CA2333544A1 - Preparation for treating human skin and human hair comprising a special active ingredient combination, and the use of this active ingredient combination - Google Patents
Preparation for treating human skin and human hair comprising a special active ingredient combination, and the use of this active ingredient combination Download PDFInfo
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- CA2333544A1 CA2333544A1 CA002333544A CA2333544A CA2333544A1 CA 2333544 A1 CA2333544 A1 CA 2333544A1 CA 002333544 A CA002333544 A CA 002333544A CA 2333544 A CA2333544 A CA 2333544A CA 2333544 A1 CA2333544 A1 CA 2333544A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Birds (AREA)
- Epidemiology (AREA)
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- Cosmetics (AREA)
Abstract
The invention relates to preparations which contain an active ingredient combination made up of biotin and of at least one glycoprotein. Said preparations increase cell vitality. By applying corresponding agents on skin or hair, corresponding increases in vitality are obtained which, for example, lead to an improved elasticity of the skin.
Description
"Preparation for treating human skin and human hair comprising a special. active ingredient combination, and use of this active ingredient combination"
The invention re-~ates to preparations comprising a special active ingredient combination of biotin and at least one glycoprotein for treating human skin and human hair, and to the use of this active ingredient combination.
Human skin and human hair are treated with cosmetic preparations in diverse ways. Since time immemorial, this has included, i_rl particular, the cleansing and the care of skin and r~air. However, recent times have seen ever greater interest in products which, in addition to the customary cleansing or care, are intended to preserve or restore a condition which corresponds t=o a certain ideal of beauty. Apart from the coverings of gray hair, thi~~ includes, in particular, the maintenance or restoration of vital hair and a full head of hair, and also counteraction of the development of wrinkles in the skin. There is therefore an increasing need for new active ingredients or active ingredient combinations having corresponding positive effects on skin arid hair. These active ingredients and active ingredient combinations can be applied in the form of special formulations. However, it is also advantageously the aim that they can be incorporated into customary s)<:i:n- and hair-treatment compositions and then develop t:he desired additional effect upon application of said compositions.
Surprisingly, we have now found that an active ingredi-ent combination consisting of biotin and at least one glycoprotein increases the protein production in human cells upon topica_1_ application. A corresponding appli-cation :results not. only in the above-mentioned undesired developments being counteracted, but a:Lso, associated with the increase in the vitality of cells, the vitality of sl~;:in and hair significantly increases, which is evident, for example, from improved ;skin elasticity.
The invention therefore firstly provides preparations for treating human skin and human hair, characterized in that they compi:~ise an active ingredient combination consisting of biotin and at least one glycoprotein.
Both biotin (seE~ e.g. Fey, Otto, Worterbuch der Kosmetik [Cosmetic:s Dictionary], 4th edition, Wissen-schaftliche Verlagsgesellschaft mbH Stuttgart, 1997, page 39) and glycoproteins (see e.g. Product Specifica-tion 12/94 regarding "Phytodermin" from the company Chemisches Laborator.ium Dr. Kurt Richter GmbH, Berlin) are known as active ingredients for cosmetics. However, these publications rnake no reference to the combination 2 0 according to the _Lnvent ion or the influence thereof on the protein production in human cells and the positive effects on human skin and hair effected thereby.
The first: component of the active ingredient combina-tion according to the invention is biotin. Biotin is understood as meaning (3aS,4S,6aR)-2-oxohexahydro-thienol[3,4-d]-imidazole-4-valeric acid. The compound is also referred to as vitamin H or vitamin B~.
The active ingredient combination according to the invention also cc:>mprises at least one glycoprotein.
Glycoproteins is the term used to refer to compounds which contain carbohydrates and protein in the same molecule.
Preference is given according to the invention to glycoproteins of vegetable origin, in which case the glycoprotein origi.n<~tes in particular from a primary plant cel:L wall.
Glycoproteins which have proven particularly suitable according to the in~aention are those from soybe<~ns, rice, oats, wheat, potatoes, peaches, almonds, mush-rooms and peas . Glycoproteins from soybeans are parti-cularly preferred according to the invention. From the primary cell wal:L of soybeans, it is possible to obtain, in particular, hydroxyproline-rich glycoproteins or extensins, arabinogalactan proteins and proline-rich proteins. Approximately 20-30% by weight of: the dry mass of the primary cell wall of soybeans consist of these three components.
As the c:arbohydrat~? portion, the glycoproteins used according to the :invention preferably comprise ara:bin-ose, galactose, m~~nnose, glucose and fucose. Arabi:nose and galactose are preferred carbohydrates.
A glycoprotein which is particularly suitable according to the invention is the product obtainable commercially under the name Phytodermin .
The preparations according to the invention preferably comprise biotin in amounts of 0.000001-0.5% by weight, based on the total preparation. Amounts of 0.000005-0.05% by weight, in particular 0.00001-0.01% by weight, are particularly preferred.
The glycoprotein:> are preferably present in the preparations according to the invention in amount: of from 0.0001-5% b~.~ weight, in particular 0.001-1°-<. by weight, likewise bared on the total preparation.
The active ingredient combination according to the invention can be incorporated, in principle, into all customary hair- a~~d. skin-treatment compositions provi-ded known instabilities do not prevent this. Thus, biotin is unstable, for example, in combination with strong oxidizing a.g~~nt.s. However, in principle, it is not the intention to exclude preparations with such incompatibilities within the scope of the present invention. Instead, it may be entirely possible accord-ing to the invention to pack in this case one of the incompatible components separately and only to add it to the preparation d.i.rectly prior to application.
According to a first: preferred embodiment, the prep<~ra-tions according to t:he invention also comprise at least one penetration auxiliary.
Penetration auxiliaries which can be used according to the invention are, for example, polyethylene glycols having molar masses of from about 200 to 45,000, in particular about 4C0, glycols, urea and glucose, and glycerol, propylene glycol monoethyl ether, carbonates, hydrogenc,arbonates, guanidines, and primary, secondary and tertiary phosphates. Preferred penetration auxili-aries are the polyethylene glycols, propylene glycols, butylene glycols, urea and glucose.
The preparations according to the invention preferably comprise the penetration auxiliaries in amounts of from 0.1-15o by weight,. based on the total preparation.. If the field of application is skin, amounts of 0.1-loo by weight are preferred, and if the field of application is hair, amounts of 0.1-15o by weight are preferred. In both cases, partic=ular preference is given to amounts of about 0.1-5% by weight.
According to a ,second embodiment, the compositions according to the :invention comprise a protein hydroly-sate. Within the scope of the application, this; is understood as meaning both protein hydrolysates them-selves and also condensation products thereof with fatty acids, and quaternized protein hydrolysat;es.
Preferred protein hydrolysates are elastin, collagen, keratin, milk protr~in, soybean protein, almond protein, pea protein, rice protein and wheat protein hydroly-sates. Vegetable protein hydrolysates are particularly preferred. Furthermore, those protein hydrolysates which have a high proportion of the amino acids hydroxyproline anc~. proline are particularly suitable according to the invention. The protein hydrolysates are preferably present in the compositions according to the invention in amounts of 0.05-5% by weight, based on the total composition.
According to a further preferred embodiment, the preparations according to the invention comprise a further vitamin component, chosen from panthenol, toco-pherol and vitamin A and precursors and derivatives thereof.
Derivatives of panthenol which can be used according to the invention are, 7_T1 particular, the esters and ethers of panthenol, and canonically derivatized panthenols.
Individual representatives are, for example, panthenol triacetate, panthE,nol monoethyl ether and its mono-acetate, and the cationic panthenol derivatives dis-closed in WO 92/7.3829. Panthenol itself is preferred within this group. Panthenol and its derivatives are preferably present 7_I1 the compositions according to the invention in amounts of 0.05-10% by weight, based on the total composition. Amounts of 0.1-5% by weight are particularly preferred.
Tocopherol and it;~ derivatives, which include, in particular, the esters, such as the acetate, the nico-tinate, the phosphat=e and the succinate, are preferably present in the prE-~parations according to the invention in amounts of 0 . ()5-1 % by weight, based on the total preparation.
The invention re-~ates to preparations comprising a special active ingredient combination of biotin and at least one glycoprotein for treating human skin and human hair, and to the use of this active ingredient combination.
Human skin and human hair are treated with cosmetic preparations in diverse ways. Since time immemorial, this has included, i_rl particular, the cleansing and the care of skin and r~air. However, recent times have seen ever greater interest in products which, in addition to the customary cleansing or care, are intended to preserve or restore a condition which corresponds t=o a certain ideal of beauty. Apart from the coverings of gray hair, thi~~ includes, in particular, the maintenance or restoration of vital hair and a full head of hair, and also counteraction of the development of wrinkles in the skin. There is therefore an increasing need for new active ingredients or active ingredient combinations having corresponding positive effects on skin arid hair. These active ingredients and active ingredient combinations can be applied in the form of special formulations. However, it is also advantageously the aim that they can be incorporated into customary s)<:i:n- and hair-treatment compositions and then develop t:he desired additional effect upon application of said compositions.
Surprisingly, we have now found that an active ingredi-ent combination consisting of biotin and at least one glycoprotein increases the protein production in human cells upon topica_1_ application. A corresponding appli-cation :results not. only in the above-mentioned undesired developments being counteracted, but a:Lso, associated with the increase in the vitality of cells, the vitality of sl~;:in and hair significantly increases, which is evident, for example, from improved ;skin elasticity.
The invention therefore firstly provides preparations for treating human skin and human hair, characterized in that they compi:~ise an active ingredient combination consisting of biotin and at least one glycoprotein.
Both biotin (seE~ e.g. Fey, Otto, Worterbuch der Kosmetik [Cosmetic:s Dictionary], 4th edition, Wissen-schaftliche Verlagsgesellschaft mbH Stuttgart, 1997, page 39) and glycoproteins (see e.g. Product Specifica-tion 12/94 regarding "Phytodermin" from the company Chemisches Laborator.ium Dr. Kurt Richter GmbH, Berlin) are known as active ingredients for cosmetics. However, these publications rnake no reference to the combination 2 0 according to the _Lnvent ion or the influence thereof on the protein production in human cells and the positive effects on human skin and hair effected thereby.
The first: component of the active ingredient combina-tion according to the invention is biotin. Biotin is understood as meaning (3aS,4S,6aR)-2-oxohexahydro-thienol[3,4-d]-imidazole-4-valeric acid. The compound is also referred to as vitamin H or vitamin B~.
The active ingredient combination according to the invention also cc:>mprises at least one glycoprotein.
Glycoproteins is the term used to refer to compounds which contain carbohydrates and protein in the same molecule.
Preference is given according to the invention to glycoproteins of vegetable origin, in which case the glycoprotein origi.n<~tes in particular from a primary plant cel:L wall.
Glycoproteins which have proven particularly suitable according to the in~aention are those from soybe<~ns, rice, oats, wheat, potatoes, peaches, almonds, mush-rooms and peas . Glycoproteins from soybeans are parti-cularly preferred according to the invention. From the primary cell wal:L of soybeans, it is possible to obtain, in particular, hydroxyproline-rich glycoproteins or extensins, arabinogalactan proteins and proline-rich proteins. Approximately 20-30% by weight of: the dry mass of the primary cell wall of soybeans consist of these three components.
As the c:arbohydrat~? portion, the glycoproteins used according to the :invention preferably comprise ara:bin-ose, galactose, m~~nnose, glucose and fucose. Arabi:nose and galactose are preferred carbohydrates.
A glycoprotein which is particularly suitable according to the invention is the product obtainable commercially under the name Phytodermin .
The preparations according to the invention preferably comprise biotin in amounts of 0.000001-0.5% by weight, based on the total preparation. Amounts of 0.000005-0.05% by weight, in particular 0.00001-0.01% by weight, are particularly preferred.
The glycoprotein:> are preferably present in the preparations according to the invention in amount: of from 0.0001-5% b~.~ weight, in particular 0.001-1°-<. by weight, likewise bared on the total preparation.
The active ingredient combination according to the invention can be incorporated, in principle, into all customary hair- a~~d. skin-treatment compositions provi-ded known instabilities do not prevent this. Thus, biotin is unstable, for example, in combination with strong oxidizing a.g~~nt.s. However, in principle, it is not the intention to exclude preparations with such incompatibilities within the scope of the present invention. Instead, it may be entirely possible accord-ing to the invention to pack in this case one of the incompatible components separately and only to add it to the preparation d.i.rectly prior to application.
According to a first: preferred embodiment, the prep<~ra-tions according to t:he invention also comprise at least one penetration auxiliary.
Penetration auxiliaries which can be used according to the invention are, for example, polyethylene glycols having molar masses of from about 200 to 45,000, in particular about 4C0, glycols, urea and glucose, and glycerol, propylene glycol monoethyl ether, carbonates, hydrogenc,arbonates, guanidines, and primary, secondary and tertiary phosphates. Preferred penetration auxili-aries are the polyethylene glycols, propylene glycols, butylene glycols, urea and glucose.
The preparations according to the invention preferably comprise the penetration auxiliaries in amounts of from 0.1-15o by weight,. based on the total preparation.. If the field of application is skin, amounts of 0.1-loo by weight are preferred, and if the field of application is hair, amounts of 0.1-15o by weight are preferred. In both cases, partic=ular preference is given to amounts of about 0.1-5% by weight.
According to a ,second embodiment, the compositions according to the :invention comprise a protein hydroly-sate. Within the scope of the application, this; is understood as meaning both protein hydrolysates them-selves and also condensation products thereof with fatty acids, and quaternized protein hydrolysat;es.
Preferred protein hydrolysates are elastin, collagen, keratin, milk protr~in, soybean protein, almond protein, pea protein, rice protein and wheat protein hydroly-sates. Vegetable protein hydrolysates are particularly preferred. Furthermore, those protein hydrolysates which have a high proportion of the amino acids hydroxyproline anc~. proline are particularly suitable according to the invention. The protein hydrolysates are preferably present in the compositions according to the invention in amounts of 0.05-5% by weight, based on the total composition.
According to a further preferred embodiment, the preparations according to the invention comprise a further vitamin component, chosen from panthenol, toco-pherol and vitamin A and precursors and derivatives thereof.
Derivatives of panthenol which can be used according to the invention are, 7_T1 particular, the esters and ethers of panthenol, and canonically derivatized panthenols.
Individual representatives are, for example, panthenol triacetate, panthE,nol monoethyl ether and its mono-acetate, and the cationic panthenol derivatives dis-closed in WO 92/7.3829. Panthenol itself is preferred within this group. Panthenol and its derivatives are preferably present 7_I1 the compositions according to the invention in amounts of 0.05-10% by weight, based on the total composition. Amounts of 0.1-5% by weight are particularly preferred.
Tocopherol and it;~ derivatives, which include, in particular, the esters, such as the acetate, the nico-tinate, the phosphat=e and the succinate, are preferably present in the prE-~parations according to the invention in amounts of 0 . ()5-1 % by weight, based on the total preparation.
Suitable vitamin A components according to the inven-tion are,, for example, vitamin A acid and esters thereof, vitamin P, aldehyde and vitamin A alcohol and esters thereof , such as the palmitate and the acetate .
The preparations according to the invention preferably comprise the vitamin A component in amounts of 0.05-1%
by weight, based on the total preparation.
According to a further preferred embodiment, the preparations according to the invention comprise a plant extract .
These extracts are usually prepared by extraction of the whole plant. In individual cases, however, it may also be preferred t.o prepare the extracts exclusively from flowers and/o:r_ leaves of the plant.
With regard to the plant extracts which can be used according to the invention, reference is made in parti-cular to the extr<:~cts listed in the table starting on page 44 of the third edition of the guidelines relating to the declaration of. ingredients of cosmetic composi-tions, published k:~y the Industrieverband Korperpfl~~ge-and Waschmittel a .~V. ( IKW) , Frankfurt .
According to the invention, the extracts from oak bark, stinging nettle, hamamelis, hops, camomile, burdock, horsetail, hawthorn, :Lime blossom, almond, aloe vera, spruce needle, roast chestnut, sandalwood, juniper, coconut, mango, apricot, lemon, wheat, kiwi, melon, orange, grapefruit, sage, rosemary, birch, mallow, lady's ~~mock, wi~!_d thyme, yarrow, thyme, balm, restharrow, coltsfoot, marshmallow, meristem, ginseng, root ginger and green tea, in particular, can be used.
Preference is given to the extracts from oak bark, stinging nettle, h~amamelis, hops, camomile, burdock, -horsetail,, lime blossom, almond, aloe vera, coconut, mango, apricot, lemon, wheat, kiwi, melon, orange, grapefruii~, sage, rosemary, birch, lady's smock, wild thyme, yarrow, re~;tharrow, meristem, ginseng, root ginger and green tea.
For the use according to the invention, the extr<~cts from almond, aloe vera, coconut, mango, apricot, lemon, wheat, kiwi, melon <~nd green tea are very particularly suitable.
As extra~~tants for the preparation of said p:Lant extracts it is po~;s:ible to use water, alcohols, wai~er-alcohol mixtures, and C02. Of the alcohols, preference is given here to lower alcohols, such as ethanol and isopropanol, but in particular to polyhydric alcohols, such as ethylene g:Lycol and propylene glycol, both as a sole extractant and also as a mixture with water. P.Lant extracts based on water/propylene glycol in the ratio 1:10 to 10:1 have proven particularly suitable.
The plant extracts can be used according to the inven-tion both in pure form and in dilute form. If they are used in dilute foxrm, they usually comprise about 2-80%
by weighty of active substance and, as solvent, the extractant or ext:ra.ctant mixture used in obtaining them.
In addition, it may be preferred to use mixtures of two or more, in particu7_ar of two, different plant extracts in the compositions according to the invention.
Honey extracts are obtained in an analogous mannez- to the plant extract~~ and usually comprise 1-10% by weight, in particular 3-5o by weight, of active substance. V,Iater/propylene glycol mixtures may also be preferred extractant.:~:here.
- g Plant extracts are preferably used in compositions according to the invention in amounts of 0.1-20% by weight, in particular in amounts of 0.2-8% by weight.
Amounts of 0.5-5% by weight may be very particularly preferred. This quantitative data is firstly basecL on the total composition according to the invention, and secondly on the p ant extract in the form in which it is added to the composition. As already stated above, the plant. extract may be pure or in the form of a solution usually containing 2-80% by weight of active substance.
With regard to the quantitative data and the formula-tion form of the honey extracts, the same applie~~ as for plant extract.:, where extracts containing 0.01-10%
by weight, in particular 3-5% by weight, of active sub-stance may be preferred.
In addition, the preparations according to the inwen-tion alsc> preferably comprise a film former. Suitable film formers are prz_marily ionic and, in particular, nonionogenic polymers.
Preferred nonioniw polymers are polyvinylpyrrolidone and vinylpyrrolidone/vinyl acetate copolymers (for example the products Luviskol K 30, K 90, VA 64 and VA 37) and polysiloxanes (such as, for example, the commercial products Dow Corning 345, 190, 193, 200, 245, 246, 1401 and 7.403).
Preferred cationic' polymers according to the invention are quaternized cellulose ethers, such as, for example, the commercial procLuct Polymer JR 400, polysiloxanes having quaternary groups, such as Dow Corning DC 929, dimethyldiallylammonium chloride polymers, such as Merquat 100, acrylamide-dimethyldiallylammonium chlor-ide copo:Lymers, such as Merquat 550, dimethylamino-ethyl met~hacrylate=_-vinylpyrrolidone copolymers quater-nized with diethyl sulfate, such as Gafquat 734 and 755, vinylpyrrolic3one-imidazolinium methochloride co-polymers, such as the commercial products of the Luviquat series, ~:~n.d quaternized polyvinyl alcohol.
Suitable zwittericn_Lc and amphoteric polymers are, for example, acrylamidopropyltrimethylammonium chloride/-acrylate copolymer:, octylacrylamide/methylmethacryl-ate/tert-butylaminoethyl methacrylate/2-hydroxypropyl methacrylate copolymers, such as the commercial product Amphomer , and dimethyldiallylammonium chloride acrylic acid copolyrners, such as the commercial product Merquat 280.
Preferred anionic polymers according to the invention are pol~~acrylic acids and crosslinked polyacrylic acids, such as, for example, the commercial groducts of R
the Carbopol serie:~, in particular Carbopol ETD 2020, vinyl acetate/crotonic acid copolymers and terpolymers, such as the prod~,zcts of the Luviset series, vinyl pyrrolidone/vinyl acrylate copolymers, vinyl acetate/
butyl ma.leate/isobornyl acrylate copolymers, methyl vinyl etlzer/maleic: anh~dride copolymers, such as the P
products of the Gantrez series, and acrylic acid/ethyl acrylate/N-tert-butylacrylamide terpolymers.
The preparations according to the invention can be formulated on an aqueous, aqueous-alcoholic or alcoho-lic basi:~. Suitable alcohols here are, in particular, lower alc:ohols, Sl:lCh as ethanol and isopropanol. Here, aqueous-alcoholic bases may comprise water and alcohol preferably in a ratio of 1:5 to 5:1.
The active ingredient combination according to the invention. can be appl.i.ed to the hair either in the form of a separate formulation or as an additional component in other compositloIls .
According to a fs.rst embodiment, the preparations according to the invention are formulated as hair tonic, hair rinse or as hair cure . Hair tonics usually remain on the hair until the next hair treatment, e.g.
daily hair washing . Hair rinses are usually formul<~ted such that: rinsing out of the active ingredients is intended with water or an at least predominantly wai~er-containing composition after the desired contact tame.
The conta~~t time w:it:h the hair is generally short . Hair cures comprise the active ingredient combination i.n a higher concentration than hair rinses and are intended for the intensive treatment of the hair and, where appropriate, of the scalp. The contact time may be short, for example in the order of magnitude of the contact time of hair rinses, although it can also be as much as 20 minute::, depending on the degree of damage to the hair. When this contact time is over, the hair cures according to t:he invention can also be rinsed out with water or an at least predominantly water-containing composition; they may, however, also be left on the hair. These compositions can be formulated in a preferred variant as foam aerosols. For this, the compositions may comprise propellants. However, in this variant, preference is given to the formulation as a pump spray with air as propellant.
According to further embodiments, the compositions according to the invention may be, for example, clean-sing compositions, such as shampoos, setting composi-tions, such as hair-setting products, hairsprays and blow-waving product:, permanent shaping agents, such as permanent waving compositions and permanent fixing compositions, color-changing compositions, such as bleaching agents, oxidation colorants and tinting agents based on dirE=ct dyes, hair lotions and split-end fluids.
For the treatment of the skin, the preparations according to the invention can be formulated, for example, as skincare compositions and skin-cleansing compositions. Particularly in the case of skin-s treatment compositions, preference is given according to the invention t:o those compositions which remain on the body, in this ~:a.se the skin, following application.
Accordingly, the preparations can be formulated as solutions, oil-in--water emulsions, water-in-oil emul-sions, nanoemulsions, microemulsions, in particular those of the PI'r type, gels, creams, aerosols or lotions. The preparations can also be formulated. in encapsulated form, Eor example in gelatin or polyvinyl alcohol, and in t.r~.e form of liposomes, e.g. with leci-thin. If these preparations comprise components which cannot be formula.t:ed in a storage-stable manner together with one or more constituents) of the active ingredient combination according to the invention, it is possible, as alrE=_ady stated above, to formulate this active ingredient:. component or active ingredient combination according to the invention in the form of a separate formulation and only to mix it into the preparation directly prior to application.
According to the type of composition chosen, the preparations accor.-dinc~ to the invention may comprise the further constit:uents customary in these composi-tions. Further customary constituents of the prepara-tions according to t:he invention may thus be:
- anionic surfactants such as, in particular, alkyl-sulfates, alkylpolyglycol ether sulfates and ether carboxylic aci.d;~ having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule, and also sulfosuccinic mono- and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl esters having 8 to 18 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups, - nonionogenic :~urf:actants such as, in particular, the addition products of from 2 to 30 mol of ethyl ene oxide and/or 0 to 5 mol of propylene oxide to linear fatty alc:ohols having 8 to 22 carbon atoms, to fatty acid~~ having 12 to 22 carbon atoms, to alkylphenols r.a~aing 8 to 15 carbon atoms in the alkyl group, a:nd to corresponding fatty acid amides and fatty amines, C12-C22-fatty acid mono- and di-ester:~ of addition products of from 1 to 30 mo:L of ethylene oxide to glycerol, C8-C22-alkyl mono- and oligoglycoside:~ and ethoxylated analogs thereof, fatty acid N-~ul:k~~lglucamides, addition product: of from 5 to 60 mol of ethylene oxide to castor oil and hydrogenated castor oil, polyol fatty acid ester;, sugar c=_sters, sorbitan esters and poly-sorbai~es. If the nonionic surfactants contain poly-glyco:L ether chains, they may have a conventional or narrowed homologue distribution, - zwitterionic :surfactants, in particular the so-called betaine:~, such as N-alkyl-N,N-dimet:hyl-ammon:ium glycicza.tes, for example cocoalkyldimet:hyl-ammon:ium glyci:nat=e, N-acylaminopropyl-N,N-dimethyl-ammonium glycinate, for example cocoacylamino propy:Ldimethyl<:~mmonium glycinate, and 2-alkyl-3 carbo:~ymethyl-3-hydroxyethylimidazolines having in each case 8 to 1.8 carbon atoms in the alkyl or acyl group, and cor_c>acylaminoethyl hydroxyethylcarboxy methyl glycinat:e, - ampho:Lytic sur_-factants, such as N-alkylglyci:nes, N-alkylpropion:ic acids, N-alkylaminobutyric acids, N-alkylaminoditpropionic acids, N-hydroxyet:hyl-N-alkylamidopropy:Lglycines, N-alkyltaurines, N-alk~~lsarcosines, 2-alkylaminopropionic acids and alkyl<~minoacet:ic acids having in each case about 8 to 18 carbon atoms in the alkyl group, cationic surfactants of the quaternary ammonium compound type, preferably ammonium halides, in particular chlox-ides and bromides, such as al:kyl-trimet~hylammonium chlorides, dialkyldimethyl-ammon_i.um chlorides and trialkylmethylammonium chlor_i.des, e.g. cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, disteary:ldi-methylammonium chloride, lauryldimethylammonium chlor_ude, laur;yld.imethylbenzylammonium chloride and tricet:ylmethylammonium chloride, behenyltrimetlzyl-ammon~_um methosulfate, and the imidazo:Lium compounds known under the INCI names Quaternium-27 and Quaterniurn-83, of the esterquat type, for examp7_e based on triethanolamine, diethanol-alkylamines or 1,2-dihydroxypropyldialkylamines on the one hand and fatty acids, such as caproic acid, capry7_ic acid, ~~apric acid, lauric acid, myristic acid, palmitic acid, isostearic acid, stearic acid, oleic acid, el.aidi.c acid, arachidic acid, behenic acid and eruc:ic acid or technical-grade mixtures thereof, as are produced, for example, during the pressurized cleavage of natural fats and oils, such as, for example,, t=he products available under the trade names l~ehyquart and Armocare , and the alkylamidoamine type, such as the stearamidopropyl-dimethylamine available commercially under the name Tegoamid S 18, - symmet:rical and unsymmetrical, linear and branched dialkyl ethers having a total of between 12 and 36 carbon atoms, i.n particular 12 and 24 carbon atoms, such as, for ex<~mple, di-n-octyl ether, di-n-decyl ether, di-n-norxyl ether, di-n-undecyl ether and di-n-dodecyl ether, n-hexyl n-octyl ether, n-octyl n-decyl ether, n-decyl n-undecyl ether, n-undecyl n-dodecyl ethex:~ and n-hexyl n-undecyl ether and di-tert-butyl ether, diisopentyl ether, di-3-ethyl-decyl ether, tert--butyl n-octyl ether, isopentyl. n-octyl ether and.:z-methylpentyl n-octyl ether, - antifoams, such as silicones, - thickeners, such. as agar agar, guar gum, alginates, xanthan gum, gelatins, pectins, hydroxyet:hyl cellulose, and polyacrylamides and copolymers thereof, - struct~urants, such as malefic acid, - mono-, di- ancL oligosaccharides, such as, for example, glucose, galactose, fructose, fruit sugar and lactose, - ceramides, - veget<~ble oils, such as jojoba oil, sunflower oil, orange oil, almond oil, wheatgerm oil and peach stone oil, and paraffin oils, - saturated and unsaturated, linear and branched fatty alcohols having 8 to 22 carbon atoms, and mixtures there~:~f , which form by reducing naturally occurring triglycerides such as beef tallow, palm oil, groundnut oil, rapeseed oil, cottonseed oil, soy o_L1, sunflc:~wer oil and linseed oil, - monoesters of ratty acids with alcohols having 6 to 24 carbon atoms, - hair-condition_i.ng compounds of the phosphol:ipid type, for example soy lecithin, egg lecithin and cephalins, - perfurne oils, dimethyl isosorbide and cyclo-dextrins, - solubility promoters, such as ethanol, isopropanol, ethylene glycc;~l, propylene glycol, glycerol and diethylene glyc:vol, - dyes t:o color t:.he composition, - antidandruff active ingredients, such as piroctone olamine, zinc omadine and climbazole, - further substances for adjusting the pH, - active ingrediE:mts, such as allantoin, pyrrolidone-carboxylic acids and bisabolol, - light protecti<:>n agents, - consi~~tency-imparting agents, such as sugar estc=_rs, polyo7_ esters c:~r polyol alkyl ethers, fats and waxes, such as spermaceti, beeswax, mo:ntan wax and paraffins, - fatty acid alkanclamides, - opacif_iers, ;such as latex, styrene/PVP and styrene/acrylarnide copolymers, - pearlizing age:nt~s, such as ethylene glycol mono-and distearate,, and PEG-3 distearate, - complE~xing ageni~s, such as EDTA, NTA, (3-alanine-diacet~ic acid and. phosphonic acids, - directs dyes, - so-called coupler and developer components as oxidation dye precursors, - reducing agents such as e.g. thioglycolic acid and derivatives thereof, thiolactic acid, cysteamine, thiomalic acid anal a-mercaptoethanesulfonic acid, - oxidizing agent=s, such as hydrogen peroxide, potassium bromate and sodium bromate, - propellants, such as propane/butane mixtures, N20, dimethyl ether; CO~, N2 and air, and - antioxidants.
