CA2307664A1 - Disinfecting contact lenses with bis(biguanides) and polymeric biguanides - Google Patents
Disinfecting contact lenses with bis(biguanides) and polymeric biguanides Download PDFInfo
- Publication number
- CA2307664A1 CA2307664A1 CA002307664A CA2307664A CA2307664A1 CA 2307664 A1 CA2307664 A1 CA 2307664A1 CA 002307664 A CA002307664 A CA 002307664A CA 2307664 A CA2307664 A CA 2307664A CA 2307664 A1 CA2307664 A1 CA 2307664A1
- Authority
- CA
- Canada
- Prior art keywords
- solution
- ppm
- lens
- biguanide
- disinfecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940123208 Biguanide Drugs 0.000 title claims abstract description 72
- 230000000249 desinfective effect Effects 0.000 title claims abstract description 59
- 150000004283 biguanides Chemical class 0.000 title claims description 24
- 239000000243 solution Substances 0.000 claims abstract description 151
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims abstract description 49
- 239000000203 mixture Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 28
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- 239000007864 aqueous solution Substances 0.000 claims abstract description 8
- -1 alkoxyalkyl ether Chemical compound 0.000 claims description 42
- 150000003839 salts Chemical class 0.000 claims description 29
- 238000004659 sterilization and disinfection Methods 0.000 claims description 20
- 239000004094 surface-active agent Substances 0.000 claims description 19
- 238000004140 cleaning Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 238000002791 soaking Methods 0.000 claims description 11
- 239000002736 nonionic surfactant Substances 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 7
- 239000012458 free base Substances 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
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- 230000000845 anti-microbial effect Effects 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000003389 potentiating effect Effects 0.000 abstract description 3
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- 229920002413 Polyhexanide Polymers 0.000 description 70
- 239000000047 product Substances 0.000 description 24
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 23
- 229950010221 alexidine Drugs 0.000 description 23
- 150000001875 compounds Chemical class 0.000 description 18
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- 239000000645 desinfectant Substances 0.000 description 15
- 230000003115 biocidal effect Effects 0.000 description 13
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- 244000005700 microbiome Species 0.000 description 10
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 10
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- 239000000882 contact lens solution Substances 0.000 description 9
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- 241000222122 Candida albicans Species 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 239000002280 amphoteric surfactant Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 150000004985 diamines Chemical class 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 6
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 5
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
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- 229910021538 borax Inorganic materials 0.000 description 4
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- IXBPPZBJIFNGJJ-UHFFFAOYSA-N sodium;cyanoiminomethylideneazanide Chemical compound [Na+].N#C[N-]C#N IXBPPZBJIFNGJJ-UHFFFAOYSA-N 0.000 description 4
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
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- 125000004183 alkoxy alkyl group Chemical group 0.000 description 3
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- 238000003780 insertion Methods 0.000 description 3
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- CXCSZVYZVSDARW-UHFFFAOYSA-N 1,2-dicyanoguanidine Chemical compound N#CNC(N)=NC#N CXCSZVYZVSDARW-UHFFFAOYSA-N 0.000 description 2
- IPVTWNBWVXXRLE-UHFFFAOYSA-N 1-(diaminomethylidene)-2-(2-ethylhexyl)guanidine Chemical compound CCCCC(CC)CNC(=N)NC(N)=N IPVTWNBWVXXRLE-UHFFFAOYSA-N 0.000 description 2
- YXZZOMVBHPCKMM-UHFFFAOYSA-N 2-[6-[[amino-(cyanoamino)methylidene]amino]hexyl]-1-cyanoguanidine Chemical compound N#CNC(N)=NCCCCCCN=C(N)NC#N YXZZOMVBHPCKMM-UHFFFAOYSA-N 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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- 229960003975 potassium Drugs 0.000 description 1
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- 235000011082 potassium citrates Nutrition 0.000 description 1
- JVUYWILPYBCNNG-UHFFFAOYSA-N potassium;oxido(oxo)borane Chemical compound [K+].[O-]B=O JVUYWILPYBCNNG-UHFFFAOYSA-N 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 239000002453 shampoo Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
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- 239000008223 sterile water Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- 239000011885 synergistic combination Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
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- 229910052725 zinc Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
- A61L12/142—Polymeric biguanides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/32—Amides; Substituted amides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3719—Polyamides or polyimides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
- C11D3/3773—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines in liquid compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/008—Polymeric surface-active agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/40—Specific cleaning or washing processes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6550197P | 1997-11-12 | 1997-11-12 | |
| US60/065,501 | 1997-11-12 | ||
| PCT/US1998/023818 WO1999024542A1 (en) | 1997-11-12 | 1998-11-10 | Disinfecting contact lenses with bis(biguanides) and polymeric biguanides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2307664A1 true CA2307664A1 (en) | 1999-05-20 |
Family
ID=22063167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002307664A Abandoned CA2307664A1 (en) | 1997-11-12 | 1998-11-10 | Disinfecting contact lenses with bis(biguanides) and polymeric biguanides |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1030902A1 (id) |
| JP (1) | JP2001522672A (id) |
| KR (1) | KR20010031986A (id) |
| CN (1) | CN1285866A (id) |
| BR (1) | BR9813994A (id) |
| CA (1) | CA2307664A1 (id) |
| ID (1) | ID25783A (id) |
| WO (1) | WO1999024542A1 (id) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000011514A1 (fr) * | 1998-08-21 | 2000-03-02 | Senju Pharmaceutical Co., Ltd. | Compositions destinees a des verres de contact |
| US6309596B1 (en) * | 1998-12-15 | 2001-10-30 | Bausch & Lomb Incorporated | Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by a poloxamine |
| JP2001242428A (ja) * | 1999-12-20 | 2001-09-07 | Tomey Corp | コンタクトレンズ用液剤およびソフトコンタクトレンズの洗浄、消毒、保存方法 |
| MY128134A (en) | 2000-09-28 | 2007-01-31 | Novartis Ag | Compositions and methods for cleaning contact lenses |
| WO2004112848A1 (en) * | 2003-06-16 | 2004-12-29 | Bausch & Lomb Incorporated | Lens care solutions for hydrogel contact lenses |
| WO2005016994A1 (en) * | 2003-08-18 | 2005-02-24 | Sk Chemicals Co., Ltd. | Method for preparing polyalkylenebiguanidine salt |
| US20060292105A1 (en) * | 2005-06-28 | 2006-12-28 | Lever O W Jr | Topical preservative compositions |
| CN102993056A (zh) * | 2012-12-04 | 2013-03-27 | 甘肃省化工研究院 | 一种双氯苯双胍己烷化合物的制备方法 |
| CN102993057B (zh) * | 2012-12-04 | 2014-09-17 | 甘肃省化工研究院 | 1,6-双氰基胍基己烷的合成方法 |
| US11044912B2 (en) | 2017-01-03 | 2021-06-29 | Hwang-Hsing Chen | Branched polymeric biguanide compounds and their uses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1432345A (en) * | 1972-04-13 | 1976-04-14 | Smith Enphew Research Ltd | Ophthalmic compositions and contact lens disinfecting compo sitions |
| US4758595A (en) * | 1984-12-11 | 1988-07-19 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| DE3575672D1 (de) * | 1985-07-22 | 1990-03-08 | Bausch & Lomb | Verfahren und loesung zur desinfektion und konservierung von kontaktlinsen. |
| US4891423A (en) * | 1989-03-20 | 1990-01-02 | Stockel Richard F | Polymeric biguanides |
| BR9405653A (pt) * | 1993-01-07 | 1995-11-14 | Polymer Technology Corp | Solução oftálmica solução aquosa para tratamento de lentes de contato método para tratar lentes de contato e método para preservar uma solução oftálmica |
| JPH0892017A (ja) * | 1994-09-19 | 1996-04-09 | Tomey Technol Corp | コンタクトレンズ用液剤 |
| BR9713049A (pt) * | 1996-11-13 | 2000-04-04 | Bausch & Lomb | Solução desinfetante oftalmicamente segura para uma lente de contato, método para desinfetar ou limpar e desinfetar uma lente de contato macia e kit para desinfetar ou desinfetar e limpar uma lente de contato. |
| EP0938344B1 (en) * | 1996-11-13 | 2002-02-20 | Bausch & Lomb Incorporated | Method for providing rapid disinfection of contact lenses |
-
1998
- 1998-11-10 EP EP98957702A patent/EP1030902A1/en not_active Withdrawn
- 1998-11-10 KR KR1020007005096A patent/KR20010031986A/ko not_active Application Discontinuation
- 1998-11-10 WO PCT/US1998/023818 patent/WO1999024542A1/en not_active Application Discontinuation
- 1998-11-10 ID IDW20000877A patent/ID25783A/id unknown
- 1998-11-10 JP JP2000520538A patent/JP2001522672A/ja active Pending
- 1998-11-10 BR BR9813994-0A patent/BR9813994A/pt not_active IP Right Cessation
- 1998-11-10 CA CA002307664A patent/CA2307664A1/en not_active Abandoned
- 1998-11-10 CN CN98811015A patent/CN1285866A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ID25783A (id) | 2000-11-02 |
| WO1999024542A1 (en) | 1999-05-20 |
| CN1285866A (zh) | 2001-02-28 |
| KR20010031986A (ko) | 2001-04-16 |
| JP2001522672A (ja) | 2001-11-20 |
| EP1030902A1 (en) | 2000-08-30 |
| BR9813994A (pt) | 2000-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20021112 |