CA2304981A1 - Antagonistes de la famille rho et leur utilisation pour bloquer l'inhibition de l'excroissance des neurites - Google Patents
Antagonistes de la famille rho et leur utilisation pour bloquer l'inhibition de l'excroissance des neurites Download PDFInfo
- Publication number
- CA2304981A1 CA2304981A1 CA002304981A CA2304981A CA2304981A1 CA 2304981 A1 CA2304981 A1 CA 2304981A1 CA 002304981 A CA002304981 A CA 002304981A CA 2304981 A CA2304981 A CA 2304981A CA 2304981 A1 CA2304981 A1 CA 2304981A1
- Authority
- CA
- Canada
- Prior art keywords
- rho
- growth
- rho family
- family members
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4722—G-proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Cette invention concerne l'utilisation d'antagonistes de Rho, ou de protéines apparentées à Rho en tant que cibles thérapeutiques pour des agents conçus pour bloquer l'inhibition de la croissance par la myéline ou des protéines myéliniques. Un mode de réalisation a trait à l'utilisation d'antagonistes de Rho développant la régénération des axones dans le système nerveux central. L'agent ou l'antagoniste thérapeutique peut se présenter sous la forme de petites molécules, protéines ou peptides, ou n'importe quel agent se liant à Rho ou aux membres de sa famille pour inactiver cette voie. On peut citer parmi les modes de réalisation l'utilisation de la voie régulatrice de Rho en tant que cible d'antagonistes de Rho; l'utilisation d'inhibiteurs de dissociation de GDP (GDI) inhibe la dissociation de GDP de Rho, et par conséquent empêche la liaison de GDP nécessaire à l'activation de Rho; l'utilisation d'une protéine d'activation de GTPase (GAP) spécifique de Rho en tant que cibles pour régulation de l'activité de Rho; l'utilisation d'agents stimulant la liaison de Rho à GDI et bloquant la liaison de Rho à la membrane du plasma est également considérée comme faisant partie de cette invention; l'utilisation de C3 transférase et de toxines apparentées telles que A et B, présentant une activité inhibitrice de Rho apparentée destinée à inactiver Rho et à stimuler la croissance des axones; et l'utilisation de formes négative dominantes de Rho, pour inactiver Rho, afin de développer la croissance des axones.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002304981A CA2304981A1 (fr) | 1997-10-31 | 1998-11-02 | Antagonistes de la famille rho et leur utilisation pour bloquer l'inhibition de l'excroissance des neurites |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002214841A CA2214841A1 (fr) | 1997-10-31 | 1997-10-31 | Les antagonistes rho et leurs utilisations pour arreter l'inhibition d'excroissance d'axone et des dendrites |
CA2,214,841 | 1997-10-31 | ||
CA002304981A CA2304981A1 (fr) | 1997-10-31 | 1998-11-02 | Antagonistes de la famille rho et leur utilisation pour bloquer l'inhibition de l'excroissance des neurites |
PCT/CA1998/001013 WO1999023113A2 (fr) | 1997-10-31 | 1998-11-02 | Antagonistes de la famille rho et leur utilisation pour bloquer l'inhibition de l'excroissance des neurites |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2304981A1 true CA2304981A1 (fr) | 1999-05-14 |
Family
ID=4161412
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002214841A Withdrawn CA2214841A1 (fr) | 1997-10-31 | 1997-10-31 | Les antagonistes rho et leurs utilisations pour arreter l'inhibition d'excroissance d'axone et des dendrites |
CA002304981A Abandoned CA2304981A1 (fr) | 1997-10-31 | 1998-11-02 | Antagonistes de la famille rho et leur utilisation pour bloquer l'inhibition de l'excroissance des neurites |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002214841A Withdrawn CA2214841A1 (fr) | 1997-10-31 | 1997-10-31 | Les antagonistes rho et leurs utilisations pour arreter l'inhibition d'excroissance d'axone et des dendrites |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1049715A2 (fr) |
AU (1) | AU9732198A (fr) |
CA (2) | CA2214841A1 (fr) |
WO (1) | WO1999023113A2 (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7141428B2 (en) | 2000-11-02 | 2006-11-28 | Mckerracher Lisa | Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof |
WO2008077236A1 (fr) * | 2006-12-22 | 2008-07-03 | Bioaxone Therapeutique Inc. | Protéines variantes de fusion d'adp-ribosyl transférase |
US7572913B2 (en) | 2004-02-24 | 2009-08-11 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
US7910554B2 (en) | 2001-04-12 | 2011-03-22 | Bioaxone Therapeutique Inc. | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions |
US9687483B2 (en) | 2015-01-26 | 2017-06-27 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors |
US10106525B2 (en) | 2015-01-26 | 2018-10-23 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US10149856B2 (en) | 2015-01-26 | 2018-12-11 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US10537567B2 (en) | 2017-07-11 | 2020-01-21 | BioAxone BioSciences, Inc. | Kinase inhibitors for treatment of disease |
US10857157B2 (en) | 2015-01-26 | 2020-12-08 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US11198680B2 (en) | 2016-12-21 | 2021-12-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03002410A (es) | 2000-09-20 | 2003-06-19 | Merck Patent Gmbh | 4-amino-quinazolinas. |
CN101310771B (zh) * | 2001-04-11 | 2012-08-08 | 千寿制药株式会社 | 视觉功能障碍改善剂 |
CA2367636C (fr) | 2001-04-12 | 2010-05-04 | Lisa Mckerracher | Proteines de fusion |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
WO2003030836A2 (fr) | 2001-10-12 | 2003-04-17 | Case Western Reserve University | Regeneration neuronale |
DE60320933D1 (de) | 2002-01-10 | 2008-06-26 | Bayer Healthcare Ag | Rho-kinase inhibitoren |
WO2003062227A1 (fr) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Inhibiteurs de kinase rho |
MXPA04007191A (es) | 2002-01-23 | 2005-03-31 | Bayer Pharmaceuticals Corp | Derivados de pirimidina como inhibidores de rho-quinasa. |
CA2513584A1 (fr) * | 2003-01-20 | 2004-08-05 | Vib Vzw | Utilisation de proteines yop ou d'inhibiteurs rho gtpase comme inhibiteurs de caspase-1 |
CN101340912A (zh) | 2005-12-22 | 2009-01-07 | 爱尔康研究有限公司 | 用于治疗rho激酶介导的疾病和病状的(吲唑-5-基)-吡嗪和(1,3-二氢-吲哚-2-酮)-吡嗪 |
US7867999B1 (en) | 2005-12-22 | 2011-01-11 | Alcon Research, Ltd. | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions |
AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
EP2177218A1 (fr) * | 2008-10-15 | 2010-04-21 | Medizinische Universität Wien | Thérapie régénératrice |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005723A1 (fr) * | 1988-11-24 | 1990-05-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane et leur utilisation en medecine |
WO1997018303A1 (fr) * | 1995-11-16 | 1997-05-22 | Novartis Ag | Proteine kinase rac utile en tant qu'agent therapeutique ou dans des diagnostics |
US6060297A (en) * | 1997-04-17 | 2000-05-09 | Incyte Pharmaceuticals, Inc. | Rho protein |
WO1999008533A1 (fr) * | 1997-08-13 | 1999-02-25 | Yale University | Regeneration d'axones dans le systeme nerveux central |
-
1997
- 1997-10-31 CA CA002214841A patent/CA2214841A1/fr not_active Withdrawn
-
1998
- 1998-11-02 EP EP98951138A patent/EP1049715A2/fr not_active Withdrawn
- 1998-11-02 WO PCT/CA1998/001013 patent/WO1999023113A2/fr not_active Application Discontinuation
- 1998-11-02 CA CA002304981A patent/CA2304981A1/fr not_active Abandoned
- 1998-11-02 AU AU97321/98A patent/AU9732198A/en not_active Abandoned
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7141428B2 (en) | 2000-11-02 | 2006-11-28 | Mckerracher Lisa | Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof |
US7491692B2 (en) | 2000-11-02 | 2009-02-17 | Mckerracher Lisa | Methods for making and delivering Rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof |
US7795218B2 (en) | 2001-04-12 | 2010-09-14 | Bioaxone Therapeutique Inc. | ADP-ribosyl transferase fusion variant proteins |
US7910554B2 (en) | 2001-04-12 | 2011-03-22 | Bioaxone Therapeutique Inc. | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions |
US7572913B2 (en) | 2004-02-24 | 2009-08-11 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
WO2008077236A1 (fr) * | 2006-12-22 | 2008-07-03 | Bioaxone Therapeutique Inc. | Protéines variantes de fusion d'adp-ribosyl transférase |
EP2407536A1 (fr) | 2006-12-22 | 2012-01-18 | Bioaxone Therapeutique Inc. | Protéines variantes de fusion d'ADP-ribosyl transférase |
US10106525B2 (en) | 2015-01-26 | 2018-10-23 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US9687483B2 (en) | 2015-01-26 | 2017-06-27 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors |
US10149856B2 (en) | 2015-01-26 | 2018-12-11 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US10526313B2 (en) | 2015-01-26 | 2020-01-07 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US10857157B2 (en) | 2015-01-26 | 2020-12-08 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US11701366B2 (en) | 2015-01-26 | 2023-07-18 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US11198680B2 (en) | 2016-12-21 | 2021-12-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US11814361B2 (en) | 2016-12-21 | 2023-11-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US10537567B2 (en) | 2017-07-11 | 2020-01-21 | BioAxone BioSciences, Inc. | Kinase inhibitors for treatment of disease |
Also Published As
Publication number | Publication date |
---|---|
AU9732198A (en) | 1999-05-24 |
WO1999023113A2 (fr) | 1999-05-14 |
CA2214841A1 (fr) | 1999-04-30 |
WO1999023113A3 (fr) | 1999-08-26 |
EP1049715A2 (fr) | 2000-11-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |