CA2332336A1 - Procede permettant d'augmenter des lymphocytes b de primates chez la souris immunodeprimee, et de produire de grands nombres de lymphocytes b specifiques de l'antigene pour la production d'anticorps monoclonaux de primates - Google Patents
Procede permettant d'augmenter des lymphocytes b de primates chez la souris immunodeprimee, et de produire de grands nombres de lymphocytes b specifiques de l'antigene pour la production d'anticorps monoclonaux de primates Download PDFInfo
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- CA2332336A1 CA2332336A1 CA002332336A CA2332336A CA2332336A1 CA 2332336 A1 CA2332336 A1 CA 2332336A1 CA 002332336 A CA002332336 A CA 002332336A CA 2332336 A CA2332336 A CA 2332336A CA 2332336 A1 CA2332336 A1 CA 2332336A1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/246—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne un procédé permettant de conférer des cellules de primate à une souris immunodéprimée. Ce procédé comprend les étapes consistant à: (a) préparer une souris immunodéprimée en lui administrant un anticorps contre la chaîne béta du récepteur (IL-2) de l'interleukine 2 de la souris, et plus particulièrement, l'anticorps monoclonal TM-.beta.1 de la souris et/ou en la soumettant à un rayonnement gamma; et (b) à administrer, par injection dans la rate de la souris immunodéprimée pré-traitée des cellules de primate. Ces cellules de primate proviennent, de préférence, d'un donneur primate et ce donneur peut avoir été immunisé par un antigène bien défini. Ce procédé permet d'augmenter de manière appropriée des lymphocytes B de primates chez un modèle animal avec rapidité et sans égal. D'autres modes de réalisation de la présente invention concernent des souris immunodéprimées obtenues par le procédé susmentionné et également l'utilisation de ces dernières comme modèles animaux, des cultures de lymphocytes B de primates ainsi produits et des anticorps monoclonaux de primates dérivés de ces dernières.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98870121.5 | 1998-05-26 | ||
| EP98870121 | 1998-05-26 | ||
| PCT/EP1999/003605 WO1999060846A1 (fr) | 1998-05-26 | 1999-05-25 | Procede permettant d'augmenter des lymphocytes b de primates chez la souris immunodeprimee, et de produire de grands nombres de lymphocytes b specifiques de l'antigene pour la production d'anticorps monoclonaux de primates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2332336A1 true CA2332336A1 (fr) | 1999-12-02 |
Family
ID=8237050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332336A Abandoned CA2332336A1 (fr) | 1998-05-26 | 1999-05-25 | Procede permettant d'augmenter des lymphocytes b de primates chez la souris immunodeprimee, et de produire de grands nombres de lymphocytes b specifiques de l'antigene pour la production d'anticorps monoclonaux de primates |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1079688A1 (fr) |
| AU (1) | AU751647B2 (fr) |
| CA (1) | CA2332336A1 (fr) |
| WO (1) | WO1999060846A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ521540A (en) | 2000-04-11 | 2004-09-24 | Genentech Inc | Multivalent antibodies and uses therefor |
| ATE321069T1 (de) | 2000-05-12 | 2006-04-15 | Vlaams Interuniv Inst Biotech | Verwendung von inhibitoren des plazenta wachstumsfactors für die behandlung einer pathologischen angiogenese, pathologischen arteriogenese, entzündung, tumorbildung und/oder gefässdurchlässigkeit (ödem) |
| CA2402459A1 (fr) | 2000-12-01 | 2002-06-06 | Central Institute For Experimental Animals | Procede pour produire une souris adaptee aux greffes, a la differenciation et a la proliferation de cellules heterogenes, souris obtenue selon cette methode et utilisation de la souris |
