CA2321168A1 - Activation de la proliferation des keratinocytes - Google Patents

Activation de la proliferation des keratinocytes Download PDF

Info

Publication number
CA2321168A1
CA2321168A1 CA002321168A CA2321168A CA2321168A1 CA 2321168 A1 CA2321168 A1 CA 2321168A1 CA 002321168 A CA002321168 A CA 002321168A CA 2321168 A CA2321168 A CA 2321168A CA 2321168 A1 CA2321168 A1 CA 2321168A1
Authority
CA
Canada
Prior art keywords
seq
group
active agent
pro
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002321168A
Other languages
English (en)
Inventor
Kathleen E. Rodgers
Gere Dizerega
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2321168A1 publication Critical patent/CA2321168A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C12N5/063—Kereatinocyte stem cells; Keratinocyte progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des procédés, des milieux de culture cellulaire améliorés et des ensembles de matériel permettant d'activer la prolifération et la différentiation des cellules souche épithéliales et des kératinocytes par une croissance effectuée en présence d'antgiotensinogènes, d'AI, d'analogues d'AI et/ou de fragments d'AI et d'analogues de ces derniers, d'analogues d'AII, de fragments ou d'analogues d'AII, d'agonistes de récepteurs d'AII AT¿2? de type 2, utilisés seuls ou combinés à d'autres facteurs de croissance et cytokines.
CA002321168A 1998-02-09 1999-02-08 Activation de la proliferation des keratinocytes Abandoned CA2321168A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7410598P 1998-02-09 1998-02-09
US60/074,105 1998-02-09
PCT/US1999/002725 WO1999040107A2 (fr) 1998-02-09 1999-02-08 Activation de la proliferation des keratinocytes

Publications (1)

Publication Number Publication Date
CA2321168A1 true CA2321168A1 (fr) 1999-08-12

Family

ID=22117765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002321168A Abandoned CA2321168A1 (fr) 1998-02-09 1999-02-08 Activation de la proliferation des keratinocytes

Country Status (5)

Country Link
EP (1) EP1053005A2 (fr)
JP (1) JP2002502858A (fr)
AU (1) AU2593599A (fr)
CA (1) CA2321168A1 (fr)
WO (1) WO1999040107A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002522505A (ja) 1998-08-13 2002-07-23 ユニヴァースティ オブ サザーン カリフォルニア 虚血組織への血流を増加させる方法
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
US6747008B1 (en) 2000-06-19 2004-06-08 University Of Southern California Methods for treating and preventing alopecia
AU2002257970B2 (en) 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
JP4623967B2 (ja) 2002-01-14 2011-02-02 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 幹細胞の移動および増殖を促進するための修飾されたピリミジン化合物の使用
US7998737B2 (en) 2006-09-12 2011-08-16 Deutsches Krebsforschungszentrum Cell culture of keratinocytes under non-differentiating conditions
AT508569A1 (de) * 2009-07-23 2011-02-15 Affiris Ag Pharmaceutical compound
EP2455388A1 (fr) 2010-11-23 2012-05-23 LanthioPep B.V. Nouveaux agonistes du récepteur 2 (AT2) de type angiotensine et leurs utilisations
PT2536422E (pt) 2011-02-02 2014-07-18 Univ Southern California Métodos para o tratamento de úlceras do pé diabético
WO2016107879A2 (fr) * 2014-12-30 2016-07-07 Vicore Pharma Ab Nouvelle utilisation d'agonistes du récepteur de l'angiotensine ii
US20220257698A1 (en) 2019-08-02 2022-08-18 Lanthiopep B.V. Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955430A (en) * 1993-09-24 1999-09-21 University Of Southern California Use of angiotensin II fragments and analogs thereof in tissue repair
US5693332C1 (en) * 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure

Also Published As

Publication number Publication date
JP2002502858A (ja) 2002-01-29
EP1053005A2 (fr) 2000-11-22
AU2593599A (en) 1999-08-23
WO1999040107A2 (fr) 1999-08-12
WO1999040107A3 (fr) 1999-09-30

Similar Documents

Publication Publication Date Title
US6248587B1 (en) Method for promoting mesenchymal stem and lineage-specific cell proliferation
US7744927B2 (en) Methods of promoting hematopoietic and mesenchymal cell proliferation and differentiation
US6482800B1 (en) Methods to stimulate angiogenesis
US6239109B1 (en) Method of promoting erythropoiesis
US6498138B1 (en) Method of promoting production of living tissue equivalents
EP1158997A2 (fr) Methode de stimulation de la proliferation de myocytes et de la reparation des tissus myocardiques
CA2321168A1 (fr) Activation de la proliferation des keratinocytes
WO1999026644A1 (fr) Procede favorisant la proliferation et la differentiation des cellules hematopoitiques et mesenchymateuses
AU2680999A (en) Method of promoting embryonic stem cell proliferation
AU750029B2 (en) Method of promoting neuronal cell proliferation and diffrentiation
WO1999039743A2 (fr) Procede de stimulation de la proliferation des cellules hepatiques
MXPA00007704A (en) Method of promoting keratinocyte proliferation
EP1410801A1 (fr) Procédé favorisant la prolifération et la différentiation des cellules hématopoitiques
MXPA00008070A (es) Metodo para promover la proliferacion de celulaspluripotenciales embrionicas
CA2339328A1 (fr) Proteines associees au recepteur de benzodiazepine du type peripherique, clonage, expression et procedes d'utilisation de celles-ci
MXPA01001638A (en) Methods to increase blood flow to ischemic tissue
MXPA00007509A (en) Method of promoting erythropoiesis
MXPA00008071A (en) Method of promoting neuronal cell proliferation and diffrentiation

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued