CA2319119C - Modele de circulation cerebrale et applications correspondantes - Google Patents
Modele de circulation cerebrale et applications correspondantes Download PDFInfo
- Publication number
- CA2319119C CA2319119C CA002319119A CA2319119A CA2319119C CA 2319119 C CA2319119 C CA 2319119C CA 002319119 A CA002319119 A CA 002319119A CA 2319119 A CA2319119 A CA 2319119A CA 2319119 C CA2319119 C CA 2319119C
- Authority
- CA
- Canada
- Prior art keywords
- model
- flow
- modeling
- living subject
- simulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004087 circulation Effects 0.000 title claims abstract description 46
- 230000002490 cerebral effect Effects 0.000 title abstract description 58
- 238000000034 method Methods 0.000 claims abstract description 73
- 238000005259 measurement Methods 0.000 claims description 57
- 210000001367 artery Anatomy 0.000 claims description 41
- 230000017531 blood circulation Effects 0.000 claims description 36
- 238000004088 simulation Methods 0.000 claims description 35
- 210000000275 circle of willis Anatomy 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 18
- 210000003484 anatomy Anatomy 0.000 claims description 8
- 238000002583 angiography Methods 0.000 claims description 8
- 238000013152 interventional procedure Methods 0.000 claims description 8
- 238000004422 calculation algorithm Methods 0.000 claims description 5
- 230000003727 cerebral blood flow Effects 0.000 abstract description 5
- 230000007404 cerebral physiology Effects 0.000 abstract description 2
- 230000000541 pulsatile effect Effects 0.000 description 26
- 238000005094 computer simulation Methods 0.000 description 23
- 230000008569 process Effects 0.000 description 22
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- 206010002329 Aneurysm Diseases 0.000 description 12
- 238000013459 approach Methods 0.000 description 12
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- 238000012278 balloon occlusion test Methods 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 11
- 210000004204 blood vessel Anatomy 0.000 description 10
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- 210000003657 middle cerebral artery Anatomy 0.000 description 10
- 238000001356 surgical procedure Methods 0.000 description 10
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- 238000002399 angioplasty Methods 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
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- 230000009286 beneficial effect Effects 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 238000003908 quality control method Methods 0.000 description 2
- 230000000250 revascularization Effects 0.000 description 2
- 210000001154 skull base Anatomy 0.000 description 2
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- 200000000007 Arterial disease Diseases 0.000 description 1
- 208000032862 Clinical Deterioration Diseases 0.000 description 1
- 208000003164 Diplopia Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 201000008450 Intracranial aneurysm Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000004497 NIR spectroscopy Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000002551 anterior cerebral artery Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 238000013172 carotid endarterectomy Methods 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000003728 cerebral autoregulation Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000011833 dog model Methods 0.000 description 1
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- 230000002708 enhancing effect Effects 0.000 description 1
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- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 238000007917 intracranial administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- 208000017376 neurovascular disease Diseases 0.000 description 1
- 230000009022 nonlinear effect Effects 0.000 description 1
- 210000001636 ophthalmic artery Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 210000003388 posterior cerebral artery Anatomy 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000010206 sensitivity analysis Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000003874 surgical anastomosis Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/484—Diagnostic techniques involving phase contrast X-ray imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0263—Measuring blood flow using NMR
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- High Energy & Nuclear Physics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Instructional Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7358098P | 1998-02-03 | 1998-02-03 | |
| US60/073,580 | 1998-02-03 | ||
| PCT/US1999/002276 WO1999038433A1 (fr) | 1998-02-03 | 1999-02-03 | Modele de circulation cerebrale et applications correspondantes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2319119A1 CA2319119A1 (fr) | 1999-08-05 |
| CA2319119C true CA2319119C (fr) | 2008-04-22 |
Family
ID=22114563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002319119A Expired - Lifetime CA2319119C (fr) | 1998-02-03 | 1999-02-03 | Modele de circulation cerebrale et applications correspondantes |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1059874A4 (fr) |
| JP (1) | JP2002501774A (fr) |
| AU (1) | AU762822B2 (fr) |
| CA (1) | CA2319119C (fr) |
| WO (1) | WO1999038433A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6860266B2 (en) | 2000-11-03 | 2005-03-01 | Dartmouth-Hitchcock Clinic | Physiological object displays |
| US7191110B1 (en) | 1998-02-03 | 2007-03-13 | University Of Illinois, Board Of Trustees | Patient specific circulation model |
| EP2028608A3 (fr) * | 1999-09-20 | 2009-03-04 | The Board Of Trustees Of The University Of Illinois | Modèle de circulation et applications |
| EP1377204A2 (fr) * | 2001-01-23 | 2004-01-07 | Alliance Pharmaceutical Corporation | Affichages d'objets physiologiques |
| US8062224B2 (en) * | 2004-10-28 | 2011-11-22 | Uab Vittamed | Method and apparatus for non-invasive continuous monitoring of cerebrovascular autoregulation state |
| US7865001B2 (en) * | 2004-12-17 | 2011-01-04 | Koninklijke Philips Electronics N.V. | System and method for predicting physical properties of an aneurysm from a three-dimensional model thereof |
| WO2007069166A2 (fr) * | 2005-12-15 | 2007-06-21 | Koninklijke Philips Electronics, N.V. | Systeme, dispositif et procede d'acquisition de flux reproductibles et comparables |
| JP2008161277A (ja) * | 2006-12-27 | 2008-07-17 | Hitachi Ltd | 血管情報管理装置 |
| US8200466B2 (en) | 2008-07-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Method for tuning patient-specific cardiovascular simulations |
| US9405886B2 (en) | 2009-03-17 | 2016-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining cardiovascular information |
| US8157742B2 (en) | 2010-08-12 | 2012-04-17 | Heartflow, Inc. | Method and system for patient-specific modeling of blood flow |
| US8315812B2 (en) | 2010-08-12 | 2012-11-20 | Heartflow, Inc. | Method and system for patient-specific modeling of blood flow |
| JP5745390B2 (ja) * | 2011-11-30 | 2015-07-08 | 富士フイルム株式会社 | 画像処理装置、方法およびプログラム |
| US8548778B1 (en) | 2012-05-14 | 2013-10-01 | Heartflow, Inc. | Method and system for providing information from a patient-specific model of blood flow |
| WO2016056643A1 (fr) * | 2014-10-08 | 2016-04-14 | イービーエム株式会社 | Dispositif de construction de forme de vaisseau sanguin pour la simulation d'un flux sanguin, méthode associée, et programme informatique |
| JP6513413B2 (ja) | 2015-02-13 | 2019-05-15 | キヤノンメディカルシステムズ株式会社 | 医用画像処理装置及び磁気共鳴イメージング装置 |
| IL246009B (en) | 2016-06-02 | 2018-11-29 | Ezer Haim | A system and method for monitoring the condition of a cerebral aneurysm |
| EP4410212A1 (fr) * | 2023-02-02 | 2024-08-07 | Koninklijke Philips N.V. | Appareil et procede de diagnostic vasculaire |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5151856A (en) * | 1989-08-30 | 1992-09-29 | Technion R & D Found. Ltd. | Method of displaying coronary function |
| US5273038A (en) * | 1990-07-09 | 1993-12-28 | Beavin William C | Computer simulation of live organ |
| US5603322A (en) * | 1993-01-19 | 1997-02-18 | Mcw Research Foundation | Time course MRI imaging of brain functions |
| FR2708166A1 (fr) * | 1993-07-22 | 1995-01-27 | Philips Laboratoire Electroniq | Procédé de traitement d'images numérisées pour la détection automatique de sténoses. |
| US5812691A (en) * | 1995-02-24 | 1998-09-22 | Udupa; Jayaram K. | Extraction of fuzzy object information in multidimensional images for quantifying MS lesions of the brain |
| JPH0966040A (ja) * | 1995-08-31 | 1997-03-11 | Res Dev Corp Of Japan | 磁気共鳴画像の取得方法と、糖尿病診断方法 |
| DE19620371A1 (de) * | 1996-05-21 | 1997-12-04 | Philips Patentverwaltung | Röntgenaufnahme-Verfahren |
-
1999
- 1999-02-03 CA CA002319119A patent/CA2319119C/fr not_active Expired - Lifetime
- 1999-02-03 EP EP99932414A patent/EP1059874A4/fr not_active Ceased
- 1999-02-03 WO PCT/US1999/002276 patent/WO1999038433A1/fr active IP Right Grant
- 1999-02-03 AU AU32858/99A patent/AU762822B2/en not_active Expired
- 1999-02-03 JP JP2000529172A patent/JP2002501774A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3285899A (en) | 1999-08-16 |
| CA2319119A1 (fr) | 1999-08-05 |
| JP2002501774A (ja) | 2002-01-22 |
| EP1059874A4 (fr) | 2003-05-07 |
| EP1059874A1 (fr) | 2000-12-20 |
| AU762822B2 (en) | 2003-07-03 |
| WO1999038433A1 (fr) | 1999-08-05 |
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|---|---|---|
| US11869669B2 (en) | Method and system for image processing to model vasculasture | |
| US7739090B2 (en) | Method and system for 3D blood vessel localization | |
| CA2319119C (fr) | Modele de circulation cerebrale et applications correspondantes | |
| EP1222627B1 (fr) | Modele de circulation et applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190204 |