CA2339047A1 - Secreted proteins and polynucleotides encoding them - Google Patents

Secreted proteins and polynucleotides encoding them Download PDF

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CA2339047A1
CA2339047A1 CA002339047A CA2339047A CA2339047A1 CA 2339047 A1 CA2339047 A1 CA 2339047A1 CA 002339047 A CA002339047 A CA 002339047A CA 2339047 A CA2339047 A CA 2339047A CA 2339047 A1 CA2339047 A1 CA 2339047A1
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seq
nucleotide sequence
nucleotide
amino acid
protein
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Kenneth Jacobs
John M. Mccoy
Edward R. Lavallie
Lisa A. Collins-Racie
Cheryl Evans
David Merberg
Maurice Treacy
Michael J. Agostino
Robert J. Ii Steininger
Vikki Spaulding
Gordon G. Wong
Hilary F. Clark
Kim Fechtel
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Genetics Institute LLC
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

Novel polynucleotides and the proteins encoded thereby are disclosed.

Description

r .
a DEMANDES OU BREVETS VOLUMINEUX

COMPREND PLUS D'UN TOME.
CECI EST LE TOME '( DE
NOTE: ~ Pour les tomes additionels, veuillez contacter le Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS
THIS SECTION OF THE APPLICATIONIPATENT CONTAINS MORE
THAN ONE VOLUME
THIS IS VOLUME ~ , OF
NOTE: For additional volumes please contact the Canadian Patent Office SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
This application is a continuation-in-part of the following applications:
(1) provisional application Ser. No. 60/096,622 (GI 6075), filed August 14,1998;
(2) provisional application Ser. No. 60/096,815 (GI 6076), filed August 17,1998;
(3) provisional application Ser. No. 60/099,229 (GI 6077), filed September 4,1998;
(4) provisional application Ser. No. 60/105,368 (GI 6078), filed October 23,1998;
(5} provisional application Ser. No. 60/I15,234 (GI 6079), filed January 8,1999;
(6) provisional application Ser. No. 60/119,931 (GI 6080), filed Febxuary 12,1999;
(7) provisional application Ser. No. 60/120,575 (GI 6081), filed February 18,1999;
(8) provisional application Ser. No. 60/132,020 (GI 6082), filed April 30,1999;
2 0 (9) provisional application Ser. No. 60/XXX,XXX (GI 6083), filed August 11,1999;
all of which are incorporated by reference herein.
FIELD OF THE INVENTION
The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins.

BACKGROUND OF THE INVENTION
Technology aimed at the discovery of protein factors (including e.g., cytokines, such as lymphokines, interferons, CSFs and interleukins) has matured rapidly over the past decade. The now routine hybridization cloning and expression cloning techniques clone novel polynucleotides "directly" in the sense that they rely on information directly related to the discovered protein (i.e., partial DNA/amino acid sequence of the protein in the case of hybridization cloning; activity of the protein in the case of expression cloning). More recent "indirect" cloning techniques such as signal sequence cloning, which isolates DNA sequences based on the presence of a now well-recognized secretory leader sequence motif, as well as various PCR-based or low stringency hybridization cloning techniques, have advanced the state of the art by making available large numbers of DNA/amino acid sequences for proteins that are known to have biological activity by virtue of their secreted nature in the case of leader sequence cloning, or by virtue of the cell or tissue source in the case of PCR-based techniques. It is to these proteins and the polynucleotides encoding them that the present invention is directed.
SUMMARY OF THE INVENTION
In one embodiment, the present invention provides a composition comprising an 2 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:1;
(b) a polynudeotide comprising the nucleotide sequence of SEQ ID
NO:1 from nucleotide 87 to nucleotide 821;
2 5 (c) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:1 from nucleotide 120 to nucleotide 821;
(d) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:1 from nucleotide 1 to nucleotide 1625;
(e) a polynucleotide comprising the nucleotide sequence of the full-3 0 length protein coding sequence of clone co62_12 deposited under accession number ATCC 98825;
(f) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;

(g) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone co62_12 deposited under accession number ATCC 98825;
(h) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone co62_12 deposited under accession number ATCC 98825;
(i) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:2;
(j) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:2 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:2;
(k) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(h) above;
(1) a polynucleotide which encodes a species homologue of the protein of (i) or (j) above ;
(m) a polynudeotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(j); and (n) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(j) and that has a length that is at least 25% of the length of SEQ ID NO:1.
2 0 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
NO:1 from nucleotide 87 to nucleotide 821; the nucleotide sequence of SEQ ID
NO:1 from nucleotide 120 to nucleotide 821; the nucleotide sequence of SEQ ID NO:1 from nucleotide 1 to nucleotide 1625; the nucleotide sequence of the full-length protein coding sequence of clone co62_12 deposited under accession number ATCC 98825; or the 2 5 nucleotide sequence of a mature protein coding sequence of clone co62_12 deposited under accession number ATCC 98825. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone co62_12 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein 3 0 comprising a fragment of the amino acid sequence of SEQ ID N0:2 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:2, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:2.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:1.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:1, but excluding the poly(A) tail at the 3' end of SEQ ID N0:1; and (ab) the nucleotide sequence of the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 {b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID NO:1, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:1; and (bb) the nucleotide sequence of the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:1, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ ID
N0:1 to a nucleotide sequence corresponding to the 3' end of SEQ ID NO:1 , but excluding the poly(A) tail at the 3' end of SEQ ID NO:1. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:1 from nucleotide 87 to nucleotide 821, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:1 from nucleotide 87 to nucleotide 821, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:1 from nucleotide 87 to nucleotide 821. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:1 from nucleotide 120 to nucleotide 821, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
NO:1 from nucleotide 120 to nucleotide 821, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:1 from nucleotide 120 to nucleotide 821. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:1 from nucleotide 1 to nucleotide 1625, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:1 from nucleotide 1 to nucleotide 1625, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:1 from nucleotide 1 to nucleotide 1625.
2 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:2;
(b) a fragment of the amino acid sequence of SEQ ID N0:2, the 2 5 fragment comprising eight contiguous amino acids of SEQ ID N0:2; and (c) the amino acid sequence encoded by the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:2. In further preferred 3 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:2 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:2, or a protein comprising a fragment of the amino acid sequence of SEQ

ID N0:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:2.
1n one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:3;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:3 from nucleotide 9 to nucleotide 1013;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:3 from nucleotide 96 to nucleotide 1013;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone 10311 8 deposited under accession number ATCC 98825;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone 10311 8 deposited under accession number ATCC 98825;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone 10311 8 deposited under accession number ATCC 98825;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
2 0 insert of clone 10311 8 deposited under accession number ATCC 98825;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:4;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:4 having biological activity, the fragment 2 5 comprising eight contiguous amino acids of SEQ ID N0:4;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
3 0 (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(i) and that has a length that is at least 25% of the length of SEQ ID N0:3.

Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:3 from nucleotide 9 to nucleotide 1013; the nucleotide sequence of SEQ ID
N0:3 from nucleotide 96 to nucleotide 2013; the nucleotide sequence of the full-length protein coding sequence of clone Io311 8 deposited under accession number ATCC 98825; or the nucleotide sequence of a mature protein coding sequence of clone 10311_8 deposited under accession number ATCC 98825. In other nreferrPrl Pm~,n~ima"+e +~,o polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone 10311 8 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:4 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:4, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:4 having biological activity, the fragment comprising the amino acid sequence from amino acid 162 to amino acid 171 of SEQ ID N0:4.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:3.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
2 0 (a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:3, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:3; and (ab) the nucleotide sequence of the cDNA insert of clone 10311_8 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 3 0 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:

(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:3, but excluding the poly(A) tail at the 3' end of SEQ ID N0:3; and (bb) the nucleotide sequence of the cDNA insert of clone 10311 8 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying.human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:3, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ ID
N0:3 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:3 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:3. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:3 from nucleotide 9 to nucleotide 1013, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of 2 0 SEQ ID N0:3 from nucleotide 9 to nucleotide 1013, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:3 from nucleotide 9 to nucleotide 2013. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:3 from nucleotide 96 to nucleotide 1013, and extending contiguously from a 2 5 nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:3 from nucleotide 96 to nucleotide 1013, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:3 from nucleotide 96 to nucleotide 1013.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 3 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:4;
(b) a fragment of the amino acid sequence of SEQ ID N0:4, the fragment comprising eight contiguous amino acids of SEQ ID N0:4; and (c) the amino acid sequence encoded by the cDNA insert of clone 10311 8 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:4. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:4 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty} contiguous amino acids of SEQ ID N0:4, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:4 having biological activity, the fragment comprising the amino acid sequence from amino acid 162 to amino acid 171 of SEQ ID N0:4.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:5;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:5 from nucleotide 352 to nucleotide 825;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ns197 1 deposited under accession number ATCC 98825;
2 0 (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ns197 1 deposited under accession number ATCC 98825;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ns197_1 deposited under accession number ATCC 98825;
2 5 (f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ns197 1 deposited under accession number ATCC 98825;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:6;
(h) a polynucleotide encoding a protein comprising a fragment of the 3 0 amino acid sequence of SEQ ID NO:6 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:6;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j} a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynudeotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:5.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:5 from nucleotide 352 to nucleotide 825; the nucleotide sequence of the full-length protein coding sequence of clone ns197 1 deposited under accession number ATCC
98825;
or the nucleotide sequence of a mature protein coding sequence of clone ns197 deposited under accession number ATCC 98825. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone ns197 1 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:6 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:6, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:6 having 2 0 biological activity, the fragment comprising the amino acid sequence from amino acid 74 to amino acid 83 of SEQ ID N0:6.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:5.
Further embodiments of the invention provide isolated polynucleotides produced 2 5 according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
3 0 (aa) SEQ ID N0:5, but excluding the poly(A) tail at the 3' end of SEQ ID N0:5; and (ab) the nucleotide sequence of the cDNA insert of clone ns197_1 deposited under accession number ATCC 98825;

(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:5, but excluding the poly(A) tail at the 3' end of SEQ ID N0:5; and (bb) the nucleotide sequence of the cDNA insert of clone ns197 1 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:5, and extending 2 0 contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:5 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:5 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:5. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:5 from nucleotide 352 to nucleotide 825, and extending 2 5 contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:5 from nucleotide 352 to nucleotide 825, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:5 from nucleotide 352 to nucleotide 825.
In other embodiments, the present invention provides a composition comprising 3 0 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:6;
(b) a fragment of the amino acid sequence of SEQ ID N0:6, the fragment comprising eight contiguous amino acids of SEQ ID N0:6; and (c) the amino acid sequence encoded by the cDNA insert of clone ns197_1 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:6. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:6 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:6, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:6 having biological activity, the fragment comprising the amino acid sequence from amino acid 74 to amino acid 83 of SEQ ID N0:6.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:7;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:7 from nucleotide 86 to nucleotide 829;
(c} a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:7 from nucleotide 149 to nucleotide 829;
(d) a polynucleotide comprising the nucleotide sequence of the full-2 0 length protein coding sequence of clone pj193 5 deposited under accession number ATCC 98825;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pj193_5 deposited under accession number ATCC 98825;
(f) a polynucleotide comprising the nucleotide sequence of a mature 2 5 protein coding sequence of clone pj193_5 deposited under accession number ATCC 98825;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pj193 5 deposited under accession number ATCC 98825;
(h) a polynucleotide encoding a protein comprising the amino acid 3 0 sequence of SEQ ID N0:8;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:8 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:8;

(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:7.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:7 from nucleotide 8b to nucleotide 829; the nucleotide sequence of SEQ ID
N0:7 from nucleotide 149 to nucleotide 829; the nucleotide sequence of the full-length protein coding sequence of clone pj193_5 deposited under accession number ATCC 98825; or the nucleotide sequence of a mature protein coding sequence of clone pj193_5 deposited under accession number ATCC 98825. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pj193_5 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:8 having biological 2 0 activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:8, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:8 having biological activity, the fragment comprising the amino acid sequence from amino acid 119 to amino acid 128 of SEQ ID N0:8.
2 5 Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:7.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
3 0 (i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:7, but excluding the poly(A} tail at the 3' end of SEQ ID N0:7; and (ab) the nucleotide sequence of the cDNA insert of clone pj193 5 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:7, but excluding the poly(A) tail at the 3' end of SEQ ID N0:7; and (bb) the nucleotide sequence of the cDNA insert of clone pj193_5 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 0 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:7, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ ID
N0:7 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:7 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:7. Also preferably the polynucleotide isolated 2 5 according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:7 from nucleotide 86 to nucleotide 829, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:7 from nucleotide 86 to nucleotide 829, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:7 from nucleotide 86 to 3 0 nucleotide 829. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:7 from nucleotide 149 to nucleotide 829, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:7 from nucleotide 149 to nucleotide 829, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:7 from nucleotide 149 to nucleotide 829.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:8;
(b) a fragment of the amino acid sequence of SEQ ID N0:8, the fragment comprising eight contiguous amino acids of SEQ ID N0:8; and (c) the amino acid sequence encoded by the cDNA insert of clone pj193_5 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:8. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:8 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:8, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:8 having biological activity, the fragment comprising the amino acid sequence from amino acid 119 to amino acid 128 of SEQ ID N0:8.
In one embodiment, the present invention provides a composition comprising an 2 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:9;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:9 from nucleotide 174 to nucleotide 1292;
2 5 (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pj317 2 deposited under accession number ATCC 98825;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pj317 2 deposited under accession number ATCC 98825;
3 0 (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pj317_2 deposited under accession number ATCC 98825;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pj317 2 deposited under accession number ATCC 98825;

(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:10;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:10;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-{h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynudeotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:9.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:9 from nucleotide 174 to nucleotide 1292; the nucleotide sequence of the full-length protein coding sequence of clone pj317 2 deposited under accession number ATCC
98825;
or the nucleotide sequence of a mature protein coding sequence of clone pj317_2 deposited under accession number ATCC 98825. In other preferred embodiments, the 2 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone pj317 2 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment preferably comprising eight (more preferably twenty, most 2 5 preferably thirty) contiguous amino acids of SEQ ID N0:10, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment comprising the amino acid sequence from amino acid 181 to amino acid 190 of SEQ ID NO:10.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
3 0 ID N0:9.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:

_ WO 00/09552 PCT/US99/18298 (i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:9, but excluding the poly(A) tail at the 3' end of SEQ ID N0:9; and (ab) the nucleotide sequence of the cDNA insert of clone pj317 2 deposited under accession number ATCC 98825;
(ii) hybridizing said probes} to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:9, but excluding the poly(A) tail at the 3' end of SEQ ID N0:9; and (bb) the nucleotide sequence of the cDNA insert of clone 2 0 pj317 2 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 5 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:9, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ ID
N0:9 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:9 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:9. Also preferably the polynucleotide isolated 3 0 according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:9 from nucleotide 174 to nucleotide 1292, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:9 from nucleotide 174 to nucleotide 1292, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:9 from nucleotide 174 to nucleotide 1292.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a} the amino acid sequence of SEQ ID N0:10;
(b) a fragment of the amino acid sequence of SEQ ID NO:10, the fragment comprising eight contiguous amino acids of SEQ ID N0:10; and (c} the amino acid sequence encoded by the cDNA insert of clone pj317 2 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:10. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:10, or a protein comprising a fragment of the amino acid sequence of SEQ
ID NO:10 having biological activity, the fragment comprising the amino acid sequence from amino acid 181 to amino acid 190 of SEQ ID NO:20.
In one embodiment, the present invention provides a composition comprising an 2 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:11;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:11 from nucleotide 7 to nucleotide 2517;
2 5 (c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:11 from nucleotide 904 to nucleotide 2517;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pt332_1 deposited under accession number ATCC 98825;
3 0 (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pt332_1 deposited under accession number ATCC 98825;

_ WO 00/09552 PCTNS99/18298 (g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pt332_1 deposited under accession number ATCC 98825;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:12;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:12 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:12;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:11.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:11 from nucleotide 7 to nucleotide 2517; the nucleotide sequence of SEQ ID
N0:11 from nucleotide 904 to nucleotide 2517; the nucleotide sequence of the full-length protein 2 0 coding sequence of clone pt332_1 deposited under accession number ATCC
98825; or the nucleotide sequence of a mature protein coding sequence of clone pt332_1 deposited under accession number ATCC 98825. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pt332_1 deposited under accession number ATCC 98825. In further preferred 2 5 embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:12 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:12, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:12 having 3 0 biological activity, the fragment comprising the amino acid sequence from amino acid 413 to amino acid 422 of SEQ ID N0:12.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:11.

Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID NO:11, but excluding the poly(A) tail at the 3' end of SEQ ID N0:11; and (ab) the nucleotide sequence of the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
2 0 (ba) SEQ ID N0:11, but excluding the poly(A) tail at the 3' end of SEQ ID N0:11; and (bb) the nucleotide sequence of the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in 2 5 conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:11, and 3 0 extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID NO:11 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:11 , but excluding the poly(A) tail at the 3' end of SEQ ID NO:11. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:11 from nucleotide 7 to nucleotide WO 00/09552 PCT/US99/t8298 2517, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID NO:11 from nucleotide 7 to nucleotide 2517, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:11 from nucleotide 7 to nucleotide 2517. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
NO:11 from nucleotide 904 to nucleotide 2517, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:11 from nucleotide 904 to nucleotide 2517, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:11 from nucleotide 904 to nucleotide 2517.
In other embodiments, the present. invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:12;
(b) a fragment of the amino acid sequence of SEQ ID N0:12, the fragment comprising eight contiguous amino acids of SEQ ID N0:12; and (c) the amino acid sequence encoded by the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:12. In further preferred 2 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:12 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:12, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:12 having biological activity, the fragment comprising the amino acid sequence 2 5 from amino acid 413 to amino acid 422 of SEQ ID N0:12.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:13;
3 0 (b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:13 from nucleotide 18 to nucleotide 257;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qc297 15 deposited under accession number ATCC 98825;

(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qc297 15 deposited under accession number ATCC 98825;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qc297 15 deposited under accession number ATCC 98825;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qc297 15 deposited under accession number ATCC 98825;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:14;
(h) a polynudeotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:14 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:14;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:13.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:13 from nucleotide 18 to nucleotide 257; the nucleotide sequence of the full-length protein coding sequence of clone qc297 15 deposited under accession number ATCC
2 5 98825; or the nucleotide sequence of a mature protein coding sequence of clone qc297 15 deposited under accession number ATCC 98825. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qc297 15 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein 3 0 comprising a fragment of the amino acid sequence of SEQ ID N0:14 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:14, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:14 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID N0:14.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:13.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:13, but excluding the poly(A) tail at the 3' end of SEQ ID N0:13; and (ab) the nucleotide sequence of the cDNA insert of clone qc297 15 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:13, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:13; and (bb) the nucleotide sequence of the cDNA insert of clone qc297 15 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:13, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:13 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:13 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:13. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:13 from nucleotide 18 to nucleotide 257, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:13 from nucleotide 18 to nucleotide 257, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:13 from nucleotide 18 to nucleotide 257.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:14;
(b) a fragment of the amino acid sequence of SEQ ID N0:14, the fragment comprising eight contiguous amino acids of SEQ ID N0:14; and (c) the amino acid sequence encoded by the cDNA insert of clone qc297_15 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:14. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:14 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:14, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:14 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID N0:14.
2 5 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:15;
{b} a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:15 from nucleotide 21 to nucleotide 2432;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qg596_12 deposited under accession number ATCC 98825;

(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qg596_12 deposited under accession number ATCC 98825;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qg596_12 deposited under accession number ATCC 98825;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qg596_12 deposited under accession number ATCC 98825;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:16;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:16 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:16;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
{k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (ar(h) and that has a length that is at least 25% of the length of SEQ ID N0:15.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:15 from nucleotide 21 to nucleotide 2432; the nucleotide sequence of the full-length protein coding sequence of clone qg596_12 deposited under accession number ATCC
2 5 98825; or the nucleotide sequence of a mature protein coding sequence of clone qg596_12 deposited under accession number ATCC 98825. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qg596_12 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein 3 0 comprising a fragment of the amino acid sequence of SEQ ID N0:16 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:16, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:16 having biological activity, the fragment comprising the amino acid sequence from amino and 397 to amino acid 406 of SEQ ID N0:16.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:15.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:15, but excluding the poly(A) tail at the 3' end of SEQ ID N0:15; and (ab) the nucleotide sequence of the cDNA insert of clone qg596_12 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
{i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:15, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:15; and (bb) the nucleotide sequence of the cDNA insert of clone qg596_12 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:15, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:15 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:15 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:15. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:15 from nucleotide 21 to nucleotide 2432, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:15 from nucleotide 21 to nucleotide 2432, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:15 from nucleotide 21 to nucleotide 2432.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a} the amino acid sequence of SEQ ID N0:16;
(b) a fragment of the amino acid sequence of SEQ ID N0:16, the fragment comprising eight contiguous amino acids of SEQ ID NO:I6; and (c) the amino acid sequence encoded by the cDNA insert of clone qg596_12 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:16. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID NO:I6 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably tlvrty) contiguous amino acids of SEQ ID N0:16, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:16 having biological activity, the fragment comprising the amino acid sequence from amino acid 397 to amino acid 406 of SEQ ID N0:16.
2 5 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:17;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:17 from nucleotide 339 to nucleotide 2105;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:17 from nucleotide 501 to nucleotide 2105;

(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rb649_3 deposited under accession number ATCC 98825;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rb649_3 deposited under accession number ATCC 98825;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rbb49_3 deposited under accession number ATCC 98825;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rb649_3 deposited.under accession number ATCC 98825;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:18;
(i} a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:18;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
2 0 (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(i) and that has a length that is at least 25% of the length of SEQ ID N0:17.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:17 from nucleotide 339 to nucleotide 2105; the nucleotide sequence of SEQ
ID N0:17 from nucleotide 501 to nucleotide 2105; the nucleotide sequence of the full-length protein coding sequence of clone rb649_3 deposited under accession number ATCC 98825;
or the nucleotide sequence of a mature protein coding sequence of clone rb649_3 deposited 3 0 under accession number ATCC 98825. In other nrPfPrrP~ a",~""~;.,.,o"E~
.~,..
polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone rb649_3 deposited under accession number ATCC 98825. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:18 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:18, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:18 having biological activity, the fragment comprising the amino acid sequence from amino acid 289 to amino acid 298 of SEQ ID N0:18.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:17.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:17, but excluding the poly(A) tail at the 3' end of SEQ ID N0:17; and (ab) the nucleotide sequence of the cDNA insert of clone rbti49 3 deposited under accession number ATCC 98825;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 0 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 2 5 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:17, but excluding the poly(A) tail at the 3' end of SEQ ID N0:17; and (bb) the nucleotide sequence of the cDNA insert of clone 3 0 rb649_3 deposited under accession number ATCC 98825;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

_ WO 00/09552 PCT/US99/18298 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:17, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:17 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:17 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:17. Also preferably the polynudeotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:17 from nucleotide 339 to nucleotide 2105, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:17 from nucleotide 339 to nucleotide 2105, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:17 from nucleotide 339 to nucleotide 2105. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:17 from nucleotide 501 to nucleotide 2105, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:17 from nucleotide 501 to nucleotide 2105, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:17 from nucleotide 501 to nucleotide 2105.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
2 0 (a) the amino acid sequence of SEQ ID N0:18;
(b) a fragment of the amino acid sequence of SEQ ID N0:18, the fragment comprising eight contiguous amino acids of SEQ ID NO:18; and (c) the amino arid sequence encoded by the cDNA insert of clone rb649_3 deposited under accession number ATCC 98825;
2 5 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:18. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:18 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 3 0 of SEQ ID N0:18, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:18 having biological activity, the fragment comprising the amino acid sequence from amino acid 289 to amino acid 298 of SEQ ID N0:18.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:

(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:19;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:19 from nucleotide 509 to nucleotide 2467;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ca106_19x deposited under accession number ATCC 98835;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ca106_19x deposited under accession number ATCC 98835;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ca106_19x deposited under accession number ATCC 98835;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ca106_19x deposited under accession number ATCC 98835;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:20;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:20 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:20;
2 0 (i} a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:19.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
3 0 N0:19 from nucleotide 509 to nucleotide 2467; the nucleotide sequence of the full-length protein coding sequence of clone ca106_19x deposited under accession number ATCC
98835; or the nucleotide sequence of a mature protein coding sequence of clone ca106_19x deposited under accession number ATCC 98835. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone ca106_19x deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:20 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:20, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:20 having biological activity, the fragment comprising the amino acid sequence from amino acid 321 to amino acid 330 of SEQ ID N0:20.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:19.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:19, but excluding the poly(A) tail at the 3' end of SEQ ID N0:19; and (ab} the nucleotide sequence of the cDNA insert of clone 2 0 ca106_19x deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
2 5 and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
3 0 (ba) SEQ ID N0:19, but excluding the poly(A) tail at the 3' end of SEQ ID N0:19; and (bb) the nucleotide sequence of the cDNA insert of clone ca106_19x deposited under accession number ATCC 98835;

(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:19, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:19 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:19 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:19. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:19 from nucleotide 509 to nucleotide 2467, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:19 from nucleotide 509 to nucleotide 2467, to a nucleoside sequence corresponding to the 3' end of said sequence of SEQ ID N0:19 from nucleotide 509 to nucleotide 2467.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:20;
2 0 (b) a fragment of the amino acld sequence of SEQ ID N0:20, the fragment comprising eight contiguous amino acids of SEQ ID N0:20; and (c) the amino acid sequence encoded by the cDNA insert of clone ca106_19x deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such 2 5 protein comprises the amino acid sequence of SEQ ID N0:20. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:20 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:20, or a protein comprising a fragment of the amino acid sequence of SEQ
3 0 ID N0:20 having biological activity, the fragment comprising the amino acid sequence from amino acid 321 to amino acid 330 of SEQ ID N0:20.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:

(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:21;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:21 from nucleotide 179 to nucleotide 802;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:21 from nucleotide 242 to nucleotide 802;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ci52 2 deposited under accession number ATCC 98835;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ci52_2 deposited under accession number ATCC 98835;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ci52 2 deposited under accession number ATCC
98835;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ci52 2 deposited under accession number ATCC 98835;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:22;
(i) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:22 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:22;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein 2 5 of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:21.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:21 from nucleotide 179 to nucleotide 802; the nucleotide sequence of SEQ ID
N0:21 from nucleotide 242 to nucleotide 802; the nucleotide sequence of the full-length protein coding sequence of clone ci52 2 deposited under accession number ATCC 98835;
or the nucleotide sequence of a mature protein coding sequence of clone ci52_2 deposited under accession number ATCC 98835. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ci52 2 deposited under accession number ATCC 98835. In further preferred embodiments;
the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:22 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:22, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:22 having biological activity, the fragment comprising the amino acid sequence from amino acid 99 to amino acid 108 of SEQ ID N0:22.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:21.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynudeotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
2 0 (aa) SEQ ID N0:21, but excluding the poly(A) tail at the 3' end of SEQ ID N0:21; and (ab) the nucleotide sequence of the cDNA insert of clone ci52_2 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in 2 5 conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotldes detected with the probe(s);
and (b) a process comprising the steps of:
3 0 (i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:21, but excluding the poly(A) tail at the 3' end of SEQ ID N0:21; and _ WO 00/09552 PCT/US99/18298 (bb) the nucleotide sequence of the cDNA insert of clone ci52_2 deposited under accession number ATCC 98835;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:21, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:21 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:21 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:21. Also preferably the polynudeotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:21 from nucleotide 179 to nucleotide 802, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:21 from nucleotide 179 to nucleotide 802, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:21 from nucleotide 179 to nucleotide 802. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:21 from nucleotide 242 to nucleotide 802, and extending contiguously from a 2 0 nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:21 from nucleotide 242 to nucleotide 802, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:21 from nucleotide 242 to nucleotide 802.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 5 consisting of:
(a) the amino acid sequence of SEQ ID N0:22;
(b) a fragment of the amino acid sequence of SEQ ID N0:22, the fragment comprising eight contiguous amino acids of SEQ ID N0:22; and (c) the amino acid sequence encoded by the cDNA insert of clone 3 0 ci52_2 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:22. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:22 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:22, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:22 having biological activity, the fragment comprising the amino acid sequence from amino acid 99 to amino acid 108 of SEQ ID N0:22.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:23;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:23 from nucleotide 46 to nucleotide 714;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:23 from nucleotide 538 to nucleotide 714;
(d) a polynucleotide comprising the nucleotide sequence of the full length protein coding sequence of clone md124_16 deposited under accession number ATCC 98835;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone md124_16 deposited under accession number ATCC 98835;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone md124_16 deposited under accession number 2 0 ATCC 98835;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone md124_16 deposited under accession number ATCC 98835;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:24;
2 5 (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ TD N0:24 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:24;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
3 0 (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynudeotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:23.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:23 from nucleotide 46 to nucleotide 714; the nucleotide sequence of SEQ ID
N0:23 from nucleotide 538 to nucleotide 714; the nucleotide sequence of the full-length protein coding sequence of clone md124_16 deposited under accession number ATCC 98835;
or the nucleotide sequence of a mature protein coding sequence of clone md124_16 deposited under accession number ATCC 98835. In other preferred embodiments, the polynucleotide encodes the full-length or. a mature protein encoded by the cDNA insert of clone md124_16 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:24 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:24, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:24 having biological activity, the fragment comprising the amino acid sequence from amino acid 106 to amino acid 115 of SEQ ID N0:24.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
2 0 ID N0:23.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 5 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa} SEQ ID N0:23, but excluding the poly(A) tail at the 3' end of SEQ ID N0:23; and (ab) the nucleotide sequence of the cDNA insert of clone 3 0 md124_16 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);

and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:23, but excluding the poly(A) tail at the 3' end of SEQ ID N0:23; and {bb) the nucleotide sequence of the cDNA insert of clone md124_16 deposited under accession number ATCC 98835;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:23, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:23 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:23 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:23. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence 2 0 corresponding to the cDNA sequence of SEQ ID N0:23 from nucleotide 46 to nucleotide 714, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:23 from nucleotide 46 to nucleotide 714, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:23 from nucleotide 46 to nucleotide 714. Also preferably the polynucleotide isolated according to the above 2 5 process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:23 from nucleotide 538 to nucleotide 714, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:23 from nucleotide 538 to nucleotide 714, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:23 from nucleotide 538 to nucleotide 714.
3 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:24;

(b) a fragment of the amino acid sequence of SEQ ID N0:24, the fragment comprising eight contiguous amino acids of SEQ ID N0:24; and (c) the amino acid sequence encoded by the cDNA insert of clone md124_16 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:24. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:24 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:24, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:24 having biological activity, the fragment comprising the amino acid sequence from amino acid 106 to amino acid 115 of SEQ ID N0:24.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ TI7 N0:25;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:25 from nucleotide 92 to nucleotide 1726;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
2 0 N0:25 from nucleotide 1211 to nucleotide 1726;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pk366_7 deposited under accession number ATCC 98835;
(e) a polynucleotide encoding the full-length protein encoded by the 2 5 cDNA insert of clone pk366_7 deposited under accession number ATCC 98835;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pk366_7 deposited under accession number ATCC 98835;
{g) a polynucleotide encoding a mature protein encoded by the cDNA
3 0 insert of clone pk366_7 deposited under accession number ATCC 98835;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:26;

(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:26 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:26;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:25.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:25 from nucleotide 92 to nucleotide 1726; the nucleotide sequence of SEQ ID
N0:25 from nucleotide 1211 to nucleotide 1726; the nucleotide sequence of the full-length protein coding sequence of clone pk366_7 deposited under accession number ATCC
98835; or the nucleotide sequence of a mature protein coding sequence of clone pk366_7 deposited under accession number ATCC 98835. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert 2 0 of clone pk366_7 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:26 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:26, or a polynucleotide encoding 2 5 a protein comprising a fragment of the amino acid sequence of SEQ ID N0:26 having biological activity, the fragment comprising the amino acid sequence from amino acid 267 to amino acid 276 of SEQ ID N0:26.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:25.
3 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:

(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:25, but excluding the poly(A) tail at the 3' end of SEQ ID N0:25; and (ab) the nucleotide sequence of the cDNA insert of clone pk366_7 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:25, but excluding the poly(A) tail at the 3' end of SEQ ID N0:25; and (bb) the nucleotide sequence of the cDNA insert of clone 2 0 pk366_7 deposited under accession number ATCC 98835;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 5 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:25, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:25 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:25 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:25. Also preferably the 3 0 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:25 from nucleotide 92 to nucleotide 1726, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:25 from nucleotide 92 to nucleotide 1726, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:25 from nucleotide WO 00/09552 PC1'/US99/18298 92 to nucleotide 1726. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:25 from nucleotide 1211 to nucleotide 1726, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:25 from nucleotide 1211 to nucleotide 1726, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:25 from nucleotide 1211 to nucleotide 1726.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:26;
(b) a fragment of the amino acid sequence of SEQ ID N0:26, the fragment comprising eight contiguous amino acids of SEQ ID N0:26; and (c) the amino acid sequence encoded by the cDNA insert of clone pk366_7 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:26. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:26 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 0 of SEQ ID N0:26, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:26 having biological activity, the fragment comprising the amino acid sequence from amino acid 267 to amino acid 276 of SEQ ID N0:26.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
2 5 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:27;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:27 from nucleotide 16 to nucleotide 1788;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:27 from nucleotide 61 to nucleotide 1788;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone p1741 5 deposited under accession number ATCC 98835;

(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone p1741 5 deposited under accession number ATCC 98835;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone p1741 5 deposited under accession number ATCC 98835;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone p1741 5 deposited under accession number ATCC 98835;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:28;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:28 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:28;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a)-(i} and that has a length that is at least 25% of the length of SEQ ID N0:27.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:27 from nucleotide 16 to nucleotide 1788; the nucleotide sequence of SEQ ID
N0:27 from nucleotide 61 to nucleotide 1788; the nucleotide sequence of the full-length protein 2 5 coding sequence of clone p1741 5 deposited under accession number ATCC
98835; or the nucleotide sequence of a mature protein coding sequence of clone p1741 5 deposited under accession number ATCC 98835. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone p1741_5 deposited under accession number ATCC 98835. In further preferred 3 0 embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:28 having biological activity, the fragment preferably comprising eight {more preferably twenty, most preferably thirty} contiguous amino ands of SEQ ID N0:28, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:28 having biological activity, the fragment comprising the amino acid sequence from amino acid 290 to amino acid 299 of SEQ ID N0:28.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:27.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
{i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:27, but excluding the poly(A) tail at the 3' end of SEQ ID N0:27; and (ab) the nucleotide sequence of the cDNA insert of clone p1741 5 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:27, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:27; and (bb) the nucleotide sequence of the cDNA insert of clone p1741 5 deposited under accession number ATCC 98835;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii}.
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:27, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:27 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:27 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:27. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:27 from nucleotide 16 to nucleotide 1788, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:27 from nucleotide 16 to nucleotide 1788, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:27 from nucleotide 16 to nucleotide 1788. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:27 from nucleotide 61 to nucleotide 1788, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:27 from nucleotide 61 to nucleotide 1788, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:27 from nucleotide 61 to nucleotide 1788.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:28;
(b) a fragment of the amino acid sequence of SEQ ID N0:28, the fragment comprising eight contiguous amino acids of SEQ ID N0:28; and 2 0 (c) the amino acid sequence encoded by the cDNA insert of clone p1741 5 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:28. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 5 amino acid sequence of SEQ ID N0:28 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:28, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:28 having biological activity, the fragment comprising the amino acid sequence from amino acid 290 to amino acid 299 of SEQ ID N0:28.
3 0 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a} a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:29;

(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:29 from nucleotide 629 to nucleotide 2338;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pp314_19 deposited under accession number ATCC 98835;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pp314_19 deposited under accession number ATCC 98835;
(e) a polynudeotide comprising the nucleotide sequence of a mature protein coding sequence of clone pp314_19 deposited under accession number 2 0 ATCC 98835;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pp314_19 deposited under accession number ATCC 98835;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:30;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:30 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:30;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
2 0 (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:29.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:29 from nucleotide 629 to nucleotide 2338; the nucleotide sequence of the full-length protein coding sequence of clone pp314_19 deposited under accession number ATCC
3 0 98835; or the nucleotide sequence of a mature protein coding sequence of clone pp314_19 deposited under accession number ATCC 98835. In other preferred embodiments, the polynudeotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pp314_19 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:30 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:30, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:30 having biological activity, the fragment comprising the amino acid sequence from amino acid 280 to amino acid 289 of SEQ ID N0:30.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:29.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:29, but excluding the poly(A) tail at the 3' end of SEQ ID N0:29; and (ab) the nucleotide sequence of the cDNA insert of clone pp314_19 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in 2 0 conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
2 5 (i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:29, but excluding the poly(A) tail at the 3' end of SEQ ID N0:29; and 3 0 (bb) the nucleotide sequence of the cDNA insert of clone pp314_19 deposited under accession number ATCC 98835;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:29, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:29 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:29 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:29. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:29 from nucleotide 629 to nucleotide 2338, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:29 from nucleotide 629 to nucleotide 2338, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:29 from nucleotide 629 to nucleotide 2338.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:30;
(b) a fragment of the amino acid sequence of SEQ ID N0:30, the fragment comprising eight contiguous amino acids of SEQ ID N0:30; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 0 pp314_19 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:30. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:30 having biological activity, the fragment preferably 2 5 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:30, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:30 having biological activity, the fragment comprising the amino acid sequence from amino acid 280 to amino acid 289 of SEQ ID N0:30.
In one embodiment, the present invention provides a composition comprising an 3 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:31;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:31 from nucleotide 158 to nucleotide 1102;

_ WO 00/09552 PCT/US99/18298 (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pv35_1 deposited under accession number ATCC 98835;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pv35_1 deposited under accession number ATCC 98835;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pv35_1 deposited under accession number ATCC 98835;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:32;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:32 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:32;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:31.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:31 from nucleotide 158 to nucleotide 1102; the nucleotide sequence of the full-length protein coding sequence of clone pv35_1 deposited under accession number ATCC
98835;
or the nucleotide sequence of a mature protein coding sequence of clone pv35_1 deposited under accession number ATCC 98835. In other nrPfPrrPrl am~,na;".,o.,~~ ~~...
3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:32 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:32, or a polynudeotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:32 having biological activity, the fragment comprising the amino acid sequence from amino acid 152 to amino acid 161 of SEQ ID N0:32.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:31.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:31, but excluding the poly(A) tail at the 3' end of SEQ ID N0:31; and (ab) the nucleotide sequence of the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:31, but excluding the poly(A) tail at the 3' end of SEQ ID N0:31; and (bb) the nucleotide sequence of the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:31, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:31 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:31 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:31. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:31 from nucleotide 158 to nucleotide 1102, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:31 from nucleotide 158 to nucleotide 1102, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:31 from nucleotide 158 to nucleotide 1102.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:32;
(b) a fragment of the amino acid sequence of SEQ ID N0:32, the fragment comprising eight contiguous amino acids of SEQ ID N0:32; and (c) the amino acid sequence encoded by the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:32. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:32 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino atids 2 5 of SEQ ID N0:32, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:32 having biological activity, the fragment comprising the amino acid sequence from amino acid 152 to amino acid 161 of SEQ ID N0:32.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:33;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:33 from nucleotide 413 to nucleotide 733;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pw337_6 deposited under accession number ATCC 98835;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pw337 6 deposited under accession number ATCC 98835;
{e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pw337_6 deposited under accession number ATCC 98835;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pw337_6 deposited under accession number ATCC 98835;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:34;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:34 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:34;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h} above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~{h) and that has a length that is at least 25% of the length of SEQ ID N0:33.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:33 from nucleotide 413 to nucleotide 733; the nucleotide sequence of the full-length protein coding sequence of clone pw337_6 deposited under accession number ATCC
98835; or the nucleotide sequence of a mature protein coding sequence of clone pw337 6 deposited under accession number ATCC 98835. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone pw337 6 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:34 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:34, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:34 having biological activity, the fragment comprising the amino acid sequence from amino acid 48 to amino acid 57 of SEQ ID N0:34.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:33.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:33, but excluding the poly(A) tail at the 3' end of SEQ ID N0:33; and (ab) the nucleotide sequence of the cDNA insert of clone pw337_6 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:33, but excluding the poly(A) tail at the 3' end of SEQ ID N0:33; and (bb) the nucleotide sequence of the cDNA insert of clone pw337_6 deposited under accession number ATCC 98835;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
{iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:33, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:33 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:33 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:33. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:33 from nucleotide 413 to nucleotide 733, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:33 from nucleotide 413 to nucleotide 733, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:33 from nucleotide 413 to nucleotide 733.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:34;
(b) a fragment of the amino acid sequence of SEQ ID N0:34, the fragment comprising eight contiguous amino acids of SEQ ID N0:34; and (c) the amino acid sequence encoded by the cDNA insert of clone pw337_6 deposited under accession number ATCC 98835;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:34. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:34 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:34, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:34 having biological activity, the fragment comprising the amino acid sequence from amino acid 48 to amino acid 57 of SEQ ID N0:34.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:35;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:35 from nucleotide 678 to nucleotide 938;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rd6lU_1 deposited under accession number ATCC 98835;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rd610_1 deposited under accession number ATCC 98835;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rd610_1 deposited under accession number ATCC 98835;
(g} a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:36;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:36 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:36;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:35.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:35 from nucleotide 678 to nucleotide 938; the nucleotide sequence of the full-length protein coding sequence of clone rd610_1 deposited under accession number ATCC
98835;
or the nucleotide sequence of a mature protein coding sequence of clone rd610_1 deposited under accession number ATCC 98835. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:36 having biological activity, the fragment preferably comprising eight (more preferably twenty, most _ WO 00/09552 PCTNS99/18298 preferably thirty) contiguous amino acids of SEQ ID N0:36, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:36 having biological activity, the fragment comprising the amino acid sequence from amino acid 38 to amino acid 47 of SEQ ID NO:36.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:35.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
{i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:35, but excluding the poly(A) tail at the 3' end of SEQ ID N0:35; and 25 (ab) the nucleotide sequence of the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:35, but excluding the poly(A) tail at the 3' end of SEQ ID N0:35; and (bb) the nucleotide sequence of the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:35, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:35 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:35 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:35. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:35 from nucleotide 678 to nucleotide 938, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:35 from nucleotide 678 to nucleotide 938, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:35 from nucleotide 678 to nucleotide 938.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:36;
(b) a fragment of the amino acid sequence of SEQ ID N0:36, the fragment comprising eight contiguous amino acids of SEQ ID N0:36; and (c) the amino acid sequence encoded by the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:36. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:36 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:36, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:36 having biological activity, the fragment comprising the amino acid sequence from amino acid 38 to amino acid 47 of SEQ ID N0:36.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:37;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:37 from nucleotide 75 to nucleotide 494;

(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:37 from nucleotide 447 to nucleotide 494;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rd810 6 deposited under accession number ATCC 98835;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rd810_6 deposited under accession number ATCC 98835;
(g} a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rd810_6 deposited under accession number ATCC 98835;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:38;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:38 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:38;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
2 0 (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:37.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:37 from nucleotide 75 to nucleotide 494; the nucleotide sequence of SEQ ID
N0:37 from nucleotide 447 to nucleotide 494; the nucleotide sequence of the full-length protein 3 0 coding sequence of clone rd810_6 deposited under accession number ATCC
98835; or the nucleotide sequence of a mature protein coding sequence of clone rd810_6 deposited under accession number ATCC 98835. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone rd810_6 deposited under accession number ATCC 98835. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:38 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:38, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:38 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID N0:38.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:37.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID NO:37, but excluding the poly(A) tail at the 3' end of SEQ ID N0:37; and (ab) the nucleotide sequence of the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
2 0 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 5 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:37, but excluding the poly(A) tail at the 3 0 3' end of SEQ ID N0:37; and (bb) the nucleotide sequence of the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;

(iii) amplifying human DNA sequences; and (iv) isolating the polynucleoHde products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:37, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:37 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:37 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:37. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:37 from nucleotide 75 to nucleotide 494, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:37 from nucleotide 75 to nucleotide 494, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:37 from nucleotide 75 to nucleotide 494. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:37 from nucleotide 447 to nucleotide 494, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:37 from nucleotide 447 to nucleotide 494, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:37 from nucleotide 447 to nucleotide 494.
In other embodiments, the present invention provides a composition comprising 2 0 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:38;
(b) a fragment of the amino acid sequence of SEQ ID N0:38, the fragment comprising eight contiguous amino acids of SEQ ID N0:38; and 2 5 {c) the amino acid sequence encoded by the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:38. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 3 0 amino acid sequence of SEQ ID N0:38 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:38, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:38 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID N0:38.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:39;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:39 from nucleotide 181 to nucleotide 1080;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone cf85_1 deposited under accession number ATCC 98850;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone cf85_1 deposited under accession number ATCC 98850;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone cf85 1 deposited under accession number ATCC
98850;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone cf85_1 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:40;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:40 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:40;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:39.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:39 from nucleotide 181 to nucleotide 1080; the nucleotide sequence of the full-length protein coding sequence of clone cf85_1 deposited under accession number ATCC
98850;
or the nucleotide sequence of a mature protein coding sequence of clone cf85_1 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone cf85_I deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:40 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:40, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:40 having biological activity, the fragment comprising the amino acid sequence from amino acid 145 to amino acid 154 of SEQ ID N0:40.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:39.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:39, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:39; and (ab) the nucleotide sequence of the cDNA insert of clone cf85_1 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:39, but excluding the poly(A) tail at the 3' end of SEQ ID N0:39; and (bb) the nucleotide sequence of the cDNA insert of clone cf85_1 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genonuc DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:39, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:39 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:39 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:39. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:39 from nucleotide 181 to nucleotide 1080, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:39 from nucleotide 181 to nucleotide 1080, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:39 from nucleotide 181 to nucleotide 1080.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:40;
(b) a fragment of the amino acid sequence of SEQ ID N0:40, the fragment comprising eight contiguous amino acids of SEQ ID N0:40; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 cf85_1 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:40. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:40 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:40, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:40 having biological activity, the fragment comprising the amino acid sequence from amino acid 145 to amino acid 154 of SEQ ID N0:40.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleoride comprising the nucleotide sequence of SEQ ID
N0:41;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:41 from nucleotide 161 to nucleotide 1348;
(c) a polynucleoHde comprising the nucleotide sequence of SEQ ID
N0:41 from nucleotide 599 to nucleotide 1348;
(d) a polynucleotide comprising the nucleotide sequence of the full length protein coding sequence.of clone dd504_18 deposited under accession number ATCC 98850;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone dd504_18 deposited under accession number ATCC 98850;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone dd504_18 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone dd504_18 deposited under accession number ATCC 98850;
(h) a polynucleotide encoding a protein comprising the amino acid 2 0 sequence of SEQ ID N0:42;
(i} a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:42 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:42;
(j) a polynucleotide which is an allelic variant of a polynucleotide of 2 5 (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 3 0 (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a Length that is at least 25% of the length of SEQ ID N0:41.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:41 from nucleotide 161 to nucleotide 1348; the nucleotide sequence of SEQ
ID N0:41 WO 00/09552 PC'T/US99/18298 from nucleotide 599 to nucleotide 1348; the nucleotide sequence of the full-length protein coding sequence of clone dd504_18 deposited under accession number ATCC 98850;
or the nucleotide sequence of a mature protein coding sequence of clone dd504_18 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone dd504_18 deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:42 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:42, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:42 having biological activity, the fragment comprising the amino acid sequence from amino acid 193 to amino acid 202 of SEQ ID N0:42.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:41.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 0 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:41, but excluding the poly(A) tail at the 3' end of SEQ ID N0:41; and (ab) the nucleotide sequence of the cDNA insert of clone 2 5 dd504_18 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
3 0 and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:

(ba) SEQ ID N0:41, but excluding the poly(A) tail at the 3' end of SEQ ID N0:41; and (bb) the nucleotide sequence of the cDNA insert of clone dd504_18 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to . the cDNA sequence of SEQ ID N0:41, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:41 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:41 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:41. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:41 from nucleotide 161 to nucleotide 1348, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:41 from nucleotide 161 to nucleotide 1348, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:41 from nucleotide 161 to nucleotide 1348. Also preferably the polynucleotide isolated according to the above 2 0 process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:41 from nucleotide 599 to nucleotide 1348, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:41 from nucleotide 599 to nucleotide 1348, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:41 from nucleotide 599 to nucleotide 1348.
2 5 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:42;
(b) a fragment of the amino acid sequence of SEQ ID N0:42, the 3 0 fragment comprising eight contiguous amino acids of SEQ ID N0:42; and (c) the amino acid sequence encoded by the cDNA insert of clone dd504_18 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:42. In further preferred _ WO 00/09552 PCT/US99/18298 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:42 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands of SEQ ID N0:42, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:42 having biological activity, the fragment comprising the amino acid sequence from amino acid 193 to amino acid 202 of SEQ ID N0:42.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:43;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:43 from nucleotide 70 to nucleotide 1386;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone np26_3 deposited under accession number ATCC 98850;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone np26 3 deposited under accession number ATCC 98850;
(e) a polynucleotide comprising the .nucleotide sequence of a mature protein coding sequence of clone np26_3 deposited under accession number 2 0 ATCC 98850;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone np26_3 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:44;
2 5 (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:44 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:44;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
3 0 (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:43.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:43 from nucleotide 70 to nucleotide 1386; the nucleotide sequence of the full-length protein coding sequence of clone np26_3 deposited under accession number ATCC
98850;
or the nucleotide sequence of a mature protein coding sequence of clone np26 3 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone np26_3 deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:44 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:44, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:44 having biological activity, the fragment comprising the amino acid sequence from amino acid 214 to amino acid 223 of SEQ ID N0:44.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:43.
2 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group 2 5 consisting of:
(aa) SEQ ID N0:43, but excluding the poly(A) tail at the 3' end of SEQ ID N0:43; and (ab) the nucleotide sequence of the cDNA insert of done np26_3 deposited under accession number ATCC 98850;
3 0 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i} preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:43, but excluding the poly(A) tail at the 3' end of SEQ ID N0:43; and (bb) the nucleotide sequence of the cDNA insert of clone np26_3 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isalated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:43, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:43 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:43 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:43. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:43 from nucleotide 70 to nucleotide 2 0 1386, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:43 from nucleotide 70 to nucleotide 1386, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:43 from nucleotide 70 to nucleotide 1386.
In other embodiments, the present invention provides a composition comprising 2 5 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:44;
(b) a fragment of the amino acid sequence of SEQ ID N0:44, the fragment comprising eight contiguous amino acids of SEQ ID N0:44; and 3 0 (c) the amino acid sequence encoded by the cDNA insert of clone np26_3 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:44. 1n further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:44 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:44, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:44 having biological activity, the fragment comprising the amino acid sequence from amino acid 214 to amino acid 223 of SEQ ID N0:44.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:45;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:45 from nucleotide 60 to nucleotide 3515;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pm412_12 deposited under accession number ATCC 98850;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pm412_12 deposited under accession number ATCC 98850;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pm412_12 deposited under accession number ATCC 98850;
2 0 (f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pm412_12 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:46;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 5 amino acid sequence of SEQ ID N0:46 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:46;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 3 0 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:45.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:45 from nucleotide 60 to nucleotide 3515; the nucleotide sequence of the full-length protein coding sequence of clone pm412_12 deposited under accession number ATCC
98850; or the nucleotide sequence of a mature protein coding sequence of clone pm412_12 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pm412_12 deposited under acces$ion number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:46 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:46, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:46 having biological activity, the fragment comprising the amino acid sequence from amino acid 571 to amino acid 580 of SEQ ID N0:46.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:45.
2 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group 2 5 consisting of:
(aa) SEQ ID N0:45, but excluding the poly(A) tail at the 3' end of SEQ ID N0:45; and (ab) the nucleotide sequence of the cDNA insert of clone pm412_12 deposited under accession number ATCC 98850;
3 0 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probes};
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
{ba) SEQ ID N0:45, but excluding the poly(A) tail at the 3' end of SEQ ID N0:45; and (bb) the nucleotide sequence of the cDNA insert of clone pm412_12 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:45, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:4S to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:45 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:45. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:45 from nucleotide 60 to nucleotide 2 0 3515, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:45 from nucleotide 60 to nucleotide 3515, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:45 from nucleotide 60 to nucleotide 3515.
In other embodiments, the present invention provides a composition comprising 2 5 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:46;
(b) a fragment of the amino acid sequence of SEQ ID N0:46, the fragment comprising eight contiguous amino acids of SEQ ID N0:46; and 3 0 (c) the amino acid sequence encoded by the cDNA insert of clone pm412_12 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:46. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:46 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:46, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:46 having biological activity, the fragment comprising the amino acid sequence from amino acid 571 to amino acid 580 of SEQ ID N0:46.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:47;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:47 from nucleotide 1490 to nucleotide 1780;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:47 from nucleotide 1556 to nucleotide 1780;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pm421 3 deposited under accession number ATCC 98850;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pm421 3 deposited under accession number ATCC 98850;
(f) a polynucleotide comprising the nucleotide sequence of a mature 2 0 protein coding sequence of clone pm421 3 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pm421 3 deposited under accession number ATCC 98850;
(h) a polynucleotide encoding a protein comprising the amino acid 2 5 sequence of SEQ ID N0:48;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:48 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:48;
(j) a polynucleotide which is an allelic variant of a polynucleotide of 3 0 (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to arty one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:47.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:47 from nucleotide 1490 to nucleotide 1780; the nucleotide sequence of SEQ
ID N0:47 from nucleotide 1556 to nucleotide 1780; the nucleotide sequence of the full-length protein coding sequence of clone pm421 3 deposited under accession number ATCC
98850; or the nucleotide sequence of a mature protein coding sequence of clone pm421_3 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pm421 3 deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:48 having biological activity, the fragment preferably comprising eight (more preferably twenty, most 2 5 preferably thirty) contiguous amino ands of SEQ ID N0:48, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:48 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID N0:48.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
2 0 ID N0:47.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 5 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:47, but excluding the poly(A) tail at the 3' end of SEQ ID N0:47; and (ab) the nucleotide sequence of the cDNA insert of clone 3 0 pm421_3 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);

and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:47, but excluding the poly{A) tail at the 3' end of SEQ ID N0:47; and (bb) the nucleotide sequence of the cDNA insert of clone pm421 3 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and {iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:47, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:47 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:47 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:47. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence 2 0 corresponding to the cDNA sequence of SEQ ID N0:47 from nucleotide 1490 to nucleotide 1780, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:47 from nucleotide 1490 to nucleotide 1780, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:47 from nucleotide 1490 to nucleotide 1780. Also preferably the polynucleotide isolated according to the 2 5 above process comprises a nucleotide sequence corresponding to the cDNA
sequence of SEQ ID N0:47 from nucleotide 1556 to nucleotide 1780, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:47 from nucleotide 1556 to nucleotide 1780, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:47 from nucleotide 1556 to nucleotide 1780.
3 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:48;

(b) a fragment of the amino acid sequence of SEQ ID N0:48, the fragment comprising eight contiguous amino acids of SEQ ID N0:48; and (c) the amino acid sequence encoded by the cDNA insert of clone pm421 3 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ 1D N0:48. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:48 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:48, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:48 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID N0:48.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:49;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:49 from nucleotide 64 to nucleotide 486;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
2 0 N0:49 from nucleotide 217 to nucleotide 486;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pv6_1 deposited under accession number ATCC 98850;
(e) a polynucleotide encoding the full-length protein encoded by the 2 5 cDNA insert of clone pv6_1 deposited under accession number ATCC 98850;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pv6_1 deposited under accession number ATCC
98850;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
3 0 insert of clone pv6_1 deposited under accession number ATCC 98850;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:50;

(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:50 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:50;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynudeotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (ar(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:49.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:49 from nucleotide 64 to nucleotide 486; the nucleotide sequence of SEQ ID
N0:49 from nucleotide 217 to nucleotide 486; the nucleotide sequence of the full-length protein coding sequence of clone pv6_1 deposited under accession number ATCC 98850; or the nucleotide sequence of a mature protein coding sequence of clone pv6_1 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone pv6_1 2 0 deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID, N0:50 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:50, or a polynucleotide encoding a protein comprising a 2 5 fragment of the amino acid sequence of SEQ ID N0:50 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ
ID N0:50.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:49.
3 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:

(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
{aa) SEQ ID N0:49, but excluding the poly(A) tail at the 3' end of SEQ ID N0:49; and (ab) the nucleotide sequence of the cDNA insert of clone pv6_1 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and {iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:49, but excluding the poly(A) tail at the 3' end of SEQ ID NO:49; and (bb) the nucleotide sequence of the cDNA insert of clone 2 0 pv6_1 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 5 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:49, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:49 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:49 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:49. Also preferably the 3 0 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:49 from nucleotide 64 to nucleotide 486, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:49 from nucleotide 64 to nucleotide 486, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:49 from nucleotide 64 to nucleotide 486. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:49 from nucleotide 217 to nucleotide 486, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:49 from nucleotide 217 to nucleotide 486, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:49 from nucleotide 217 to nucleotide 486.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:50;
(b) a fragment of the amino acid sequence of SEQ ID N0:50, the fragment comprising eight contiguous amino acids of SEQ ID N0:50; and (c) the amino acid sequence encoded by the cDNA insert of clone pv6_1 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:50. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:50 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 0 of SEQ ID N0:50, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:50 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID N0:50.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
2 5 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:51;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:51 from nucleotide 379 to nucleotide 3783;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:51 from nucleotide 460 to nucleotide 3783;
(d) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:51 from nucleotide 1983 to nucleotide 3938;

(e) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qsl4 3 deposited under accession number ATCC 98850;
(f) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qsl4 3 deposited under accession number ATCC 98850;
(g) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qsl4 3 deposited under accession number ATCC
98850;
(h) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qsl4 3 deposited under accession number ATCC 98850;
(i) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:52;
(j) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:52 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:52;
(k) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(h) above;
(1) a polynucleotide which encodes a species homologue of the protein of (i) or (j) above ;
2 0 (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(j); and (n) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(j) and that has a length that is at least 25% of the length of SEQ ID N0:51.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:51 from nucleotide 379 to nucleotide 3783; the nucleotide sequence of SEQ
ID N0:51 from nucleotide 460 to nucleotide 3783; the nucleotide sequence of SEQ ID
N0:51 from nucleotide 1983 to nucleotide 3938; the nucleotide sequence of the full-length protein coding sequence of clone qsl4_3 deposited under accession number ATCC 98850;
or the 3 0 nucleotide sequence of a mature protein coding sequence of clone qsl4 3 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone qsl4 3 deposited under accession number ATCC 98850. In yet other preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising the amino _ WO 00/09552 PCT/US99/18298 acid sequence of SEQ ID N0:52 from amino acid 536 to amino acid 1135. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:52 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:52, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:52 having biological activity, the fragment comprising the amino acid sequence from amino acid 562 to amino acid 571 of SEQ ID NO:52.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:51.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:51, but excluding the poly(A) tail at the 3' end of SEQ ID N0:51; and (ab) the nucleotide sequence of the cDNA insert of clone 2 0 qsl4 3 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
2 5 and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
3 0 (ba) SEQ ID N0:51, but excluding the poly(A) tail at the 3' end of SEQ ID N0:51; and (bb) the nucleotide sequence of the cDNA insert of clone qsl4 3 deposited under accession number ATCC 98850;