With regard to further compounds, reference is made to the handbooks known to the person skilled in the art, e.g. K. Schrade:r, Grundlagen and Rezepturen der Kosmetika [Cosmetic fundamentals and formulations], 2na edition, Hizthig Bu:~h Verlag, Heidelberg, 1989.
The pH of the preparations according to the invention may be, in principle, between 4.5 and 7, the person skilled in the art t=aking into consideration instabili-ties known to him, i=or example of the basic substance panthenol in the alkaline medium. The pH of the compo-sitions according to the invention is preferably :bet-ween 6 and 6.5. T.:~ adjust this pH, virtually any acid useable for cosmetic purposes can be used. Food a~~ids are usually used. Food acids are understood as meaning those acids which are taken in in the course of usual food consumption and have positive effects on the human organism. Food acids are, for example, acetic acid, lactic acid, tartaric acid, citric acid, malic acid, ascorbic acid and gluconic acid. Within the scope of the invention, the use of lactic acid and citric acid is particularly preferred.
The invention further provides for the use of an active ingredient combinat.i_on consisting of biotin and at least one glycoprotein for treating human skin and human hair, and for the use of this active ingredient combination for increasing the protein production in human cells.
- 17 _ Examples 1. Determination o:E the protein production in human cells Normal human keratinocytes were placed in culture in 24-well dishes in accordance with the supplier's instructions (PRObZO CELL) (5% of C02, 37°C, saturated water vapor atmo:>phere) and placed in subconfluence with the substances dissolved in the medium. After 24 hours, the total protein was determined in accordance with Low_ra (n - E. wells). The total protein is a measure of the biomass produced, which can be regarded as a characteristic value of the vitality of the cell.
The compositions investigated and the results obtained for the protein forrnation are given in the table below.
Mixture C1 is a phy:>.iological sodium chloride solution diluted by a factor of 10. Unless stated otherwise, all amounts are parts by weight.
C1 C2 C3 El Components:
~ Sodium chloride 0.09 0.09 0.09 0.09 ~ Biotin - 0.00001 - 0.00001 ~ Phytodermine~ 1 - - 0.5 0.5 ~ Water <- - - - - ad 100 - - - - - - - - ->
Amount of protein formed [~] 100 98 99 138 Proteins from the soybean (hydroxyproline-:rich glycoproteins as existensins, arabinose galactans as proteoglycan equivalents and proline-rich glyco-proteins from the plant matrix of the soybean in natural distribution: INCI name: Soybean (Glycine Soya) protein; (CLR Chemisches Laboratorium Dr.
Kurt Richter) 2. Working Examples Unless stated otfzerwise, all amounts are parts by weight.
2.1 Hair tonic Biotin 0.005 Phytodermin° 0.5 D-panthenol 0.2 Gluadin~ W 20~' 0.1 Cremophor~ RH 403 0.3 Perfume oil 0.15 Ethanol 30.0 Water ad 100 Wheat protein hydrolysate (20% of active substance in water; INCI name: Aqua (and) Hydrolized Wheat Protean (and) Sodium Benzoate (and) Phenoxyethanol (and) Methylparaben (and) Propylparaben) (HENKEL) Hydrogenated caw>t:or oil + 45 EO (INCI name: PEG-40 Hydrogenated Castor Oil) (BASF) 2.2 Hair tonic Biotin 0.003 Phytodermin~ 0.3 D-panthenol 0.1 Honey extract HS 25E.0 G4 0.2 Gluadin° W 405 0.1 Carbopol ETD 2020' 0.1 Cremophor~ RH 40 0.3 Perfume oil 0.15 Isopropanol 35.0 Water ad 100 Honey extract (12-150 of active substance; INCI
name : honey ) ( (~RAU AROMAT I C S ) Wheat protein hydrolysate (40% of active substance in water; INCI name: Aqua (and) Hydrolized Wheat Protean (and) Sodium Benzoate (and) Phenoxyethanol (and) Methylparaben (and) Propylparaben) (HENKEL) Polyacrylic acid copolymer (INCI name: Acrylates/-C10-30 Alkyl A:~ry.late Crosspolymer) (GOODRICH)
The preparations according to the invention preferably comprise the vitamin A component in amounts of 0.05-1%
by weight, based on the total preparation.
According to a further preferred embodiment, the preparations according to the invention comprise a plant extract .
These extracts are usually prepared by extraction of the whole plant. In individual cases, however, it may also be preferred t.o prepare the extracts exclusively from flowers and/o:r_ leaves of the plant.
With regard to the plant extracts which can be used according to the invention, reference is made in parti-cular to the extr<:~cts listed in the table starting on page 44 of the third edition of the guidelines relating to the declaration of. ingredients of cosmetic composi-tions, published k:~y the Industrieverband Korperpfl~~ge-and Waschmittel a .~V. ( IKW) , Frankfurt .
According to the invention, the extracts from oak bark, stinging nettle, hamamelis, hops, camomile, burdock, horsetail, hawthorn, :Lime blossom, almond, aloe vera, spruce needle, roast chestnut, sandalwood, juniper, coconut, mango, apricot, lemon, wheat, kiwi, melon, orange, grapefruit, sage, rosemary, birch, mallow, lady's ~~mock, wi~!_d thyme, yarrow, thyme, balm, restharrow, coltsfoot, marshmallow, meristem, ginseng, root ginger and green tea, in particular, can be used.
Preference is given to the extracts from oak bark, stinging nettle, h~amamelis, hops, camomile, burdock, -horsetail,, lime blossom, almond, aloe vera, coconut, mango, apricot, lemon, wheat, kiwi, melon, orange, grapefruii~, sage, rosemary, birch, lady's smock, wild thyme, yarrow, re~;tharrow, meristem, ginseng, root ginger and green tea.
For the use according to the invention, the extr<~cts from almond, aloe vera, coconut, mango, apricot, lemon, wheat, kiwi, melon <~nd green tea are very particularly suitable.
As extra~~tants for the preparation of said p:Lant extracts it is po~;s:ible to use water, alcohols, wai~er-alcohol mixtures, and C02. Of the alcohols, preference is given here to lower alcohols, such as ethanol and isopropanol, but in particular to polyhydric alcohols, such as ethylene g:Lycol and propylene glycol, both as a sole extractant and also as a mixture with water. P.Lant extracts based on water/propylene glycol in the ratio 1:10 to 10:1 have proven particularly suitable.
The plant extracts can be used according to the inven-tion both in pure form and in dilute form. If they are used in dilute foxrm, they usually comprise about 2-80%
by weighty of active substance and, as solvent, the extractant or ext:ra.ctant mixture used in obtaining them.
In addition, it may be preferred to use mixtures of two or more, in particu7_ar of two, different plant extracts in the compositions according to the invention.
Honey extracts are obtained in an analogous mannez- to the plant extract~~ and usually comprise 1-10% by weight, in particular 3-5o by weight, of active substance. V,Iater/propylene glycol mixtures may also be preferred extractant.:~:here.
- g Plant extracts are preferably used in compositions according to the invention in amounts of 0.1-20% by weight, in particular in amounts of 0.2-8% by weight.
Amounts of 0.5-5% by weight may be very particularly preferred. This quantitative data is firstly basecL on the total composition according to the invention, and secondly on the p ant extract in the form in which it is added to the composition. As already stated above, the plant. extract may be pure or in the form of a solution usually containing 2-80% by weight of active substance.
