CA2333751A1 - Ameliorations apportees a l'absorption de substances par des cellules - Google Patents

Ameliorations apportees a l'absorption de substances par des cellules Download PDF

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Publication number
CA2333751A1
CA2333751A1 CA002333751A CA2333751A CA2333751A1 CA 2333751 A1 CA2333751 A1 CA 2333751A1 CA 002333751 A CA002333751 A CA 002333751A CA 2333751 A CA2333751 A CA 2333751A CA 2333751 A1 CA2333751 A1 CA 2333751A1
Authority
CA
Canada
Prior art keywords
molecule
moiety
dynamin
endocytosis
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002333751A
Other languages
English (en)
Inventor
Harvey Thomas Mcmahon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2333751A1 publication Critical patent/CA2333751A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une molécule à perméabilité membranaire destinée à inhiber, dans une cellule eucaryote, une endocytose ayant pour origine la dynamine, cette molécule renfermant un fragment hydrophobe à perméabilité membranaire et un fragment peptidique renfermant la séquence aminoacide QVPSRPNRAP.
CA002333751A 1998-06-01 1999-06-01 Ameliorations apportees a l'absorption de substances par des cellules Abandoned CA2333751A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9811692.4 1998-06-01
GBGB9811692.4A GB9811692D0 (en) 1998-06-01 1998-06-01 Improvements in or relating to uptake of substances by cells
PCT/GB1999/001723 WO1999062494A2 (fr) 1998-06-01 1999-06-01 Ameliorations apportees a l'absorption de substances par des cellules

Publications (1)

Publication Number Publication Date
CA2333751A1 true CA2333751A1 (fr) 1999-12-09

Family

ID=10832985

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002333751A Abandoned CA2333751A1 (fr) 1998-06-01 1999-06-01 Ameliorations apportees a l'absorption de substances par des cellules

Country Status (5)

Country Link
EP (1) EP1084144A2 (fr)
AU (1) AU4274899A (fr)
CA (1) CA2333751A1 (fr)
GB (1) GB9811692D0 (fr)
WO (1) WO1999062494A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348047A1 (fr) 2000-04-21 2011-07-27 New England Medical Center Agonistes et antagonistes du récepteur couplé à la protéine G (GPCR) et procédés d'activation et d'inhibition de GPCR au moyen de ces agonistes et antagonistes
US7696168B2 (en) 2000-04-21 2010-04-13 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
JP2007515399A (ja) * 2003-11-21 2007-06-14 ザ ユニバーシティ オブ ニューキャッスル リサーチ アソシエイツ リミテッド ダイナミン依存エンドサイトーシスを阻害する方法および薬剤
JP2008519039A (ja) 2004-11-04 2008-06-05 ニュー イングランド メデカル センター ホスピタルズ インク Ｇタンパク質共役型受容体アゴニストおよびアンタゴニストならびに使用方法
EP2862928A1 (fr) 2013-10-18 2015-04-22 Université de Strasbourg Inhibiteur de dynamine 2 pour le traitement de myopathies centronucléaires
WO2024178250A1 (fr) * 2023-02-22 2024-08-29 Radella Pharmaceuticals Llc Inhibiteurs de l'interaction ptp1b/nck1 et leurs procédés de fabrication et d'utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2237095A (en) * 1994-04-01 1995-10-23 Arcturus Pharmaceutical Corporation Method for delivering biologically active materials using a thioester or thioether prodrug
US6184205B1 (en) * 1994-07-22 2001-02-06 University Of North Carolina At Chapel Hill GRB2 SH3 binding peptides and methods of isolating and using same

Also Published As

Publication number Publication date
EP1084144A2 (fr) 2001-03-21
AU4274899A (en) 1999-12-20
GB9811692D0 (en) 1998-07-29
WO1999062494A3 (fr) 2000-03-02
WO1999062494A2 (fr) 1999-12-09

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Legal Events

Date Code Title Description
FZDE Discontinued