CA2311170A1 - Famille nip3 de proteines - Google Patents
Famille nip3 de proteines Download PDFInfo
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- CA2311170A1 CA2311170A1 CA002311170A CA2311170A CA2311170A1 CA 2311170 A1 CA2311170 A1 CA 2311170A1 CA 002311170 A CA002311170 A CA 002311170A CA 2311170 A CA2311170 A CA 2311170A CA 2311170 A1 CA2311170 A1 CA 2311170A1
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- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000012301 transgenic model Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des protéines Nip, Nix et Nox purifiées et isolées, ainsi qu'un procédé d'induction de l'apoptose dans des cellules par transfection desdites cellules avec des protéines Nip, Nix et Nox. Elle concerne en outre un procédé d'induction de l'apoptose dans des cellules par création d'anticorps qui reconnaissent des protéines Nip, Nix et Nox spécifiques dans un muscle ou dans la peau d'un patient. Elle concerne encore un procédé d'induction de l'apoptose dans des cellules par création d'un transgène surexprimant le gène pour les protéines Nip, Nix et Nox. Elle concerne enfin un animal transgénique et sa descendance, possédant un facteur d'expression constitué essentiellement de protéines Nip, Nix et Nox choisies dans le groupe constitué essentiellement des Seq. ID No 1 à 6.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6664997P | 1997-11-24 | 1997-11-24 | |
| US60/066,649 | 1997-11-24 | ||
| US9815998P | 1998-08-27 | 1998-08-27 | |
| US60/098,159 | 1998-08-27 | ||
| PCT/IB1998/001959 WO1999027093A2 (fr) | 1997-11-24 | 1998-11-24 | Famille nip3 de proteines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2311170A1 true CA2311170A1 (fr) | 1999-06-03 |
Family
ID=26746998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002311170A Abandoned CA2311170A1 (fr) | 1997-11-24 | 1998-11-24 | Famille nip3 de proteines |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1034263A1 (fr) |
| AU (1) | AU1255999A (fr) |
| CA (1) | CA2311170A1 (fr) |
| WO (1) | WO1999027093A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999060124A2 (fr) * | 1998-05-15 | 1999-11-25 | Fei Huang | Sequences liees a la differenciation et procede d'utilisation correspondant |
| US7452869B2 (en) * | 2000-06-30 | 2008-11-18 | University Of Manitoba | NIP3 family of proteins |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858678A (en) * | 1994-08-02 | 1999-01-12 | St. Louis University | Apoptosis-regulating proteins |
| US5847093A (en) * | 1996-12-27 | 1998-12-08 | Incyte Pharmaceuticals, Inc. | Human apoptosis regulator |
-
1998
- 1998-11-24 CA CA002311170A patent/CA2311170A1/fr not_active Abandoned
- 1998-11-24 WO PCT/IB1998/001959 patent/WO1999027093A2/fr not_active Application Discontinuation
- 1998-11-24 AU AU12559/99A patent/AU1255999A/en not_active Abandoned
- 1998-11-24 EP EP98955851A patent/EP1034263A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1034263A1 (fr) | 2000-09-13 |
| AU1255999A (en) | 1999-06-15 |
| WO1999027093A2 (fr) | 1999-06-03 |
| WO1999027093A3 (fr) | 1999-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |