CA2332349A1 - Predictive test for pre-eclampsia - Google Patents
Predictive test for pre-eclampsia Download PDFInfo
- Publication number
- CA2332349A1 CA2332349A1 CA002332349A CA2332349A CA2332349A1 CA 2332349 A1 CA2332349 A1 CA 2332349A1 CA 002332349 A CA002332349 A CA 002332349A CA 2332349 A CA2332349 A CA 2332349A CA 2332349 A1 CA2332349 A1 CA 2332349A1
- Authority
- CA
- Canada
- Prior art keywords
- free
- levels
- eclampsia
- risk
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 201000011461 pre-eclampsia Diseases 0.000 title claims abstract description 56
- 238000012360 testing method Methods 0.000 title description 10
- 108010067471 inhibin A Proteins 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 37
- 238000012216 screening Methods 0.000 claims abstract description 31
- 210000002966 serum Anatomy 0.000 claims abstract description 23
- 238000004458 analytical method Methods 0.000 claims abstract description 16
- 230000035935 pregnancy Effects 0.000 claims description 47
- 239000003550 marker Substances 0.000 claims description 33
- 239000000523 sample Substances 0.000 claims description 31
- 238000009826 distribution Methods 0.000 claims description 25
- 229960004407 chorionic gonadotrophin Drugs 0.000 claims description 20
- 230000008774 maternal effect Effects 0.000 claims description 15
- 238000004364 calculation method Methods 0.000 claims description 13
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims description 9
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 210000003754 fetus Anatomy 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 7
- 238000000491 multivariate analysis Methods 0.000 claims description 7
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 239000013068 control sample Substances 0.000 claims description 2
- 201000001474 proteinuria Diseases 0.000 description 18
- 238000001514 detection method Methods 0.000 description 14
- 201000010374 Down Syndrome Diseases 0.000 description 7
- 206010044688 Trisomy 21 Diseases 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 108010004250 Inhibins Proteins 0.000 description 4
- 102000002746 Inhibins Human genes 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 239000000893 inhibin Substances 0.000 description 4
- 108010059616 Activins Proteins 0.000 description 3
- 102000005606 Activins Human genes 0.000 description 3
- 239000000488 activin Substances 0.000 description 3
- 108010023082 activin A Proteins 0.000 description 3
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 3
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 3
- 229960000258 corticotropin Drugs 0.000 description 3
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000003821 menstrual periods Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 2
- 101800000414 Corticotropin Proteins 0.000 description 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 206010062237 Renal impairment Diseases 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 229940028334 follicle stimulating hormone Drugs 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 108010067479 inhibin B Proteins 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 239000003488 releasing hormone Substances 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010070531 Foetal growth restriction Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000004576 Placental Lactogen Human genes 0.000 description 1
- 108010003044 Placental Lactogen Proteins 0.000 description 1
- 239000000381 Placental Lactogen Substances 0.000 description 1
- 208000005107 Premature Birth Diseases 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 108010023079 activin B Proteins 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 239000003150 biochemical marker Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000002296 eclampsia Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 210000001733 follicular fluid Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000002260 hypophysiotrophic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 201000010193 neural tube defect Diseases 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000035581 susceptibility to neural tube defects Diseases 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812432.4A GB9812432D0 (en) | 1998-06-09 | 1998-06-09 | Predictive test |
| GB9812432.4 | 1998-06-09 | ||
| PCT/GB1999/001828 WO1999064860A2 (en) | 1998-06-09 | 1999-06-09 | Predictive test for pre-eclampsia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2332349A1 true CA2332349A1 (en) | 1999-12-16 |
Family
ID=10833482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332349A Abandoned CA2332349A1 (en) | 1998-06-09 | 1999-06-09 | Predictive test for pre-eclampsia |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6735529B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1084412A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2002517755A (cg-RX-API-DMAC7.html) |
| AU (1) | AU751415B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2332349A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB9812432D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1999064860A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4891511B2 (ja) * | 2000-03-29 | 2012-03-07 | ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン | 自己モニタリングデータから糖尿病の血糖管理を評価する方法、システム及びコンピユータプログラム製品 |
| RU2243562C1 (ru) * | 2003-07-04 | 2004-12-27 | Новокузнецкий государственный институт усовершенствования врачей | Способ прогнозирования риска развития эклампсии у беременных |
| EP1571451A1 (en) * | 2004-03-05 | 2005-09-07 | Inverness Medical Switzerland GmbH | Method and apparatus for estimating due date |
| US20050196812A1 (en) * | 2004-03-05 | 2005-09-08 | Williams David E. | Determining the estimated date of embryo implantation and related dates |
| WO2007030889A1 (en) * | 2005-09-15 | 2007-03-22 | Victor Voroteliak | Method of diagnosing pre-eclampsia |
| EP2657697B1 (en) | 2008-01-25 | 2016-06-08 | Wallac Oy | Methods for determining the risk of chromosomal abnormality in a fetus |
| WO2010091253A1 (en) | 2009-02-06 | 2010-08-12 | Women & Infants' Hospital Of Rhode Island | Compositions, formulations and methods of treating preeclampsia-type disorders of pregnancy |
| US10670610B2 (en) | 2012-06-15 | 2020-06-02 | Wayne State University | Biomarker test for prediction or early detection of preeclampsia and/or HELLP syndrome |
| US10656163B2 (en) | 2014-09-02 | 2020-05-19 | Wallac Oy | Method for determining risk of pre-eclampsia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04505804A (ja) * | 1988-12-14 | 1992-10-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 子癇前症の検出のための診断的検定 |
| US5712103A (en) * | 1995-02-13 | 1998-01-27 | Regents Of The University Of California | Diagnostic assay for the prediction of preeclampsia |
| GB9614615D0 (en) * | 1996-07-11 | 1996-09-04 | Isis Innovation | Diagnosis of pre-eclampsia |
| AU5331298A (en) | 1996-12-23 | 1998-07-17 | Cambridge University Technical Services Limited | Diagnosis and treatment of pathological pregnancies |
-
1998
- 1998-06-09 GB GBGB9812432.4A patent/GB9812432D0/en not_active Ceased
-
1999
- 1999-06-09 AU AU42802/99A patent/AU751415B2/en not_active Ceased
- 1999-06-09 JP JP2000553804A patent/JP2002517755A/ja active Pending
- 1999-06-09 EP EP99955538A patent/EP1084412A2/en not_active Withdrawn
- 1999-06-09 US US09/719,055 patent/US6735529B1/en not_active Expired - Fee Related
- 1999-06-09 WO PCT/GB1999/001828 patent/WO1999064860A2/en not_active Ceased
- 1999-06-09 CA CA002332349A patent/CA2332349A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999064860A3 (en) | 2000-03-02 |
| GB9812432D0 (en) | 1998-08-05 |
| AU4280299A (en) | 1999-12-30 |
| AU751415B2 (en) | 2002-08-15 |
| EP1084412A2 (en) | 2001-03-21 |
| JP2002517755A (ja) | 2002-06-18 |
| WO1999064860A2 (en) | 1999-12-16 |
| US6735529B1 (en) | 2004-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |