The Royal College of Surgeons in Ireland Pharmacogenomics des agents abaissant de la tension artérielle
BRPI0609702A2 (pt) * 2005-03-22 2010-04-20 Novartis Ag biomarcadores para a eficácia de aliskiren como um agente hipertensivo
WO2007008604A2 (fr) * 2005-07-08 2007-01-18 Bristol-Myers Squibb Company Polymorphismes de nucleotides simples associes a l'oedeme dose-dependant, et leurs procedes d'utilisation
CA2729640A1 (fr) 2008-07-03 2010-01-07 Mor Research Applications Ltd Polymorphismes diagnostiques d'une maladie cardiaque

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002709A1 (fr) * 1985-10-24 1987-05-07 Biotechnology Research Partners, Ltd. Teste sanguin pour diagnostiquer une hypertension
AU1728088A (en) * 1987-04-30 1988-12-02 Biotechnology Research Partners Limited Hypertension-related blood tests useful as genetic markers
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US6197505B1 (en) * 1997-04-04 2001-03-06 Pyrosequencing Ab Methods for assessing cardiovascular status and compositions for use thereof
WO1999037761A1 (fr) * 1997-12-30 1999-07-29 Max-Delbrück-Centrum für Molekulare Medizin Nouvelles variantes de sequences du gene recepteur beta2-adrenergique humain et leur utilisation

Also Published As

Publication number Publication date
NO20011847L (no) 2001-06-14
JP2002527079A (ja) 2002-08-27
NO20011847D0 (no) 2001-04-10
WO2000022166A3 (fr) 2000-09-14
IL142548A0 (en) 2002-03-10
EP1121462A2 (fr) 2001-08-08
WO2000022166A2 (fr) 2000-04-20
AU6116399A (en) 2000-05-01

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FZDE Discontinued