CA2337097A1 - Non-invasive glucose monitor - Google Patents

Non-invasive glucose monitor Download PDF

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Publication number
CA2337097A1
CA2337097A1 CA002337097A CA2337097A CA2337097A1 CA 2337097 A1 CA2337097 A1 CA 2337097A1 CA 002337097 A CA002337097 A CA 002337097A CA 2337097 A CA2337097 A CA 2337097A CA 2337097 A1 CA2337097 A1 CA 2337097A1
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spectrum
interest
subject
determining
level
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CA002337097A
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French (fr)
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CA2337097C (en
Inventor
James L. Lambert
Mark S. Borchert
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California Institute of Technology CalTech
Childrens Hospital Los Angeles
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

This invention is a non-invasive method for determining blood level of an analyte of interest, such as glucose, comprising generating an excitation laser beam (10) (e.g., at a wavelength of 700 nanometers to 900 nanometers); focusing (13) the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor in the anterior chamber is illuminated; detecting (32) (preferably confocally (22) detecting) a Raman spectrum from the illuminated aqueous humor; and then determining the blood glucose level (or the level of another analyte of interest) for the subject from the Raman spectrum.
Preferably, the detecting step is followed by the step of subtracting a confounding fluorescence spectrum from the Raman spectrum to produce a difference spectrum; and determining the blood level of the analyte of interest for the subject from that difference spectrum, preferably using linear or nonlinear multi-variate analysis such as partial least squares analysis. Apparatus for carrying out the foregoing method is also disclosed.
CA002337097A 1998-07-13 1999-07-12 Non-invasive glucose monitor Expired - Fee Related CA2337097C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9254598P 1998-07-13 1998-07-13
US60/092,545 1998-07-13
PCT/US1999/015731 WO2000002479A1 (en) 1998-07-13 1999-07-12 Non-invasive glucose monitor

Publications (2)

Publication Number Publication Date
CA2337097A1 true CA2337097A1 (en) 2000-01-20
CA2337097C CA2337097C (en) 2008-12-23

Family

ID=22233745

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002337097A Expired - Fee Related CA2337097C (en) 1998-07-13 1999-07-12 Non-invasive glucose monitor

Country Status (5)

Country Link
US (2) US6181957B1 (en)
EP (1) EP1093343A4 (en)
AU (1) AU4986899A (en)
CA (1) CA2337097C (en)
WO (1) WO2000002479A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105067528A (en) * 2015-07-20 2015-11-18 中国科学院上海光学精密机械研究所 Two dimension confocal microscopynon-linear intensity scanning system and measurement method
US9442065B2 (en) 2014-09-29 2016-09-13 Zyomed Corp. Systems and methods for synthesis of zyotons for use in collision computing for noninvasive blood glucose and other measurements
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing

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US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
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US9442065B2 (en) 2014-09-29 2016-09-13 Zyomed Corp. Systems and methods for synthesis of zyotons for use in collision computing for noninvasive blood glucose and other measurements
US9448164B2 (en) 2014-09-29 2016-09-20 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
US9448165B2 (en) 2014-09-29 2016-09-20 Zyomed Corp. Systems and methods for control of illumination or radiation collection for blood glucose and other analyte detection and measurement using collision computing
US9453794B2 (en) 2014-09-29 2016-09-27 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
US9459202B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for collision computing for detection and noninvasive measurement of blood glucose and other substances and events
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
US9459203B2 (en) 2014-09-29 2016-10-04 Zyomed, Corp. Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements
US9610018B2 (en) 2014-09-29 2017-04-04 Zyomed Corp. Systems and methods for measurement of heart rate and other heart-related characteristics from photoplethysmographic (PPG) signals using collision computing
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US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing

Also Published As

Publication number Publication date
EP1093343A1 (en) 2001-04-25
US6181957B1 (en) 2001-01-30
WO2000002479A9 (en) 2000-06-22
EP1093343A4 (en) 2005-04-27
WO2000002479A1 (en) 2000-01-20
US6424850B1 (en) 2002-07-23
AU4986899A (en) 2000-02-01
CA2337097C (en) 2008-12-23

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