CA2308112A1 - Polypeptides de caspase-14 - Google Patents

Polypeptides de caspase-14 Download PDF

Info

Publication number
CA2308112A1
CA2308112A1 CA002308112A CA2308112A CA2308112A1 CA 2308112 A1 CA2308112 A1 CA 2308112A1 CA 002308112 A CA002308112 A CA 002308112A CA 2308112 A CA2308112 A CA 2308112A CA 2308112 A1 CA2308112 A1 CA 2308112A1
Authority
CA
Canada
Prior art keywords
caspase
polypeptide
amino acid
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308112A
Other languages
English (en)
Inventor
Steven M. Ruben
Jian Ni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2308112A1 publication Critical patent/CA2308112A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une nouvelle protéine Caspase-14 (également appelée ERICE) laquelle est un nouvel effecteur de l'apoptose. L'invention concerne notamment des molécules d'acide nucléique isolées codant la protéine Caspase-14 humaine. De plus, l'invention concerne des polypeptides de Caspase-14 de même que des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant leur production. En outre, l'invention concerne des méthodes de criblage pour identifier des agonistes et des antagonistes de l'activité Caspase-14, de même que des méthodes thérapeutiques de traitement de maladies et de troubles associés à l'apoptose.
CA002308112A 1997-10-30 1998-09-30 Polypeptides de caspase-14 Abandoned CA2308112A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6359297P 1997-10-30 1997-10-30
US7605098P 1998-02-26 1998-02-26
US60/076,050 1998-02-26
US60/063,592 1998-02-26
PCT/US1998/020452 WO1999023106A1 (fr) 1997-10-30 1998-09-30 Polypeptides de caspase-14

Publications (1)

Publication Number Publication Date
CA2308112A1 true CA2308112A1 (fr) 1999-05-14

Family

ID=26743557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308112A Abandoned CA2308112A1 (fr) 1997-10-30 1998-09-30 Polypeptides de caspase-14

Country Status (5)

Country Link
EP (1) EP1036086A1 (fr)
JP (1) JP2001521730A (fr)
AU (1) AU750170B2 (fr)
CA (1) CA2308112A1 (fr)
WO (1) WO1999023106A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6432628B1 (en) 1997-08-26 2002-08-13 Thomas Jefferson University Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use
US6340740B1 (en) 1997-08-26 2002-01-22 Thomas Jefferson University Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use
AU1521501A (en) * 1999-11-10 2001-06-06 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of caspase-14 and caspase-14 modulators to diagnose and/or treat skin, eye and brain disorders
WO2002000860A2 (fr) * 2000-06-26 2002-01-03 Sugen, Inc. Nouvelles proteases
CA2416691A1 (fr) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Proteases
EP2061500A2 (fr) * 2006-09-01 2009-05-27 VIB vzw Composition pharmaceutique et écran solaire comprenant de la caspase-14
JP5562015B2 (ja) * 2009-12-04 2014-07-30 株式会社 資生堂 皮膚バリアー機能回復促進物質のスクリーニング方法

Also Published As

Publication number Publication date
AU750170B2 (en) 2002-07-11
WO1999023106A1 (fr) 1999-05-14
EP1036086A1 (fr) 2000-09-20
JP2001521730A (ja) 2001-11-13
AU9673898A (en) 1999-05-24

Similar Documents

Publication Publication Date Title
US7223840B2 (en) Antimicrobial peptide
US20060240036A1 (en) I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
AU750170B2 (en) Caspase-14 polypeptides
US20020150992A1 (en) Chemokine alpha-5
CA2275540A1 (fr) Proteine specifique du cervelet et de l'embryon
US6232100B1 (en) Cortistatin Polypeptides
US6495322B1 (en) RAIDD, a novel death adaptor molecule
WO1998029438A9 (fr) Polypeptides de cortistatine
US6929921B2 (en) Antibody which binds human blue-light photoreceptor hCRY2
US20070020277A1 (en) Human Oncogene Induced Secreted Protein I
JPH10327881A (ja) 分泌マウスタンパク質ｓＦＲＰ−１に類似した新規ヒト 遺伝子
US20040063127A1 (en) Hematopoietic signaling factor
AU734384B2 (en) Apoptosis inducing molecule II
AU771013B2 (en) Apoptosis inducing molecule II
WO1998028420A1 (fr) Proteine secretrice de parotide humaine
AU2004202460A1 (en) Apoptosis Inducing Molecule II

Legal Events

Date Code Title Description
FZDE Dead