With regard to the quantitative data and the formula-tion form of the honey extracts, the same applie~~ as for plant extract.:, where extracts containing 0.01-10%
by weight, in particular 3-5% by weight, of active sub-stance may be preferred.
In addition, the preparations according to the inwen-tion alsc> preferably comprise a film former. Suitable film formers are prz_marily ionic and, in particular, nonionogenic polymers.
Preferred nonioniw polymers are polyvinylpyrrolidone and vinylpyrrolidone/vinyl acetate copolymers (for example the products Luviskol K 30, K 90, VA 64 and VA 37) and polysiloxanes (such as, for example, the commercial products Dow Corning 345, 190, 193, 200, 245, 246, 1401 and 7.403).
Preferred cationic' polymers according to the invention are quaternized cellulose ethers, such as, for example, the commercial procLuct Polymer JR 400, polysiloxanes having quaternary groups, such as Dow Corning DC 929, dimethyldiallylammonium chloride polymers, such as Merquat 100, acrylamide-dimethyldiallylammonium chlor-ide copo:Lymers, such as Merquat 550, dimethylamino-ethyl met~hacrylate=_-vinylpyrrolidone copolymers quater-nized with diethyl sulfate, such as Gafquat 734 and 755, vinylpyrrolic3one-imidazolinium methochloride co-polymers, such as the commercial products of the Luviquat series, ~:~n.d quaternized polyvinyl alcohol.
Suitable zwittericn_Lc and amphoteric polymers are, for example, acrylamidopropyltrimethylammonium chloride/-acrylate copolymer:, octylacrylamide/methylmethacryl-ate/tert-butylaminoethyl methacrylate/2-hydroxypropyl methacrylate copolymers, such as the commercial product Amphomer , and dimethyldiallylammonium chloride acrylic acid copolyrners, such as the commercial product Merquat 280.
Preferred anionic polymers according to the invention are pol~~acrylic acids and crosslinked polyacrylic acids, such as, for example, the commercial groducts of R
the Carbopol serie:~, in particular Carbopol ETD 2020, vinyl acetate/crotonic acid copolymers and terpolymers, such as the prod~,zcts of the Luviset series, vinyl pyrrolidone/vinyl acrylate copolymers, vinyl acetate/
butyl ma.leate/isobornyl acrylate copolymers, methyl vinyl etlzer/maleic: anh~dride copolymers, such as the P
products of the Gantrez series, and acrylic acid/ethyl acrylate/N-tert-butylacrylamide terpolymers.
The preparations according to the invention can be formulated on an aqueous, aqueous-alcoholic or alcoho-lic basi:~. Suitable alcohols here are, in particular, lower alc:ohols, Sl:lCh as ethanol and isopropanol. Here, aqueous-alcoholic bases may comprise water and alcohol preferably in a ratio of 1:5 to 5:1.
The active ingredient combination according to the invention. can be appl.i.ed to the hair either in the form of a separate formulation or as an additional component in other compositloIls .
According to a fs.rst embodiment, the preparations according to the invention are formulated as hair tonic, hair rinse or as hair cure . Hair tonics usually remain on the hair until the next hair treatment, e.g.
daily hair washing . Hair rinses are usually formul<~ted such that: rinsing out of the active ingredients is intended with water or an at least predominantly wai~er-containing composition after the desired contact tame.
The conta~~t time w:it:h the hair is generally short . Hair cures comprise the active ingredient combination i.n a higher concentration than hair rinses and are intended for the intensive treatment of the hair and, where appropriate, of the scalp. The contact time may be short, for example in the order of magnitude of the contact time of hair rinses, although it can also be as much as 20 minute::, depending on the degree of damage to the hair. When this contact time is over, the hair cures according to t:he invention can also be rinsed out with water or an at least predominantly water-containing composition; they may, however, also be left on the hair. These compositions can be formulated in a preferred variant as foam aerosols. For this, the compositions may comprise propellants. However, in this variant, preference is given to the formulation as a pump spray with air as propellant.
According to further embodiments, the compositions according to the invention may be, for example, clean-sing compositions, such as shampoos, setting composi-tions, such as hair-setting products, hairsprays and blow-waving product:, permanent shaping agents, such as permanent waving compositions and permanent fixing compositions, color-changing compositions, such as bleaching agents, oxidation colorants and tinting agents based on dirE=ct dyes, hair lotions and split-end fluids.
For the treatment of the skin, the preparations according to the invention can be formulated, for example, as skincare compositions and skin-cleansing compositions. Particularly in the case of skin-s treatment compositions, preference is given according to the invention t:o those compositions which remain on the body, in this ~:a.se the skin, following application.
Accordingly, the preparations can be formulated as solutions, oil-in--water emulsions, water-in-oil emul-sions, nanoemulsions, microemulsions, in particular those of the PI'r type, gels, creams, aerosols or lotions. The preparations can also be formulated. in encapsulated form, Eor example in gelatin or polyvinyl alcohol, and in t.r~.e form of liposomes, e.g. with leci-thin. If these preparations comprise components which cannot be formula.t:ed in a storage-stable manner together with one or more constituents) of the active ingredient combination according to the invention, it is possible, as alrE=_ady stated above, to formulate this active ingredient:. component or active ingredient combination according to the invention in the form of a separate formulation and only to mix it into the preparation directly prior to application.
According to the type of composition chosen, the preparations accor.-dinc~ to the invention may comprise the further constit:uents customary in these composi-tions. Further customary constituents of the prepara-tions according to t:he invention may thus be:
- anionic surfactants such as, in particular, alkyl-sulfates, alkylpolyglycol ether sulfates and ether carboxylic aci.d;~ having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule, and also sulfosuccinic mono- and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl esters having 8 to 18 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups, - nonionogenic :~urf:actants such as, in particular, the addition products of from 2 to 30 mol of ethyl ene oxide and/or 0 to 5 mol of propylene oxide to linear fatty alc:ohols having 8 to 22 carbon atoms, to fatty acid~~ having 12 to 22 carbon atoms, to alkylphenols r.a~aing 8 to 15 carbon atoms in the alkyl group, a:nd to corresponding fatty acid amides and fatty amines, C12-C22-fatty acid mono- and di-ester:~ of addition products of from 1 to 30 mo:L of ethylene oxide to glycerol, C8-C22-alkyl mono- and oligoglycoside:~ and ethoxylated analogs thereof, fatty acid N-~ul:k~~lglucamides, addition product: of from 5 to 60 mol of ethylene oxide to castor oil and hydrogenated castor oil, polyol fatty acid ester;, sugar c=_sters, sorbitan esters and poly-sorbai~es. If the nonionic surfactants contain poly-glyco:L ether chains, they may have a conventional or narrowed homologue distribution, - zwitterionic :surfactants, in particular the so-called betaine:~, such as N-alkyl-N,N-dimet:hyl-ammon:ium glycicza.tes, for example cocoalkyldimet:hyl-ammon:ium glyci:nat=e, N-acylaminopropyl-N,N-dimethyl-ammonium glycinate, for example cocoacylamino propy:Ldimethyl<:~mmonium glycinate, and 2-alkyl-3 carbo:~ymethyl-3-hydroxyethylimidazolines having in each case 8 to 1.8 carbon atoms in the alkyl or acyl group, and cor_c>acylaminoethyl hydroxyethylcarboxy methyl glycinat:e, - ampho:Lytic sur_-factants, such as N-alkylglyci:nes, N-alkylpropion:ic acids, N-alkylaminobutyric acids, N-alkylaminoditpropionic acids, N-hydroxyet:hyl-N-alkylamidopropy:Lglycines, N-alkyltaurines, N-alk~~lsarcosines, 2-alkylaminopropionic acids and alkyl<~minoacet:ic acids having in each case about 8 to 18 carbon atoms in the alkyl group, cationic surfactants of the quaternary ammonium compound type, preferably ammonium halides, in particular chlox-ides and bromides, such as al:kyl-trimet~hylammonium chlorides, dialkyldimethyl-ammon_i.um chlorides and trialkylmethylammonium chlor_i.des, e.g. cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, disteary:ldi-methylammonium chloride, lauryldimethylammonium chlor_ude, laur;yld.imethylbenzylammonium chloride and tricet:ylmethylammonium chloride, behenyltrimetlzyl-ammon~_um methosulfate, and the imidazo:Lium compounds known under the INCI names Quaternium-27 and Quaterniurn-83, of the esterquat type, for examp7_e based on triethanolamine, diethanol-alkylamines or 1,2-dihydroxypropyldialkylamines on the one hand and fatty acids, such as caproic acid, capry7_ic acid, ~~apric acid, lauric acid, myristic acid, palmitic acid, isostearic acid, stearic acid, oleic acid, el.aidi.c acid, arachidic acid, behenic acid and eruc:ic acid or technical-grade mixtures thereof, as are produced, for example, during the pressurized cleavage of natural fats and oils, such as, for example,, t=he products available under the trade names l~ehyquart and Armocare , and the alkylamidoamine type, such as the stearamidopropyl-dimethylamine available commercially under the name Tegoamid S 18, - symmet:rical and unsymmetrical, linear and branched dialkyl ethers having a total of between 12 and 36 carbon atoms, i.n particular 12 and 24 carbon atoms, such as, for ex<~mple, di-n-octyl ether, di-n-decyl ether, di-n-norxyl ether, di-n-undecyl ether and di-n-dodecyl ether, n-hexyl n-octyl ether, n-octyl n-decyl ether, n-decyl n-undecyl ether, n-undecyl n-dodecyl ethex:~ and n-hexyl n-undecyl ether and di-tert-butyl ether, diisopentyl ether, di-3-ethyl-decyl ether, tert--butyl n-octyl ether, isopentyl. n-octyl ether and.:z-methylpentyl n-octyl ether, - antifoams, such as silicones, - thickeners, such. as agar agar, guar gum, alginates, xanthan gum, gelatins, pectins, hydroxyet:hyl cellulose, and polyacrylamides and copolymers thereof, - struct~urants, such as malefic acid, - mono-, di- ancL oligosaccharides, such as, for example, glucose, galactose, fructose, fruit sugar and lactose, - ceramides, - veget<~ble oils, such as jojoba oil, sunflower oil, orange oil, almond oil, wheatgerm oil and peach stone oil, and paraffin oils, - saturated and unsaturated, linear and branched fatty alcohols having 8 to 22 carbon atoms, and mixtures there~:~f , which form by reducing naturally occurring triglycerides such as beef tallow, palm oil, groundnut oil, rapeseed oil, cottonseed oil, soy o_L1, sunflc:~wer oil and linseed oil, - monoesters of ratty acids with alcohols having 6 to 24 carbon atoms, - hair-condition_i.ng compounds of the phosphol:ipid type, for example soy lecithin, egg lecithin and cephalins, - perfurne oils, dimethyl isosorbide and cyclo-dextrins, - solubility promoters, such as ethanol, isopropanol, ethylene glycc;~l, propylene glycol, glycerol and diethylene glyc:vol, - dyes t:o color t:.he composition, - antidandruff active ingredients, such as piroctone olamine, zinc omadine and climbazole, - further substances for adjusting the pH, - active ingrediE:mts, such as allantoin, pyrrolidone-carboxylic acids and bisabolol, - light protecti<:>n agents, - consi~~tency-imparting agents, such as sugar estc=_rs, polyo7_ esters c:~r polyol alkyl ethers, fats and waxes, such as spermaceti, beeswax, mo:ntan wax and paraffins, - fatty acid alkanclamides, - opacif_iers, ;such as latex, styrene/PVP and styrene/acrylarnide copolymers, - pearlizing age:nt~s, such as ethylene glycol mono-and distearate,, and PEG-3 distearate, - complE~xing ageni~s, such as EDTA, NTA, (3-alanine-diacet~ic acid and. phosphonic acids, - directs dyes, - so-called coupler and developer components as oxidation dye precursors, - reducing agents such as e.g. thioglycolic acid and derivatives thereof, thiolactic acid, cysteamine, thiomalic acid anal a-mercaptoethanesulfonic acid, - oxidizing agent=s, such as hydrogen peroxide, potassium bromate and sodium bromate, - propellants, such as propane/butane mixtures, N20, dimethyl ether; CO~, N2 and air, and - antioxidants.
With regard to further compounds, reference is made to the handbooks known to the person skilled in the art, e.g. K. Schrade:r, Grundlagen and Rezepturen der Kosmetika [Cosmetic fundamentals and formulations], 2na edition, Hizthig Bu:~h Verlag, Heidelberg, 1989.
The pH of the preparations according to the invention may be, in principle, between 4.5 and 7, the person skilled in the art t=aking into consideration instabili-ties known to him, i=or example of the basic substance panthenol in the alkaline medium. The pH of the compo-sitions according to the invention is preferably :bet-ween 6 and 6.5. T.:~ adjust this pH, virtually any acid useable for cosmetic purposes can be used. Food a~~ids are usually used. Food acids are understood as meaning those acids which are taken in in the course of usual food consumption and have positive effects on the human organism. Food acids are, for example, acetic acid, lactic acid, tartaric acid, citric acid, malic acid, ascorbic acid and gluconic acid. Within the scope of the invention, the use of lactic acid and citric acid is particularly preferred.
The invention further provides for the use of an active ingredient combinat.i_on consisting of biotin and at least one glycoprotein for treating human skin and human hair, and for the use of this active ingredient combination for increasing the protein production in human cells.
- 17 _ Examples 1. Determination o:E the protein production in human cells Normal human keratinocytes were placed in culture in 24-well dishes in accordance with the supplier's instructions (PRObZO CELL) (5% of C02, 37°C, saturated water vapor atmo:>phere) and placed in subconfluence with the substances dissolved in the medium. After 24 hours, the total protein was determined in accordance with Low_ra (n - E. wells). The total protein is a measure of the biomass produced, which can be regarded as a characteristic value of the vitality of the cell.
The compositions investigated and the results obtained for the protein forrnation are given in the table below.
Mixture C1 is a phy:>.iological sodium chloride solution diluted by a factor of 10. Unless stated otherwise, all amounts are parts by weight.
C1 C2 C3 El Components:
~ Sodium chloride 0.09 0.09 0.09 0.09 ~ Biotin - 0.00001 - 0.00001 ~ Phytodermine~ 1 - - 0.5 0.5 ~ Water <- - - - - ad 100 - - - - - - - - ->
Amount of protein formed [~] 100 98 99 138 Proteins from the soybean (hydroxyproline-:rich glycoproteins as existensins, arabinose galactans as proteoglycan equivalents and proline-rich glyco-proteins from the plant matrix of the soybean in natural distribution: INCI name: Soybean (Glycine Soya) protein; (CLR Chemisches Laboratorium Dr.
Kurt Richter) 2. Working Examples Unless stated otfzerwise, all amounts are parts by weight.
