CA2317760A1 - Derives de la piperazine en tant qu'antagonistes de la neurokinine - Google Patents

Derives de la piperazine en tant qu'antagonistes de la neurokinine Download PDF

Info

Publication number
CA2317760A1
CA2317760A1 CA002317760A CA2317760A CA2317760A1 CA 2317760 A1 CA2317760 A1 CA 2317760A1 CA 002317760 A CA002317760 A CA 002317760A CA 2317760 A CA2317760 A CA 2317760A CA 2317760 A1 CA2317760 A1 CA 2317760A1
Authority
CA
Canada
Prior art keywords
mmol
compound
piperazine
dichlorophenyl
endo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002317760A
Other languages
English (en)
Inventor
Ho-Jane Shue
Neng-Yang Shih
David J. Blythin
Xiao Chen
John J. Piwinski
Kevin D. Mccormick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2317760A1 publication Critical patent/CA2317760A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des antagonistes de la neurokinine de la formule (I) dans laquelle Z, R¿c?, y, m, u, Ar¿2?, n, X, R¿c'?, I et Ar¿2? sont tels que décrits dans le mémorandum descriptif. Ces composés sont efficaces dans le traitement de maladies telles que l'asthme, l'anxiété, la dépression, le vomissement et la nociception.
CA002317760A 1998-01-14 1999-01-11 Derives de la piperazine en tant qu'antagonistes de la neurokinine Abandoned CA2317760A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US694298A 1998-01-14 1998-01-14
US09/006,942 1998-01-14
PCT/US1999/000046 WO1999036424A1 (fr) 1998-01-14 1999-01-11 Derives de la piperazine en tant qu'antagonistes de la neurokinine

Publications (1)

Publication Number Publication Date
CA2317760A1 true CA2317760A1 (fr) 1999-07-22

Family

ID=21723387

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002317760A Abandoned CA2317760A1 (fr) 1998-01-14 1999-01-11 Derives de la piperazine en tant qu'antagonistes de la neurokinine

Country Status (10)

Country Link
EP (1) EP1047698A1 (fr)
JP (1) JP2002509151A (fr)
CN (1) CN1135232C (fr)
AR (1) AR014950A1 (fr)
AU (1) AU2101399A (fr)
CA (1) CA2317760A1 (fr)
CO (1) CO5080777A1 (fr)
PE (1) PE20000173A1 (fr)
WO (1) WO1999036424A1 (fr)
ZA (1) ZA99171B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007245435A1 (en) * 2006-04-26 2007-11-08 Merck & Co., Inc. Piperidines and related compounds for treatment of Alzheimer's disease
EP2117538A1 (fr) 2007-01-24 2009-11-18 Glaxo Group Limited Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-)
EP3072891A1 (fr) * 2015-03-24 2016-09-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Nouveaux Antagoniste de Récepteur 9 de type Toll

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9610277A (pt) * 1995-08-31 1999-07-06 Schering Corp Derivados de piperazino como antagonistas de neurowuinina
JP3292478B2 (ja) * 1996-10-30 2002-06-17 シェーリング コーポレイション ニューロキニンアンタゴニストとしてのピペラジノ誘導体

Also Published As

Publication number Publication date
WO1999036424A1 (fr) 1999-07-22
ZA99171B (en) 1999-07-12
CN1135232C (zh) 2004-01-21
CN1305481A (zh) 2001-07-25
AR014950A1 (es) 2001-04-11
EP1047698A1 (fr) 2000-11-02
PE20000173A1 (es) 2000-03-09
AU2101399A (en) 1999-08-02
CO5080777A1 (es) 2001-09-25
JP2002509151A (ja) 2002-03-26

Similar Documents

Publication Publication Date Title
CA2228370C (fr) Derives de piperazino antagonistes de la neurokinine
US7288656B2 (en) Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics
JP6294918B2 (ja) 選択的ＮＫ−３受容体拮抗薬としての新規なキラルＮ−アシル−５，６，７，（８位置換）−テトラヒドロ−［１，２，４］トリアゾロ［４，３−ａ］ピラジン、その医薬組成物、ＮＫ−３受容体媒介性障害で使用する方法およびキラル合成
US5795894A (en) Piperazino derivatives as neurokinn antagonists
US5869488A (en) Piperazino derivatives as neurokinin antagonists
JP2001507351A (ja) ニューロキニンアンタゴニストとしてのスピロ置換アザ環式置換ピペラジノ誘導体
TW201311674A (zh) 吲唑－及吡咯并吡啶－衍生物及其醫藥用途
US5670522A (en) Dopamine receptor subtype ligands
EP0927170B1 (fr) Derives piperazino a fonction antagoniste de la neurokinine
AU705683B2 (en) Piperazino derivatives as neurokinin antagonists
EA008921B1 (ru) Производные бензолсульфонамидов, способ их получения и их применение для лечения боли
JPWO2005030773A1 (ja) 新規ピラゾロピリミジン誘導体
US20090275555A1 (en) Substituted indole ligands for the ORL-1 receptor
CA2269128C (fr) Derives piperazino convenant comme antagonistes de la neurokinine
JP3001978B2 (ja) ブラジキニンアンタゴニストとしてのジヒドロピリジン誘導体
CA2317760A1 (fr) Derives de la piperazine en tant qu'antagonistes de la neurokinine
AU2012309556A1 (en) Pyrrolidine-3-ylacetic acid derivative
EP2346848B1 (fr) Dérivés de quinazoline comme antagonistes des récepteurs nk3
JPH06157518A (ja) 新規なオキサジアゾール誘導体又はその塩
MXPA00006906A (en) Piperazino derivatives as neurokinin antagonists
NZ318493A (en) Piperazino derivatives as neurokinin antagonists

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead