CA2323637A1 - Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines - Google Patents
Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines Download PDFInfo
- Publication number
- CA2323637A1 CA2323637A1 CA002323637A CA2323637A CA2323637A1 CA 2323637 A1 CA2323637 A1 CA 2323637A1 CA 002323637 A CA002323637 A CA 002323637A CA 2323637 A CA2323637 A CA 2323637A CA 2323637 A1 CA2323637 A1 CA 2323637A1
- Authority
- CA
- Canada
- Prior art keywords
- rap
- protein
- cells
- rip
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne une nouvelle protéine capable de moduler ou d'intervenir dans l'activité intracellulaire de RIP dans des voies d'inflammation, de survie cellulaire et de mort cellulaire. Font aussi l'objet de cette invention l'ADN codant pour cette protéine, son procédé de production et ses applications.
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12602498A IL126024A0 (en) | 1998-03-19 | 1998-09-01 | Modulators of the function of receptors of the tnf/ngf receptor family and other proteins |
AT99910646T ATE318310T1 (de) | 1998-03-19 | 1999-03-18 | Modulatoren der funktion von rezeptoren der tnf/ngf rezeptorenfamilie |
PCT/IL1999/000158 WO1999047672A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
EA200000961A EA004062B1 (ru) | 1998-03-19 | 1999-03-18 | Модуляторы функций рецепторов семейства рецепторов tnf/ngf и других белков |
ES99910646T ES2258838T3 (es) | 1998-03-19 | 1999-03-18 | Moduladores de la funcion de los receptores de la familia de receptores de tnf/ngf. |
SK1376-2000A SK285804B6 (sk) | 1998-03-19 | 1999-03-18 | DNA sekvencia, ktorá kóduje RAP-2 proteín, replikovateľné expresné vehikulum, transformované eukaryotické alebo prokaryotické hostiteľské bunky, RAP-2 proteín, spôsob jeho výroby, protilátky, farmaceutický prostriedok s ich obsahom a ich použitie |
NZ506776A NZ506776A (en) | 1998-03-19 | 1999-03-18 | Modulators of the function of receptors of the tnf/ngf receptor family and other proteins |
EP99910646A EP1062336B1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf |
CA002625284A CA2625284A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
EEP200000538A EE200000538A (et) | 1998-03-19 | 1999-03-18 | TNF/NGF retseptoriperekonna retseptorite ja muudevalkude talitluse modulaatorid, nende valmistamine ja kasutamine ning farmatseutiline kompositsioon |
AU29545/99A AU760900B2 (en) | 1998-03-19 | 1999-03-18 | Modulators of the function of receptors of the TNF/NGF receptor family and other proteins |
PT99910646T PT1062336E (pt) | 1998-03-19 | 1999-03-18 | Moduladores da funcao de receptores da familia dos receptores tnf/ngf e outras proteinas |
JP2000536855A JP4351389B2 (ja) | 1998-03-19 | 1999-03-18 | Tnf/ngfレセプターファミリーおよびほかのタンパク質のレセプター機能調節物質 |
DE69929958T DE69929958T2 (de) | 1998-03-19 | 1999-03-18 | Modulatoren der funktion von rezeptoren der tnf/ngf rezeptorenfamilie |
US09/646,403 US6734174B1 (en) | 1998-03-19 | 1999-03-18 | Modulators of the function of receptors of the TNF/NGF receptor |
NZ52556699A NZ525566A (en) | 1998-03-19 | 1999-03-18 | Modulators of the function of receptors of the TNF/NGF receptor family and other proteins |
CNB998041513A CN1232641C (zh) | 1998-03-19 | 1999-03-18 | Tnf/ngf受体家族和其它蛋白质的受体的功能的调节剂 |
HU0101612A HUP0101612A3 (en) | 1998-03-19 | 1999-03-18 | Modulators of the function of receptors of the tnf/ngf receptor family and other proteins |
PL343262A PL200763B1 (pl) | 1998-03-19 | 1999-03-18 | Sekwencja DNA i kodowane przez nią białko RAP-2, izoforma, fragment, analog funkcjonalny i pochodna, oraz sposób ich wytwarzania, nośnik ekspresji i transformowana nim komórka gospodarza, przeciwciało i jego czynny fragment i pochodna, kompozycja farmaceutyczna oraz zastosowania |
BR9909659-5A BR9909659A (pt) | 1998-03-19 | 1999-03-18 | Moduladores da função de receptores da famìlia dos receptores para tnf/ngf e outras proteìnas |
KR1020057019204A KR100748293B1 (ko) | 1998-03-19 | 1999-03-18 | Tnf/ngf 수용체 페밀리와 다른 단백질의 수용체의기능조절물질 |
DK99910646T DK1062336T3 (da) | 1998-03-19 | 1999-03-18 | Modulatorer af funktionen af receptorer af TNF/NGF-receptorfamilien |
CA002323637A CA2323637A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
BG104769A BG64990B1 (bg) | 1998-03-19 | 2000-09-14 | Модулатори на функцията на рецептори от tnf/ngf рецепторното семейство и други протеини |
NO20004649A NO327854B1 (no) | 1998-03-19 | 2000-09-18 | DNA-sekvens, replikerbar ekspresjonsvektor, transformert eukaryot eller prokaryot vertscelle; RAP-2 protein, isoform, fragment, funksjonell analog eller derivater derav samt fremgangsmate for fremstilling og anvendelse derav; farmasoytisk preparat, anvendelse av en rekombinant dyrevirusvektor og en vektor kodende for ribozym sekvens. |
HK01105500A HK1034995A1 (en) | 1998-03-19 | 2001-08-08 | Modulators of the function of receptors of the tnf/ngf receptor family and other proteins |
BG109537A BG65684B1 (bg) | 1998-03-19 | 2006-05-09 | Модулатори на функцията на рецептори от tnf/ngf рецептурното семейство и други протеини |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12375898A IL123758A0 (en) | 1998-03-19 | 1998-03-19 | Modulators of the function of receptors of the TNF/NGF receptor family and other proteins |
IL123758 | 1998-03-19 | ||
IL12602498A IL126024A0 (en) | 1998-03-19 | 1998-09-01 | Modulators of the function of receptors of the tnf/ngf receptor family and other proteins |
IL126024 | 1998-09-01 | ||
PCT/IL1999/000158 WO1999047672A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
CA002323637A CA2323637A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002625284A Division CA2625284A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2323637A1 true CA2323637A1 (fr) | 1999-09-23 |
Family
ID=39598416
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002625284A Abandoned CA2625284A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
CA002323637A Abandoned CA2323637A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002625284A Abandoned CA2625284A1 (fr) | 1998-03-19 | 1999-03-18 | Modulateurs de la fonction de recepteurs de la famille des recepteurs tnf/ngf et d'autres proteines |
Country Status (24)
Country | Link |
---|---|
US (1) | US6734174B1 (fr) |
EP (1) | EP1062336B1 (fr) |
JP (1) | JP4351389B2 (fr) |
KR (1) | KR100748293B1 (fr) |
CN (1) | CN1232641C (fr) |
AT (1) | ATE318310T1 (fr) |
AU (1) | AU760900B2 (fr) |
BG (2) | BG64990B1 (fr) |
BR (1) | BR9909659A (fr) |
CA (2) | CA2625284A1 (fr) |
DE (1) | DE69929958T2 (fr) |
DK (1) | DK1062336T3 (fr) |
EA (1) | EA004062B1 (fr) |
EE (1) | EE200000538A (fr) |
ES (1) | ES2258838T3 (fr) |
HK (1) | HK1034995A1 (fr) |
HU (1) | HUP0101612A3 (fr) |
IL (1) | IL126024A0 (fr) |
NO (1) | NO327854B1 (fr) |
NZ (2) | NZ506776A (fr) |
PL (1) | PL200763B1 (fr) |
PT (1) | PT1062336E (fr) |
SK (1) | SK285804B6 (fr) |
WO (1) | WO1999047672A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189832B1 (en) * | 1998-08-20 | 2007-03-13 | The Regents Of The University Of California | Gamma subunit of cytokine responsive IκB-alpha kinase complex and methods of using same |
US7745579B1 (en) | 1998-09-01 | 2010-06-29 | David Wallach | Inhibitor of NF-KB activation |
NZ530765A (en) | 2001-06-26 | 2006-11-30 | Amgen Fremont Inc | Antibodies that bind OPGL and compositions and methods for the treatment of bone diseases |
US7521534B1 (en) * | 2003-03-03 | 2009-04-21 | The University Board Of Regents Of Texas System | IKK gamma gene products and methods for making and using same |
US7700553B2 (en) | 2003-09-24 | 2010-04-20 | Institut Pasteur | Selective inhibition of NF-κB activation by peptides designed to disrupt nemo oligomerization |
KR101278690B1 (ko) | 2009-10-19 | 2013-06-24 | 한올바이오파마주식회사 | 변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법 |
CN102399819B (zh) * | 2011-08-24 | 2013-06-19 | 西北农林科技大学 | 一种质粒型腺病毒载体pAd-NRIP1及其构建方法 |
DE102011115480A1 (de) * | 2011-10-06 | 2013-04-11 | Biostep Gmbh | Substrat und Vorrichtung zur Chemilumineszenzdetektion |
EP3229807A4 (fr) | 2014-12-11 | 2018-10-17 | President and Fellows of Harvard College | Inhibiteurs de nécrose cellulaire et procédés associés |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
IL94039A (en) * | 1989-08-06 | 2006-09-05 | Yeda Res & Dev | Antibodies to tbp - 1 and their use |
DE69017753T3 (de) * | 1989-05-18 | 2013-06-20 | Yeda Research And Development Co., Ltd. | Tumor-Nekrosefaktor-Bindungsprotein II, seine Reinigung und spezifische Antikörper |
ES2242195T3 (es) | 1995-02-22 | 2005-11-01 | YEDA RESEARCH & DEVELOPMENT COMPANY, LTD. | Moduladores de proteinas reguladoras. |
US5674734A (en) * | 1995-05-18 | 1997-10-07 | President And Fellows Of Harvard College | Cell death protein |
AU7457796A (en) | 1995-10-23 | 1997-05-15 | Tularik Inc. | Rip: novel human protein involved in tumor necrosis factor signal transduction, and screening assays |
JP2000512494A (ja) * | 1996-05-29 | 2000-09-26 | ジェンザイム・コーポレーション | 細胞増殖調節遺伝子 |
-
1998
- 1998-09-01 IL IL12602498A patent/IL126024A0/xx unknown
-
1999
- 1999-03-18 PT PT99910646T patent/PT1062336E/pt unknown
- 1999-03-18 CA CA002625284A patent/CA2625284A1/fr not_active Abandoned
- 1999-03-18 ES ES99910646T patent/ES2258838T3/es not_active Expired - Lifetime
- 1999-03-18 EE EEP200000538A patent/EE200000538A/xx unknown
- 1999-03-18 JP JP2000536855A patent/JP4351389B2/ja not_active Expired - Fee Related
- 1999-03-18 BR BR9909659-5A patent/BR9909659A/pt not_active Application Discontinuation
- 1999-03-18 AU AU29545/99A patent/AU760900B2/en not_active Ceased
- 1999-03-18 WO PCT/IL1999/000158 patent/WO1999047672A1/fr active Application Filing
- 1999-03-18 NZ NZ506776A patent/NZ506776A/xx unknown
- 1999-03-18 NZ NZ52556699A patent/NZ525566A/xx unknown
- 1999-03-18 EA EA200000961A patent/EA004062B1/ru unknown
- 1999-03-18 SK SK1376-2000A patent/SK285804B6/sk not_active IP Right Cessation
- 1999-03-18 PL PL343262A patent/PL200763B1/pl not_active IP Right Cessation
- 1999-03-18 CA CA002323637A patent/CA2323637A1/fr not_active Abandoned
- 1999-03-18 HU HU0101612A patent/HUP0101612A3/hu unknown
- 1999-03-18 DE DE69929958T patent/DE69929958T2/de not_active Expired - Fee Related
- 1999-03-18 CN CNB998041513A patent/CN1232641C/zh not_active Expired - Fee Related
- 1999-03-18 US US09/646,403 patent/US6734174B1/en not_active Expired - Fee Related
- 1999-03-18 KR KR1020057019204A patent/KR100748293B1/ko not_active IP Right Cessation
- 1999-03-18 DK DK99910646T patent/DK1062336T3/da active
- 1999-03-18 AT AT99910646T patent/ATE318310T1/de not_active IP Right Cessation
- 1999-03-18 EP EP99910646A patent/EP1062336B1/fr not_active Expired - Lifetime
-
2000
- 2000-09-14 BG BG104769A patent/BG64990B1/bg unknown
- 2000-09-18 NO NO20004649A patent/NO327854B1/no not_active IP Right Cessation
-
2001
- 2001-08-08 HK HK01105500A patent/HK1034995A1/xx not_active IP Right Cessation
-
2006
- 2006-05-09 BG BG109537A patent/BG65684B1/bg unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |