CA2328984A1 - Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives - Google Patents

Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives Download PDF

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Publication number
CA2328984A1
CA2328984A1 CA002328984A CA2328984A CA2328984A1 CA 2328984 A1 CA2328984 A1 CA 2328984A1 CA 002328984 A CA002328984 A CA 002328984A CA 2328984 A CA2328984 A CA 2328984A CA 2328984 A1 CA2328984 A1 CA 2328984A1
Authority
CA
Canada
Prior art keywords
compound
formula
group
amino
cooh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002328984A
Other languages
English (en)
Inventor
Hassan Pajouhesh
Kenneth Curry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002328984A priority Critical patent/CA2328984A1/fr
Priority claimed from PCT/CA1999/000311 external-priority patent/WO1999054280A1/fr
Publication of CA2328984A1 publication Critical patent/CA2328984A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/28—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/383—Cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/90—Ring systems containing bridged rings containing more than four rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de cubane thérapeutiquement actifs, un procédé de préparation desdits composés et des compositions pharmaceutiques contenant lesdits composés. Ces nouveaux composés sont utiles pour le traitement de maladies du système nerveux central liées au système récepteur du glutamate métabotropique.
CA002328984A 1998-04-17 1999-04-19 Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives Abandoned CA2328984A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002328984A CA2328984A1 (fr) 1998-04-17 1999-04-19 Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,235,119 1998-04-17
CA2235119 1998-04-17
PCT/CA1999/000311 WO1999054280A1 (fr) 1998-04-17 1999-04-19 Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives
CA002328984A CA2328984A1 (fr) 1998-04-17 1999-04-19 Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives

Publications (1)

Publication Number Publication Date
CA2328984A1 true CA2328984A1 (fr) 1999-10-28

Family

ID=25680146

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328984A Abandoned CA2328984A1 (fr) 1998-04-17 1999-04-19 Derives du cubane agissant comme antagonistes du recepteur du glutamate metabotropique, et procede de preparation desdits derives

Country Status (1)

Country Link
CA (1) CA2328984A1 (fr)

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