CA2304803A1 - Administration de proteines par l'expression des glandes secretoires - Google Patents
Administration de proteines par l'expression des glandes secretoires Download PDFInfo
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- CA2304803A1 CA2304803A1 CA002304803A CA2304803A CA2304803A1 CA 2304803 A1 CA2304803 A1 CA 2304803A1 CA 002304803 A CA002304803 A CA 002304803A CA 2304803 A CA2304803 A CA 2304803A CA 2304803 A1 CA2304803 A1 CA 2304803A1
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- dna
- protein
- pancreas
- insulin
- cells
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention porte sur les cellules des glandes sécrétoires, notamment les cellules des glandes pancréatiques, hépatiques et salivaires qui sont modifiées génétiquement pour incorporer un gène qui exprime une protéine ayant un effet thérapeutique désiré sur un sujet mammalien. La protéine exprimée est directement sécrétée dans le courant sanguin de façon à obtenir des taux thérapeutiques de la protéine en traitant le patient. Les cellules transformées des glandes sécrétoires permettent d'effectuer des thérapies à long et court terme pour les maladies associées à une déficience d'une protéine donnée ou qui peuvent être amenées à être traitées par la surexpression d'une protéine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/942,939 US6004944A (en) | 1995-03-24 | 1997-10-02 | Protein delivery by secretory gland expression |
| US08/942,939 | 1997-10-02 | ||
| PCT/US1998/020199 WO1999017610A1 (fr) | 1997-10-02 | 1998-09-24 | Administration de proteines par l'expression des glandes secretoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2304803A1 true CA2304803A1 (fr) | 1999-04-15 |
Family
ID=25478850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002304803A Abandoned CA2304803A1 (fr) | 1997-10-02 | 1998-09-24 | Administration de proteines par l'expression des glandes secretoires |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1030557A4 (fr) |
| JP (1) | JP2001518316A (fr) |
| AU (1) | AU744279B2 (fr) |
| CA (1) | CA2304803A1 (fr) |
| WO (1) | WO1999017610A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531455B1 (en) | 1995-03-24 | 2003-03-11 | The Regents Of The University Of California | Delivery of polynucleotides by secretory gland expression |
| CN100379860C (zh) * | 1999-04-23 | 2008-04-09 | 圭尔夫大学 | 表达唾液蛋白的转基因动物 |
| US7115795B1 (en) | 1999-04-23 | 2006-10-03 | University Of Guelph | Transgenic animals expressing salivary proteins |
| US9897565B1 (en) | 2012-09-11 | 2018-02-20 | Aseko, Inc. | System and method for optimizing insulin dosages for diabetic subjects |
| US9171343B1 (en) | 2012-09-11 | 2015-10-27 | Aseko, Inc. | Means and method for improved glycemic control for diabetic patients |
| US9486580B2 (en) | 2014-01-31 | 2016-11-08 | Aseko, Inc. | Insulin management |
| US9898585B2 (en) | 2014-01-31 | 2018-02-20 | Aseko, Inc. | Method and system for insulin management |
| US11081226B2 (en) | 2014-10-27 | 2021-08-03 | Aseko, Inc. | Method and controller for administering recommended insulin dosages to a patient |
| JP6989262B2 (ja) | 2014-10-27 | 2022-01-05 | アセコー インコーポレイテッド | 皮下外来患者管理 |
| JP6858751B2 (ja) | 2015-08-20 | 2021-04-14 | アセコー インコーポレイテッド | 糖尿病管理療法アドバイザ |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792751A (en) * | 1992-04-13 | 1998-08-11 | Baylor College Of Medicine | Tranformation of cells associated with fluid spaces |
| US5885971A (en) * | 1995-03-24 | 1999-03-23 | The Regents Of The University Of California | Gene therapy by secretory gland expression |
-
1998
- 1998-09-24 JP JP2000514522A patent/JP2001518316A/ja not_active Withdrawn
- 1998-09-24 WO PCT/US1998/020199 patent/WO1999017610A1/fr not_active Application Discontinuation
- 1998-09-24 AU AU96689/98A patent/AU744279B2/en not_active Ceased
- 1998-09-24 CA CA002304803A patent/CA2304803A1/fr not_active Abandoned
- 1998-09-24 EP EP98950707A patent/EP1030557A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU9668998A (en) | 1999-04-27 |
| EP1030557A1 (fr) | 2000-08-30 |
| EP1030557A4 (fr) | 2002-07-31 |
| WO1999017610A1 (fr) | 1999-04-15 |
| AU744279B2 (en) | 2002-02-21 |
| JP2001518316A (ja) | 2001-10-16 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |