CA2341718A1 - Synthese amelioree de 3-hydroxy-4-amino-benzonitrile - Google Patents

Synthese amelioree de 3-hydroxy-4-amino-benzonitrile Download PDF

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Publication number
CA2341718A1
CA2341718A1 CA002341718A CA2341718A CA2341718A1 CA 2341718 A1 CA2341718 A1 CA 2341718A1 CA 002341718 A CA002341718 A CA 002341718A CA 2341718 A CA2341718 A CA 2341718A CA 2341718 A1 CA2341718 A1 CA 2341718A1
Authority
CA
Canada
Prior art keywords
alkyl
optionally substituted
aryl
alkenyl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002341718A
Other languages
English (en)
Inventor
Neil H. Baine
William M. Clark, Jr.
Ann Marie Eldridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2341718A1 publication Critical patent/CA2341718A1/fr
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827X being H
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Abstract

L'invention concerne un procédé de préparation de 3-hydroxy-4-amino-benzonitrile.
CA002341718A 1998-08-28 1999-08-26 Synthese amelioree de 3-hydroxy-4-amino-benzonitrile Abandoned CA2341718A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9824998P 1998-08-28 1998-08-28
US60/098,249 1998-08-28
PCT/US1999/019492 WO2000012468A1 (fr) 1998-08-28 1999-08-26 Synthese amelioree de 3-hydroxy-4-amino-benzonitrile

Publications (1)

Publication Number Publication Date
CA2341718A1 true CA2341718A1 (fr) 2000-03-09

Family

ID=22268356

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002341718A Abandoned CA2341718A1 (fr) 1998-08-28 1999-08-26 Synthese amelioree de 3-hydroxy-4-amino-benzonitrile

Country Status (4)

Country Link
EP (1) EP1107948A4 (fr)
JP (1) JP2002523487A (fr)
CA (1) CA2341718A1 (fr)
WO (1) WO2000012468A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR041834A1 (es) 2002-10-29 2005-06-01 Smithkline Beecham Corp Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
AU2006332680A1 (en) 2005-12-29 2007-07-12 Anthrogenesis Corporation Improved composition for collecting and preserving placental stem cells and methods of using the composition
MY145810A (en) 2006-04-21 2012-04-30 Smithkline Beecham Corp Il-8 receptor antagonists
BRPI0710559A2 (pt) 2006-04-21 2011-08-16 Smithkline Beecham Corp antagonistas de receptores de il-8
JP5270943B2 (ja) * 2008-03-28 2013-08-21 大阪瓦斯株式会社 フルオレン誘導体およびこのフルオレン誘導体を用いたアミノ基含有フルオレン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2195076A (en) * 1936-10-24 1940-03-26 Gen Aniline & Film Corp Process of replacing halogen in cyclic halogen compounds and product thereof
SE370866B (fr) * 1968-03-21 1974-11-04 Ciba Geigy Ag
CA1181070A (fr) * 1979-11-28 1985-01-15 Kiyoshi Murase Methode de preparation de derives de l'acide 2- hydroxyoxanilique
EP0809492A4 (fr) * 1995-02-17 2007-01-24 Smithkline Beecham Corp Antagonistes des recepteurs d'il-8

Also Published As

Publication number Publication date
EP1107948A1 (fr) 2001-06-20
WO2000012468A1 (fr) 2000-03-09
EP1107948A4 (fr) 2002-01-02
JP2002523487A (ja) 2002-07-30

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Legal Events

Date Code Title Description
FZDE Discontinued