CA2340086A1 - Procede relatif a la transduction de cellules mammaliennes, et produits connexes - Google Patents

Procede relatif a la transduction de cellules mammaliennes, et produits connexes Download PDF

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Publication number
CA2340086A1
CA2340086A1 CA002340086A CA2340086A CA2340086A1 CA 2340086 A1 CA2340086 A1 CA 2340086A1 CA 002340086 A CA002340086 A CA 002340086A CA 2340086 A CA2340086 A CA 2340086A CA 2340086 A1 CA2340086 A1 CA 2340086A1
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CA
Canada
Prior art keywords
cells
cell
virus
fibronectin
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002340086A
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English (en)
Inventor
Harry L. Malech
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States, REPRESENTED BY DEPARTMENT OF HEALTH AND HU MAN SERVICES
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Individual
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Filing date
Publication date
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Publication of CA2340086A1 publication Critical patent/CA2340086A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

L'invention concerne des procédés relatifs à la transduction de cellules qui consistent à utiliser un contenant à culture clos et flexible renfermant des cellules, et à mettre ces cellules en contact avec un vecteur viral en présence d'une fraction chimique multivalente. L'invention concerne également des procédés relatifs à l'administration d'une protéine fonctionnelle à un sujet ayant besoin de cette protéine, qui consistent à assurer la transduction de cellules mammaliennes selon les procédés de transduction susmentionnés et à introduire lesdites cellules dans l'organisme d'un sujet ayant besoin de ces cellules. L'invention concerne en outre des systèmes de culture cellulaire permettant d'assurer la transduction de cellules, qui comprennent un contenant à culture clos et flexible dans lequel on utilise une fraction chimique multivalente.
CA002340086A 1998-08-11 1998-08-11 Procede relatif a la transduction de cellules mammaliennes, et produits connexes Abandoned CA2340086A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/016699 WO2000009168A1 (fr) 1998-08-11 1998-08-11 Procede relatif a la transduction de cellules mammaliennes, et produits connexes

Publications (1)

Publication Number Publication Date
CA2340086A1 true CA2340086A1 (fr) 2000-02-24

Family

ID=22267668

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002340086A Abandoned CA2340086A1 (fr) 1998-08-11 1998-08-11 Procede relatif a la transduction de cellules mammaliennes, et produits connexes

Country Status (4)

Country Link
JP (1) JP2002522513A (fr)
AU (1) AU8780198A (fr)
CA (1) CA2340086A1 (fr)
WO (1) WO2000009168A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8728811B2 (en) 2002-03-25 2014-05-20 Takara Bio Inc. Process for producing cytotoxic lymphocyte
EP1666589B1 (fr) 2003-08-22 2010-02-17 Takara Bio Inc. Procede de production de lymphocytes cytotoxiques
GB0410130D0 (en) * 2004-05-06 2004-06-09 Molmed Spa Cell preparation
JP4929174B2 (ja) 2005-08-17 2012-05-09 タカラバイオ株式会社 リンパ球の製造方法
EA016168B1 (ru) 2005-09-30 2012-02-28 Такара Био Инк. Способ получения т-клеточной популяции и ее применение
EP2028266A4 (fr) 2006-06-09 2010-08-11 Takara Bio Inc Procede de production de lymphocytes
JP5659448B2 (ja) * 2006-08-23 2015-01-28 株式会社フコク 培養容器及び同容器を用いた細胞培養方法
JP5485139B2 (ja) 2008-03-27 2014-05-07 タカラバイオ株式会社 遺伝子導入細胞の製造方法
CN102656263A (zh) 2009-08-25 2012-09-05 宝生物工程株式会社 用于在视黄酸存在下制备t细胞群的方法
KR101679602B1 (ko) 2009-09-11 2016-11-25 다카라 바이오 가부시키가이샤 내추럴킬러 세포의 제조방법
IL305656A (en) * 2013-09-23 2023-11-01 Wilson Wolf Mfg Corporation Improved methods for genetic modification in animal cells
AU2016331082B2 (en) * 2015-09-30 2023-12-07 Vycellix, Inc. Enhanced gene delivery to natural killer cells, hematopoietic stem cells and macrophages
JP7023228B2 (ja) 2016-07-29 2022-02-21 タカラバイオ株式会社 幹細胞の製造に用いられるフィブロネクチンフラグメント
EP3572502B1 (fr) 2017-01-20 2023-01-11 Kyoto University Procédé de production de lymphocytes t cd8 alpha+ beta+ cytotoxiques
CN111655842B (zh) 2018-01-25 2023-10-20 宝生物工程株式会社 淋巴细胞生产方法
JPWO2021200901A1 (fr) 2020-03-31 2021-10-07
CN114409763A (zh) * 2022-03-15 2022-04-29 湖南华腾制药有限公司 一种重组纤连蛋白肽的纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763266A (en) * 1989-06-15 1998-06-09 The Regents Of The University Of Michigan Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
EP0725134A3 (fr) * 1995-02-03 1998-05-13 NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen B.V. Bioréacteur flexible pour cellules thérapeutiques

Also Published As

Publication number Publication date
WO2000009168A1 (fr) 2000-02-24
JP2002522513A (ja) 2002-07-23
AU8780198A (en) 2000-03-06

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