| EP1474444A1 (fr) | 2002-01-10 | 2004-11-10 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Nouveau variant a epissage du myd88 et utilisations correspondantes |
| BRPI0609151B8 (pt) | 2005-03-24 | 2021-05-25 | Life Sciences Res Partners Vzw | molécula de ligação ao antígeno capaz de se ligar a plgf, usos da mesma, linhagem celular de hibridoma, composição farmacêutica e polinucleotídeo |
| US7867490B2 (en) | 2005-06-30 | 2011-01-11 | Vib Vzw | Treatment of liver cirrhosis and its complications |
| DK2352761T3 (en) | 2008-10-02 | 2016-10-03 | Vib Vzw | INHIBITION OF PLGF TO TREAT PHILADELPHIA CHROMOSOMPOSITIVE LEUKEMIS |
| EP2756092A4 (fr) * | 2011-09-16 | 2015-10-28 | Giovanni Amabile | Procédés de fabrication de cellules, de tissus et d'anticorps |
| AU2012321082B2 (en) | 2011-12-01 | 2015-03-12 | Oxurion NV | Improving trabeculectomy outcome |
| EP2914628A1 (fr) | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | Anticorps qui se lie à cd269 (bcma) pouvant être utilisé dans le traitement de maladies des cellules plasmatiques comme le myélome multiple et les maladies auto-immunes |
| AR093447A1 (es) * | 2012-11-13 | 2015-06-10 | Genentech Inc | Enriquecimiento de plasmablastos especificos de antigeno |
| WO2017132627A2 (fr) | 2016-01-29 | 2017-08-03 | Achaogen, Inc. | Procédés de criblage permettant d'identifier des anticorps qui se lient à des épitopes à la surface des cellules |
| CA3026778A1 (fr) | 2016-06-07 | 2017-12-14 | Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft | Recepteur d'antigene chimere et cellules t-car se liant a bcma |
| CN111094349A (zh) | 2017-08-23 | 2020-05-01 | 马克思-德布鲁克-分子医学中心亥姆霍兹联合会 | 嵌合抗原受体和结合cxcr5的car-t细胞 |
| US20210230245A1 (en) | 2018-04-20 | 2021-07-29 | Medizinische Hochschule Hannover | Chimeric antigen receptor and car-t cells that bind a herpes virus antigen |
| ES2967879T3 (es) | 2019-03-25 | 2024-05-06 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Mejora de la actividad de los linfocitos T citolíticos mediante la inhibición de EBAG9 |
| JP2023540023A (ja) | 2020-08-24 | 2023-09-21 | シャリテ－ウニベルジテーツメディツィン ベルリン | Ｃｅａを認識するキメラ抗原受容体（ｃａｒ）発現細胞 |
| EP4199959A1 (fr) | 2020-08-24 | 2023-06-28 | Charité - Universitätsmedizin Berlin | Construction de récepteur antigénique chimérique codant pour une molécule inhibitrice de point de contrôle et une cytokine immunostimulante et cellules exprimant car reconnaissant cd44v6 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2071620T3 (es) * | 1987-12-23 | 1995-07-01 | Univ Leland Stanford Junior | Mamiferos inmunodeficientes quimericos y su utilizacion. |
| WO1993005796A1 (fr) * | 1991-09-19 | 1993-04-01 | The Scripps Research Institute | Procede de production d'anticorps humains dans un animal non humain, et animaux utilises a cet effet |
| CA2103693A1 (fr) * | 1993-08-06 | 1995-02-07 | Steven Gallinger | Modele animal du systeme immunitaire humain |
| AU6222996A (en) * | 1995-06-07 | 1996-12-30 | Novartis Ag | Human hepatocellular tissue in chimeric immunocompromised an imals |
-
1999
- 1999-05-25 CA CA002332336A patent/CA2332336A1/fr not_active Abandoned
- 1999-05-25 EP EP99926411A patent/EP1079688A1/fr not_active Withdrawn
- 1999-05-25 AU AU43681/99A patent/AU751647B2/en not_active Ceased
- 1999-05-25 WO PCT/EP1999/003605 patent/WO1999060846A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4368199A (en) | 1999-12-13 |
| AU751647B2 (en) | 2002-08-22 |
| WO1999060846A1 (fr) | 1999-12-02 |
| EP1079688A1 (fr) | 2001-03-07 |
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