(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b}(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:51, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:51 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:51, but excluding the poly(A) tail at the 3' end of SEQ ID N0:51. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:51 from nucleotide 379 to nucleotide 3783, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:51 from nucleotide 379 to nucleotide 3783, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:51 from nucleotide 379 to nucleotide 3783. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:51 from nucleotide 460 to nucleotide 3783, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:51 from nucleotide 460 to nucleotide 3783, to a nucleotide sequence corresponding to the 3' end 2 0 of said sequence of SEQ ID N0:51 from nucleotide 460 to nucleotide 3783.
Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:51 from nucleotide 1983 to nucleotide 3938, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:51 from nucleotide 1983 to nucleotide 3938, 2 5 to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:51 from nucleotide 1983 to nucleotide 3938.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
3 0 (a} the amino acid sequence of SEQ ID N0:52;
(b) the amino acid sequence of SEQ ID N0:52 from amino acid 536 to amino acid 1135;
(c) a fragment of the amino acid sequence of SEQ ID N0:52, the fragment comprising eight contiguous amino acids of SEQ ID N0:52; and (d) the amino acid sequence encoded by the cDNA insert of clone qsl4_3 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:52 or the amino acid sequence of SEQ ID N0:52 from amino acid 536 to amino acid 1135. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino and sequence of SEQ ID N0:52 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:52, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:52 having biological activity, the, fragment comprising the amino acid sequence from amino acid 562 to amino acid 571 of SEQ ID N0:52.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:53;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:53 from nucleotide 1 to nucleotide 843;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:53 from nucleotide 469 to nucleotide 843;
2 0 (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qy338 9 deposited under accession number ATCC 98850;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qy338 9 deposited under accession number ATCC 98850;
2 5 (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qy338_9 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qy338_9 deposited under accession number ATCC 98850;
3 0 (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:54;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:54 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:54;

(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:53.
Preferably, such polynucleotide, comprises the nucleotide sequence of SEQ ID
N0:53 from nucleotide 1 to nucleotide 843; the nucleotide sequence of SEQ ID
N0:53 from nucleotide 469 to nucleotide 843; the nucleotide sequence of the full-length protein coding sequence of clone qy338_9 deposited under accession number ATCC 98850; or the nucleotide sequence of a mature protein coding sequence of clone qy338 9 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qy338_9 deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucieotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:54 having biological 2 0 activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino atids of SEQ ID N0:54, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:54 having biological activity, the fragment comprising the amino acid sequence from amino acid 135 to amino acid 144 of SEQ ID N0:54.
2 5 Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:53.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
3 0 (i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:53, but excluding the poly(A) tail at the 3' end of SEQ ID N0:53; and (ab) the nucleotide sequence of the cDNA insert of clone qy338 9 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:53, but excluding the poly(A) tail at the 3' end of SEQ ID N0:53; and (bb) the nucleotide sequence of the cDNA insert of clone qy338 9 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 0 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:53, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:53 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:53 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:53. Also preferably the 2 5 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:53 from nucleotide 1 to nucleotide 843, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:53 from nucleotide 1 to nucleotide 843, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:53 from nucleotide 3 0 1 to nucleotide 843. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:53 from nucleotide 469 to nucleotide 843, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:53 from nucleotide 469 to nucleotide 843, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:53 from nucleotide 469 to nucleotide 843.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:54;
(b) a fragment of the amino acid sequence of SEQ ID N0:54, the fragment comprising eight contiguous amino acids of SEQ ID N0:54; and (c) the amino acid sequence encoded by the cDNA insert of clone qy338_9 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:54. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:54 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:54, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:54 having biological activity, the fragment comprising the amino acid sequence from amino acid 135 to amino acid 144 of SEQ ID N0:54.
In one embodiment, the present invention provides a composition comprising an 2 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:55;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:55 from nucleotide 283 to nucleotide 906;
2 5 (c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:55 from nucleotide 325 to nucleotide 906;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rc58_1 deposited under accession number ATCC 98850;
3 0 (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rc58_1 deposited under accession number ATCC
98850;

(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rc58_1 deposited under accession number ATCC 98850;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:56;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:56 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:56;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynudeotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(i) and that has a length that is at least 25% of the length of SEQ ID N0:55.
Preferably, such polynudeotide comprises the nucleotide sequence of SEQ ID
N0:55 from nucleotide 283 to nucleotide 906; the nucleotide sequence of SEQ ID
N0:55 from nucleotide 325 to nucleotide 906; the nucleotide sequence of the full-length protein 2 0 coding sequence of clone rc58_1 deposited under accession number ATCC
98850; or the nucleotide sequence of a mature protein coding sequence of clone rc58_1 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850. In further preferred embodiments, the 2 5 present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:56 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:56, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:56 having biological activity, the 3 0 fragment comprising the amino acid sequence from amino acid 99 to amino acid 108 of SEQ ID N0:56.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:55.

Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more palynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:55, but excluding the poly(A) tail at the 3' end of SEQ ID N0:55; and (ab) the nucleotide sequence of the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
2 0 (ba) SEQ ID N0:55, but excluding the poly(A) tail at the 3' end of SEQ ID N0:55; and (bb) the nucleotide sequence of the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in 2 5 conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleatide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:55, and 3 0 extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:55 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:55 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:55. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:55 from nucleotide 283 to nucleotide 906, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:55 from nucleotide 283 to nucleotide 906, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:55 from nucleotide 283 to nucleotide 906. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:55 from nucleotide 325 to nucleotide 906, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:55 from nucleotide 325 to nucleotide 906, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:55 from nucleotide 325 to nucleotide 906.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:56;
(b) a fragment of the amino acid sequence of SEQ ID N0:56, the fragment comprising eight contiguous amino acids of SEQ ID N0:56; and (c) the amino acid sequence encoded by the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:56. In further preferred 2 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:56 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:56, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:56 having biological activity, the fragment comprising the amino acid sequence 2 5 from amino acid 99 to amino acid 108 of SEQ ID N0:56.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:57;
3 0 (b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:57 from nucleotide 56 to nucleotide 973;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rd232 5 deposited under accession number ATCC 98850;

(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rd232_5 deposited under accession number ATCC 98850;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rd232 5 deposited under accession number ATCC 98850;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rd232 5 deposited under accession number ATCC 98850;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:58;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:58 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:58;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k} a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:57.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:57 from nucleotide 56 to nucleotide 973; the nucleotide sequence of the full-length protein coding sequence of clone rd232_5 deposited under accession number ATCC
98850;
2 5 or the nucleotide sequence of a mature protein coding sequence of clone rd232_5 deposited under accession number ATCC 98850. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone rd232_5 deposited under accession number ATCC 98850. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein 3 0 comprising a fragment of the amino acid sequence of SEQ ID N0:58 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:58, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:58 having biological activity, the fragment comprising the amino acid sequence from amino and 148 to amino acid 157 of SEQ ID N0:58.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:57.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:57, but excluding the poly(A) tail at the 3' end of SEQ ID N0:57; and (ab) the nucleotide sequence of the cDNA insert of clone rd232_5 deposited under accession number ATCC 98850;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:57, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:57; and (bb) the nucleotide sequence of the cDNA insert of clone rd232_5 deposited under accession number ATCC 98850;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv} isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:57, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:57 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:57 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:57. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:57 from nucleotide 56 to nucleotide 973, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:57 from nucleotide 56 to nucleotide 973, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:57 from nucleotide 56 to nucleotide 973.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:58;
(b) a fragment of the amino acid sequence of SEQ ID N0:58, the fragment comprising eight contiguous amino acids of SEQ ID N0:58; and (c) the amino acid sequence encoded by the cDNA insert of clone rd232_5 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:58. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID NOSE having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:58, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:58 having biological activity, the fragment comprising the amino acid sequence from amino acid 148 to amino acid 157 of SEQ ID N0:58.
2 5 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:59;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:59 from nucleotide 893 to nucleotide 2596;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ck213_12 deposited under accession number ATCC 98918;

_ WO 00/09552 PCT/US99/18298 (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ck213_12 deposited under accession number ATCC 98918;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ck213_12 deposited under accession number ATCC 98918;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ck223 12 deposited under accession number ATCC 98918;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:60;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:60 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:60;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:59.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:59 from nucleotide 893 to nucleotide 2596; the nucleotide sequence of the full-length protein coding sequence of clone ck213_12 deposited under accession number ATCC
2 5 98918; or the nucleotide sequence of a mature protein coding sequence of clone ck213_12 deposited under accession number ATCC 98918. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone ck213_12 deposited under accession number ATCC 98918. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein 3 0 comprising a fragment of the amino acid sequence of SEQ ID N0:60 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:60, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:60 having biological activity, the fragment comprising the amino acid sequence from amino acid 279 to amino acid 288 of SEQ ID N0:60.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:59.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:59, but excluding the poly(A) tail at the 3' end of SEQ ID N0:59; and (ab) the nucleotide sequence of the cDNA insert of clone ck213_12 deposited under accession number ATCC 98918;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii} isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:59, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:59; and (bb) the nucleotide sequence of the cDNA insert of clone ck213_12 deposited under accession number ATCC 98918;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:59, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

WO 00/09552 PC'TNS99/18298 ID N0:59 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:59 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:59. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:59 from nucleotide 893 to nucleotide 2596, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:59 from nucleotide 893 to nucleotide 2596, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:59 from nucleotide 893 to nucleotide 2596.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:60;
(b) a fragment of the amino acid sequence of SEQ ID N0:60, the fragment comprising eight contiguous amino acids of SEQ ID N0:60; and (c) the amino acid sequence encoded by the cDNA insert of done ck213_12 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:60. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:60 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:60, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:60 having biological activity, the fragment comprising the amino acid sequence from amino acid 279 to amino acid 288 of SEQ ID N0:60.
2 5 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:61;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:61 from nucleotide 29 to nucleotide 1750;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pg195_1 deposited under accession number ATCC 98918;

(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pg195_1 deposited under accession number ATCC 98918;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pg195_1 deposited under accession number ATCC 98918;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pg195 1 deposited under accession number ATCC 98918;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:62;
(h) a polynudeotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:62 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:62;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:61.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:61 from nucleotide 29 to nucleotide 1750; the nucleotide sequence of the full-length protein coding sequence of clone pg195 1 deposited under accession number ATCC
2 5 98918; or the nucleotide sequence of a mature protein coding sequence of clone pg195_1 deposited under accession number ATCC 98918. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pg195_1 deposited under accession number ATCC 98918. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein 3 0 comprising a fragment of the amino acid sequence of SEQ ID N0:62 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:62, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:62 having biological activity, the fragment comprising the amino acid sequence from amino acid 282 to amino acid 291 of SEQ ID N0:62.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:61.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:61, but excluding the poly(A) tail at the 3' end of SEQ ID N0:61; and (ab) the nucleotide sequence of the cDNA insert of clone pg195_1 deposited under accession number ATCC 98918;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:61, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:61; and (bb) the nucleotide sequence of the cDNA insert of clone pg195_1 deposited under accession number ATCC 98918;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:61, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:61 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:61 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:61. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:61 from nucleotide 29 to nucleotide 1750, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:61 from nucleotide 29 to nucleotide 1750, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:61 from nucleotide 29 to nucleotide 1750.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:62;
(b) a fragment of the amino acid sequence of SEQ ID N0:62, the fragment comprising eight contiguous amino acids of SEQ ID N0:62; and (c) the amino acid sequence encoded by the cDNA insert of clone pg195_1 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:62. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:62 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:62, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:62 having biological activity, the fragment comprising the amino acid sequence from amino acid 282 to amino acid 291 of SEQ ID N0:62.
2 5 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:63;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:63 from nucleotide 1147 to nucleotide 1440;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:63 from nucleotide 1234 to nucleotide 1440;

(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pw460_5 deposited under accession number ATCC 98918;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone pw460_5 deposited under accession number ATCC 98918;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pw460_5 deposited under accession number ATCC 98918;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone pw460 5 deposited under accession number ATCC 98918;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:64;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:64 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:64;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
2 0 (1} a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:63.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:63 from nucleotide 1147 to nucleotide 1440; the nucleotide sequence of SEQ
ID N0:63 from nucleotide 1234 to nucleotide 1440; the nucleotide sequence of the full-length protein coding sequence of clone pw460_5 deposited under accession number ATCC
98918; or the nucleotide sequence of a mature protein coding sequence of clone pw460_5 3 0 deposited under accession number ATCC 98918. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone pw460_5 deposited under accession number ATCC 98918. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:64 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:64, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:64 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID N0:64.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:63.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:63, but excluding the poly(A} tail at the 3' end of SEQ ID N0:63; and (ab) the nucleotide sequence of the cDNA insert of clone pw460_5 deposited under accession number ATCC 98918;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 0 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 2 5 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:63, but excluding the poly(A) tail at the 3' end of SEQ ID N0:63; and (bb) the nucleotide sequence of the cDNA insert of clone 3 0 pw460_5 deposited under accession number ATCC 98918;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step {b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:63, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:63 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:63 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:63. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:63 from nucleotide 1147 to nucleotide 1440, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:63 from nucleotide 1147 to nucleotide 1440, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:63 from nucleotide 1147 to nucleotide 1440. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA
sequence of SEQ ID N0:63 from nucleotide 1234 to nucleotide 1440, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:63 from nucleotide 1234 to nucleotide 1440, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:63 from nucleotide 1234 to nucleotide 1440.
1n other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
2 0 (a) the amino acid sequence of SEQ ID N0:64;
(b) a fragment of the amino acid sequence of SEQ ID N0:64, the fragment comprising eight contiguous amino acids of SEQ ID N0:64; and (c) the amino acid sequence encoded by the cDNA insert of clone pw460 5 deposited under accession number ATCC 98918;
2 5 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:64. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino and sequence of SEQ ID N0:64 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 3 0 of SEQ ID N0:64, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:64 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID N0:64.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:

(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:65;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:65 from nucleotide 46 to nucleotide 1356;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:65 from nucleotide 127 to nucleotide 1356;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qa136_1 deposited under accession number ATCC 98918;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qa136_1 deposited under accession number ATCC 98918;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qa136_1 deposited under accession number ATCC 98918;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:66;
(i) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:66 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:66;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein 2 5 of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:65.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:65 from nucleotide 46 to nucleotide 1356; the nucleotide sequence of SEQ ID
N0:65 from nucleotide 127 to nucleotide 1356; the nucleotide sequence of the full-length protein coding sequence of clone qa136_1 deposited under accession number ATCC 98918;
or the nucleotide sequence of a mature protein coding sequence of clone qa136_1 deposited under accession number ATCC 98918. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qa136_1 deposited under accession number AT CC 98918. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:66 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:66, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:66 having biological activity, the fragment comprising the amino acid sequence from amino acid 213 to amino acid 222 of SEQ ID N0:66.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:65.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
2 0 (aa) SEQ ID N0:65; and (ab) the nucleotide sequence of the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:65; and (bb) the nucleotide sequence of the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;

(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:65, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:65 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:65 . Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:65 from nucleotide 46 to nucleotide 1356, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:65 from nucleotide 46 to nucleotide 1356, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:65 from nucleotide 46 to nucleotide 1356. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:65 from nucleotide 127 to nucleotide 1356, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:65 from nucleotide 127 to nucleotide 1356, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:65 from nucleotide 2 0 127 to nucleotide 1356.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino and sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:66;
2 5 (b) a fragment of the amino acid sequence of SEQ ID N0:66, the fragment comprising eight contiguous amino acids of SEQ ID N0:66; and (c) the amino acid sequence encoded by the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins. Preferably such 3 0 protein comprises the amino acid sequence of SEQ ID N0:66. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:66 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands of SEQ ID N0:66, or a protein comprising a fragment of the amino acid sequence of SEQ

ID N0:66 having biological activity, the fragment comprising the amino acid sequence from amino acid 213 to amino acid 222 of SEQ ID N0:66.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:67;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:67 from nucleotide 206 to nucleotide 1624;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:67 from nucleotide 542 to nucleotide 1624;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qy1261 2 deposited under accession number ATCC 98918;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qy1261 2 deposited under accession number ATCC 98918;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qy1261 2 deposited under accession number ATCC 98918;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
2 0 insert of clone qy1261 2 deposited under accession number ATCC 98918;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:68;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:68 having biological activity, the fragment 2 5 comprising eight contiguous amino acids of SEQ ID N0:68;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k} a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
3 0 (1} a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:67.

WO 00/09552 PC1'/US99/18298 Preferably, such poiynucleotide comprises the nucleotide sequence of SEQ ID
NCr67 from nucleotide 206 to nucleotide 1624; the nucleotide sequence of SEQ
ID N0:67 from nucleotide 542 to nucleotide 1624; the nucleotide sequence of the full-length protein coding sequence of clone qy1261 2 deposited under accession number ATCC 98918;
or the nucleotide sequence of a mature protein coding sequence of clone qy1261 2 deposited under accession number ATCC 98918. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qy1261_2 deposited under accession number ATCC 98918. In further preferred embodiments, the present invention provides a poiynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:68 having biological activity, the fragment preferably comprising eight {more preferably twenty, most preferably thirty) contiguous amino ands of SEQ ID NO:68, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:68 having biological activity, the fragment comprising the amino acid sequence from amino and 231 to amino acid 240 of SEQ ID N0:68.
C?ther embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:67.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
2 0 (a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:67, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:67; and (ab) the nucleotide sequence of the cDNA insert of clone qy1261 2 deposited under accession number ATCC 98918;
(ii) hybridizing said probes} to human genomic DNA in conditions at least as stringent as 4X SSC: at 50 degrees C; and 3 0 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:

(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:67, bu.t excluding the poly(A) tail at the 3' end of SEQ ID N0:67; and (bb) the nucleotide sequence of the cDNA insert of clone qy1261_2 deposited under accession number ATCC 98918;
(ii) hybridizing said primer{s) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:67, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:67 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:67 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:67. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:67 from nucleotide 206 to nucleotide 1624, and extending contiguously from a nucleotide sequence corresponding to the 5' end 2 0 of said sequence of SEQ ID N0:67 from nucleotide 206 to nucleotide 1624, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:67 from nucleotide 206 to nucleotide 1624. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:67 from nucleotide 542 to nucleotide 1624, and extending contiguously from a 2 5 nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:67 from nucleotide 542 to nucleotide 1624, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:67 from nucleotide 542 to nucleotide 1624.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 3 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:68;
(b) a fragment of the amino acid sequence of SEQ ID N0:68, the fragment comprising eight contiguous amino acids of SEQ ID N0:68; and (c) the amino acid sequence encoded by the cDNA insert of clone qy1261 2 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:68. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:68 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:68, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:68 having biological activity, the fragment comprising the amino acid sequence from amino acid 231 to amino acid 240 of SEQ ID N0:68.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynudeotide comprising the nucleotide sequence of SEQ ID
N0:69;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:69 from nucleotide 1359 to nucleotide 1817;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rd432 4 deposited under accession number ATCC 98918;
2 0 (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rd432 4 deposited under accession number ATCC 98918;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rd432_4 deposited under accession number ATCC 98918;
2 5 (f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rd432 4 deposited under accession number ATCC 98918;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:70;
(h) a polynucleotide encoding a protein comprising a fragment of the 3 0 amino acid sequence of SEQ ID N0:70 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:70;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;

(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:69.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:69 from nucleotide 1359 to nucleotide 1817; the nucleotide sequence of the full-length protein coding sequence of clone rd432 4 deposited under accession number ATCC
98918;
or the nucleotide sequence of a mature protein coding sequence of clone rd432 deposited under accession number ATCC 98918. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone rd432_4 deposited under accession number A TCC 98918. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:70 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably tlvrty) contiguous amino acids of SEQ ID N0:70, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:70 having 2 0 biological activity, the fragment comprising the amino acid sequence from amino acid 71 to amino acid 80 of SEQ ID N0:70.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:69.
Further embodiments of the invention provide isolated polynucleotides produced 2 5 according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
3 0 (aa) SEQ ID N0:69, but excluding the poly(A) tail at the 3' end of SEQ ID N0:69; and (ab) the nucleotide sequence of the cDNA insert of clone rd432 4 deposited under accession number ATCC 98918;

(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:69, but excluding the poly(A) tail at the 3' end of SEQ ID NO:69; and (bb) the nucleotide sequence of the cDNA insert of clone rd432 4 deposited under accession number ATCC 98918;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:69, and 2 0 extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:69 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:69 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:69. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:69 from nucleotide 1359 to nucleotide 2 5 1817, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:69 from nucleotide 1359 to nucleotide 1817, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:69 from nucleotide 1359 to nucleotide 1817.
In other embodiments, the present invention provides a composition comprising 3 0 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:70;
(b} a fragment of the amino acid sequence of SEQ ID N0:70, the fragment comprising eight contiguous amino acids of SEQ ID N0:70; and (c) the amino acid sequence encoded by the cDNA insert of clone rd432_4 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:70. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino and sequence of SEQ ID N0:70 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:70, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:70 having biological activity, the fragment comprising the amino acid sequence from amino acid 71 to amino acid 80 of SEQ ID N0:70.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:71;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:71 from nucleotide 884 to nucleotide 1195;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:71 from nucleotide 947 to nucleotide 1195;
(d) a polynucleotide comprising the nucleotide sequence of the full-2 0 length protein coding sequence of clone rb789_14 deposited under accession number ATCC 207004;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rb789_14 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature 2 5 protein coding sequence of clone rb789_14 deposited under accession number ATCC 207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rb789_14 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid 3 0 sequence of SEQ ID N0:72;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:72 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:72;

(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(i}; and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:71.
Preferably, such polynudeotide .comprises the nucleotide sequence of SEQ ID
N0:71 from nucleotide 884 to nucleotide 1195; the nucleotide sequence of SEQ
ID N0:71 from nucleotide 947 to nucleotide 1195; the nucleotide sequence of the full-length protein coding sequence of clone rb789_14 deposited under accession number ATCC
207004; or the nucleotide sequence of a mature protein coding sequence of clone rb789_14 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone rb789_14 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:72 having biological 2 0 activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:72, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:72 having biological activity, the fragment comprising the amino acid sequence from amino acid 47 to amino acid 56 of SEQ ID N0:72.
2 5 Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:71.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
3 0 (i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:71, but excluding the poly(A) tail at the 3' end of SEQ ID N0:71; and (ab) the nucleotide sequence of the cDNA insert of clone rb789_14 deposited under accession number ATCC 207004;
(ii) hybridizing said probes} to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:71, but excluding the poly(A) tail at the 3' end of SEQ ID N0:71; and (bb) the nucleotide sequence of the cDNA insert of clone rb789_14 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 0 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:71, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:71 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:71 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:71. Also preferably the 2 5 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:71 from nucleotide 884 to nucleotide 1195, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:71 from nucleotide 884 to nucleotide 1195, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:71 from nucleotide 3 0 884 to nucleotide 1195. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:71 from nucleotide 947 to nucleotide 1195, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:71 from nucleotide 947 to nucleotide 1195, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:71 from nucleotide 947 to nucleotide 1195.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:72;
(b) a fragment of the amino acid sequence of SEQ ID N0:72, the fragment comprising eight contiguous amino acids of SEQ ID N0:72; and (c) the amino acid sequence encoded by the cDNA insert of clone rb789_14 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:72. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:72 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:72, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:72 having biological activity, the fragment comprising the amino acid sequence from amino acid 47 to amino acid 56 of SEQ ID N0:72.
In one embodiment, the present invention provides a composition comprising an 2 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:73;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:73 from nucleotide 69 to nucleotide 374;
2 5 (c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:73 from nucleotide 186 to nucleotide 374;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd137_1 deposited under accession number ATCC 207004;
3 0 (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd137_1 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd137_1 deposited under accession number ATCC 207004;

(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone yd137_1 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:74;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:74 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:74;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
{k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1} a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(i) and that has a length that is at least 25% of the length of SEQ ID N0:73.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:73 from nucleotide 69 to nucleotide 374; the nucleotide sequence of SEQ ID
N0:73 from nucleotide 186 to nucleotide 374; the nucleotide sequence of the full-length protein 2 0 coding sequence of clone yd137_1 deposited under accession number ATCC
207004; or the nucleotide sequence of a mature protein coding sequence of clone yd137_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone yd137_1 deposited under accession number ATCC 207004. In further preferred 2 5 embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:74 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:74, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:74 having 3 0 biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID N0:74.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:73.

WO 00/09552 PCTlUS99/18298 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:73, but excluding the poly(A) tail at the 3' end of SEQ ID N0:73; and (ab) the nucleotide sequence of the cDNA insert of clone yd137_1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
2 0 (ba) SEQ ID N0:73, but excluding the poly(A) tail at the 3' end of SEQ ID N0:73; and (bb) the nucleotide sequence of the cDNA insert of clone yd137_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in 2 5 conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:73, and 3 0 extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:73 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:73 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:73. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:73 from nucleotide 69 to nucleotide WO 00/09552 PC'T/US99/18298 374, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:73 from nucleotide 69 to nucleotide 374, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:73 from nucleotide 69 to nucleotide 374. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:73 from nucleotide 186 to nucleotide 374, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:73 from nucleotide 186 to nucleotide 374, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:73 from nucleotide 186 to nucleotide 374.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:74;
(b) a fragment of the amino acid sequence of SEQ ID N0:74, the fragment comprising eight contiguous amino acids of SEQ ID N0:74; and (c) the amino acid sequence encoded by the cDNA insert of clone yd137_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:74. In further preferred 2 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:74 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:74, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:74 having biological activity, the fragment comprising the amino acid sequence 2 5 from amino acid 46 to amino acid 55 of SEQ ID N0:74.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:75;
3 0 (b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:75 from nucleotide 8 to nucleotide 343;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:75 from nucleotide 50 to nucleotide 343;

(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd218_1 deposited under accession number ATCC 207004;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd218_1 deposited under accession number ATCC 207004;
(f} a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd218_1 deposited under accession number ATCC 207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone yd218_1 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:76;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:76 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:76;
(j} a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
2 0 (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:75.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:75 from nucleotide 8 to nucleotide 343; the nucleotide sequence of SEQ ID
N0:75 from nucleotide 50 to nucleotide 343; the nucleotide sequence of the full-length protein coding sequence of clone yd218_1 deposited under accession number ATCC 207004; or the nucleotide sequence of a mature protein coding sequence of clone yd218_1 deposited 3 0 under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone yd218_1 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:76 having biological WO 00/09552 PG"T/US99/18298 activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:76, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:76 having biological activity, the fragment comprising the amino acid sequence from amino acid 51 to amino acid 60 of SEQ ID N0:76.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:75.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:75, but excluding the poly(A) tail at the 3' end of SEQ ID N0:75; and (ab) the nucleotide sequence of the cDNA insert of clone yd218_1 deposited under accession number ATCC 207004;
(ii} hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 0 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b} a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 2 5 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:75, but excluding the poly(A) tail at the 3' end of SEQ ID N0:75; and (bb) the nucleotide sequence of the cDNA insert of clone 3 0 yd218_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleodde isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:75, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:75 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:75 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:75. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:75 from nucleotide 8 to nucleotide 343, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:75 from nucleotide 8 to nucleotide 343, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:75 from nucleotide 8 to nucleotide 343. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:75 from nucleotide 50 to nucleotide 343, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:75 from nucleotide 50 to nucleotide 343, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:75 from nucleotide 50 to nucleotide 343.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
2 0 (a) the amino acid sequence of SEQ ID N0:76;
(b) a fragment of the amino acid sequence of SEQ ID N0:76, the fragment comprising eight contiguous amino acids of SEQ ID N0:76; and (c) the amino acid sequence encoded by the cDNA insert of clone yd218_1 deposited under accession number A'TCC 207004;
2 5 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:76. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino aad sequence of SEQ ID N0:76 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands 3 0 of SEQ ID N0:76, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:76 having biological activity, the fragment comprising the amino acid sequence from amino acid 51 to amino acid 60 of SEQ ID N0:76.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:

(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:77;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:77 from nucleotide 84 to nucleotide 1679;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yel l_1 deposited under accession number ATCC 207004;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yell 1 deposited under accession number ATCC 207004;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yel l 1 deposited under accession number ATCC
207004;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone yell 1 deposited under accession number ATCC 207004;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:78;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:78 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:78;
2 0 (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:77.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
3 0 N0:77 from nucleotide 84 to nucleotide 1679; the nucleotide sequence of the full-length protein coding sequence of clone yell 1 deposited under accession number ATCC
207004; or the nucleotide sequence of a mature protein coding sequence of clone yell_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone yell 1 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:78 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:78, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:78 having biological activity, the fragment comprising the amino acid sequence from amino acid 261 to amino acid 270 of SEQ ID N0:78.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:77.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:77, but excluding the poly(A) tail at the 3' end of SEQ ID N0:77; and (ab) the nucleotide sequence of the cDNA insert of clone 2 0 yel l 1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
2 5 and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
3 0 (ba) SEQ ID N0:77, but excluding the poly(A) tail at the 3' end of SEQ ID N0:77; and (bb) the nucleotide sequence of the cDNA insert of clone yell 1 deposited under accession number ATCC 207004;

(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:77, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:77 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:77 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:77. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:77 from nucleotide 84 to nucleotide 1679, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:77 from nucleotide 84 to nucleotide 1679, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:77 from nucleotide 84 to nucleotide 1679.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:78;
2 0 (b) a fragment of the amino acid sequence of SEQ ID N0:78, the fragment comprising eight contiguous amino acids of SEQ ID N0:78; and (c) the amino acid sequence encoded by the cDNA insert of clone yell_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such 2 5 protein comprises the amino acid sequence of SEQ ID N0:78. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:78 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:78, or a protein comprising a fragment of the amino acid sequence of SEQ
3 0 ID N0:78 having biological activity, the fragment comprising the amino acid sequence from amino acid 261 to amino acid 270 of SEQ ID N0:78.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:

(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:79;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:79 from nucleotide 72 to nucleotide 1646;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:79 from nucleotide 180 to nucleotide 1646;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye72_1 deposited under accession number ATCC 207004;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye72_1 deposited under accession number ATCC
207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ye72_1 depasited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:80;
(i) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:80 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:80;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein 2 5 of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:79.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:79 from nucleotide 72 to nucleotide 1646; the nucleotide sequence of SEQ ID
N0:79 from nucleotide 180 to nucleotide 1646; the nucleotide sequence of the full-length protein coding sequence of clone ye72_1 deposited under accession number ATCC 207004;
or the nucleotide sequence of a mature protein coding sequence of clone ye72_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:80 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:80, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:80 having biological activity, the fragment comprising the amino acid sequence from amino acid 257 to amino acid 266 of SEQ ID N0:80.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:79.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
2 0 (aa) SEQ ID N0:79, but excluding the poly(A} tail at the 3' end of SEQ ID N0:79; and (ab) the nucleotide sequence of the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in 2 5 conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
3 0 (i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:79, but excluding the poly(A) tail at the 3' end of SEQ ID N0:79; and (bb) the nucleotide sequence of the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:79, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:79 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:79 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:79. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:79 from nucleotide 72 to nucleotide 1646, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:79 from nucleotide 72 to nucleotide 1646, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:79 from nucleotide 72 to nucleotide 1646. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:79 from nucleotide 180 to nucleotide 1646, and extending contiguously from a 2 0 nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:79 from nucleotide 180 to nucleotide 1646, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:79 from nucleotide 180 to nucleotide 1646.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino and sequence selected from the group 2 5 consisting of:
(a) the amino acid sequence of SEQ ID N0:80;
(b) a fragment of the amino acid sequence of SEQ ID N0:80, the fragment comprising eight contiguous amino acids of SEQ ID N0:80; and (c) the amino acid sequence encoded by the cDNA insert of clone 3 0 ye72_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:80. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:80 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:80, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:80 having biological activity, the fragment comprising the amino acid sequence from amino acid 257 to amino acid 266 of SEQ ID N0:80.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:81;
(b} a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:81 from nucleotide 954 to nucleotide 2423;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:81 from nucleotide 1224 to nucleotide 2423;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye78_1 deposited under accession number ATCC 207004;
(e) a polynucleatide encoding the full-length protein encoded by the cDNA insert of clone ye78_1 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye78_1 deposited under accession number ATCC
2 0 207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ye78_1 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:82;
2 5 (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:82 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:82;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
3 0 (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:81.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:81 from nucleotide 954 to nucleotide 2423; the nucleotide sequence of SEQ
ID N0:81 from nucleotide 1224 to nucleotide 2423; the nucleotide sequence of the full-length protein coding sequence of clone ye78_1 deposited under accession number ATCC
207004; or the nucleotide sequence of a mature protein coding sequence of clone ye78_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone ye78_1 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:82 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands of SEQ ID N0:82, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:82 having biological activity, the fragment comprising the amino acid sequence from amino acid 240 to amino acid 249 of SEQ ID N0:82.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
2 0 ID N0:81.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 5 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:81, but excluding the poly(A) tail at the 3' end of SEQ ID N0:81; and (ab) the nucleotide sequence of the cDNA insert of clone 3 0 ye78_1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);

and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:81, but excluding the poly(A) tail at the 3' end of SEQ ID N0:81; and (bb) the nucleotide sequence of the cDNA insert of clone ye78_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:81, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:81 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:81 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:81. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence 2 0 corresponding to the cDNA sequence of SEQ ID N0:81 from nucleotide 954 to nucleotide 2423, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:81 from nucleotide 954 to nucleotide 2423, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:81 from nucleotide 954 to nucleotide 2423. Also preferably the polynucleotide isolated according to the above 2 5 process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:81 from nucleotide 1224 to nucleotide 2423, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:81 from nucleotide 1224 to nucleotide 2423, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:81 from nucleotide 1224 to nucleotide 2423.
3 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:82;

(b) a fragment of the amino acid sequence of SEQ ID N0:82, the fragment comprising eight contiguous amino acids of SEQ ID N0:82; and (c) the amino acid sequence encoded by the cDNA insert of clone ye78_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:82. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:82 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:82, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:82 having biological activity, the fragment comprising the amino acid sequence from amino acid 240 to amino acid 249 of SEQ ID N0:82.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ iD
N0:83;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:83 from nucleotide 176 to nucleotide 1321;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
2 0 N0:83 from nucleotide 233 to nucleotide 1321;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye90_1 deposited under accession number ATCC 207004;
(e) a polynucleotide encoding the full-length protein encoded by the 2 5 cDNA insert of clone ye90_1 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye90 1 deposited under accession number ATCC
207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
3 0 insert of clone ye90_1 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:84;

(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:84 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:84;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(i) and that has a length that is at least 25% of the length of SEQ ID N0:83.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:83 from nucleotide 176 to nucleotide 1321; the nucleotide sequence of SEQ
ID N0:83 from nucleotide 233 to nucleotide 1321; the nucleotide sequence of the full-length protein coding sequence of clone ye90_1 deposited under accession number ATCC 207004;
or the nucleotide sequence of a mature protein coding sequence of clone ye90_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye90_1 2 0 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:84 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:84, or a polynucleotide encoding a protein comprising a 2 5 fragment of the amino acid sequence of SEQ ID N0:84 having biological activity, the fragment comprising the amino acid sequence from amino acid 186 to amino acid 195 of SEQ ID N0:84.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:83.
3 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:

(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:83, but excluding the poly(A) tail at the 3' end of SEQ ID N0:83; and (ab) the nucleotide sequence of the cDNA insert of clone ye90_1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating .the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or mare polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:83, but excluding the poly(A) tail at the 3' end of SEQ ID N0:83; and (bb) the nucleotide sequence of the cDNA insert of clone 2 0 ye90_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 5 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:83, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:83 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:83 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:83. Also preferably the 3 0 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:83 from nucleotide 176 to nucleotide 1321, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:83 from nucleotide 176 to nucleotide 1321, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:83 from nucleotide 176 to nucleotide 1321. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:83 from nucleotide 233 to nucleotide 1321, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:83 from nucleotide 233 to nucleotide 1321, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:83 from nucleotide 233 to nucleotide 1321.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:84;
(b) a fragment of the amino acid sequence of SEQ ID N0:84, the fragment comprising eight contiguous amino acids of SEQ ID N0:84; and (c) the amino acid sequence encoded by the cDNA insert of clone ye90_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:84. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:84 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 0 of SEQ ID N0:84, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:84 having biological activity, the fragment comprising the amino acid sequence from amino acid 186 to amino acid 195 of SEQ ID N0:84.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
2 5 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:85;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:85 from nucleotide 105 to nucleotide 605;
(c) a polynucleotide comprising the nucleotide sequence of the full-3 0 length protein coding sequence of clone yi62_1 deposited under accession number ATCC 207004;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi62_1 deposited under accession number ATCC 207004;

(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi62_1 deposited under accession number ATCC
207004;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone yi62_1 deposited under accession number ATCC 207004;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:86;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:86 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:86;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:85.
2 0 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:85 from nucleotide 105 to nucleotide 605; the nucleotide sequence of the full-length protein coding sequence of clone yi62_1 deposited under accession number ATCC
207004;
or the nucleotide sequence of a mature protein coding sequence of clone yi62_1 deposited under accession number ATCC 207004. In other preferred embodiments, the 2 5 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi62_1 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:86 having biological activity, the fragment preferably comprising eight (more preferably twenty, most 3 0 preferably thirty) contiguous amino acids of SEQ ID N0:86, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:86 having biological activity, the fragment comprising the amino acid sequence from amino acid 78 to amino acid 87 of SEQ ID N0:86.

Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:85.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:85, but excluding the poly(A) tail at the 3' end of SEQ ID N0:85; and (ab) the nucleotide sequence of the cDNA insert of clone yi62_1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 2 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:85, but excluding the poly(A) tail at the 3' end of SEQ ID N0:85; and (bb) the nucleotide sequence of the cDNA insert of clone 2 5 yi62_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii} amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
3 0 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:85, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:85 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:85 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:85. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:85 from nucleotide 105 to nucleotide 605, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:85 from nucleotide 105 to nucleotide 605, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:85 from nucleotide 105 to nucleotide 605.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:86;
(b) a fragment of the amino acid sequence of SEQ ID N0:86, the fragment comprising eight contiguous amino acids of SEQ ID N0:86; and (c) the amino acid sequence encoded by the cDNA insert of clone yi62_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:86. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:86 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 0 of SEQ ID N0:86, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:86 having biological activity, the fragment comprising the amino acid sequence from amino acid 78 to amino acid 87 of SEQ ID N0:86.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
2 5 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:87;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:87 from nucleotide 223 to nucleotide 798;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:87 from nucleotide 430 to nucleotide 798;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk78_1 deposited under accession number ATCC 207004;

(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk78_1 deposited under accession number ATCC
207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone yk78_1 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:88;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:88 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:88;
(j) a polynucleatide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:87.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:87 from nucleotide 223 to nucleotide 798; the nucleotide sequence of SEQ ID
N0:87 from nucleotide 430 to nucleotide 798; the nucleotide sequence of the full-length protein 2 5 coding sequence of clone yk78_1 deposited under accession number ATCC
207004; or the nucleotide sequence of a mature protein coding sequence of clone yk78_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004. In further preferred embodiments, the 3 0 present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:88 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:88, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:88 having biological activity, the fragment comprising the amino acid sequence from amino acid 91 to amino acid 100 of SEQ ID N0:88.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:87.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:87, but excluding the poly(A) tail at the 3' end of SEQ ID N0:87; and (ab) the nucleotide sequence of the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba} SEQ ID N0:87, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:87; and (bb) the nucleotide sequence of the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:87, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:87 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:87 , but excluding the poly(A} tail at the 3' end of SEQ ID N0:87. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:87 from nucleoside 223 to nucleotide 798, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:87 from nucleotide 223 to nucleotide 798, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:87 from nucleotide 223 to nucleotide 798. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:87 from nucleotide 430 to nucleotide 798, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:87 from nucleotide 430 to nucleotide 798, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:87 from nucleotide 430 to nucleotide 798.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:88;
(b) a fragment of the amino acid sequence of SEQ ID N0:88, the fragment comprising eight contiguous amino acids of SEQ ID N0:88; and 2 0 (c) the amino acid sequence encoded by the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:88. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 5 amino acid sequence of SEQ ID N0:88 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:88, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:88 having biological activity, the fragment comprising the amino acid sequence from amino acid 91 to amino acid 100 of SEQ ID N0:88.
3 0 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:89;

(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:89 from nucleotide 211 to nucleotide 942;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:89 from nucleotide 298 to nucleotide 942;
(d} a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk251 1 deposited under accession number ATCC 207004;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk251_1 deposited under accession number ATCC 207004;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk251 1 deposited under accession number ATCC 207004;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone yk251 1 deposited under accession number ATCC 207004;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:90;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:90 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:90;
2 0 (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of {h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(i); and {m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:89.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
3 0 N0:89 from nucleotide 211 to nucleotide 942; the nucleotide sequence of SEQ ID N0:89 from nucleotide 298 to nucleotide 942; the nucleotide sequence of the full-length protein coding sequence of clone yk251 1 deposited under accession number ATCC 207004;
or the nucleotide sequence of a mature protein coding sequence of clone yk251 1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone y1c251 1 deposited under accession number ATCC 207004. In further »rPfP,~,~P~
embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:90 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:90, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:90 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:90.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:89.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:89, but excluding the poly(A) tail at the 3' end of SEQ ID N0:89; and 2 0 (ab) the nucleotide sequence of the cDNA insert of clone yk251 1 deposited under accession number ATCC 207004;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 5 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 3 0 the group consisting of:
(ba) SEQ ID N0:89, but excluding the poly(A) taff at the 3' end of SEQ ID N0:89; and (bb) the nucleotide sequence of the cDNA insert of clone yk251 1 deposited under accession number ATCC 207004;

(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:89, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:89 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:89 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:89. Also preferably the polynucleotide isolated according to the. above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:89 from nucleotide 211 to nucleotide 942, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:89 from nucleotide 211 to nucleotide 942, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:89 from nucleotide 211 to nucleotide 942. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:89 from nucleotide 298 to nucleotide 942, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said. sequence of SEQ ID
N0:89 from nucleotide 298 to nucleotide 942, to a nucleotide sequence corresponding to the 3' end of 2 0 said sequence of SEQ ID N0:89 from nucleotide 298 to nucleotide 942.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:90;
2 5 (b) a fragment of the amino acid sequence of SEQ ID N0:90, the fragment comprising eight contiguous amino acids of SEQ ID N0:90; and (c) the amino acid sequence encoded by the cDNA insert of clone yk251 1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such 3 0 protein comprises the amino acid sequence of SEQ ID N0:90. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:90 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:90, or a protein comprising a fragment of the amino acid sequence of SEQ

ID N0:90 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:90.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
S (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:91;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:91 from nucleotide 149 to nucleotide 784;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ytl4_1 deposited under accession number ATCC 207004;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ytl4_1 deposited under accession number ATCC 207004;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ytl4_1 deposited under accession number ATCC
207004;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ytl4_1 deposited under accession number ATCC 207004;
(g) a polynucleotide encoding a protein comprising the amino acid 2 0 sequence of SEQ ID N0:92;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:92 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:92;
(i) a polynucleotide which is an allelic variant of a polynucleotide of 2 5 (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 3 0 (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:91.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:91 from nucleotide 149 to nucleotide 784; the nucleotide sequence of the full-length protein coding sequence of clone ytl4_1 deposited under accession number ATCC
207004;
or the nucleotide sequence of a mature protein coding sequence of clone ytl4_1 deposited under accession number ATCC 207004. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone ytl4_1 deposited under accession number ATCC 207004. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:92 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:92, or a polynucleotide encoding a protein comprising a fragment of the, amino acid sequence of SEQ ID N0:92 having biological activity, the fragment comprising the amino acid sequence from amino acid 101 to amino acid 110 of SEQ ID N0:92.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:91.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group 2 0 consisting of:
(aa) SEQ ID N0:91, but excluding the poly(A) tail at the 3' end of SEQ ID N0:91; and (ab) the nucleotide sequence of the cDNA insert of clone ytl4_1 deposited under accession number ATCC 207004;
2 5 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 3 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:

(ba) SEQ ID N0:91, but excluding the poly(A) tail at the 3' end of SEQ ID N0:91; and (bb) the nucleotide sequence of the cDNA insert of clone ytl4_1 deposited under accession number ATCC 207004;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii}.
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:91, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:91 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:91 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:91. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:91 from nucleotide 149 to nucleotide 784, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:91 from nucleotide 149 to nucleotide 784, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:91 from nucleotide 149 to nucleotide 784.
2 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:92;
(b) a fragment of the amino acid sequence of SEQ ID N0:92, the 2 5 fragment comprising eight contiguous amino acids of SEQ ID N0:92; and (c) the amino acid sequence encoded by the cDNA insert of clone ytl4_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:92. In further preferred 3 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:92 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:92, or a protein comprising a fragment of the amino acid sequence of SEQ

ID N0:92 having biological activity, the fragment comprising the amino acid sequence from amino acid 101 to amino acid 110 of SEQ ID N0:92.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:93;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:93 from nucleotide 89 to nucleotide 1441;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone bf157_16 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone bf157 16 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of done bf157_16 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone bf157_16 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid 2 0 sequence of SEQ ID N0:94;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:94 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:94;
(i) a polynucleotide which is an allelic variant of a polynucleotide of 2 5 (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 3 0 (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:93.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:93 from nucleotide 89 to nucleotide 1441; the nucleotide sequence of the full-length WO 00!09552 PCTNS99/18298 protein coding sequence of clone bf157_16 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone bf157 16 deposited under accession number ATCC 207088. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone bf157_16 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:94 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:94, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:94 having biological activity, the fragment comprising the amino acid sequence from amino acid 220 to amino acid 229 of SEQ ID N0:94.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:93.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group 2 0 consisting of:
(aa) SEQ ID N0:93, but excluding the poly(A) tail at the 3' end of SEQ ID N0:93; and (ab) the nucleotide sequence of the cDNA insert of clone bf157_16 deposited under accession number ATCC 207088;
2 5 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 3 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:

(ba) SEQ ID N0:93, but excluding the poly(A) tail at the 3' end of SEQ ID N0:93; and (bb) the nucleotide sequence of the cDNA insert of clone bf157_16 deposited under accession number ATCC 207088;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to. the cDNA sequence of SEQ ID N0:93, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:93 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:93 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:93. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:93 from nucleotide 89 to nucleotide 1441, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:93 from nucleotide 89 to nucleotide 1441, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:93 from nucleotide 89 to nucleotide 1441.
2 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting af:
(a) the amino acid sequence of SEQ ID N0:94;
(b) a fragment of the amino acid sequence of SEQ ID N0:94, the 2 5 fragment comprising eight contiguous amino acids of SEQ ID N0:94; and (c) the amino acid sequence encoded by the cDNA insert of clone bf157_16 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:94. In further preferred 3 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:94 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:94, or a protein comprising a fragment of the amino acid sequence of SEQ

ID N0:94 having biological activity, the fragment comprising the amino acid sequence from amino acid 220 to amino acid 229 of SEQ ID N0:94.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:95;
(h) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:95 from nucleotide 219 to nucleotide 629;
(c} a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone bk343_2 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone bk343_2 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone bk343 2 deposited under accession number ATCC 207088;
(f} a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone bk343 2 deposited under accession number ATCC 207088;
{g) a polynucleotide encoding a protein comprising the amino acid 2 0 sequence of SEQ ID N0:96;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:96 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:96;
(i) a polynucleotide which is an allelic variant of a polynucleotide of 2 5 (a)-{f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 3 0 (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:95.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:95 from nucleotide 2I9 to nucleotide 629; the nucleotide sequence of the full-length protein coding sequence of clone bk343_2 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone bk343 2 deposited under accession number ATCC 207088. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone bk343_2 deposited under accession number AT'CC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:96 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:96, or a polynucleotide encoding a protein comprising a fragment of the.amino acid sequence of SEQ ID N0:96 having biological activity, the fragment comprising the amino acid sequence from amino acid 63 to amino acid 72 of SEQ ID N0:96.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:95.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group 2 0 consisting of:
(aa) SEQ ID N0:95, but excluding the poly(A) tail at the 3' end of SEQ ID N0:95; and (ab) the nucleotide sequence of the cDNA insert of clone bk343 2 deposited under accession number ATCC 207088;
2 5 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 3 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:

(ba) SEQ ID N0:95, but excluding the poly(A) tail at the 3' end of SEQ ID N0:95; and (bb) the nucleotide sequence of the cDNA insert of clone bk343_2 deposited under accession number ATCC 207088;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:95, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:95 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:95 , but excluding the poly(A) tail at the 3' end of SEQ TD N0:95. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:95 from nucleotide 219 to nucleotide 629, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:95 from nucleotide 219 to nucleotide 629, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:95 from nucleotide 219 to nucleotide 629.
2 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:96;
(b) a fragment of the amino acid sequence of SEQ ID N0:96, the fragment comprising eight contiguous amino acids of SEQ ID N0:96; and (c) the amino acid sequence encoded by the cDNA insert of clone bk343 2 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:96. In further preferred 3 0 embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:96 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:96, or a protein comprising a fragment of the amino acid sequence of SEQ

ID N0:96 having biological activity, the fragment comprising the amino acid sequence from amino acid 63 to amino acid 72 of SEQ ID N0:96.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:97;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:97 from nucleotide 556 to nucleotide 951;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:97 from nucleotide 868 to nucleotide 951;
(d) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:97 from nucleotide 9 to nucleotide 1295;
(e} a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone cd205 2 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone cd205 2 deposited under accession number ATCC 207088;
(g) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone cd205 2 deposited under accession number 2 0 ATCC 207088;
(h) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone cd205_2 deposited under accession number ATCC 207088;
(i) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:98;
2 5 (j) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:98 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:98;
(k) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(h) above;
3 0 (1) a polynucleotide which encodes a species homologue of the protein of (i) or (j) above ;
(m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(j); and (n) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(j) and that has a length that is at least 25% of the length of SEQ ID N0:97.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:97 from nucleotide 556 to nucleotide 951; the nucleotide sequence of SEQ ID
N0:97 from nucleotide 868 to nucleotide 951; the nucleotide sequence of SEQ ID N0:97 from nucleotide 9 to nucleotide 1295; the nucleotide sequence of the full-length protein coding sequence of clone cd205 2 deposited under accession number ATCC 207088; or the nucleotide sequence of a mature protein coding sequence of clone cd205 2 deposited under accession number ATCC 207088. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone cd205 2 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:98 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:98, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:98 having biological activity, the fragment comprising the amino acid sequence from amino acid 61 to amino acid 70 of SEQ ID N0:98.
2 0 Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:97.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
2 5 (i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:97, but excluding the poly(A) tail at the 3' end of SEQ ID N0:97; and 3 0 {ab) the nucleotide sequence of the cDNA insert of clone cd205_2 deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:97, but excluding the poly(A) tail at the 3' end of SEQ ID N0:97; and (bb) the nucleotide sequence of the cDNA insert of clone cd205 2 deposited under accession number ATCC 207088;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:97, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:97 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:97 , but 2 0 excluding the poly(A) tail at the 3' end of SEQ ID N0:97. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:97 from nucleotide 556 to nucleotide 951, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:97 from nucleotide 556 to nucleotide 951, to a nucleotide 2 5 sequence corresponding to the 3' end of said sequence of SEQ ID N0:97 from nucleotide 556 to nucleotide 951. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:97 from nucleotide 868 to nucleotide 951, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:97 from 3 0 nucleotide 868 to nucleotide 951, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:97 from nucleotide 868 to nucleotide 951. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:97 from nucleotide 9 to nucleotide 1295, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:97 from nucleotide 9 to nucleotide 1295, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID
N0:97 from nucleotide 9 to nucleotide 1295.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:98;
(b) a fragment of the amino acid sequence of SEQ ID N0:98, the fragment comprising eight contiguous amino acids of SEQ ID N0:98; and (c) the amino acid sequence encoded by the cDNA insert of clone cd205 2 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:98. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:98 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:98, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:98 having biological activity, the fragment comprising the amino acid sequence from amino acid 61 to amino acid 70 of SEQ ID N0:98.
2 0 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:99;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
2 5 N0:99 from nucleotide 216 to nucleotide 443;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:99 from nucleotide 306 to nucleotide 443;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone cw1292_8 deposited under accession 3 0 number ATCC 207088;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone cw1292_8 deposited under accession number ATCC 207088;

(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone cw1292_8 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone cw1292_8 deposited under accession number ATCC 207088;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:100;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:100;
(j} a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(I) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:99.
2 0 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:99 from nucleotide 216 to nucleotide 443; the nucleotide sequence of SEQ ID
N0:99 from nucleotide 306 to nucleotide 443; the nucleotide sequence of the full-length protein coding sequence of clone cw1292_8 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone cw1292_8 deposited 2 5 under accession number ATCC 207088. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone cw1292_8 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:100 having biological 3 0 activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:200, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:100 having biological activity, the fragment comprising the amino acid sequence from amino acid 33 to amino acid 42 of SEQ ID N0:100.

Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:99.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:99, but excluding the poly{A) tail at the 3' end of SEQ ID N0:99; and (ab) the nucleotide sequence of the cDNA insert of done cw1292_8 deposited under accession number ATCC 207088;
(ii} hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 2 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:99, but excluding the poly(A) tail at the 3' end of SEQ ID N0:99; and (bb) the nucleotide sequence of the cDNA insert of clone 2 5 cw1292_8 deposited under accession number ATCC 207088;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
3 0 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:99, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:99 to a nucleotide sequence corresponding to the 3' end of SEQ ID N0:99 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:99. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:99 from nucleotide 216 to nucleotide 443, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:99 from nucleotide 216 to nucleotide 443, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:99 from nucleotide 216 to nucleotide 443. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:99 from nucleotide 306 to nucleotide 443, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:99 from nucleotide 306 to nucleotide 443, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:99 from nucleotide 306 to nucleotide 443.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:100;
(b) a fragment of the amino acid sequence of SEQ ID NO:100, the fragment comprising eight contiguous amino acids of SEQ ID NO:100; and (c) the amino acid sequence encoded by the cDNA insert of clone cw1292_8 deposited under accession number ATCC 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID NO:100. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:100 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands 2 5 of SEQ ID NO:100, or a protein comprising a fragment of the amino acid sequence of SEQ
ID NO:100 having biological activity, the fragment comprising the amino acid sequence from amino acid 33 to amino acid 42 of SEQ ID N0:100.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:101;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:101 from nucleotide 2136 to nucleotide 2447;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone cw1475 2 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone cw1475 2 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone cw1475 2 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone cw1475_2 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:102;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:102 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:102;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that.hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:101.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
NO:101 from nucleotide 2136 to nucleotide 2447; the nucleotide sequence of the full-length protein coding sequence of clone cw1475 2 deposited under accession number ATCC 207088; or the nucleotide sequence of a mature protein coding sequence of clone cw1475_2 deposited under accession number ATCC 207088. In other preferred 3 0 embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone cw1475 2 deposited under accession number ATCC
207088.
In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:102 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:102, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:102 having biological activity, the fragment comprising the amino acid sequence from amino acid 47 to amino acid 56 of SEQ ID N0:102.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:101.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:101, but excluding the poly(A) tail at the 3' end of SEQ ID N0:101; and (ab) the nucleotide sequence of the cDNA insert of clone cw1475_2 deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID NO:101, but excluding the poly(A) tail at the 3' end of SEQ ID NO:101; and (bb) the nucleotide sequence of the cDNA insert of clone cw1475 2 deposited under accession number ATCC 207088;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:101, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:101 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:101, but excluding the poly(A) tail at the 3' end of SEQ ID NO:101. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:101 from nucleotide 2136 to nucleotide 2447, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:101 from nucleotide 2136 to nucleotide 2447, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ
ID N0:101 from nucleotide 2136 to nucleotide 2447.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:102;
(b) a fragment of the amino acid sequence of SEQ ID N0:102, the fragment comprising eight contiguous amino acids of SEQ ID N0:102; and (c) the amino acid sequence encoded by the cDNA insert of clone cw1475_2 deposited under accession number ATCC 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:102. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:102 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:102, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:102 having biological activity, the fragment comprising the amino acid sequence from amino acid 47 to amino acid 56 of SEQ ID N0:102.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:103;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:103 from nucleotide 310 to nucleotide 954;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone dd428 4 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone dd428_4 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone dd428_4 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone dd428 4 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:104;
(h) a polynudeotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:104 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:104;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynudeotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:103.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:103 from nucleotide 310 to nucleotide 954; the nucleotide sequence of the full-length protein coding sequence of clone dd428_4 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone dd428 4 deposited under accession number ATCC 207088. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone dd428 4 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:104 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:104, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:104 having biological activity, the fragment comprising the amino acid sequence from amino acid 102 to amino acid 111 of SEQ ID N0:104.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:103.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:103, but excluding the poly(A) tail at the 3' end of SEQ ID N0:103; and (ab) the nucleotide sequence of the cDNA insert of clone dd428 4 deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:103, but excluding the poly(A) tail at the 3' end of SEQ ID N0:103; and (bb) the nucleotide sequence of the cDNA insert of clone dd428 4 deposited under accession number ATCC 207088;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b}(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:103, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:103 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:103 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:103. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:103 from nucleotide 310 to nucleotide 954, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:103 from nucleotide 310 to nucleotide 954, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:103 from nucleotide 310 to nucleotide 954.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
I5 (a) the amino acid sequence of SEQ ID N0:104;
(b) a fragment of the amino acid sequence of SEQ ID N0:104, the fragment comprising eight contiguous amino acids of SEQ ID N0:104; and (c) the amino acid sequence encoded by the cDNA insert of clone dd428_4 deposited under accession number ATCC 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:104. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:104 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:104, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:104 having biological activity, the fragment comprising the amino acid sequence from amino acid 102 to amino acid 111 of SEQ ID N0:1.04.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:105;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:105 from nucleotide 1698 to nucleotide 1895;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone dh1073_12 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone dh1073_12 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone dh1073_12 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone dh1073_12 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:106;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:106 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:106;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:105.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:105 from nucleotide 1698 to nucleotide 1895; the nucleotide sequence of the full-length protein coding sequence of clone dh1073_12 deposited under accession number ATCC 207088; or the nucleotide sequence of a mature protein coding sequence of clone dh1073_12 deposited under accession number ATCC 207088. In other preferred 3 0 embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone dh1073_I2 deposited under accession number ATCC
207088.
In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:106 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:106, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:106 having biological activity, the fragment comprising the amino acid sequence from amino acid 28 to amino acid 37 of SEQ ID N0:106.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:105.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps af:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:105, but excluding the poly(A) tail at the 3' end of SEQ ID N0:105; and (ab) the nucleotide sequence of the cDNA insert of clone dh1073_12 deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:105, but excluding the poly(A) tail at the 3' end of SEQ ID N0:105; and (bb) the nucleotide sequence of the cDNA insert of clone dh1073_12 deposited under accession number ATCC 207088;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:105, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:105 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:105 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:105. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:105 from nucleotide 1698 to nucleotide 1895, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:105 from nucleotide 1698 to nucleotide 1895, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ
ID N0:105 from nucleotide 1698 to nucleotide 1895.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:106;
{b) a fragment of the amino acid sequence of SEQ ID N0:106, the fragment comprising eight contiguous amino acids of SEQ ID N0:106; and (c) the amino acid sequence encoded by the cDNA insert of clone dh1073_12 deposited under accession number ATCC 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:106. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:106 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:106, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:106 having biological activity, the fragment comprising the amino acid sequence from amino acid 28 to amino acid 37 of SEQ ID N0:106.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:107;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:107 from nucleotide 423 to nucleotide 791;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone dw78_1 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone dw78_1 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone dw78_1 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone dw78_1 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:108;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:108 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:108;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specifiied in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:107.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:107 from nucleotide 423 to nucleotide 791; the nucleotide sequence of the full-length protein coding sequence of clone dw78 1 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone dw78_1 deposited under accession number ATCC 207088. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of done dw78_1 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:108 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:I08, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:108 having biological acfivity, the fragment comprising the amino acid sequence from amino acid 56 to amino acid 65 of SEQ ID N0:108.
S Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:107.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:107, but excluding the poly(A) tail at the 3' end of SEQ ID N0:107; and (ab) the nucleotide sequence of the cDNA insert of clone dw78_1 deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b} a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:107, but excluding the poly(A) tail at the 3' end of SEQ ID N0:107; and (bb) the nucleotide sequence of the cDNA insert of clone dw78_1 deposited under accession number ATCC 207088;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:107, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:107 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:107 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:107. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:107 from nucleotide 423 to nucleotide 791, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:107 from nucleotide 423 to nucleotide 791, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:107 from nucleotide 423 to nucleotide 791.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:108;
(b) a fragment of the amino acid sequence of SEQ ID N0:108, the fragment comprising eight contiguous amino acids of SEQ ID N0:108; and (c) the amino acid sequence encoded by the cDNA insert of clone dw78_1 deposited under accession number ATC:C 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:108. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:108 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:108, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:108 having biological activity, the fragment comprising the amino acid sequence from amino acid 56 to amino acid 65 of SEQ ID N0:108.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:109;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:109 from nucleotide 96 to nucleotide 944;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone fh116_ll deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of done fh116_11 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone fh116_11 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone fh116_ll deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:110;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:110 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:110;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:109.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:109 from nucleotide 96 to nucleotide 944; the nucleotide sequence of the full-length protein coding sequence of clone fh116_11 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone fh116_11 deposited under accession number ATCC 207088. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone fh116_ll deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:110 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:110, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
NO:110 having biological activity, the fragment comprising the amino acid sequence from amino acid 136 to amino acid 145 of SEQ ID NO:110.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:109.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:109, but excluding the poly(A) tail at the 3' end of SEQ ID N0:109; and (ab) the nucleotide sequence of the cDNA insert of clone fh116_ll deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:109, but excluding the poly(A} tail at the 3' end of SEQ ID N0:109; and (bb) the nucleotide sequence of the cDNA insert of clone fh116_11 deposited under accession number ATCC 207088;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:109, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:109 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:109 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:209. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:109 from nucleotide 96 to nucleotide 944, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:109 from nucleotide 96 to nucleotide 944, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:109 from nucleotide 96 to nucleotide 944.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:110;
(b) a fragment of the amino acid sequence of SEQ ID NO:110, the fragment comprising eight contiguous amino acids of SEQ ID NO:110; and (c) the amino acid sequence encoded by the cDNA insert of clone fh116_ll deposited under accession number ATCC 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID NO:110. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:110, or a protein comprising a fragment of the amino acid sequence of SEQ
ID NO:I10 having biological activity, the fragment comprising the amino acid sequence from amino acid 136 to amino acid 145 of SEQ ID N0:110.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:111;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:111 from nucleotide 150 to nucleotide 1610;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone fy356_14 deposited under accession number ATCC 207088;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone fy356_14 deposited under accession number ATCC 207088;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone fy356_14 deposited under accession number ATCC 207088;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone fy356_14 deposited under accession number ATCC 207088;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:112;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:112 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:112;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
{j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:111.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
NO:111 from nucleotide 150 to nucleotide 1610; the nucleotide sequence of the full-length protein coding sequence of clone fy356_14 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone fy356_14 deposited under accession number ATCC 207088. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone fy356_14 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:112 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ TD N0:112, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:112 having biological activity, the fragment comprising the amino acid sequence from amino acid 238 to amino acid 247 of SEQ ID N0:112.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID NO:111.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing.one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:111, but excluding the poly(A) tail at the 3' end of SEQ ID N0:111; and (ab} the nucleotide sequence of the cDNA insert of clone fy356_14 deposited under accession number ATCC 207088;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID NO:111, but excluding the poly(A) tail at the 3' end of SEQ ID N0:111; and (bb) the nucleotide sequence of the cDNA insert of clone fy356_14 deposited under accession number ATCC 207088;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:111, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:111 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:111 , but excluding the poly(A) tail at the 3' end of SEQ ID NO:111. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:111 from nucleotide 150 to nucleotide 1610, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:111 from nucleotide 150 to nucleotide 1610, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:111 from nucleotide 150 to nucleotide 1610.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ aD N0:112;
(b) a fragment of the amino acid sequence of SEQ ID N0:112, the fragment comprising eight contiguous amino acids of SEQ ID N0:112; and (c) the amino acid sequence encoded by the cDNA insert of clone fy356_14 deposited under accession number ATCC 207088;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:112. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:112 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:112, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:112 having biological activity, the fragment comprising the amino acid sequence from amino acid 238 to amino acid 247 of SEQ ID N0:112.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleoride sequence of SEQ ID
N0:113;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:113 from nucleotide 49 to nucleotide 669;

(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:113 from nucleotide 112 to nucleotide 669;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone iw66_1 deposited under accession number ATCC 207088;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone iw66_1 deposited under accession number ATCC
207088;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone iw66_1 deposited under accessian number ATCC 207088;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:114;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:114 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:114;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
2 0 (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:113.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:113 from nucleotide 49 to nucleotide 669; the nucleotide sequence of SEQ ID
N0:113 from nucleotide 112 to nucleotide 669; the nucleotide sequence of the full-length protein 3 0 coding sequence of clone iw66_1 deposited under accession number ATCC
207088; or the nucleotide sequence of a mature protein coding sequence of clone iw66_1 deposited under accession number ATCC 207088. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:114 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:114, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:114 having biological activity, the fragment comprising the amino acid sequence from amino acid 98 to amino acid 107 of SEQ ID N0:114.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:113.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:113, but excluding the poly(A) tail at the 3' end of SEQ ID N0:113; and (ab) the nucleotide sequence of the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
2 0 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC: at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 5 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:113, but excluding the poly(A) tail at the 3 0 3' end of SEQ ID N0:113; and (bb) the nucleotide sequence of the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;

(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:113, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:113 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:113 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:113. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:113 from nucleotide 49 to nucleotide 669, and extending contiguously from a ,nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:113 from nucleotide 49 to nucleotide 669, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:113 from nucleotide 49 to nucleotide 669. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:113 from nucleotide 112 to nucleotide 669, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:113 from nucleotide 112 to nucleotide 669, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:113 from nucleotide 112 to nucleotide 669.
In other embodiments, the present invention provides a composition comprising 2 0 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:114;
(b) a fragment of the amino acid sequence of SEQ ID N0:114, the fragment comprising eight contiguous amino acids of SEQ ID N0:114; and 2 5 (c) the amino acid sequence encoded by the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:114. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 3 0 amino acid sequence of SEQ ID N0:114 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:114, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:114 having biological activity, the fragment comprising the amino acid sequence from amino acid 98 to amino acid 107 of SEQ ID N0:114.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:115;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:115 from nucleotide 165 to nucleotide 416;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone khl3 4 deposited under accession number ATCC 207089;
(d) a polynucleotide.encoding the full-length protein encoded by the cDNA insert of clone khl3 4 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone khl3 4 deposited under accession number ATCC
207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone khl3_4 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:116;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:116 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:116;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at Ieast 3 0 25% of the length of SEQ ID N0:115.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:115 from nucleotide 165 to nucleotide 416; the nucleotide sequence of the full-length protein coding sequence of clone khl3 4 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone khl3 4 deposited under accession number ATCC 207089. In other preferred embodiments, the polynudeotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone khl3_4 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:116 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ TD N0:116, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
NO:116 having biological activity, the fragment comprising the amino acid sequence from amino acid 37 to amino acid 46 of SEQ ID N0:116.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:115.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:115, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:115; and (ab) the nucleotide sequence of the cDNA insert of clone khl3_4 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:115, but excluding the poly(A) tail at the 3' end of SEQ ID N0:115; and (bb) the nucleotide sequence of the cDNA insert of clone khl3 4 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:115, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:115 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:115 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:115. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:115 from nucleotide 165 to nucleotide 416, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:115 from nucleotide 165 to nucleotide 416, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:115 from nucleotide 165 to nucleotide 416.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:116;
(b) a fragment of the amino acid sequence of SEQ ID N0:116, the fragment comprising eight contiguous amino acids of SEQ ID N0:116; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 khl3 4 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:lI6. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:116 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:116, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:116 having biological activity, the fragment comprising the amino acid sequence from amino acid 37 to amino acid 46 of SEQ ID N0:116.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:117;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:117 from nucleotide 204 to nucleotide 602;
{c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ko258 4 deposited under accession number ATCC 207089;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ko258 4 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ko258 4 deposited under accession number ATCC 207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ko258 4 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:118;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:118 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:118;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (ar(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:117.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:117 from nucleotide 204 to nucleotide 602; the nucleotide sequence of the full-length protein coding sequence of clone ko258_4 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone ko258_4 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone ko258 4 deposited under accession number ATCC 207089. In further nrPfPnP~t embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:118 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:118, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:118 having biological activity, the fragment comprising the amino acid sequence from amino acid 61 to amino acid 70 of SEQ ID N0:118.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:117.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:127, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:117; and (ab) the nucleotide sequence of the cDNA insert of clone ko258 4 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:117, but excluding the poly(A) tail at the 3' end of SEQ ID N0:117; and (bb) the nucleotide sequence of the cDNA insert of clone ko258 4 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv} isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:117, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:117 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:117 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:117. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:117 from nucleotide 204 to nucleotide 602, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:117 from nucleotide 204 to nucleotide 602, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID NO:lI7 from nucleotide 204 to nucleotide 602.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected fram the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:118;
(b) a fragment of the amino acid sequence of SEQ II7 N0:118, the fragment comprising eight contiguous amino acids of SEQ ID N0:118; and (c} the amino acid sequence encoded by the cDNA insert of clone 2 5 ko258_4 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:118. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:118 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:118, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:118 having biological activity, the fragment comprising the amino acid sequence from amino acid 61 to amino acid 70 of SEQ ID N0:118.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:119;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:119 from nucleotide 434 to nucleotide 739;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone kvl0_8 deposited under accession number ATCC 207089;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone kvl0_8 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone kvl0_8 deposited under accession number ATCC
207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone kvl0_8 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:120;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:120 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:120;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:119.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:119 from nucleotide 434 to nucleotide 739; the nucleotide sequence of the full-length protein coding sequence of clone kvl0 8 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone kvl0_8 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone kvl0_8 deposited under accession number ATCC 207089. In further nreferred~
embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:120 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:120, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:120 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID N0:120.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:119.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:119, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:119; and (ab) the nucleotide sequence of the cDNA insert of clone kvl0 8 deposited under accession number ATCC 207089;
(ii) hybridizing said probe{s) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:119, but excluding the poly(A) tail at the 3' end of SEQ ID N0:119; and (bb) the nucleotide sequence of the cDNA insert of clone kvl0_8 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii}.
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:119, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:119 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:119 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:119. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:119 from nucleotide 434 to nucleotide 739, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:119 from nucleotide 434 to nucleotide 739, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:119 from nucleotide 434 to nucleotide 739.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of: .
(a) the amino acid sequence of SEQ ID N0:120;
(b) a fragment of the amino acid sequence of SEQ ID N0:120, the fragment comprising eight contiguous amino acids of SEQ ID N0:120; and (c) the amino acid sequence encoded by the cDNA insert of clone kvl0 8 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:120. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:120 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:120, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:120 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID N0:120.

in one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:121;
(b) a polynucleatide comprising the nucleotide sequence of SEQ ID
N0:121 from nucleotide 149 to nucleotide 310;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone LL89_3 deposited under accession number ATCC 207089;
(d) a polynucleotide encoding the full-Length protein encoded by the cDNA insert of clone LL89 3 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone LL89_3 deposited under accession number ATCC 207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone LL89_3 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:122;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:122 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:122;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:121.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:121 from nucleotide 149 to nucleotide 310; the nucleotide sequence of the full-length protein coding sequence of clone LL89 3 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone LL89_3 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone LL89_3 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:122 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty} contiguous amino acids of SEQ ID N0:122, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:122 having biological activity, the fragment comprising the amino acid sequence from amino acid 22 to amino acid 31 of SEQ ID N0:122.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:121.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:121, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:121; and (ab) the nucleotide sequence of the cDNA insert of clone LL89_3 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:121, but excluding the poly(A) tail at the 3' end of SEQ ID N0:121; and (bb) the nucleotide sequence of the cDNA insert of clone LL89_3 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:121, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:121 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:121, but excluding the poly(A) tail at the 3' end of SEQ ID N0:121. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:121 from nucleotide 149 to nucleotide 310, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:121 from nucleotide 149 to nucleotide 310, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:121 from nucleotide 149 to nucleotide 310.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:122;
(b) a fragment of the amino acid sequence of SEQ ID N0:122, the fragment comprising eight contiguous amino acids of SEQ ID N0:122; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 LL89 3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such .
protein comprises the amino acid sequence of SEQ ID N0:122. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:122 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:122, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:122 having biological activity, the fragment comprising the amino acid sequence from amino acid 22 to amino acid 31 of SEQ ID N0:122.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:123;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:123 from nucleotide 22 to nucleotide 288;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone mc300_1 deposited under accession number ATCC 207089;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone mc300_1 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone mc300_1 deposited under accession number ATCC 207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone mc300_1 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:124;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:124 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:124;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-{h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:123.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:123 from nucleotide 22 to nucleotide 288; the nucleotide sequence of the full-length protein coding sequence of clone mc300_1 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone mc300_1 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone mc300_1 deposited under accession number ATCC 207089. In further nrPfP~P~
embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:124 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:124, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:124 having biological activity, the fragment comprising the amino acid sequence from amino acid 39 to amino acid 48 of SEQ ID N0:124.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:123.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:123, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:123; and (ab) the nucleotide sequence of the cDNA insert of clone mc300_1 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:123, but excluding the poly(A) tail at the 3' end of SEQ ID N0:123; and (bb) the nucleotide sequence of the cDNA insert of clone mc300_1 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:123, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:123 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:123 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:123. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:123 from nucleotide 22 to nucleotide 288, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:123 from nucleotide 22 to nucleotide 288, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:123 from nucleotide 22 to nucleotide 288.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:124;
(b) a fragment of the amino acid sequence of SEQ ID N0:124, the fragment comprising eight contiguous amino acids of SEQ ID N0:124; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 mc300_1 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:124. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:124 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:124, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:124 having biological activity, the fragment comprising the amino acid sequence from amino acid 39 to amino acid 48 of SEQ ID N0:124.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:125;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:125 from nucleotide 200 to nucleotide 2449;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone m1227_1 deposited under accession number ATCC 207089;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone m1227 1 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone m1227_1 deposited under accession number ATCC 207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone m1227_1 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:126;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:126 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:126;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID NO:I25.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:125 from nucleotide 200 to nucleotide 2449; the nucleotide sequence of the full-length protein coding sequence of clone mI227_1 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone m1227_1 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone m1227 1 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:126 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:126, or a polynucleodde encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:126 having biological activity, the fragment comprising the amino acid sequence from amino I 0 acid 370 to amino acid 379 of SEQ ID N0:126.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:125.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:125, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:125; and (ab) the nucleotide sequence of the cDNA insert of clone m1227 1 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nueleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:125, but excluding the poly(A) tail at the 3' end of SEQ ID N0:125; and (bb) the nucleotide sequence of the cDNA insert of clone m1227 1 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleatide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:125, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:125 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:125 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:125. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:125 from nucleotide 200 to nucleotide 2449, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:125 from nucleotide 200 to nucleotide 2449, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:125 from nucleotide 200 to nucleotide 2449.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:126;
(b) a fragment of the amino acid sequence of SEQ ID N0:126, the fragment comprising eight contiguous amino acids of SEQ ID N0:126; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 m1227_1 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:126. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:126 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:126, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:126 having biological activity, the fragment comprising the amino acid sequence from amino acid 370 to amino acid 379 of SEQ ID N0:126.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:127;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:127 from nucleotide 82 to nucleotide 1980;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone mm367_6 deposited under accession number ATCC 207089;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone mm367 6 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone mm367_6 deposited under accession number ATCC 207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone mm367 6 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:128;
(h) a polynucleotide encoding a pratein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:128 having biological activity, the fragment comprising eight contiguous amino acids of SEQ 1D N0:128;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:127.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:127 from nucleotide 82 to nucleotide 1980; the nucleotide sequence of the full-length protein coding sequence of clone mm367_6 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone mm367_6 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone mm367_6 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:128 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty} contiguous amino acids of SEQ 1:D N0:128, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:128 having biological activity, the fragment comprising the amino acid sequence from amino acid 311 to amino acid 320 of SEQ ID N0:128.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:127.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:127, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:127; and (ab) the nucleotide sequence of the cDNA insert of clone mm367_6 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:127, but excluding the poly(A) tail at the 3' end of SEQ ID N0:127; and (bb) the nucleotide sequence of the cDNA insert of clone mm367_6 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv} isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:127, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:127 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:127 , but excluding the poly(A) tail at the 3' end of SEQ IL7 N0:127. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:12? from nucleotide 82 to nucleotide 1980, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:127 from nucleotide 82 to nucleotide 1980, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:127 from nucleotide 82 to nucleotide 1980.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:128;
(b} a fragment of the amino acid sequence of SEQ ID N0:128, the fragment comprising eight contiguous amino acids of SEQ ID N0:128; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 mm367_6 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:128. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:128 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:128, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:128 having biological activity, the fragment comprising the amino acid sequence from amino acid 311 to amino acid 320 of SEQ ID N0:128.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:129;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:129 from nucleotide 125 to nucleotide 856;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone mt124_3 deposited under accession number ATCC 207089;
(d) a polynucleotide.encoding the full-length protein encoded by the cDNA insert of clone mt124_3 deposited under accession number ATCC 207089;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone mt124 3 deposited under accession number ATCC 207089;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone mt124_3 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:130;
(h) a polynucleotide encoding a protein comprising a fragment of the 2 0 amino acid sequence of SEQ ID N0:130 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:130;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a}-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein 2 5 of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 3 0 25% of the length of SEQ ID N0:129.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:129 from nucleotide 125 to nucleotide 856; the nucleotide sequence of the full-length protein coding sequence of clone mt124 3 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone mt124_3 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone mt124_3 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:130 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:130, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:130 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:130.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:129.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps af:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:129, but excluding the poly(A) tail at the 2 0 3' end of SEQ ID N0:129; and (ab) the nucleotide sequence of the cDNA insert of clone mt124_3 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and 2 5 (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 3 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:129, but excluding the poly(A) tail at the 3' end of SEQ ID N0:129; and (bb) the nucleotide sequence of the cDNA insert of clone mt124 3 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv} isolating the polynucleotide products of step (b}(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:129, and extending contiguously from a nucleotide sequence carresponding to the 5' end of SEQ
ID N0:129 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:129 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:129. Also preferably the polynudeotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:129 from nucleotide 125 to nucleotide 856, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:129 from nucleotide 125 to nucleotide 856, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:129 from nucleotide 125 to nucleotide 856.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group 2 0 consisting of:
(a) the amino acid sequence of SEQ ID N0:130;
(b) a fragment of the amino acid sequence of SEQ ID N0:130, the fragment comprising eight contiguous amino acids of SEQ ID N0:130; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 5 mt124 3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:130. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:130 having biological activity, the fragment preferably 3 0 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:130, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:130 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:130.

WO 00/09552 PCTlUS99/18298 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:131;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:131 from nucleotide 856 to nucleotide 2940;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:131 from nucleotide 901 to nucleotide 2940;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone nf56 3 deposited under accession number ATCC 207089;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone nf56_3 deposited under accession number ATCC 207089;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone nf56_3 deposited under accession number ATCC
207089;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone nf56_3 deposited under accession number ATCC 207089;
(h) a polynucleotide encoding a protein comprising the amino acid 2 0 sequence of SEQ ID N0:132;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:132 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:132;
(j) a polynucleotide which is an allelic variant of a polynucleotide of 2 5 (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 3 0 (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:131.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:131 from nucleotide 856 to nucleotide 2940; the nucleotide sequence of SEQ
ID

N0:131 from nucleotide 901 to nucleotide 2940; the nucleotide sequence of the full-length protein coding sequence of clone nf56_3 deposited under accession number ATCC
207089;
or the nucleotide sequence of a mature protein coding sequence of clone nf56 3 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone nf56_3 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:132 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:132, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:132 having biological activity, the fragment comprising the amino acid sequence from amino acid 342 to amino acid 351 of SEQ ID N0:132.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:131.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a} a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 0 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:131, but excluding the poly(A} tail at the 3' end of SEQ ID N0:131; and (ab) the nucleotide sequence of the cDNA insert of clone 2 5 nf56_3 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
3 0 and (b} a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:

(ba) SEQ ID N0:131, but excluding the poly(A) tail at the 3' end of SEQ ID N0:13I; and (bb) the nucleotide sequence of the cDNA insert of clone nf56_3 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to . the cDNA sequence of SEQ ID N0:131, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:131 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:131 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:131. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:131 from nucleotide 856 to nucleotide 2940, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:131 from nucleotide 856 to nucleotide 2940, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:131 from nucleotide 856 to nucleotide 2940. Also preferably the polynucleotide isolated according to the above 2 0 process comprises a nucleotide sequence corresponding to the eDNA sequence of SEQ ID
N0:131 from nucleotide 901 to nucleotide 2940, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:131 from nucleotide 901 to nucleotide 2940, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:131 from nucleotide 901 to nucleotide 2940.
2 5 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:132;
(b) a fragment of the amino acid sequence of SEQ ID N0:132, the 3 0 fragment comprising eight contiguous amino acids of SEQ ID N0:132; and (c) the amino acid sequence encoded by the cDNA insert of clone nf56_3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:132. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:132 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:132, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:132 having biological activity, the fragment comprising the amino acid sequence from amino acid 342 to amino acid 351 of SEQ ID N0:132.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:133;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:133 from nucleotide 122 to nucleotide 448;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:133 from nucleotide 167 to nucleotide 448;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qy442_2 deposited under accession number ATCC 207089;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qy442 2 deposited under accession number ATCC 207089;
2 0 (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qy442._2 deposited under accession number ATCC 207089;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qy442_2 deposited under accession number ATCC 207089;
2 5 (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:134;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:134 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:134;
3 0 (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;

(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (ar(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynudeotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:133.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:133 from nucleotide 122 to nucleotide 448; the nucleotide sequence of SEQ
ID N0:133 from nucleotide 167 to nucleotide 448; the nucleotide sequence of the full-length protein coding sequence of clone qy442_2 deposited under accession number ATCC 207089;
or the nucleotide sequence of a mature protein coding sequence of clone qy442_2 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qy442 2 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:134 having biological activity, the fragment preferably comprising eight {more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:134, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:134 having biological activity, the fragment comprising the amino acid sequence from amino 2 0 acid 49 to amino acid 58 of SEQ ID N0:134.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:133.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
2 5 (a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:133, but excluding the poly(A) tail at the 3 0 3' end of SEQ ID N0:133; and (ab) the nucleotide sequence of the cDNA insert of clone qy442_2 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:133, but excluding the poly(A) tail at the 3' end of SEQ ID N0:133; and (bb) the nucleotide sequence of the cDNA insert of clone qy442_2 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:133, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:133 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:133 , but 2 0 excluding the poly(A) tail at the 3' end of SEQ ID N0:133. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:133 from nucleotide 122 to nucleotide 448, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:133 from nucleotide 122 to nucleotide 448, to a nucleotide 2 5 sequence corresponding to the 3' end of said sequence of SEQ ID N0:133 from nucleotide 122 to nucleotide 448. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:133 from nucleotide 167 to nucleotide 448, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:133 from 3 0 nucleotide I67 to nucleotide 448, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:133 from nucleotide 167 to nucleotide 448.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID N0:134;
(b) a fragment of the amino acid sequence of SEQ ID N0:134, the fragment comprising eight contiguous amino acids of SEQ ID N0:134; and (c) the amino acid sequence encoded by the cDNA insert of clone qy442_2 deposited under accession number AT'CC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:134. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:134 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:134, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:134 having biological activity, the fragment comprising the amino acid sequence from amino acid 49 to amino acid 58 of SEQ ID N0:134.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:135;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:135 from nucleotide 28 to nucleotide 777;
2 0 (c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:135 from nucleotide 73 to nucleotide 777;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rj214_14 deposited under accession number ATCC 207089;
2 5 (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rj214_14 deposited under accession number ATCC 207089;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rj214_14 deposited under accession number ATCC 207089;
3 0 (g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rj214_14 deposited under accession number ATCC 207089;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:136; w (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:136 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:136;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:135.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
NO:135 from nucleotide 28 to nucleotide 777; the nucleotide sequence of SEQ ID
N0:135 from nucleotide 73 to nucleotide 777; the nucleotide sequence of the full-length protein coding sequence of clone rj214_14 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone rj214_14 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert 2 0 of clone rj214_14 deposited under accession number ATCC 207089. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:136 having biological activity, the fragment preferably comprising eight {more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:136, or a polynucleotide 2 5 encoding a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:136 having biological activity, the fragment comprising the amino acid sequence from amino acid 120 to amino acid 129 of SEQ ID N0:136.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:135.
3 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:

(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:135, but excluding the poly(A) tail at the 3' end of SEQ ID N0:135; and (ab) the nucleotide sequence of the cDNA insert of clone rj214_14 deposited under accession number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps af:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:235, but excluding the poly(A) tail at the 3' end of SEQ ID N0:135; and (bb) the nucleotide sequence of the cDNA insert of clone 2 0 rj214_14 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 5 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:135, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:135 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:135 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:135. Also preferably the 3 0 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:135 from nucleotide 28 to nucleotide 777, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:135 from nucleotide 28 to nucleotide 777, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:135 from nucleotide 28 to nucleotide 777. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:135 from nucleotide 73 to nucleotide 777, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:135 from nucleotide 73 to nucleotide 777, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:135 from nucleotide 73 to nucleotide 777.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:136;
(b) a fragment of the amino acid sequence of SEQ ID N0:136, the fragment comprising eight contiguous amino acids of SEQ ID N0:136; and (c) the amino acid sequence encoded by the cDNA insert of clone rj214_14 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:136. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:136 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 0 of SEQ ID N0:136, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:136 having biological activity, the fragment comprising the amino acid sequence from amino acid 120 to amino acid 129 of SEQ ID N0:136.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:137;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:137 from nucleotide 179 to nucleotide 745;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
3 0 N0:137 from nucleotide 233 to nucleotide 745;
(d} a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone rk80_3 deposited under accession number ATCC 207089;

(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone rk80 3 deposited under accession number ATCC 207089;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone rk80 3 deposited under accession number ATCC
207089;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone rk80 3 deposited under accession number ATCC 207089;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:138;
(i) a polynucleoiide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:138 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:138;
a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h} or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any 2 0 one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:137.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:137 from nucleotide 179 to nucleotide 745; the nucleotide sequence of SEQ
ID N0:137 from nucleotide 233 to nucleotide 745; the nucleotide sequence of the full-length protein 2 5 coding sequence of clone rk80 3 deposited under accession number ATCC
207089; or the nucleotide sequence of a mature protein coding sequence of clone rk80 3 deposited under accession number ATCC 207089. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone rk80 3 deposited under accession number ATCC 207089. In further preferred embodiments, the 3 0 present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:138 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:138, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:138 having biological activity, the fragment comprising the amino acid sequence from amino acid 89 to amino acid 98 of SEQ
ID N0:138.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:137.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps af:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:137, but excluding the poly(A) tail at the 3' end of SEQ ID N0:137; and (ab) the nucleotide sequence of the cDNA insert of clone rk80_3 deposited under accessian number ATCC 207089;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 0 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:137, but excluding the poly(A) tail at the 2 5 3' end of SEQ ID N0:137; and (bb) the nucleotide sequence of the cDNA insert of clone rk80_3 deposited under accession number ATCC 207089;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC: at 50 degrees C;
3 0 (iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:137, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ

ID N0:137 to a nucleotide sequence corresponding to the 3' end of SEQ ID
NO:I37 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:137. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:137 from nucleotide 179 to nucleotide 745, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:137 from nucleotide 179 to nucleotide 745, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:137 from nucleotide 179 to nucleotide 745. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:137 from nucleotide 233 to nucleotide 745, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:137 from nucleotide 233 to nucleotide 745, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:137 from nucleotide 233 to nucleotide 745.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:138;
(b) a fragment of the amino acid sequence of SEQ ID N0:138, the fragment comprising eight contiguous amino acids of SEQ ID N0:138; and 2 0 (c) the amino acid sequence encoded by the cDNA insert of clone rk80 3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:138. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 2 5 amino acid sequence of SEQ ID N0:138 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:138, or a protein comprising a fragment of the amino and sequence of SEQ
ID N0:138 having biological activity, the fragment comprising the amino acid sequence from amino acid 89 to amino acid 98 of SEQ ID N0:138.
3 0 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
NO:I39;

(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:139 from nucleotide 1017 to nucleotide 1274;
(c) a polynucleotide comprising the nucleotide sequence of the full length protein coding sequence of clone au36_42 deposited under accession number ATCC 207187;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone au36 42 deposited under accession number ATCC 207187;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone au36 42 deposited under accession number , ATCC 207187;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone au36 42 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:140;
25 (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:140 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:140;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
2 0 (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (ar(h) and that has a length that is at least 25% of the length of SEQ ID N0:139.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:139 from nucleotide 1017 to nucleotide 1274; the nucleotide sequence of the full-length protein coding sequence of clone au36_42 deposited under accession number 3 0 ATCC 207187; or the nucleotide sequence of a mature protein coding sequence of clone au36_42 deposited under accession number ATCC 207187. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone au36 42 deposited under accession number ATCC 207187.
In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:140 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:140, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:140 having biological activity, the fragment comprising the amino acid sequence from amino acid 38 to amino acid 47 of SEQ ID N0:140.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:139.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:139, but excluding the poly(A) tail at the 3' end of SEQ ID N0:139; and (ab) the nucleotide sequence of the cDNA insert of clone au36 42 deposited under accession number ATCC 207187;
(ii) hybridizing said probe{s) to human genomic DNA in 2 0 conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
2 5 (i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:139, but excluding the poly(A) tail at the 3' end of SEQ ID N0:139; and 3 0 (bb) the nucleotide sequence of the cDNA insert of clone au36_42 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:139, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:139 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:139 , but excluding the poly(A) tail at the 3' end of SEQ IL) N0:139. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:139 from nucleotide 1017 to nucleotide 1274, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:139 from nucleotide 1017 to nucleotide 1274, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ
ID N0:139 from nucleotide 1017 to nucleotide 1274.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:140;
(b) a fragment of the amino acid sequence of SEQ ID N0:140, the fragment comprising eight contiguous amino acids of SEQ ID N0:140; and (c) the amino acid sequence encoded by the cDNA insert of clone 2 0 au36_42 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:140. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:140 having biological activity, the fragment preferably 2 5 comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:140, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:140 having biological activity, the fragment comprising the amino acid sequence from amino acid 38 to amino acid 47 of SEQ ID N0:140.
In one embodiment, the present invention provides a composition comprising an 3 0 isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:141;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:141 from nucleotide 580 to nucleotide 774;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone bo549 13 deposited under accession number ATCC 207187;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone bo549_13 deposited under accession number ATCC 207187;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone bo549_13 deposited under accession number ATCC 207187;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone bo549_13 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:142;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:142 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:142;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:141.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:141 from nucleotide 580 to nucleotide 774; the nucleotide sequence of the full-length protein coding sequence of clone bo549 13 deposited under accession number ATCC
207187; or the nucleotide sequence of a mature protein coding sequence of clone bo549_13 deposited under accession number ATCC 207187. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone bo549 13 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:142 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:142, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:142 having biological activity, the fragment comprising the amino acid sequence from amino acid 27 to amino acid 36 of SEQ ID N0:142.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:141.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
{a) a process comprising the steps of:
(i) preparing.one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:141, but excluding the poly(A) tail at the 3' end of SEQ ID N0:141; and (ab) the nucleotide sequence of the cDNA insert of clone bo549_13 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii} isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:141, but excluding the poly(A) tail at the 3' end of SEQ ID N0:141; and (bb) the nucleotide sequence of the cDNA insert of clone bo549_13 deposited under accession number ATCC 207187;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:141, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:141 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:141, but excluding the poly(A) tail at the 3' end of SEQ ID N0:141. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:141 from nucleotide 580 to nucleotide 774, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:141 from nucleotide 580 to nucleotide 774, to a nucleotide 2 0 sequence corresponding to the 3' end of said sequence of SEQ ID N0:141 from nucleotide 580 to nucleotide 774.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:142;
(b) a fragment of the amino acid sequence of SEQ ID N0:142, the fragment comprising eight contiguous amino acids of SEQ ID N0:142; and (c) the amino acid sequence encoded by the cDNA insert of clone bo549_13 deposited under accession number ATCC 207187;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:142. In further preferred embodiments, the present, invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:142 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:142, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:142 having biological activity, the fragment comprising the amino acid sequence from amino acid 27 to amino acid 36 of SEQ ID N0:142.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:143;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:143 from nucleotide 172 to nucleotide 969;

(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:143 from nucleotide 385 to nucleotide 969;
(d) a polynucleotide comprising the nucleotide sequence of the full length protein coding sequence of clone da529_3 deposited under accession number ATCC 207187;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone da529_3 deposited under accession number ATCC 207187;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone da529_3 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone da529 3 deposited under accession number ATCC 207187;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:144;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:144 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:144;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
2 0 (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynudeotide that hybridizes under stringent conditions to any 2 5 one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:143.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:143 from nucleotide 172 to nucleotide 969; the nucleotide sequence of SEQ
ID N0:143 from nucleotide 385 to nucleotide 969; the nucleotide sequence of the full-length protein 3 0 coding sequence of clone da529_3 deposited under accession number ATCC
207187; or the nucleotide sequence of a mature protein coding sequence of clone da529_3 deposited under accession number ATCC 207187. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone da529_3 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:144 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:144, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:144 having biological activity, the fragment comprising the amino acid sequence from amino acid 128 to amino acid 137 of SEQ ID N0:144.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:143.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:143, but excluding the poly(A) tail at the 3' end of SEQ ID N0:143; and (ab) the nucleotide sequence of the cDNA insert of clone da529_3 deposited under accession number ATCC 207187;
2 0 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and 2 5 (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:143, but excluding the poly(A) tail at the 3 0 3' end of SEQ ID N0:143; and (bb) the nucleotide sequence of the cDNA insert of clone da529 3 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;

(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:143, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:143 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:143 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:143. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:143 from nucleotide 172 to nucleotide 969, and extending contiguously from a.nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:143 from nucleotide 172 to nucleotide 969, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:143 from nucleotide 172 to nucleotide 969. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:143 from nucleotide 385 to nucleotide 969, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:143 from nucleotide 385 to nucleotide 969, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:143 from nucleotide 385 to nucleotide 969.
In other embodiments, the present invention provides a composition comprising 2 0 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:144;
(b) a fragment of the amino acid sequence of SEQ ID N0:144, the fragment comprising eight contiguous amino acids of SEQ ID N0:144; and 2 5 (c) the amino acid sequence encoded by the cDNA insert of clone da529 3 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:144. In further preferred embodiments, the present invention provides a protein comprising a fragment of the 3 0 amino acid sequence of SEQ ID N0:144 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:144, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:144 having biological activity, the fragment comprising the amino acid sequence from amino acid 128 to amino acid 137 of SEQ ID N0:144.

In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:145;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:145 from nucleotide 329 to nucleotide 667;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:145 from nucleotide 368 to nucleotide 667;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone dm365_3 deposited under accession number ATCC 207187;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone dm365 3 deposited under accession number ATCC 207187;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone dm365_3 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone dm365_3 deposited under accession number ATCC 207187;
(h) a polynucleotide encoding a protein comprising the amino acid 2 0 sequence of SEQ ID N0:146;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:146 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:146;
(j) a polynucleotide which is an allelic variant of a polynucleotide of 2 5 (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 3 0 (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:145.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:145 from nucleotide 329 to nucleotide 667; the nucleotide sequence of SEQ
ID N0:145 from nucleotide 368 to nucleotide 667; the nucleotide sequence of the full-length protein coding sequence of clone dm365_3 deposited under accession number ATCC 207187;
or the nucleotide sequence of a mature protein coding sequence of clone dm365 3 deposited under accession number ATCC 207187. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone dm365_3 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:146 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:146, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:146 having biological activity, the fragment comprising the amino acid sequence from amino acid 51 to amino acid 60 of SEQ ID N0:146.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:145.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 0 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa} SEQ ID N0:145, but excluding the poly(A) tail at the 3' end of SEQ ID N0:145; and (ab) the nucleotide sequence of the cDNA insert of clone 2 5 dm365 3 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probes};
3 0 and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:

(ba) SEQ ID N0:145, but excluding the poly(A) tail at the 3' end of SEQ ID N0:145; and (bb) the nucleotide sequence of the cDNA insert of clone dm365 3 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:145, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:145 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:145 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:145. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:145 from nucleotide 329 to nucleotide 667, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:145 from nucleotide 329 to nucleotide 667, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID NO:145 from nucleotide 329 to nucleotide 667. Also preferably the polynucleotide isolated according to the above 2 0 process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:145 from nucleotide 368 to nucleotide 667, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:145 from nucleotide 368 to nucleotide 667, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:145 from nucleotide 368 to nucleotide 667.
2 5 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:146;
(b) a fragment of the amino acid sequence of SEQ ID N0:146, the 3 0 fragment comprising eight contiguous amino acids of SEQ ID N0:146; and (c) the amino acid sequence encoded by the cDNA insert of clone dm365_3 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:146. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:146 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands of SEQ ID N0:146, or a protein comprising a fragment of the amino acid sequence of SEQ
5 ID N0:146 having biological activity, the fragment comprising the amino acid sequence from amino acid 51 to amino acid 60 of SEQ ID N0:146.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:147;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:147 from nucleotide 103 to nucleotide 1368;
(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone fal7l 1 deposited under accession number ATCC 207187;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone fa171 1 deposited under accession number ATCC 207187;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone fa171 1 deposited under accession number 2 0 ATCC 207187;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone fa171 1 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:148;
2 5 {h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:148 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:148;
(i) a polynucleotide which is an. allelic variant of a polynucleotide of (a)-(f) above;
3 0 (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a~(h) and that has a length that is at least 25% of the length of SEQ ID N0:147.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
5 N0:147 from nucleotide 103 to nucleotide 1368; the nucleotide sequence of the full-length protein coding sequence of clone fa171_1 deposited under accession number ATCC
207187; or the nucleotide sequence of a mature protein coding sequence of clone fa171_1 deposited under accession number ATCC 207287. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert 10 of clone fa171 1 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:148 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:148, or a polynucleotide 15 encoding a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:148 having biological activity, the fragment comprising the amino acid sequence from amino acid 206 to amino acid 215 of SEQ ID N0:148.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:147.
2 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group 2 5 consisting of:
(aa) SEQ ID N0:147, but excluding the poly(A) tail at the 3' end of SEQ ID N0:147; and (ab) the nucleotide sequence of the cDNA insert of clone fa172_1 deposited under accession number ATCC 207187;
3 0 (ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:147, but excluding the poly(A) tail at the 3' end of SEQ ID N0:147; and (bb) the nucleotide sequence of the cDNA insert of clone fa171_1 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:147, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:147 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:147 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:147. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:147 from nucleotide 103 to nucleotide 2 0 1368, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:147 from nucleotide 103 to nucleotide 1368, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:147 from nucleotide 103 to nucleotide 1368.
In other embodiments, the present invention provides a composition comprising 2 5 a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:148;
(b) a fragment of the amino acid sequence of SEQ ID N0:148, the fragment comprising eight contiguous amino acids of SEQ ID N0:148; and 3 0 (c) the amino acid sequence encoded by the cDNA insert of clone fa171_1 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:148. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:148 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:148, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:148 having biological activity, the fragment comprising the amino acid sequence from amino acid 206 to amino acid 215 of SEQ ID N0:148.
In one embodiment, the present invention pxovides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:149;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:149 from nucleotide 190 to nucleotide 1407;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:149 from nucleotide 463 to nucleotide 1407;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone 1p572_2 deposited under accession number ATCC 207187;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone 1p572 2 deposited under accession number ATCC 207187;
(f) a polynucleotide comprising the nucleotide sequence of a mature 2 0 protein coding sequence of clone 1p572_2 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone 1p572_2 deposited under accession number ATCC 207187;
(h) a polynucleotide encoding a protein comprising the amino acid 2 5 sequence of SEQ ID NO:150;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:150 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:150;
(j) a polynucleotide which is an allelic variant of a polynucleotide of 3 0 (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:149.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:149 from nucleotide 190 to nucleotide 1407; the nucleotide sequence of SEQ
ID
N0:149 from nucleotide 463 to nucleotide 1407; the nucleotide sequence of the full-length protein coding sequence of clone 1p572 2 deposited under accession number ATCC
207187; or the nucleotide sequence of a mature protein coding sequence of clone 1p572 2 deposited under accession number ATCC 207187. In other preferred embodiments, the polynudeotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone 1p572_2 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:150 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:150, or a polynucleoHde encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:150 having biological activity, the fragment comprising the amino acid sequence from amino acid 198 to amino acid 207 of SEQ ID N0:150.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
2 0 ID N0:149.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize 2 5 in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:149, but excluding the poly(A) tail at the 3' end of SEQ ID N0:149; and (ab) the nucleotide sequence of the cDNA insert of clone 3 0 1p572_2 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);

and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:149, but excluding the poly(A} tail at the 3' end of SEQ ID N0:149; and (bb) the nucleotide sequence of the cDNA insert of clone 1p572 2 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b}(iii}.
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:149, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:149 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:149 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:149. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence 2 0 corresponding to the cDNA sequence of SEQ ID N0:149 from nucleotide 190 to nucleotide 1407, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:149 from nucleotide 190 to nucleotide 1407, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:149 from nucleotide 190 to nucleotide 1407. Also preferably the polynucleotide isolated according to the above 2 5 process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:149 from nucleotide 463 to nucleotide 1407, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:149 from nucleotide 463 to nucleotide 1407, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:149 from nucleotide 463 to nucleotide 1407.
3 0 In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:150;

(b) a fragment of the amino acid sequence of SEQ ID N0:150, the fragment comprising eight contiguous amino acids of SEQ ID N0:150; and (c) the amino acid sequence encoded by the cDNA insert of clone 1p572 2 deposited under accession number ATCC 207187;
5 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:150. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:150 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 10 of SEQ ID N0:150, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:150 having biological activity, the fragment comprising the amino acid sequence from amino acid 198 to amino acid 207 of SEQ ID N0:150.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
15 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:151;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:151 from nucleotide 301 to nucleotide 1035;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
2 0 N0:151 from nucleotide 916 to nucleotide 1035;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone pe246_1 deposited under accession number ATCC 207187;
(e) a polynucleotide encoding the full-length protein encoded by the 2 5 cDNA insert of clone pe246_1 deposited under accession number ATCC 207187;
(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone pe246_1 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
3 0 insert of clone pe246_1 deposited under accession number ATCC 207187;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:152;

(i) a polynudeotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:152 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:152;
(j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (ar(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i} and that has a length that is at least 25% of the length of SEQ ID N0:151.
Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID
N0:151 from nucleotide 301 to nucleotide 1035; the nucleotide sequence of SEQ
ID
N0:151 from nucleotide 916 to nucleotide 1035; the nucleotide sequence of the full-length protein coding sequence of clone pe246_1 deposited under accession number ATCC
207187; or the nucleotide sequence of a mature protein coding sequence of clone pe246_1 deposited under accession number ATCC 207187. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert 2 0 of clone pe246_1 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:152 having biological activity, the fragmert preferably comprising eight (more preferably twenty, most preferably thirty} contiguous amino acids of SEQ ID N0:152, or a polynucleotide 2 5 encoding a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:152 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:152.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:151.
3 0 Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:

(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:151, but excluding the poly(A) tail at the 3' end of SEQ ID N0:151; and (ab) the nucleotide sequence of the cDNA insert of clone pe246_1 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that I 5 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:151, but excluding the poly(A) tail at the 3' end of SEQ ID N0:151; and (bb) the nucleotide sequence of the cDNA insert of clone 2 0 pe246_1 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
2 5 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:151, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:151 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:151 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:151. Also preferably the 3 0 polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:151 from nucleotide 301 to nucleotide 1035, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:151 from nucleotide 301 to nucleotide 1035, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:151 from nucleotide 301 to nucleotide 1035. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:151 from nucleotide 916 to nucleotide 1035, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:151 from 5 nucleotide 916 to nucleotide 1035, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:151 from nucleotide 916 to nucleotide 1035.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:152;
(b) a fragment of the amino acid sequence of SEQ ID N0:152, the fragment comprising eight contiguous amino acids of SEQ ID N0:152; and (c) the amino acid sequence encoded by the cDNA insert of clone pe246_1 deposited under accession number ATCC 207187;
15 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:152. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:152 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 0 of SEQ ID N0:152, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:152 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID N0:152.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
2 5 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:153;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:153 from nucleotide 94 to nucleotide 1281;
(c) a polynucleotide comprising the nucleotide sequence of the full 3 0 length protein coding sequence of clone qf122_3 deposited under accession number ATCC 207187;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qf122 3 deposited under accession number ATCC 207187;

(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qf122_3 deposited under accession number ATCC 207187;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qf122 3 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:154;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:154 having biological activity, the fragment comprising eight contiguous.amino acids of SEQ ID N0:154;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
(k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:153.
2 0 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:153 from nucleotide 94 to nucleotide 1281; the nucleotide sequence of the full-length protein coding sequence of clone qf122_3 deposited under accession number ATCC
207187; or the nucleotide sequence of a mature protein coding sequence of clone qf122_3 deposited under accession number ATCC 207187. In other preferred embodiments, the 2 5 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone qf122_3 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:154 having biological activity, the fragment preferably comprising eight (more preferably twenty, most 3 0 preferably thirty) contiguous amino acids of SEQ ID N0:154, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:154 having biological activity, the fragment comprising the amino acid sequence from amino acid 193 to amino acid 202 of SEQ ID N0:154.

Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:153.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:153; and (ab) the nucleotide sequence of the cDNA insert of clone qf122 3 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at Ieast as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 0 the group consisting of:
(ba) SEQ ID NO:I53; and (bb) the nucleotide sequence of the cDNA insert of clone qf122_3 deposited under accession number ATCC 207187;
(ii) hybridizing said prirner(s) to human genomic DNA in 2 5 conditions at least as stringent as 47C SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:153, and 3 0 extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:153 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:153 . Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:153 from nucleotide 94 to nucleotide 1281, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:153 from nucleotide 94 to nucleotide 1281, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:153 from nucleotide 94 to nucleotide 1281.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:154;
(b) a fragment of the amino acid sequence of SEQ ID N0:154, the fragment comprising eight contiguous amino acids of SEQ ID N0:154; and (c) the amino acid sequence encoded by the cDNA insert of clone qf122_3 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID N0:154. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:154 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino ands of SEQ ID N0:154, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:154 having biological activity, the fragment comprising the amino acid sequence from amino acid 193 to amino acid 202 of SEQ ID N0:154.
2 0 In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:155;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
2 5 N0:155 from nucleotide 110 to nucleotide 742;
(c) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:155 from nucleotide 170 to nucleotide 742;
(d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone qv538_1 deposited under accession 3 0 number ATCC 207187;
(e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone qv538_1 deposited under accession number ATCC 207187;

(f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone qv538_1 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone qv538_1 deposited under accession number ATCC 207187;
(h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:156;
(i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:156 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:156;
(j} a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above;
(k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above ;
(1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a}-(i); and (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID N0:155.
2 0 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:155 from nucleotide 110 to nucleotide 742; the nucleotide sequence of SEQ
ID N0:155 from nucleotide 170 to nucleotide 742; the nucleotide sequence of the full-length protein coding sequence of clone qv538_1 deposited under accession number ATCC 207187;
or the nucleotide sequence of a mature protein coding sequence of clone qv538_1 deposited 2 5 under accession number ATCC 207187. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA
insert of clone qv538_1 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:156 having biological 3 0 activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:156, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:156 having biological activity, the fragment comprising the amino acid sequence from amino acid 100 to amino acid 109 of SEQ ID N0:156.

Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:155.
Further embodiments of the invention provide isolated polynudeotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:155, but excluding the poly(A) tail at the 3' end of SEQ ID N0:155; and (ab) the nucleotide sequence of the cDNA insert of clone qv538_1 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that 2 0 hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(ba) SEQ ID N0:155, but excluding the poly(A) tail at the 3' end of SEQ ID N0:155; and (bb) the nucleotide sequence of the cDNA insert of clone 2 5 qv538_1 deposited under accession number ATCC 207187;
(ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).
3 0 Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:155, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:155 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:155 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:155. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:155 from nucleotide 110 to nucleotide 742, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:155 from nucleotide 110 to nucleotide 742, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:155 from nucleotide 110 to nucleotide 742. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID
N0:155 from nucleotide 170 to nucleotide 742, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID
N0:155 from nucleotide 170 to nucleotide 742, to a.nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:155 from nucleotide 170 to nucleotide 742.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:156;
(b) a fragment of the amino acid sequence of SEQ ID N0:156, the fragment comprising eight contiguous amino acids of SEQ ID N0:156; and (c) the amino acid sequence encoded by the cDNA insert of clone qv538_1 deposited under accession number ATCC 207187;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:156. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:156 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID NO:I56, or a protein comprising a fragment of the amino and sequence of SEQ
ID N0:156 having biological activity, the fragment comprising the amino acid sequence from amino acid 100 to amino acid 109 of SEQ ID N0:156.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:157;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:157 from nucleotide 41 to nucleotide 757;

(c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ys20,_1 deposited under accession number ATCC 207187;
(d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187;
(e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ys20_1 deposited under accession number ATCC
207187;
(f) a polynucleotide encoding a mature protein encoded by the cDNA
insert of clone ys20_1 deposited under accession number ATCC 207187;
(g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID N0:158;
(h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:158 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID N0:158;
(i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
(j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above ;
2 0 (k} a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and (1) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID N0:157.
2 5 Preferably, such polynucleotide comprises the nucleotide sequence of SEQ
ID
N0:157 from nucleotide 41 to nucleotide 757; the nucleotide sequence of the full-length protein coding sequence of clone ys20_1 deposited under accession number ATCC
207187;
or the nucleotide sequence of a mature protein coding sequence of clone ys20_1 deposited under accession number ATCC 207187. In other preferred embodiments, the 3 0 polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:158 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID N0:158, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID
N0:158 having biological activity, the fragment comprising the amino acid sequence from amino acid lI4 to amino acid 123 of SEQ ID N0:158.
Other embodiments provide the gene corresponding to the cDNA sequence of SEQ
ID N0:157.
Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of:
(a) a process comprising the steps of:
(i) preparing one or more polynucleotide probes that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from the group consisting of:
(aa) SEQ ID N0:157, but excluding the poly(A) tail at the 3' end of SEQ ID N0:157; and (ab} the nucleotide sequence of the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187;
(ii) hybridizing said probes) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C; and (iii) isolating the DNA polynucleotides detected with the 2 0 probe(s);
and (b) a process comprising the steps of:
(i) preparing one or more polynucleotide primers that hybridize in 6X SSC at 65 degrees C to a nucleotide sequence selected from 2 5 the group consisting of:
(ba) SEQ ID N0:157, but excluding the poly(A) tail at the 3' end of SEQ ID N0:157; and (bb) the nucleotide sequence of the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187;
3 0 (ii) hybridizing said primers) to human genomic DNA in conditions at least as stringent as 4X SSC at 50 degrees C;
(iii) amplifying human DNA sequences; and (iv) isolating the polynucleotide products of step (b)(iii).

Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:157, and extending contiguously from a nucleotide sequence corresponding to the 5' end of SEQ
ID N0:157 to a nucleotide sequence corresponding to the 3' end of SEQ ID
N0:157 , but excluding the poly(A) tail at the 3' end of SEQ ID N0:157. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID N0:157 from nucleotide 41 to nucleotide 757, and extending contiguously from a nucleotide sequence corresponding to the 5' end of said sequence of SEQ ID N0:157 from nucleotide 41 to nucleotide 757, to a nucleotide sequence corresponding to the 3' end of said sequence of SEQ ID N0:157 from nucleotide 41 to nucleotide 757.
In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:158;
(b) a fragment of the amino acid sequence of SEQ ID N0:158, the fragment comprising eight contiguous amino acids of SEQ ID N0:158; and (c) the amino acid sequence encoded by the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187;
2 0 the protein being substantially free from other mammalian proteins.
Preferably such protein comprises the amino acid sequence of SEQ ID N0:158. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID N0:158 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids 2 5 of SEQ ID N0:158, or a protein comprising a fragment of the amino acid sequence of SEQ
ID N0:158 having biological activity, the fragment comprising the amino acid sequence from amino acid 114 to amino acid 123 of SEQ ID N0:158.
In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of:
3 0 (a) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:159;
(b) a polynucleotide comprising the nucleotide sequence of SEQ ID
N0:159 from nucleotide 28 to nucleotide 2253;

t ' a DEMANDES OU BREVETS VOLUMINEUX

COMPREND PLUS D'UN TOME.
CECI EST LE TOME 'I DE
NOTE: ~ Pour les tomes additionels, veuilfez contacter le Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS
THiS SECTION OF THE APPLICATtONIPATENT CONTAINS MORE
THAN ONE VOLUME , THlS IS VOLUME ~ , OF
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Claims (169)

What is claimed is:
1. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:1;
(b) the nucleotide sequence of SEQ ID N0:1 from nucleotide 87 to nucleotide 821;
(c) the nucleotide sequence of SEQ ID N0:1 from nucleotide 120 to nucleotide 821;
(d) the nucleotide sequence of SEQ ID NO:1 from nucleotide 1 to nucleotide 1625;
(e) the nucleotide sequence of the full-length protein coding sequence of clone co62_12 deposited under accession number ATCC 98825;
(f) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;
(g) the nucleotide sequence of a mature protein coding sequence of clone co62_12 deposited under accession number ATCC 98825;
(h) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;
(i) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID N0:2;
(j) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:2, the fragment comprising eight contiguous amino acids of SEQ ID N0:2;
(k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(h);
and (l) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(h), and that has a length that is at least 25% of the length of SEQ ID N0:1.
2. The polynucleotide of claim 1 wherein said polynucleotide is operably linked to at least one expression control sequence.
3. A host cell transformed with the polynucleotide of claim 2.
4. The host cell of claim 3, wherein said cell is a mammalian cell.
5. A process for producing a protein encoded by the polynucleotide of claim 2, which process comprises:
(a) growing a culture of a host cell in a suitable culture medium, wherein the host cell has been transformed with the polynucleotide of claim 2;
and (b) purifying said protein from the culture.
6. A protein produced according to the process of claim 5.
7. An isolated polynucleotide encoding the protein of claim 6.
8. The polynucleotide of claim 7, wherein the polynucleotide comprises the cDNA insert of clone co62_22 deposited under accession number ATCC 98825.
9. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:2;
(b) a fragment of the amino acid sequence of SEQ ID N0:2, the fragment comprising eight contiguous amino acids of SEQ ID N0:2; and (c) the amino acid sequence encoded by the cDNA insert of clone co62_12 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
10. The protein of claim 9, wherein said protein comprises the amino acid sequence of SEQ ID N0:2.
11. A composition comprising the protein of claim 9 and a pharmaceutically acceptable carrier.
12. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID N0:3;
(b) the nucleotide sequence of SEQ ID N0:3 from nucleotide 9 to nucleotide 1013;
(c) the nucleotide sequence of SEQ ID N0:3 from nucleotide 96 to nucleotide 1013;
(d) the nucleotide sequence of the full-length protein coding sequence of clone lo311_8 deposited under accession number ATCC 98825;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone lo311_8 deposited under accession number ATCC 98825;
(f) the nucleotide sequence of a mature protein coding sequence of clone lo311_8 deposited under accession number ATCC 98825;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone lo311_8 deposited under accession number ATCC 98825;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID N0:4;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:4, the fragment comprising eight contiguous amino acids of SEQ ID N0:4;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID N0:3.
13. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:4;
(b) a fragment of the amino acid sequence of SEQ ID N0:4, the fragment comprising eight contiguous amino acids of SEQ ID N0:4; and (c) the amino acid sequence encoded by the cDNA insert of clone lo311_8 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
14. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID N0:5;
(b) the nucleotide sequence of SEQ ID N0:5 from nucleotide 352 to nucleotide 825;
(c) the nucleotide sequence of the full-length protein coding sequence of clone ns197_1 deposited under accession number ATCC 98825;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ns197_1 deposited under accession number ATCC 98825;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID N0:6;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:6, the fragment comprising eight contiguous amino acids of SEQ ID N0:6;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID N0:5.
15. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:6;
(b) a fragment of the amino acid sequence of SEQ ID N0:6, the fragment comprising eight contiguous amino acids of SEQ ID N0:6; and (c) the amino acid sequence encoded by the cDNA insert of clone ns197_1 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
16. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID N0:7;
(b) the nucleotide sequence of SEQ ID N0:7 from nucleotide 86 to nucleotide 829;
(c) the nucleotide sequence of SEQ ID N0:7 from nucleotide 149 to nucleotide 829;
(d) the nucleotide sequence of the full-length protein coding sequence of clone pj193-5 deposited under accession number ATCC 98825;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pj193_5 deposited under accession number ATCC 98825;
(f) the nucleotide sequence of a mature protein coding sequence of clone pj193_5 deposited under accession number ATCC 98825;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pj193_5 deposited under accession number ATCC 98825;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID N0:8;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:8, the fragment comprising eight contiguous amino acids of SEQ ID N0:8;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID N0:7.
17. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:8;
(b) a fragment of the amino acid sequence of SEQ ID N0:8, the fragment comprising eight contiguous amino acids of SEQ ID N0:8; and (c) the amino acid sequence encoded by the cDNA insert of clone pj193_5 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
18. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID N0:9;
(b) the nucleotide sequence of SEQ ID N0:9 from nucleotide 174 to nucleotide 1292;
(c) the nucleotide sequence of the full-length protein coding sequence of clone pj317_2 deposited under accession number ATCC 98825;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pj317_2 deposited under accession number ATCC 98825;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID:NO:10;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10, the fragment comprising eight contiguous amino acids of SEQ ID NO:10;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID N0:9.
19. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:10;
(b) a fragment of the amino acid sequence of SEQ ID N0:10, the fragment comprising eight contiguous amino acids of SEQ ID NO:10; and (c) the amino acid sequence encoded by the cDNA insert of clone pj317_2 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
20. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID N0:11;
(b) the nucleotide sequence of SEQ ID N0:11 from nucleotide 7 to nucleotide 2517;
(c) the nucleotide sequence of SEQ ID N0:11 from nucleotide 904 to nucleotide 2517;
(d) the nucleotide sequence of the full-length protein coding sequence of clone pt332_1 deposited under accession number ATCC 98825;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
(f) the nucleotide sequence of a mature protein coding sequence of clone pt332_1 deposited under accession number ATCC 98825;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID N0:12;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:12, the fragment comprising eight contiguous amino acids of SEQ ID N0:12;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID N0:11.
21. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:12;
(b) a fragment of the amino acid sequence of SEQ ID N0:12, the fragment comprising eight contiguous amino acids of SEQ ID N0:12; and (c) the amino acid sequence encoded by the cDNA insert of clone pt332_1 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
22. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID N0:13;
(b) the nucleotide sequence of SEQ ID N0:13 from nucleotide 18 to nucleotide 257;
(c) the nucleotide sequence of the full-length protein coding sequence of clone qc297_15 deposited under accession number ATCC 98825;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qc297_15 deposited under accession number ATCC
98825;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID N0:14;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID N0:14, the fragment comprising eight contiguous amino acids of SEQ ID N0:14;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID N0:13.
23. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID N0:14;
(b) a fragment of the amino acid sequence of SEQ ID N0:14, the fragment comprising eight contiguous amino acids of SEQ ID N0:14; and (c) the amino acid sequence encoded by the cDNA insert of clone qc297_15 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
24. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:15;
(b) the nucleotide sequence of SEQ ID NO:15 from nucleotide 21 to nucleotide 2432;
(c) the nucleotide sequence of the full-length protein coding sequence of clone qg596_12 deposited under accession number ATCC 98825;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qg596_12 deposited under accession number ATCC
98825;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:16;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:16, the fragment comprising eight contiguous amino acids of SEQ ID NO:16;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:15.
25. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:16;
(b) a fragment of the amino acid sequence of SEQ ID NO:16, the fragment comprising eight contiguous amino acids of SEQ ID NO:16; and (c) the amino acid sequence encoded by the cDNA insert of clone qg596_12 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
26. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:17;
(b) the nucleotide sequence of SEQ ID NO:17 from nucleotide 339 to nucleotide 2105;
(c) the nucleotide sequence of SEQ ID NO:17 from nucleotide 501 to nucleotide 2105;
(d) the nucleotide sequence of the full-length protein coding sequence of clone rb649_3 deposited under accession number ATCC 98825;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rb649_3 deposited under accession number ATCC 98825;
(f) the nucleotide sequence of a mature protein coding sequence of clone rb649_3 deposited under accession number ATCC 98825;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone rb649_3 deposited under accession number ATCC 98825;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:18;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18, the fragment comprising eight contiguous amino acids of SEQ ID NO:18;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:17.
27. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:18;
(b) a fragment of the amino acid sequence of SEQ ID NO:18, the fragment comprising eight contiguous amino acids of SEQ ID NO:18; and (c) the amino acid sequence encoded by the cDNA insert of clone rb649_3 deposited under accession number ATCC 98825;
the protein being substantially free from other mammalian proteins.
28. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:19;
(b) the nucleotide sequence of SEQ ID NO:19 from nucleotide 509 to nucleotide 2467;
(c) the nucleotide sequence of the full-length protein coding sequence of clone ca106_19x deposited under accession number ATCC 98835;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ca106_19x deposited under accession number ATCC
98835;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:20;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:20, the fragment comprising eight contiguous amino acids of SEQ ID NO:20;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a}-(d), and that has a length that is at least 25% of the length of SEQ ID NO:19.
29. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:20;
(b) a fragment of the amino acid sequence of SEQ ID NO:20, the fragment comprising eight contiguous amino acids of SEQ ID NO:20; and (c) the amino acid sequence encoded by the cDNA insert of clone ca106_19x deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
30. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:21;
(b) the nucleotide sequence of SEQ ID NO:21 from nucleotide 179 to nucleotide 802;
(c) the nucleotide sequence of SEQ ID NO:21 from nucleotide 242 to nucleotide 802;
(d) the nucleotide sequence of the full-length protein coding sequence of clone ci52_2 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ci52_2 deposited under accession number ATCC 98835;
(f) the nucleotide sequence of a mature protein coding sequence of clone ci52_2 deposited under accession number ATCC 98835;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone ci52_2 deposited under accession number ATCC 98835;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:22;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22, the fragment comprising eight contiguous amino acids of SEQ ID NO:22;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:21.
31. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:22;
(b) a fragment of the amino acid sequence of SEQ ID NO:22, the fragment comprising eight contiguous amino acids of SEQ ID NO:22; and (c) the amino acid sequence encoded by the cDNA insert of clone ci52_2 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
32. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:23;
(b) the nucleotide sequence of SEQ ID NO:23 from nucleotide 46 to nucleotide 714;
(c) the nucleotide sequence of SEQ ID NO:23 from nucleotide 538 to nucleotide 714;
(d} the nucleotide sequence of the full-length protein coding sequence of clone md124_16 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone md124_16 deposited under accession number ATCC
98835;
(f) the nucleotide sequence of a mature protein coding sequence of clone md124_16 deposited under accession number ATCC 98835;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone md124_16 deposited under accession number ATCC 98835;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:24;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:24, the fragment comprising eight contiguous amino acids of SEQ ID NO:24;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:23.
33. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:24;
(b) a fragment of the amino acid sequence of SEQ ID NO:24, the fragment comprising eight contiguous amino acids of SEQ ID NO:24; and (c) the amino acid sequence encoded by the cDNA insert of clone md124_16 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
34. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:25;
(b) the nucleotide sequence of SEQ ID NO:25 from nucleotide 92 to nucleotide 1726;
(c) the nucleotide sequence of SEQ ID NO:25 from nucleotide 1211 to nucleotide 1726;
(d) the nucleotide sequence of the full-length protein coding sequence of clone pk366_7 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pk366_7 deposited under accession number ATCC 98835;
(f) the nucleotide sequence of a mature protein coding sequence of clone pk366_7 deposited under accession number ATCC 98835;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pk366_7 deposited under accession number ATCC 98835;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:26;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:26, the fragment comprising eight contiguous amino acids of SEQ ID NO:26;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a-(g), and that has a length that is at least 25% of the length of SEQ ID NO:25.
35. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:26;
(b) a fragment of the amino acid sequence of SEQ ID NO:26, the fragment comprising eight contiguous amino acids of SEQ ID NO:26; and (c) the amino acid sequence encoded by the cDNA insert of clone pk366_7 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
36. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:27;
(b) the nucleotide sequence of SEQ ID NO:27 from nucleotide 16 to nucleotide 1788;
(c) the nucleotide sequence of SEQ ID NO:27 from nucleotide 61 to nucleotide 1788;
(d) the nucleotide sequence of the full-length protein coding sequence of clone p1741_5 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone p1741_5 deposited under accession number ATCC 98835;
(f) the nucleotide sequence of a mature protein coding sequence of clone p1741_5 deposited under accession number ATCC 98835;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone p1741_5 deposited under accession number ATCC 98835;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:28;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:28, the fragment comprising eight contiguous amino acids of SEQ ID NO:28;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:27.
37. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:28;
(b) a fragment of the amino acid sequence of SEQ ID NO:28, the fragment comprising eight contiguous amino acids of SEQ ID NO:28; and (c) the amino acid sequence encoded by the cDNA insert of clone p1741_5 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
38. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:29;
(b) the nucleotide sequence of SEQ ID NO:29 from nucleotide 629 to nucleotide 2338;
(c) the nucleotide sequence of the full-length protein coding sequence of clone pp314_19 deposited under accession number ATCC 98835;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pp314_19 deposited under accession number ATCC
98835;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:30;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:30, the fragment comprising eight contiguous amino acids of SEQ ID NO:30;

(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:29.
39. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:30;
(b) a fragment of the amino acid sequence of SEQ ID NO:30, the fragment comprising eight contiguous amino acids of SEQ ID NO:30; and (c) the amino acid sequence encoded by the cDNA insert of clone pp314_19 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
40. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:31;
(b) the nucleotide sequence of SEQ TD NO:31 from nucleotide 158 to nucleotide 1102;
(c) the nucleotide sequence of the full-length protein coding sequence of clone pv35_1 deposited under accession number ATCC 98835;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:32;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:32, the fragment comprising eight contiguous amino acids of SEQ ID NO:32;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:31.
41. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:32;
(b) a fragment of the amino acid sequence of SEQ ID NO:32, the fragment comprising eight contiguous amino acids of SEQ ID NO:32; and (c) the amino acid sequence encoded by the cDNA insert of clone pv35_1 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
42. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:33;
(b) the nucleotide sequence of SEQ ID NO:33 from nucleotide 413 to nucleotide 733;
(c) the nucleotide sequence of the full-length protein coding sequence of clone pw337_6 deposited under accession number ATCC 98835;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pw337_6 deposited under accession number ATCC
98835;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:34;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:34, the fragment comprising eight contiguous amino acids of SEQ ID NO:34;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:33.
43. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:34;
(b) a fragment of the amino acid sequence of SEQ ID NO:34, the fragment comprising eight contiguous amino acids of SEQ ID NO:34; and (c) the amino acid sequence encoded by the cDNA insert of clone pw337_6 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
44. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:35;
(b) the nucleotide sequence of SEQ ID NO:35 from nucleotide 678 to nucleotide 938;
(c) the nucleotide sequence of the full-length protein coding sequence of clone rd610_1 deposited under accession number ATCC 98835;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:36;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:36, the fragment comprising eight contiguous amino acids of SEQ ID NO:36;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:35.
45. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:36;
(b) a fragment of the amino acid sequence of SEQ ID NO:36, the fragment comprising eight contiguous amino acids of SEQ ID NO:36; and (c) the amino acid sequence encoded by the cDNA insert of clone rd610_1 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
46. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:;
(b) the nucleotide sequence of SEQ ID NO: from nucleotide 75 to nucleotide 494;
(c) the nucleotide sequence of SEQ ID NO: from nucleotide 447 to nucleotide 494;
(d) the nucleotide sequence of the full-length protein coding sequence of clone rd810_6 deposited under accession number ATCC 98835;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
(f) the nucleotide sequence of a mature protein coding sequence of clone rd810_6 deposited under accession number ATCC 98835;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:, the fragment comprising eight contiguous amino acids of SEQ ID NO:;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:.
47. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:;
(b) a fragment of the amino acid sequence of SEQ ID NO:, the fragment comprising eight contiguous amino acids of SEQ ID NO:; and (c) the amino acid sequence encoded by the cDNA insert of clone rd810_6 deposited under accession number ATCC 98835;
the protein being substantially free from other mammalian proteins.
48. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:39;
(b) the nucleotide sequence of SEQ ID NO:39 from nucleotide 181 to nucleotide 1080;
(c) the nucleotide sequence of the full-length protein coding sequence of clone cf85_1 deposited under accession number ATCC 98850;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone cf85_1 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:40;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:40, the fragment comprising eight contiguous amino acids of SEQ ID NO:40;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a}-(d), and that has a length that is at least 25% of the length of SEQ ID NO:39.
49. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:40;
(b) a fragment of the amino acid sequence of SEQ ID NO:40, the fragment comprising eight contiguous amino acids of SEQ ID NO:40; and (c) the amino acid sequence encoded by the cDNA insert of clone cf85 1 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
50. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:42;
(b) the nucleotide sequence of SEQ ID NO:41 from nucleotide 161 to nucleotide 1348;
(c) the nucleotide sequence of SEQ ID NO:41 from nucleotide 599 to nucleotide 1348;
(d) the nucleotide sequence of the full-length protein coding sequence of clone dd504_18 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone dd504_18 deposited under accession number ATCC
98850;
(f) the nucleotide sequence of a mature protein coding sequence of clone dd504_18 deposited under accession number ATCC 98850;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone dd504_18 deposited under accession number ATCC 98850;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:42;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:42, the fragment comprising eight contiguous amino acids of SEQ ID NO:42;
(j) the nucleoside sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:41.
51. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:42;
(b) a fragment of the amino acid sequence of SEQ ID NO:42, the fragment comprising eight contiguous amino acids of SEQ ID NO:42; and (c) the amino acid sequence encoded by the cDNA insert of clone dd504_18 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
52. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:43;
(b) the nucleotide sequence of SEQ ID NO:43 from nucleotide 70 to nucleotide 1386;
(c) the nucleotide sequence of the full-length protein coding sequence of clone np26 3 deposited under accession number ATCC 98850;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone np26_3 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:44;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:44, the fragment comprising eight contiguous amino acids of SEQ ID NO:44;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:43.
53. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:44;
(b) a fragment of the amino acid sequence of SEQ ID NO:44, the fragment comprising eight contiguous amino acids of SEQ ID NO:44; and (c) the amino acid sequence encoded by the cDNA insert of clone np26_3 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
54. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:45;
(b) the nucleotide sequence of SEQ ID NO:45 from nucleotide 60 to nucleotide 3515;
(c) the nucleotide sequence of the full-length protein coding sequence of clone pm412_12 deposited under accession number ATCC 98850;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pm412_12 deposited under accession number ATCC
98850;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:46;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:46, the fragment comprising eight contiguous amino acids of SEQ ID NO:46;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:45.
55. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:46;
(b) a fragment of the amino acid sequence of SEQ ID NO:46, the fragment comprising eight contiguous amino acids of SEQ ID NO:46; and (c) the amino acid sequence encoded by the cDNA insert of clone pm422_12 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
56. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:47;
(b) the nucleotide sequence of SEQ ID NO:47 from nucleotide 1490 to nucleotide 1780;
(c) the nucleotide sequence of SEQ ID NO:47 from nucleotide 1556 to nucleotide 1780;
(d) the nucleotide sequence of the full-length protein coding sequence of clone pm421_3 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pm421_3 deposited under accession number ATCC
98850;
(f) the nucleotide sequence of a mature protein coding sequence of clone pm421_3 deposited under accession number ATCC 98850;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pm421_3 deposited under accession number ATCC 98850;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:48;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:48, the fragment comprising eight contiguous amino acids of SEQ ID NO:48;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:47.
57. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:48;
(b) a fragment of the amino acid sequence of SEQ ID NO:48, the fragment comprising eight contiguous amino acids of SEQ ID NO:48; and (c) the amino acid sequence encoded by the cDNA insert of clone prn421_3 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
58. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:49;
(b) the nucleotide sequence of SEQ ID NO:49 from nucleotide 64 to nucleotide 486;
(c) the nucleotide sequence of SEQ ID NO:49 from nucleotide 217 to nucleotide 486;
(d) the nucleotide sequence of the full-length protein coding sequence of clone pv6_1 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pv6_1 deposited under accession number ATCC 98850;
(f) the nucleotide sequence of a mature protein coding sequence of clone pv6_1 deposited under accession number ATCC 98850;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pv6_1 deposited under accession number ATCC 98850;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:50;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:50, the fragment comprising eight contiguous amino acids of SEQ ID NO:50;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:49.
59. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:50;
(b) a fragment of the amino acid sequence of SEQ ID NO:50, the fragment comprising eight contiguous amino acids of SEQ ID NO:50; and (c) the amino acid sequence encoded by the cDNA insert of clone pv6_1 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
60. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:51;
(b) the nucleotide sequence of SEQ ID NO:51 from nucleotide 379 to nucleotide 3783;
(c) the nucleotide sequence of SEQ ID NO:51 from nucleotide 460 to nucleotide 3783;
(d) the nucleotide sequence of SEQ ID NO:51 from nucleotide 1983 to nucleotide 3938;
(e) the nucleotide sequence of the full-length protein coding sequence of clone qsl4_3 deposited under accession number ATCC 98850;
(f) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qsl4_3 deposited under accession number ATCC 98850;
(g) the nucleotide sequence of a mature protein coding sequence of clone qsl4_3 deposited under accession number ATCC 98850;
(h) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone qsl4_3 deposited under accession number ATCC 98850;

(i) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:52;
(j) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:52, the fragment comprising eight contiguous amino acids of SEQ ID NO:52;
(k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(h);
and (l) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(h), and that has a length that is at least 25% of the length of SEQ ID NO:51.
61. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:52;
(b) the amino acid sequence of SEQ ID NO:52 from amino acid 536 to amino acid 1135;
(c) a fragment of the amino acid sequence of SEQ ID NO:52, the fragment comprising eight contiguous amino acids of SEQ ID NO:52; and (d) the amino acid sequence encoded by the cDNA insert of clone qsl4_3 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
62. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:53;
(b) the nucleotide sequence of SEQ ID NO:53 from nucleotide 1 to nucleotide 843;
(c) the nucleotide sequence of SEQ ID NO:53 from nucleotide 469 to nucleotide 843;
(d) the nucleotide sequence of the full-length protein coding sequence of clone qy338_9 deposited under accession number ATCC 98850;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qy338_9 deposited under accession number ATCC 98850;
(f) the nucleotide sequence of a mature protein coding sequence of clone qy338_9 deposited under accession number ATCC 98850;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone qy338_9 deposited under accession number ATCC 98850;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:54;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of. SEQ ID NO:54, the fragment comprising eight contiguous amino acids of SEQ ID NO:54;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the Length of SEQ ID NO:53.
63. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:54;
(b) a fragment of the amino acid sequence of SEQ ID NO:54, the fragment comprising eight contiguous amino acids of SEQ ID NO:54; and (c) the amino acid sequence encoded by the cDNA insert of clone qy338_9 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
64. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:55;
(b) the nucleotide sequence of SEQ ID NO:55 from nucleotide 283 to nucleotide 906;

(c) the nucleotide sequence of SEQ ID NO:55 from nucleotide 325 to nucleotide 906;
(d) the nucleotide sequence of the full-length protein coding sequence of clone rc58_1 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
(f) the nucleotide sequence of a mature protein coding sequence of clone rc58_1 deposited under accession number ATCC 98850;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:56;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:56, the fragment comprising eight contiguous amino acids of SEQ ID NO:56;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:55.
65. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:56;
(b) a fragment of the amino acid sequence of SEQ ID NO:56, the fragment comprising eight contiguous amino acids of SEQ ID NO:56; and (c) the amino acid sequence encoded by the cDNA insert of clone rc58_1 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
66. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:57;
(b) the nucleotide sequence of SEQ ID NO:57 from nucleotide 56 to nucleotide 973;
(c) the nucleotide sequence of the full-length protein coding sequence of clone rd232_5 deposited under accession number ATCC 98850;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rd232_5 deposited under accession number ATCC 98850;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:58;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:58, the fragment comprising eight contiguous amino acids of SEQ ID NO:58;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:57.
67. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:58;
(b) a fragment of the amino acid sequence of SEQ ID NO:58, the fragment comprising eight contiguous amino acids of SEQ ID NO:58; and (c) the amino acid sequence encoded by the cDNA insert of clone rd232_5 deposited under accession number ATCC 98850;
the protein being substantially free from other mammalian proteins.
68. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:59;
(b) the nucleotide sequence of SEQ ID NO:59 from nucleotide 893 to nucleotide 2596;

(c) the nucleotide sequence of the full-length protein coding sequence of clone ck213_12 deposited under accession number ATCC 98918;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNAinsert of clone ck213_12 deposited under accession number ATCC
98918;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:60;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:60, the fragment comprising eight contiguous amino acids of SEQ ID NO:60;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:59.
69. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:60;
(b) a fragment of the amino acid sequence of SEQ ID NO:60, the fragment comprising eight contiguous amino acids of SEQ ID NO:60; and (c) the amino acid sequence encoded by the cDNAinsert of clone ck213_12 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins.
70. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:61;
(b) the nucleotide sequence of SEQ ID NO:61 from nucleotide 29 to nucleotide 1750;
(c) the nucleotide sequence of the full-length protein coding sequence of clone pg195_1 deposited under accession number ATCC 98918;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pg295_1 deposited under accession number ATCC 98918;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:62;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:62, the fragment comprising eight contiguous amino acids of SEQ ID NO:62;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:61.
71. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:62;
(b) a fragment of the amino acid sequence of SEQ ID NO:62, the fragment comprising eight contiguous amino acids of SEQ ID NO:62; and (c) the amino acid sequence encoded by the cDNA insert of clone pg195_1 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins.
72. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:63;
(b) the nucleotide sequence of SEQ 1D NO:63 from nucleotide 1147 to nucleotide 1440;
(c) the nucleotide sequence of SEQ ID NO:63 from nucleotide 1234 to nucleotide 1440;
(d) the nucleotide sequence of the full-length protein coding sequence of clone pw460_5 deposited under accession number ATCC 98918;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pw460_5 deposited under accession number ATCC
98918;
(f) the nucleotide sequence of a mature protein coding sequence of clone pw460_5 deposited under accession number ATCC 98918;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pw460 5 deposited under accession number ATCC 98918;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:64;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:64, the fragment comprising eight contiguous amino acids of SEQ ID NO:64;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:63.
73. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:64;
(b) a fragment of the amino acid sequence of SEQ ID NO:64, the fragment comprising eight contiguous amino acids of SEQ ID NO:64; and (c) the amino acid sequence encoded by the cDNA insert of clone pw460_5 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins.
74. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:65;
(b) the nucleotide sequence of SEQ ID NO:65 from nucleotide 46 to nucleotide 1356;

(c) the nucleotide sequence of SEQ ID NO:65 from nucleotide 127 to nucleotide 1356;
(d) the nucleotide sequence of the full-length protein coding sequence of clone qa136_1 deposited under accession number ATCC 98918;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;
(f) the nucleotide sequence of a mature protein coding sequence of clone qa136_1 deposited under accession number ATCC 98918;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:66;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:66, the fragment comprising eight contiguous amino acids of SEQ ID NO:66;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:65.
75. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:66;
(b) a fragment of the amino acid sequence of SEQ ID NO:66, the fragment comprising eight contiguous amino acids of SEQ ID NO:66; and (c) the amino acid sequence encoded by the cDNA insert of clone qa136_1 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins.
76. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:67;
(b) the nucleotide sequence of SEQ ID NO:67 from nucleotide 206 to nucleotide 1624;
(c) the nucleotide sequence of SEQ ID NO:67 from nucleotide 542 to nucleotide 1624;
(d) the nucleotide sequence of the full-length protein coding sequence of clone qy1261_2 deposited under accession number ATCC 98918;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qy1261 2 deposited under accession number ATCC
98918;
(f) the nucleotide sequence of a mature protein coding sequence of clone qy1261_2 deposited under accession number ATCC 98918;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone qy1261_2 deposited under accession number ATCC 98918;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:68;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:68, the fragment comprising eight contiguous amino acids of SEQ ID NO:68;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:67.
77. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:68;
(b) a fragment of the amino acid sequence of SEQ ID NO:68, the fragment comprising eight contiguous amino acids of SEQ ID NO:68; and (c) the amino acid sequence encoded by the cDNA insert of clone qy1261_2 deposited under accession number ATCC 98918;

the protein being substantially free from other mammalian proteins.
78. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:69;
(b) the nucleotide sequence of SEQ ID NO:69 from nucleotide 1359 to nucleotide 1817;
(c) the nucleotide sequence of the full-length protein coding sequence of clone rd432_4 deposited under accession number ATCC 98918;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rd432 4 deposited under accession number ATCC 98918;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:70;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:70, the fragment comprising eight contiguous amino acids of SEQ ID NO:70;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:69.
79. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:70;
(b) a fragment of the amino acid sequence of SEQ ID NO:70, the fragment comprising eight contiguous amino acids of SEQ ID NO:70; and (c) the amino acid sequence encoded by the cDNA insert of clone rd432_4 deposited under accession number ATCC 98918;
the protein being substantially free from other mammalian proteins.
80. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:71;
(b) the nucleotide sequence of SEQ ID NO:71 from nucleotide 884 to nucleotide 1195;
(c) the nucleotide sequence of SEQ ID NO:71 from nucleotide 947 to nucleotide 1195;
(d) the nucleotide sequence of the full-length protein coding sequence of clone rb789_14 deposited under accession number ATCC 207004;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNAinsert of clone rb789_14 deposited under accession number ATCC
207004;
(f) the nucleotide sequence of a mature protein coding sequence of clone rb789_14 deposited under accession number ATCC 207004;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNAinsert of clone rb789_14 deposited under accession number ATCC 207004;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:72;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:72, the fragment comprising eight contiguous amino acids of SEQ ID NO:72;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:71.
81. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:72;
(b) a fragment of the amino acid sequence of SEQ ID NO:72, the fragment comprising eight contiguous amino acids of SEQ ID NO:72; and (c) the amino acid sequence encoded by the cDNA insert of clone rb789_14 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
82. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:73;

(b) the nucleotide sequence of SEQ ID NO:73 from nucleotide 69 to nucleotide 374;

(c) the nucleotide sequence of SEQ ID NO:73 from nucleotide 186 to nucleotide 374;

(d) the nucleotide sequence of the full-length protein coding sequence of clone yd137_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone yd137_1 deposited under accession number ATCC
207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone yd137_1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone yd137_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:74;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:74, the fragment comprising eight contiguous amino acids of SEQ ID NO:74;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:73.
83. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:74;

(b) a fragment of the amino acid sequence of SEQ ID NO:74, the fragment comprising eight contiguous amino acids of SEQ ID NO:74; and (c) the amino acid sequence encoded by the cDNA insert of clone yd137_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
84. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:75;

(b) the nucleotide sequence of SEQ ID NO:75 from nucleotide 8 to nucleotide 343;

(c) the nucleotide sequence of SEQ ID NO:75 from nucleotide 50 to nucleotide 343;

(d) the nucleotide sequence of the full-length protein coding sequence of clone yd218_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone yd218_1 deposited under accession number ATCC
207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone yd218_1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone yd218_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:76;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:76, the fragment comprising eight contiguous amino acids of SEQ ID NO:76;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:75.
85. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:76;

(b) a fragment of the amino acid sequence of SEQ ID NO:76, the fragment comprising eight contiguous amino acids of SEQ ID NO:76; and (c) the amino acid sequence encoded by the cDNA insert of clone yd218_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
86. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:77;

(b) the nucleotide sequence of SEQ ID NO:77 from nucleotide 84 to nucleotide 1679;

(c) the nucleotide sequence of the full-length protein coding sequence of clone ye11_1 deposited under accession number ATCC 207004;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ye11_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:78;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:78, the fragment comprising eight contiguous amino acids of SEQ ID NO:78;

(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:77.
87. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:78;

(b) a fragment of the amino acid sequence of SEQ ID NO:78, the fragment comprising eight contiguous amino acids of SEQ ID NO:78; and (c) the amino acid sequence encoded by the cDNA insert of clone ye11_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
88. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:79;

(b) the nucleotide sequence of SEQ ID NO:79 from nucleotide 72 to nucleotide 1646;

(c) the nucleotide sequence of SEQ ID NO:79 from nucleotide 180 to nucleotide 1646;

(d) the nucleotide sequence of the full-length protein coding sequence of clone ye72_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone ye72_1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:80;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:80, the fragment comprising eight contiguous amino acids of SEQ ID NO:80;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:79.
89. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:80;

(b) a fragment of the amino acid sequence of SEQ ID NO:80, the fragment comprising eight contiguous amino acids of SEQ ID NO:80; and (c) the amino acid sequence encoded by the cDNA insert of clone ye72_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
90. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:81;

(b) the nucleotide sequence of SEQ ID NO:81 from nucleotide 954 to nucleotide 2423;

(c) the nucleotide sequence of SEQ ID NO:81 from nucleotide 1224 to nucleotide 2423;

(d) the nucleotide sequence of the full-length protein coding sequence of clone ye78_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ye78_1 deposited under accession number ATCC 207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone ye78_1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone ye78_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:82;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:82, the fragment comprising eight contiguous amino acids of SEQ ID NO:82;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:81.
91. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:82;

(b) a fragment of the amino acid sequence of SEQ ID NO:82, the fragment comprising eight contiguous amino acids of SEQ ID NO:82; and (c) the amino acid sequence encoded by the cDNA insert of clone ye78_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
92. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:83;

(b) the nucleotide sequence of SEQ ID NO:83 from nucleotide 176 to nucleotide 1321;

(c) the nucleotide sequence of SEQ ID N0:83 from nucleotide 233 to nucleotide 1321;

(d) the nucleotide sequence of the full-length protein coding sequence of clone ye90_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length pratein encoded by the cDNA insert of clone ye90_1 deposited under accession number ATCC 207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone ye90_1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone ye90_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:84;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:84, the fragment comprising eight contiguous amino acids of SEQ ID NO:84;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:83.
93. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:84;

(b) a fragment of the amino acid sequence of SEQ ID NO:84, the fragment comprising eight contiguous amino acids of SEQ ID NO:84; and (c) the amino acid sequence encoded by the cDNA insert of clone ye90_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
94. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:85;

(b) the nucleotide sequence of SEQ ID NO:85 from nucleotide 105 to nucleotide 605;

(c) the nucleotide sequence of the full-length protein coding sequence of clone yi62_1 deposited under accession number ATCC 207004;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone yi62_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:86;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:86, the fragment comprising eight contiguous amino acids of SEQ ID NO:86;

(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:85.
95. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:86;

(b) a fragment of the amino acid sequence of SEQ ID NO:86, the fragment comprising eight contiguous amino acids of SEQ ID NO:86; and (c) the amino acid sequence encoded by the cDNA insert of clone yi62_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
96. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:87;

(b) the nucleotide sequence of SEQ ID NO:87 from nucleotide 223 to nucleotide 798;

(c) the nucleotide sequence of SEQ ID NO:87 from nucleotide 430 to nucleotide 798;

(d) the nucleotide sequence of the full-length protein coding sequence of clone yk78_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone yk78_1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:88;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:88, the fragment comprising eight contiguous amino acids of SEQ ID NO:88;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:87.
97. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:88;

(b) a fragment of the amino acid sequence of SEQ ID NO:88, the fragment comprising eight contiguous amino acids of SEQ ID NO:88; and (c) the amino acid sequence encoded by the cDNA insert of clone yk78_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
98. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:89;

(b) the nucleotide sequence of SEQ ID NO:89 from nucleotide 211 to nucleotide 942;

(c) the nucleotide sequence of SEQ ID NO:89 from nucleotide 298 to nucleotide 942;

(d) the nucleotide sequence of the full-length protein coding sequence of clone y1c251_1 deposited under accession number ATCC 207004;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone yk251_1 deposited under accession number ATCC
207004;

(f) the nucleotide sequence of a mature protein coding sequence of clone yk251 1 deposited under accession number ATCC 207004;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone yk251_1 deposited under accession number ATCC 207004;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:90;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:90, the fragment comprising eight contiguous amino acids of SEQ ID NO:90;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:89.
99. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:90;

(b) a fragment of the amino acid sequence of SEQ ID NO:90, the fragment comprising eight contiguous amino acids of SEQ ID NO:90; and (c) the amino acid sequence encoded by the cDNA insert of clone yk251_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
100. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:91;

(b) the nucleotide sequence of SEQ ID NO:91 from nucleotide 149 to nucleotide 784;
(c) the nucleotide sequence of the full-length protein coding sequence of clone ytl4_1 deposited under accession number ATCC 207004;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ytl4_1 deposited under accession number ATCC 207004;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:92;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:92, the fragment comprising eight contiguous amino acids of SEQ ID NO:92;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:91.
101. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:92;
(b) a fragment of the amino acid sequence of SEQ ID NO:92, the fragment comprising eight contiguous amino acids of SEQ ID NO:92; and (c) the amino acid sequence encoded by the cDNA insert of clone ytl4_1 deposited under accession number ATCC 207004;
the protein being substantially free from other mammalian proteins.
102. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:93;
(b) the nucleotide sequence of SEQ ID NO:93 from nucleotide 89 to nucleotide 1441;

(c) the nucleotide sequence of the full-length protein coding sequence of clone bf157_16 deposited under accession number ATCC 207088;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone bf157_16 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:94;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:94, the fragment comprising eight contiguous amino acids of SEQ ID NO:94;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:93.
103. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:94;
(b) a fragment of the amino acid sequence of SEQ ID NO:94, the fragment comprising eight contiguous amino acids of SEQ ID NO:94; and (c) the amino acid sequence encoded by the cDNA insert of clone bf157_16 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
104. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:95;
(b) the nucleotide sequence of SEQ ID NO:95 from nucleotide 219 to nucleotide 629;
(c) the nucleotide sequence of the full-length protein coding sequence of clone bk343_2 deposited under accession number ATCC 207088;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone bk343_2 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:96;
a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:96, the fragment comprising eight contiguous amino acids of SEQ ID NO:96;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:95.
105. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:96;
(b) a fragment of the amino acid sequence of SEQ ID NO:96, the fragment comprising eight contiguous amino acids of SEQ ID NO:96; and (c) the amino acid sequence encoded by the cDNA insert of clone bk343_2 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
106. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:97;
(b) the nucleotide sequence of SEQ ID NO:97 from nucleotide 556 to nucleotide 951;
(c) the nucleotide sequence of SEQ ID NO:97 from nucleotide 868 to nucleotide 951;
(d) the nucleotide sequence of SEQ ID NO:97 from nucleotide 9 to nucleotide 1295;

(e) the nucleotide sequence of the full-length protein coding sequence of clone cd205 2 deposited under accession number ATCC 207088;
a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clane cd205_2 deposited under accession number ATCC
207088;
(g) the nucleotide sequence of a mature protein coding sequence of clone cd205_2 deposited under accession number ATCC 207088;
(h) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone cd205_2 deposited under accession number ATCC 207088;
(i) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:98;
(j) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:98, the fragment comprising eight contiguous amino acids of SEQ ID NO:98;
(k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(h);
and (l) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(h), and that has a length that is at least 25% of the length of SEQ ID NO:97.
107. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:98;
(b) a fragment of the amino acid sequence of SEQ ID NO:98, the fragment comprising eight contiguous amino acids of SEQ ID NO:98; and (c) the amino acid sequence encoded by the cDNA insert of clone cd205_2 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
108. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:99;

(b) the nucleotide sequence of SEQ ID NO:99 from nucleotide 216 to nucleotide 443;
(c) the nucleotide sequence of SEQ ID NO:99 from nucleotide 306 to nucleotide 443;
(d) the nucleotide sequence of the full-length protein coding sequence of clone cw1292_8 deposited under accession number ATCC 207088;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone cw1292_8 deposited under accession number ATCC
207088;
(f) the nucleotide sequence of a mature protein coding sequence of clone cw1292_8 deposited under accession number ATCC 207088;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone cw1292_8 deposited under accession number ATCC 207088;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:100;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100, the fragment comprising eight contiguous amino acids of SEQ ID NO:100;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:99.
109. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:100;
(b) a fragment of the amino acid sequence of SEQ ID NO:100, the fragment comprising eight contiguous amino acids of SEQ ID NO:100; and (c) the amino acid sequence encoded by the cDNA insert of clone cw1292_8 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
110. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:101;
(b) the nucleotide sequence of SEQ ID NO:101 from nucleotide 2136 to nucleotide 2447;
(c) the nucleotide sequence of the full-length protein coding sequence of clone cw1475_2 deposited under accession number ATCC 207088;
(d) a nucleotide sequence encoding the full_length protein encoded by the cDNA insert of clone cw1475_2 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:102;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:102, the fragment comprising eight contiguous amino acids of SEQ ID NO:102;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynudeotides specified by (a}-(d), and that has a length that is at least 25% of the length of SEQ ID NO:101.
111. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:102;
(b) a fragment of the amino acid sequence of SEQ ID NO:102, the fragment comprising eight contiguous amino acids of SEQ ID NO:102; and (c) the amino acid sequence encoded by the cDNA insert of clone cw1475_2 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
112. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:103;
(b) the nucleotide sequence of SEQ ID NO:103 from nucleotide 310 to nucleotide 954;
(c) the nucleotide sequence of the full-length protein coding sequence of clone dd428_4 deposited under accession number ATCC 207088;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone dd428_4 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:104;
a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:104, the fragment comprising eight contiguous amino acids of SEQ ID NO:104;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:103.
113. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:104;
(b) a fragment of the amino acid sequence of SEQ ID NO:104, the fragment comprising eight contiguous amino acids of SEQ ID NO:104; and (c) the amino acid sequence encoded by the cDNA insert of clone dd428_4 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
114. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:105;
(b) the nucleotide sequence of SEQ ID NO:105 from nucleotide 1698 to nucleotide 1895;
(c) the nucleotide sequence of the full-length protein coding sequence of clone dh1073_12 deposited under accession number ATCC 207088;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone dh1073_12 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:106;
a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:106, the fragment comprising eight contiguous amino acids of SEQ ID NO:106;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:105.
115. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:106;
(b) a fragment of the amino acid sequence of SEQ ID NO:106, the fragment comprising eight contiguous amino acids of SEQ ID NO:106; and (c) the amino acid sequence encoded by the cDNA insert of clone dh1073_12 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
116. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:107;

(b) the nucleotide sequence of SEQ ID NO:107 from nucleotide 423 to nucleotide 791;
(c) the nucleotide sequence of the full-length protein coding sequence of clone dw78_1 deposited under accession number ATCC 207088;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone dw78_1 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:108;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:108, the fragment comprising eight contiguous amino acids of SEQ ID NO:108;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:107.
117. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:108;
(b) a fragment of the amino acid sequence of SEQ ID NO:108, the fragment comprising eight contiguous amino acids of SEQ ID NO:108; and (c) the amino acid sequence encoded by the cDNA insert of clone dw78_1 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
118. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:109;
(b) the nucleotide sequence of SEQ ID NO:109 from nucleotide 96 to nucleotide 944;

(c) the nucleotide sequence of the full-length protein coding sequence of clone fh116_11 deposited under accession number ATCC 207088;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone fh116_11 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:110;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110, the fragment comprising eight contiguous amino acids of SEQ ID NO:110;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:109.
119. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:110;
(b) a fragment of the amino acid sequence of SEQ ID NO:110, the fragment comprising eight contiguous amino acids of SEQ ID NO:110; and (c) the amino acid sequence encoded by the cDNA insert of clone fh116_11 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
120. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:111;
(b) the nucleotide sequence of SEQ ID NO:111 from nucleotide 150 to nucleotide 1610;
(c) the nucleotide sequence of the full-length protein coding sequence of clone fy356_14 deposited under accession number ATCC 207088;

(d) a nucleotide sequence encoding the full-Length protein encoded by the cDNA insert of clone fy356_14 deposited under accession number ATCC
207088;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:112;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:112, the fragment comprising eight contiguous amino acids of SEQ ID NO:112;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:111.
121. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:112;
(b) a fragment of the amino acid sequence of SEQ ID NO:112, the fragment comprising eight contiguous amino acids of SEQ ID NO:112; and (c) the amino acid sequence encoded by the cDNA insert of clone fy356_14 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
122. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:113;
(b) the nucleotide sequence of SEQ ID NO:113 from nucleotide 49 to nucleotide 669;
(c) the nucleotide sequence of SEQ ID NO:113 from nucleotide 112 to nucleotide 669;
(d) the nucleotide sequence of the full-length protein coding sequence of clone iw66_1 deposited under accession number ATCC 207088;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
(f) the nucleotide sequence of a mature protein coding sequence of clone iw66_1 deposited under accession number ATCC 207088;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:114;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:114, the fragment comprising eight contiguous amino acids of SEQ ID NO:114;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:113.
123. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:114;
(b) a fragment of the amino acid sequence of SEQ ID NO:114, the fragment comprising eight contiguous amino acids of SEQ ID NO:114; and (c) the amino acid sequence encoded by the cDNA insert of clone iw66_1 deposited under accession number ATCC 207088;
the protein being substantially free from other mammalian proteins.
124. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:115;
(b) the nucleotide sequence of SEQ ID NO:115 from nucleotide 165 to nucleotide 416;

(c) the nucleotide sequence of the full-length protein coding sequence of clone kh13_4 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone kh13_4 deposited under accession number ATCC 207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:116;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:116, the fragment comprising eight contiguous amino acids of SEQ ID NO:116;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:115.
125. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:116;
(b) a fragment of the amino acid sequence of SEQ ID NO:116, the fragment comprising eight contiguous amino acids of SEQ ID NO:116; and (c) the amino acid sequence encoded by the cDNA insert of clone kh13_4 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
126. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:117;
(b) the nucleotide sequence of SEQ ID NO:117 from nucleotide 204 to nucleotide 602;
(c) the nucleotide sequence of the full-length protein coding sequence of clone ko258_4 deposited under accession number ATCC 207089;

(d) a nucleotide sequence encoding the full_length protein encoded by the cDNA insert of clone ko258_4 deposited under accession number ATCC
207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:118;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:118, the fragment comprising eight contiguous amino acids of SEQ ID NO:118;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:117.
127. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:118;
(b) a fragment of the amino acid sequence of SEQ ID NO:118, the fragment comprising eight contiguous amino acids of SEQ ID NO:118; and (c) the amino acid sequence encoded by the cDNA insert of clone ko258_4 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
128. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:119;
(b) the nucleotide sequence of SEQ ID NO:119 from nucleotide 434 to nucleotide 739;
(c) the nucleotide sequence of the full-length protein coding sequence of clone kv10_8 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone kv10_8 deposited under accession number ATCC 207089;

(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:120;
a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:120, the fragment comprising eight contiguous amino acids of SEQ ID NO:120;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:119.
129. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:120;
(b) a fragment of the amino acid sequence of SEQ ID NO:120, the fragment comprising eight contiguous amino acids of SEQ ID NO:120; and (c) the amino acid sequence encoded by the cDNA insert of clone kv10_8 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
130. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:121;
(b) the nucleotide sequence of SEQ ID NO:121 from nucleotide 149 to nucleotide 310;
(c) the nucleotide sequence of the full-length protein coding sequence of clone LL89_3 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone LL89_3 deposited under accession number ATCC
207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:122;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:122, the fragment comprising eight contiguous amino acids of SEQ ID NO:122;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:121.
131. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:122;
(b) a fragment of the amino acid sequence of SEQ ID NO:122, the fragment comprising eight contiguous amino acids of SEQ ID NO:122; and (c) the amino acid sequence encoded by the cDNA insert of clone LL89_3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
132. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:123;
(b) the nucleotide sequence of SEQ ID NO:123 from nucleotide 22 to nucleotide 288;
(c) the nucleotide sequence of the full-length protein coding sequence of clone mc300_1 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone mc300_1 deposited under accession number ATCC
207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:124;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:124, the fragment comprising eight contiguous amino acids of SEQ ID NO:124;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:123.
133. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:124;
(b) a fragment of the amino acid sequence of SEQ ID NO:124, the fragment comprising eight contiguous amino acids of SEQ ID NO:124; and (c) the amino acid sequence encoded by the cDNA insert of clone mc300_1 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
134. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:125;
(b) the nucleotide sequence of SEQ ID NO:125 from nucleotide 200 to nucleotide 2449;
(c) the nucleotide sequence of the full-length protein coding sequence of clone ml227_1 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full_length protein encoded by the cDNA insert of clone ml227_1 deposited under accession number ATCC
207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:126;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:126, the fragment comprising eight contiguous amino acids of SEQ ID NO:126;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:125.
135. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:126;
(b) a fragment of the amino acid sequence of SEQ ID NO:126, the fragment comprising eight contiguous amino acids of SEQ ID NO:126; and (c) the amino acid sequence encoded by the cDNA insert of clone ml227_1 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
136. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:127;
(b) the nucleotide sequence of SEQ ID NO:127 from nucleotide 82 to nucleotide 1980;
(c) the nucleotide sequence of the full-length protein coding sequence of clone mm367_6 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone mm367_6 deposited under accession number ATCC
207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:128;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:128, the fragment comprising eight contiguous amino acids of SEQ ID NO:128;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:127.
137. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:128;
(b) a fragment of the amino acid sequence of SEQ ID NO:128, the fragment comprising eight contiguous amino acids of SEQ ID NO:128; and (c) the amino acid sequence encoded by the cDNA insert of clone mm367_6 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
138. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:129;
(b) the nucleotide sequence of SEQ ID NO:129 from nucleotide 125 to nucleotide 856;
(c) the nucleotide sequence of the full-length protein coding sequence of clone mt124_3 deposited under accession number ATCC 207089;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone mt124_3 deposited under accession number ATCC
207089;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:130;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:130, the fragment comprising eight contiguous amino acids of SEQ ID NO:130;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:129.
139. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:130;
(b) a fragment of the amino acid sequence of SEQ ID NO:130, the fragment comprising eight contiguous amino acids of SEQ ID NO:130; and (c) the amino acid sequence encoded by the cDNA insert of clone mt124_3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
140. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:131;
(b) the nucleotide sequence of SEQ ID NO:131 from nucleotide 856 to nucleotide 2940;
(c) the nucleotide sequence of SEQ ID NO:131 from nucleotide 901 to nucleotide 2940;
(d) the nucleotide sequence of the full-length protein coding sequence of clone nf56_3 deposited under accession number ATCC 207089;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone nf56_3 deposited under accession number ATCC 207089;
the nucleotide sequence of a mature protein coding sequence of clone nf56_3 deposited under accession number ATCC 207089;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone nf56_3 deposited under accession number ATCC 207089;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:132;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:132, the fragment comprising eight contiguous amino acids of SEQ ID NO:132;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:131.
141. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:132;
(b) a fragment of the amino acid sequence of SEQ ID NO:132, the fragment comprising eight contiguous amino acids of SEQ ID NO:132; and (c) the amino acid sequence encoded by the cDNA insert of clone nf56_3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
142. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:133;
(b) the nucleotide sequence of SEQ ID NO:I33 from nucleotide 122 to nucleotide 448;
(c) the nucleotide sequence of SEQ ID NO:133 from nucleotide 167 to nucleotide 448;
(d) the nucleotide sequence of the full-length protein coding sequence of clone qy442_2 deposited under accession number ATCC 207089;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qy442_2 deposited under accession number ATCC
207089;
(f) the nucleotide sequence of a mature protein coding sequence of clone qy442_2 deposited under accession number ATCC 207089;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone qy442-2 deposited under accession number ATCC 207089;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:134;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:134, the fragment comprising eight contiguous amino acids of SEQ ID NO:134;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:133.
143. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:134;
(b) a fragment of the amino acid sequence of SEQ ID NO:134, the fragment comprising eight contiguous amino acids of SEQ ID NO:134; and (c) the amino acid sequence encoded by the cDNA insert of clone qy442_2 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
144. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:135;
(b) the nucleotide sequence of SEQ ID NO:135 from nucleotide 28 to nucleotide 777;

(c) the nucleotide sequence of SEQ ID NO:135 from nucleotide 73 to nucleotide 777;
(d) the nucleotide sequence of the full-length protein coding sequence of clone rj214_14 deposited under accession number ATCC 207089;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rj214_14 deposited under accession number ATCC
207089;
(f) the nucleotide sequence of a mature protein coding sequence of clone rj214_14 deposited under accession number ATCC 207089;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone rj214_14 deposited under accession number ATCC 207089;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:136;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:136, the fragment comprising eight contiguous amino acids of SEQ ID NO:136;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:135.
145. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:136;
(b) a fragment of the amino acid sequence of SEQ ID NO:136, the fragment comprising eight contiguous amino acids of SEQ ID NO:136; and (c) the amino acid sequence encoded by the cDNA insert of clone rj214_14 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
146. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:137;
(b) the nucleotide sequence of SEQ ID NO:137 from nucleotide 179 to nucleotide 745;
(c) the nucleotide sequence of SEQ ID NO:137 from nucleotide 233 to nucleotide 745;
(d) the nucleotide sequence of the full-length protein coding sequence of clone rk80_3 deposited under accession number ATCC 207089;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone rk80_3 deposited under accession number ATCC 207089;
(f) the nucleotide sequence of a mature protein coding sequence of clone rk80_3 deposited under accession number ATCC 207089;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone rk80_3 deposited under accession number ATCC 207089;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:138;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:138, the fragment comprising eight contiguous amino acids of SEQ ID NO:138;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:137.
147. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:138;
(b) a fragment of the amino acid sequence of SEQ ID NO:138, the fragment comprising eight contiguous amino acids of SEQ ID NO:138; and (c) the amino acid sequence encoded by the cDNA insert of clone rk80_3 deposited under accession number ATCC 207089;
the protein being substantially free from other mammalian proteins.
148. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:139;
(b) the nucleotide sequence of SEQ ID NO:139 from nucleotide 1017 to nucleotide 1274;
(c) the nucleotide sequence of the full-length protein coding sequence of clone au36_42 deposited under accession number ATCC 207187;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone au36_42 deposited under accession number ATCC
207187;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:140;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:140, the fragment comprising eight contiguous amino acids of SEQ ID NO:140;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:139.
149. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:140;
(b) a fragment of the amino acid sequence of SEQ ID NO:140, the fragment comprising eight contiguous amino acids of SEQ ID NO:140; and (c) the amino acid sequence encoded by the cDNA insert of clone au36-42 deposited under accession number ATCC 207187;

the protein being substantially free from other mammalian proteins.
150. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:141;
(b) the nucleotide sequence of SEQ ID NO:141 from nucleotide 580 to nucleotide 774;
(c) the nucleotide sequence of the full-length protein coding sequence of clone bo549_13 deposited under accession number ATCC 207187;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone bo549_13 deposited under accession number ATCC
207187;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:142;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:142, the fragment comprising eight contiguous amino acids of SEQ ID NO:142;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:141.
151. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:142;
(b) a fragment of the amino acid sequence of SEQ ID NO:142, the fragment comprising eight contiguous amino acids of SEQ ID NO:142; and (c) the amino acid sequence encoded by the cDNA insert of clone bo549_13 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
152. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:143;
(b) the nucleotide sequence of SEQ ID NO:143 from nucleotide 172 to nucleotide 969;
(c) the nucleotide sequence of SEQ ID NO:143 from nucleotide 385 to nucleotide 969;
(d) the nucleotide sequence of the full-length protein coding sequence of clone da529_3 deposited under accession number ATCC 207187;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone da529_3 deposited under accession number ATCC
207187;
(f) the nucleotide sequence of a mature protein coding sequence of clone da529_3 deposited under accession number ATCC 207187;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone da529_3 deposited under accession number ATCC 207187;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:144;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:144, the fragment comprising eight contiguous amino acids of SEQ ID NO:144;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:143.
153. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:144;
(b) a fragment of the amino acid sequence of SEQ ID NO:144, the fragment comprising eight contiguous amino acids of SEQ ID NO:144; and (c) the amino acid sequence encoded by the cDNA insert of clone da529_3 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
154. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:145;
(b) the nucleotide sequence of SEQ ID NO:145 from nucleotide 329 to nucleotide 667;
(c) the nucleotide sequence of SEQ ID NO:145 from nucleotide 368 to nucleotide 667;
(d) the nucleotide sequence of the full-length protein coding sequence of clone dm365_3 deposited under accession number ATCC 207187;
(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone dm365_3 deposited under accession number ATCC
207187;
(f) the nucleotide sequence of a mature protein coding sequence of clone dm365_3 deposited under accession number ATCC 207187;
(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone dm365_3 deposited under accession number ATCC 207187;
(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:146;
(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:146, the fragment comprising eight contiguous amino acids of SEQ ID NO:146;
(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:145.
155. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:146;
(b) a fragment of the amino acid sequence of SEQ ID NO:146, the fragment comprising eight contiguous amino acids of SEQ ID NO:146; and (c) the amino acid sequence encoded by the cDNA insert of clone dm365_3 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
156. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:147;
(b) the nucleotide sequence of SEQ ID NO:147 from nucleotide 103 to nucleotide 1368;
(c) the nucleotide sequence of the full-length protein coding sequence of clone fa171_1 deposited under accession number ATCC 207187;
(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone fa171_1 deposited under accession number ATCC
207187;
(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:148;
(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:148, the fragment comprising eight contiguous amino acids of SEQ ID NO:148;
(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:147.
157. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:148;

(b) a fragment of the amino acid sequence of SEQ ID NO:148, the fragment comprising eight contiguous amino acids of SEQ ID NO:148; and (c) the amino acid sequence encoded by the cDNA insert of clone fa171_1 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
158. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:149;

(b) the nucleotide sequence of SEQ ID NO:149 from nucleotide 190 to nucleotide 1407;

(c) the nucleotide sequence of SEQ ID NO:149 from nucleotide 463 to nucleotide 1407;

(d) the nucleotide sequence of the full-length protein coding sequence of clone 1p572_2 deposited under accession number ATCC 207187;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone 1p572 2 deposited under accession number ATCC
207187;
(f) the nucleotide sequence of a mature protein coding sequence of clone 1p572_2 deposited under accession number ATCC 207187;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone 1p572 2 deposited under accession number ATCC 207187;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:150;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:150, the fragment comprising eight contiguous amino acids of SEQ ID NO:150;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:149.
159. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:150;

(b) a fragment of the amino acid sequence of SEQ ID NO:150, the fragment comprising eight contiguous amino acids of SEQ ID NO:150; and (c) the amino acid sequence encoded by the cDNA insert of clone 1p572_2 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
160. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:151;

(b) the nucleotide sequence of SEQ ID NO:151 from nucleotide 301 to nucleotide 1035;

(c) the nucleotide sequence of SEQ ID NO:151 from nucleotide 916 to nucleotide 1035;

(d) the nucleotide sequence of the full-length protein coding sequence of clone pe246_1 deposited under accession number ATCC 207187;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone pe246_1 deposited under accession number ATCC
207187;

(f) the nucleotide sequence of a mature protein coding sequence of clone pe246_1 deposited under accession number ATCC 207187;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone pe246_1 deposited under accession number ATCC 207187;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:152;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:152, the fragment comprising eight contiguous amino acids of SEQ ID NO:152;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:151.
161. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:152;

(b) a fragment of the amino acid sequence of SEQ ID NO:152, the fragment comprising eight contiguous amino acids of SEQ ID NO:152; and (c) the amino acid sequence encoded by the cDNA insert of clone pe246_1 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
162. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:153;

(b) the nucleotide sequence of SEQ ID NO:153 from nucleotide 94 to nucleotide 1281;

(c) the nucleotide sequence of the full-length protein coding sequence of clone qf122_3 deposited under accession number ATCC 207187;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qf122_3 deposited under accession number ATCC
207187;

(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:154;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:154, the fragment comprising eight contiguous amino acids of SEQ ID NO:154;

(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:153.
163. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:154;

(b) a fragment of the amino acid sequence of SEQ ID NO:154, the fragment comprising eight contiguous amino acids of SEQ ID NO:154; and (c) the amino acid sequence encoded by the cDNA insert of clone qf122_3 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
164. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:155;

(b) the nucleotide sequence of SEQ ID NO:155 from nucleotide 110 to nucleotide 742;

(c) the nucleotide sequence of SEQ ID NO:155 from nucleotide 170 to nucleotide 742;

(d) the nucleotide sequence of the full-length protein coding sequence of clone qv538_1 deposited under accession number ATCC 207187;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone qv538_1 deposited under accession number ATCC
207187;

(f) the nucleotide sequence of a mature protein coding sequence of clone qv538_1 deposited under accession number ATCC 207187;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone qv538_1 deposited under accession number ATCC 207187;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:156;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:156, the fragment comprising eight contiguous amino acids of SEQ ID NO:156;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:155.
165. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:156;

(b) a fragment of the amino acid sequence of SEQ ID NO:156, the fragment comprising eight contiguous amino acids of SEQ ID NO:156; and (c) the amino acid sequence encoded by the cDNA insert of clone qv538_1 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
166. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:157;

(b) the nucleotide sequence of SEQ ID NO:157 from nucleotide 41 to nucleotide 757;

(c) the nucleotide sequence of the full-length protein coding sequence of clone ys20_1 deposited under accession number ATCC 207187;

(d) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187;

(e) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:158;

(f) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:158, the fragment comprising eight contiguous amino acids of SEQ ID NO:158;

(g) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d);
and (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(d), and that has a length that is at least 25% of the length of SEQ ID NO:157.
167. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:158;

(b) a fragment of the amino acid sequence of SEQ ID NO:158, the fragment comprising eight contiguous amino acids of SEQ ID NO:158; and (c) the amino acid sequence encoded by the cDNA insert of clone ys20_1 deposited under accession number ATCC 207187;
the protein being substantially free from other mammalian proteins.
168. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

(a) the nucleotide sequence of SEQ ID NO:159;

(b) the nucleotide sequence of SEQ ID NO:159 from nucleotide 28 to nucleotide 2253;

(c) the nucleotide sequence of SEQ ID NO:159 from nucleotide 568 to nucleotide 2253;

(d) the nucleotide sequence of the full-length protein coding sequence of clone as180_1 deposited under accession number ATCC XXXXXX;

(e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone as180_1 deposited under accession number ATCC
XXXXXX;

(f) the nucleotide sequence of a mature protein coding sequence of clone as180_1 deposited under accession number ATCC XXXXXX;

(g) a nucleotide sequence encoding a mature protein encoded by the cDNA insert of clone as180_1 deposited under accession number ATCC XXXXXX;

(h) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:160;

(i) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:160, the fragment comprising eight contiguous amino acids of SEQ ID NO:160;

(j) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 65 degrees C, or 4X SSC at 42 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g);
and (k) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4X SSC at 50 degrees C, or 6X SSC at 40 degrees C with 50% formamide, to any one of the polynucleotides specified by (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:159.
169. A protein comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:160;

(b) a fragment of the amino acid sequence of SEQ ID NO:160, the fragment comprising eight contiguous amino acids of SEQ ID NO:160; and (c) the amino acid sequence encoded by the cDNA insert of clone as180_1 deposited under accession number ATCC XXXXXX;
the protein being substantially free from other mammalian proteins.
CA002339047A 1998-08-14 1999-08-13 Secreted proteins and polynucleotides encoding them Abandoned CA2339047A1 (en)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US9662298P 1998-08-14 1998-08-14
US60/096,622 1998-08-14
US9681598P 1998-08-17 1998-08-17
US60/096,815 1998-08-17
US9922998P 1998-09-04 1998-09-04
US60/099,229 1998-09-04
US10536898P 1998-10-23 1998-10-23
US60/105,368 1998-10-23
US11523499P 1999-01-08 1999-01-08
US60/115,234 1999-01-08
US11993199P 1999-02-12 1999-02-12
US60/119,931 1999-02-12
US12057599P 1999-02-18 1999-02-18
US60/120,575 1999-02-18
US13202099P 1999-04-30 1999-04-30
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