2.1 Hair tonic Biotin 0.005 Phytodermin° 0.5 D-panthenol 0.2 Gluadin~ W 20~' 0.1 Cremophor~ RH 403 0.3 Perfume oil 0.15 Ethanol 30.0 Water ad 100 Wheat protein hydrolysate (20% of active substance in water; INCI name: Aqua (and) Hydrolized Wheat Protean (and) Sodium Benzoate (and) Phenoxyethanol (and) Methylparaben (and) Propylparaben) (HENKEL) Hydrogenated caw>t:or oil + 45 EO (INCI name: PEG-40 Hydrogenated Castor Oil) (BASF) 2.2 Hair tonic Biotin 0.003 Phytodermin~ 0.3 D-panthenol 0.1 Honey extract HS 25E.0 G4 0.2 Gluadin° W 405 0.1 Carbopol ETD 2020' 0.1 Cremophor~ RH 40 0.3 Perfume oil 0.15 Isopropanol 35.0 Water ad 100 Honey extract (12-150 of active substance; INCI
name : honey ) ( (~RAU AROMAT I C S ) Wheat protein hydrolysate (40% of active substance in water; INCI name: Aqua (and) Hydrolized Wheat Protean (and) Sodium Benzoate (and) Phenoxyethanol (and) Methylparaben (and) Propylparaben) (HENKEL) Polyacrylic acid copolymer (INCI name: Acrylates/-C10-30 Alkyl A:~ry.late Crosspolymer) (GOODRICH)
Claims (15)
1. A preparation for treating human skin and human hair, characterized in that it comprises an active ingredient combination consisting of - biotin and - at least one glycoprotein.
2. The preparation as claimed in claim 1, characterized in that the glycoprotein is a vegetable glycoprotein.
3. The preparation as claimed in claim 2, characterized in that the glycoprotein originates from a primary plant cell wall.
4. A preparation as claimed in either of claims 2 and 3, characterized in that the glycoprotein is chosen from the glycoproteins from soybeans, rice, oats, wheat, potatoes, peaches, almonds, mushrooms and peas.
5. The preparation as claimed in any one of claims 1 to 4, characterized in that the carbohydrate portion of the glycoprotein is chosen from galactose, arabinose, mannose, glucose and fucose.
6. The preparation as claimed in any one of claims 1 to 5, characterized in that the glycoprotein is present in an amount of from 0.0001-5% by weight, based on the total preparation.
7. The preparation as claimed in any one of claims 1 to 6, characterized in that the biotin is present in an amount of from 0.000001-0.5% by weight.
8. The preparation as claimed in any one of claims 1 to 7, characterized in that it further comprises a penetration auxiliary.
9. The preparation as claimed in any one of claims 1 to 8, characterized in that it further comprises a protein hyrolysate .
10. The preparation as claimed in any one of claims 1 to 9, characterized in that it further comprises a vitamin, chosen from panthenol, tocopherol and vitamin A and precursors and derivatives thereof.
11. The preparation as claimed in any one of claims 1 to 10, characterized in that it further comprises a plant or honey extract.
12. The preparation as claimed in any one of claims 1 to 11, characterized in that it further comprises a film former.
13. The preparation as claimed in any one of claims 1 to 12, characterized in that it remains on the hair or the skin following application.
14. The use of an active ingredient combination consisting of - biotin and.
- at least one glycoprotein for treating human skin and human hair.
- at least one glycoprotein for treating human skin and human hair.
15. The use of an active ingredient combination consisting of - biotin and - at least one glycoprotein for increasing the protein production in human cells.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823552.6 | 1998-05-27 | ||
| DE1998123552 DE19823552A1 (en) | 1998-05-27 | 1998-05-27 | Preparation for the treatment of human skin and human hair with a special combination of active ingredients and use of this combination of active ingredients |
| PCT/EP1999/003362 WO1999060989A2 (en) | 1998-05-27 | 1999-05-15 | Preparation for treating human skin and human hair comprising a special active ingredient combination, and the use of this active ingredient combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2333544A1 true CA2333544A1 (en) | 1999-12-02 |
Family
ID=7868995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002333544A Abandoned CA2333544A1 (en) | 1998-05-27 | 1999-05-15 | Preparation for treating human skin and human hair comprising a special active ingredient combination, and the use of this active ingredient combination |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1079795A2 (en) |
| JP (1) | JP2002516263A (en) |
| AU (1) | AU4262599A (en) |
| CA (1) | CA2333544A1 (en) |
| DE (1) | DE19823552A1 (en) |
| WO (1) | WO1999060989A2 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861077B1 (en) | 2000-03-17 | 2005-03-01 | L'oreal S.A. | Use of plant extracts in a cosmetic composition to protect keratinous fibers |
| WO2001089459A2 (en) * | 2000-05-23 | 2001-11-29 | L'oreal S.A. | The use of plant extracts in a cosmetic composition to protect keratinous fibers |
| WO2002019980A1 (en) * | 2000-09-11 | 2002-03-14 | Indústria e Comércio de Cosméticos Natura Ltda. | Composition of vitamin c and/or vitamin a |
| FR2813789B1 (en) * | 2000-09-11 | 2003-05-02 | Ind E Com De Cosmeticos Natura | NOVEL COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING AN ASSOCIATION OF VITAMIN C AND / OR WITH A FUCOSE COMPONENT AND USE OF SAID COSMETIC OR PHARMACY ASSOCIATION |
| JP2002308746A (en) * | 2001-04-05 | 2002-10-23 | Dongsung Pharm Co Ltd | Composition for hairdye |
| FR2824476B1 (en) * | 2001-05-14 | 2003-07-25 | Clarins Lab | COSMETIC COMPOSITION ALLOWING THE SKIN TO ADAPT TO THERMAL STRESS CONDITIONS |
| EP1398019A1 (en) | 2002-09-13 | 2004-03-17 | Cognis France S.A. | Method for protecting and modulating the dermal-epidermal junction |
| PT1583512E (en) | 2002-12-12 | 2011-01-27 | R B T Rakuto Bio Technologies Ltd | Use of lignin peroxidase in skin and hair lightening |
| FR2855968B1 (en) | 2003-06-13 | 2012-11-30 | Coletica | STIMULATION OF THE SYNTHESIS AND ACTIVITY OF A LYSYL OXIDASE-LIKE LOXL ISOFORM TO STIMULATE THE FORMATION OF ELASTIC FIBERS |
| KR101237316B1 (en) * | 2004-05-21 | 2013-02-28 | 타다시 고이노 | Scalp and hair-care composition |
| KR100784486B1 (en) * | 2007-01-08 | 2007-12-11 | 주식회사 에스티씨나라 | Cosmetic compositions for skin-tightening and method of skin-tightening using the same |
| JP6185372B2 (en) * | 2013-11-21 | 2017-08-23 | ポーラ化成工業株式会社 | Topical skin preparation |
| DE202016003916U1 (en) | 2015-06-29 | 2016-10-11 | Hans Werner Bierganns | emulsion |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5069898A (en) * | 1989-04-24 | 1991-12-03 | Revlon, Inc. | Hair enrichment composition and method of use |
-
1998
- 1998-05-27 DE DE1998123552 patent/DE19823552A1/en not_active Ceased
-
1999
- 1999-05-15 AU AU42625/99A patent/AU4262599A/en not_active Abandoned
- 1999-05-15 CA CA002333544A patent/CA2333544A1/en not_active Abandoned
- 1999-05-15 EP EP99953283A patent/EP1079795A2/en not_active Withdrawn
- 1999-05-15 JP JP2000550450A patent/JP2002516263A/en active Pending
- 1999-05-15 WO PCT/EP1999/003362 patent/WO1999060989A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999060989A2 (en) | 1999-12-02 |
| AU4262599A (en) | 1999-12-13 |
| JP2002516263A (en) | 2002-06-04 |
| EP1079795A2 (en) | 2001-03-07 |
| DE19823552A1 (en) | 1999-12-02 |
| WO1999060989A3 (en) | 2000-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |