CA2306246A1 - Proteines contenant un peptide signal et utilisation de ces dernieres - Google Patents

Proteines contenant un peptide signal et utilisation de ces dernieres Download PDF

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Publication number
CA2306246A1
CA2306246A1 CA002306246A CA2306246A CA2306246A1 CA 2306246 A1 CA2306246 A1 CA 2306246A1 CA 002306246 A CA002306246 A CA 002306246A CA 2306246 A CA2306246 A CA 2306246A CA 2306246 A1 CA2306246 A1 CA 2306246A1
Authority
CA
Canada
Prior art keywords
lsp
tap
nucleic acid
protein
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002306246A
Other languages
English (en)
Inventor
Yang Pan
David P. Gearing
Sean A. Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2306246A1 publication Critical patent/CA2306246A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

On décrit de nouvelles molécules de polypeptides, de protéines et d'acide nucléique de LSP-1, PA-I et TAP-1. Cette invention concerne des protéines isolées et entières LSP-1, PA-I et TAP-1 ainsi que des protéines de fusion isolées, des peptides antigéniques LSP-1, PA-I et TAP-1 et des anticorps anti-LSP-1, anti-PA-I et anti-TAP-1. Cette invention concerne également des molécules d'acide nucléique LSP-1, PA-I et TAP-1, des vecteurs d'expression de recombinaison contenant une molécule d'acide nucléique de l'invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène LSP-1, PA-I et TAP-1 a été introduit ou dissocié. On décrit également des procédés de diagnostic, de criblage et de thérapie dans lesquels on utilise les compositions de cette invention.
CA002306246A 1997-10-06 1998-10-06 Proteines contenant un peptide signal et utilisation de ces dernieres Abandoned CA2306246A1 (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US6114997P 1997-10-06 1997-10-06
US6115997P 1997-10-06 1997-10-06
US6114397P 1997-10-06 1997-10-06
US60/061,159 1997-10-06
US60/061,143 1997-10-06
US60/061,149 1997-10-06
US420698A 1998-01-08 1998-01-08
US09/004,206 1998-01-08
US1067498A 1998-01-22 1998-01-22
US09/010,674 1998-01-22
US1434798A 1998-01-27 1998-01-27
US09/014,347 1998-01-27
PCT/US1998/021151 WO1999018243A1 (fr) 1997-10-06 1998-10-06 Proteines contenant un peptide signal et utilisation de ces dernieres

Publications (1)

Publication Number Publication Date
CA2306246A1 true CA2306246A1 (fr) 1999-04-15

Family

ID=27555481

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002306246A Abandoned CA2306246A1 (fr) 1997-10-06 1998-10-06 Proteines contenant un peptide signal et utilisation de ces dernieres

Country Status (4)

Country Link
EP (1) EP1029034A4 (fr)
AU (1) AU9790798A (fr)
CA (1) CA2306246A1 (fr)
WO (1) WO1999018243A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105303A1 (en) 1996-12-06 2003-06-05 Schering Corporation, A New Jersey Corporation Isolated mammalian monocyte cell genes; related reagents
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
HU228582B1 (en) 1998-10-23 2013-04-29 Kirin Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
CN1352685A (zh) 1998-12-31 2002-06-05 先灵公司 单核细胞来源的核酸和相关的组合物及方法
CA3048093A1 (fr) * 2003-11-26 2005-06-23 Celera Corporation Polymorphismes nucleotides simples associes a des troubles cardiovasculaires et a une reponse au medicament, leurs procedes de detection et d'utilisation
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE456656T1 (de) * 1996-12-06 2010-02-15 Schering Corp Isolierte gene aus säuger monozyten und betreffende reagentien
WO1998025959A2 (fr) * 1996-12-11 1998-06-18 Chiron Corporation Proteines humaines secretees

Also Published As

Publication number Publication date
AU9790798A (en) 1999-04-27
WO1999018243A1 (fr) 1999-04-15
EP1029034A1 (fr) 2000-08-23
EP1029034A4 (fr) 2003-04-09

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued