CA2328132A1 - Precurseur de chaine lourde d'inhibiteur de protease associe a la croissance - Google Patents

Precurseur de chaine lourde d'inhibiteur de protease associe a la croissance Download PDF

Info

Publication number
CA2328132A1
CA2328132A1 CA002328132A CA2328132A CA2328132A1 CA 2328132 A1 CA2328132 A1 CA 2328132A1 CA 002328132 A CA002328132 A CA 002328132A CA 2328132 A CA2328132 A CA 2328132A CA 2328132 A1 CA2328132 A1 CA 2328132A1
Authority
CA
Canada
Prior art keywords
leu
val
gapip
gly
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002328132A
Other languages
English (en)
Inventor
Jennifer L. Hillman
Karl J. Guegler
Chandra Patterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2328132A1 publication Critical patent/CA2328132A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne un précurseur de chaîne lourde d'inhibiteur de protéase associé à la croissance (GAPIP) humaine, et des polynucléotides qui identifient et codent pour GAPIP. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps, des agonistes et des antagonistes. L'invention concerne également des méthodes diagnostiques, de traitement ou de prévention de troubles associés à l'expression de GAPIP.
CA002328132A 1998-05-07 1999-05-05 Precurseur de chaine lourde d'inhibiteur de protease associe a la croissance Abandoned CA2328132A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/074,579 US6001596A (en) 1998-05-07 1998-05-07 Growth-associated protease inhibitor heavy chain precursor
US09/074,579 1998-05-07
PCT/US1999/009947 WO1999057140A2 (fr) 1998-05-07 1999-05-05 Precurseur de chaine lourde d'inhibiteur de protease associe a la croissance

Publications (1)

Publication Number Publication Date
CA2328132A1 true CA2328132A1 (fr) 1999-11-11

Family

ID=22120329

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328132A Abandoned CA2328132A1 (fr) 1998-05-07 1999-05-05 Precurseur de chaine lourde d'inhibiteur de protease associe a la croissance

Country Status (6)

Country Link
US (3) US6001596A (fr)
EP (1) EP1078062A2 (fr)
JP (1) JP2002513553A (fr)
AU (1) AU3886799A (fr)
CA (1) CA2328132A1 (fr)
WO (1) WO1999057140A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US6797489B2 (en) * 2000-01-03 2004-09-28 Tr Associates, L.L.C. PP14 fusion proteins and methods for making and using the same
US20060212442A1 (en) * 2001-05-16 2006-09-21 Pandora Media, Inc. Methods of Presenting and Providing Content to a User
US20060206478A1 (en) * 2001-05-16 2006-09-14 Pandora Media, Inc. Playlist generating methods
US20030100009A1 (en) * 2001-11-23 2003-05-29 George Jackowski Inter alpha trypsin inhibitor biopolymer markers indicative of insulin resistance
AU2003239871A1 (en) * 2002-05-22 2003-12-12 Incyte Corporation Protein modification and maintenance molecules
DK2311432T3 (en) * 2002-06-07 2015-02-02 Dyax Corp Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT1663281E (pt) * 2003-08-29 2014-03-17 Dyax Corp Inibidores de proteases poli-peguilados
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2009026334A2 (fr) * 2007-08-21 2009-02-26 Genzyme Corporation Traitement par des inhibiteurs de la kallikréine
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
ES2905545T3 (es) 2010-01-06 2022-04-11 Takeda Pharmaceuticals Co Proteínas de unión a calicreína plasmática
KR102502293B1 (ko) 2011-01-06 2023-02-21 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
EP2825892A1 (fr) * 2012-03-14 2015-01-21 Centre Hospitalier Universitaire Pontchaillou Itih5 comme marqueur de diagnostic de développement utérin et de défauts fonctionnels
CA2942713A1 (fr) 2014-03-27 2015-10-01 Dyax Corp. Compositions et procedes pour le traitement de l'oedeme maculaire diabetique
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека
DE102018124022A1 (de) * 2018-09-28 2020-04-02 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Hyaluronsäurestabilisator
CN113092773A (zh) * 2019-12-23 2021-07-09 首都医科大学附属北京世纪坛医院 尿液α-胰蛋白酶抑制剂重链H4及其多肽片段在过敏性疾病中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166133A (en) * 1991-04-17 1992-11-24 Cetus Corporation Method for inhibing adhesion of white blood cells to endothelial cells
WO1999028462A2 (fr) * 1997-12-03 1999-06-10 Genentech, Inc. Polypeptides et acides nucleiques codant ces derniers
US5700924A (en) * 1995-06-07 1997-12-23 Incyte Pharmaceuticals, Inc. Serpin derived from human hypothalamus
WO1997014797A2 (fr) * 1995-10-20 1997-04-24 Dana-Farber Cancer Institute Nouvel inhibiteur de cysteine proteinase, la cystatine m

Also Published As

Publication number Publication date
AU3886799A (en) 1999-11-23
US6228991B1 (en) 2001-05-08
WO1999057140A2 (fr) 1999-11-11
JP2002513553A (ja) 2002-05-14
EP1078062A2 (fr) 2001-02-28
WO1999057140A3 (fr) 1999-12-29
US20020099178A1 (en) 2002-07-25
US6001596A (en) 1999-12-14

Similar Documents

Publication Publication Date Title
US20010010913A1 (en) Extracellular adhesive proteins
US6228991B1 (en) Growth-associated protease inhibitor heavy chain precursor
US20020031506A1 (en) Human glutathione peroxidase-6
EP1067893A2 (fr) Galactosyltransferases humaines
EP1068236A1 (fr) Recepteur de lipoproteines de faible poids moleculaire (ldl) oxydees de l'etre humain
CA2347113A1 (fr) Proteine humaine de la famille des ankyrines
EP1104473A2 (fr) Proteases et proteines associees
EP1076711A2 (fr) Proteines associees a l'apoptose humaine
US6391580B1 (en) Ras proteins
US6348576B1 (en) Human cornichon molecule
US6171790B1 (en) Human protease associated proteins
US6077693A (en) Polynucleotide encoding a promonocyte associated protein
WO2000003015A2 (fr) Homologues de proteine humaine de transport
US20030045466A1 (en) Calcium binding protein
US6277568B1 (en) Nucleic acids encoding human ubiquitin-conjugating enzyme homologs
WO1998055510A2 (fr) Proteines liees aux cyclines
EP1097203A1 (fr) Proteine humaine associee a la preseniline
US5952479A (en) Human arsenite-resistance protein
WO2000008156A2 (fr) Proteines associees a la reparation et a la replication d'adn humain
EP1100909A2 (fr) Proteines associees a la reparation et a la replication d'adn humain
CA2325848A1 (fr) Proteine liee au facteur de croissance des lymphocytes b
CA2333471A1 (fr) Molecules apparentees a l'alcool-deshydrogenase chaine courte de type humain, scrm-1 et scrm-2

Legal Events

Date Code Title Description
FZDE Discontinued