CA2314821A1 - Methodes permettant de conserver et de restaurer un phenotype approprie aux tissus dans les cellules des tissus mous - Google Patents

Methodes permettant de conserver et de restaurer un phenotype approprie aux tissus dans les cellules des tissus mous Download PDF

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Publication number
CA2314821A1
CA2314821A1 CA002314821A CA2314821A CA2314821A1 CA 2314821 A1 CA2314821 A1 CA 2314821A1 CA 002314821 A CA002314821 A CA 002314821A CA 2314821 A CA2314821 A CA 2314821A CA 2314821 A1 CA2314821 A1 CA 2314821A1
Authority
CA
Canada
Prior art keywords
morphogen
bmp
phenotype
cell
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002314821A
Other languages
English (en)
Inventor
Kuber T. Sampath
Charles M. Cohen
Eiichi Oeda
Kohei Miyazono
Masahiro Kawabata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARIEL THERAPEUTICS Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2314821A1 publication Critical patent/CA2314821A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

Cette invention concerne des méthodes permettant de conserver et de restaurer un phénotype approprié aux tissus dans des cellules pathologiques, lésées ou vieillies des tissus mous de mammifère ainsi que des méthodes permettant de traiter les troubles caractérisés par un niveau réduit d'expression endogène d'un morphogène. Les méthodes selon l'invention conviennent pour manipuler un ou plusieurs aspects des voies régulatrices, activées par un morphogène, de l'expression de la protéine spécifique du phénotype.
CA002314821A 1997-12-17 1998-12-16 Methodes permettant de conserver et de restaurer un phenotype approprie aux tissus dans les cellules des tissus mous Abandoned CA2314821A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6993197P 1997-12-17 1997-12-17
US60/069,931 1997-12-17
US11049898P 1998-12-01 1998-12-01
US60/110,498 1998-12-01
PCT/US1998/026788 WO1999031136A2 (fr) 1997-12-17 1998-12-16 Methodes permettant de conserver et de restaurer un phenotype approprie aux tissus dans les cellules des tissus mous

Publications (1)

Publication Number Publication Date
CA2314821A1 true CA2314821A1 (fr) 1999-06-24

Family

ID=26750579

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002314821A Abandoned CA2314821A1 (fr) 1997-12-17 1998-12-16 Methodes permettant de conserver et de restaurer un phenotype approprie aux tissus dans les cellules des tissus mous

Country Status (5)

Country Link
EP (1) EP1040126A2 (fr)
JP (1) JP2002508173A (fr)
AU (2) AU763488B2 (fr)
CA (1) CA2314821A1 (fr)
WO (1) WO1999031136A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US7087577B2 (en) 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6992066B2 (en) 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US20020173453A1 (en) * 2000-12-15 2002-11-21 Rama Akella Method of treating renal injury
US7232802B2 (en) 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
CN114470162B (zh) * 2022-01-28 2023-02-03 浙江大学 Gdf6及其过表达试剂在制备心肌细胞保护剂中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
DE69610826T2 (de) * 1995-03-01 2001-05-03 Stryker Corp Morphogeninduzierte regenerierung der dentin

Also Published As

Publication number Publication date
AU763488B2 (en) 2003-07-24
AU2003257871A1 (en) 2003-11-20
JP2002508173A (ja) 2002-03-19
EP1040126A2 (fr) 2000-10-04
AU1921899A (en) 1999-07-05
WO1999031136A3 (fr) 1999-08-26
WO1999031136A2 (fr) 1999-06-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20150710