CA2300964A1 - Stimulation modulation et/ou inhibition de l'activite protheolithique endotheliale et/ou de l'activite angioginique - Google Patents
Stimulation modulation et/ou inhibition de l'activite protheolithique endotheliale et/ou de l'activite angioginique Download PDFInfo
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- CA2300964A1 CA2300964A1 CA002300964A CA2300964A CA2300964A1 CA 2300964 A1 CA2300964 A1 CA 2300964A1 CA 002300964 A CA002300964 A CA 002300964A CA 2300964 A CA2300964 A CA 2300964A CA 2300964 A1 CA2300964 A1 CA 2300964A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Public Health (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Le facteur B de croissance endothéliale vasculaire (VEGF-B) et le facteur C de croissance endothéliale vasculaire (VEGF-C) sont des polypeptides angiogéniques. On a découvert que VEGF-B et VEGF-C sont angiogéniques in vitro plus particulièrement en combinaison avec b(FGF). VEGE-C augmente aussi l'activité des activateurs du plasminogène (PA) et ceci s'accompagne d'une augmentation correspondante de l'inhibiteur-1 PA. L'apport d'alpha-2-antiplasmine aux cellules endothéliales bovines traitées conjointement avec bFGF et VEGF-C permet d'inhiber partiellement l'invasion de gel collagène.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5586897P | 1997-08-15 | 1997-08-15 | |
| US60/055,868 | 1997-08-15 | ||
| PCT/US1998/016816 WO1999008522A1 (fr) | 1997-08-15 | 1998-08-14 | Stimulation modulation et/ou inhibition de l'activite protheolithique endotheliale et/ou de l'activite angioginique |
Publications (1)
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|---|---|
| CA2300964A1 true CA2300964A1 (fr) | 1999-02-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002300964A Abandoned CA2300964A1 (fr) | 1997-08-15 | 1998-08-14 | Stimulation modulation et/ou inhibition de l'activite protheolithique endotheliale et/ou de l'activite angioginique |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1011328A4 (fr) |
| JP (1) | JP2001514867A (fr) |
| KR (1) | KR20010022887A (fr) |
| CN (1) | CN1275050A (fr) |
| AU (1) | AU8905698A (fr) |
| CA (1) | CA2300964A1 (fr) |
| WO (1) | WO1999008522A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
| US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
| US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
| ES2249762T3 (es) | 1994-03-08 | 2006-04-01 | Human Genome Sciences, Inc. | Factor de crecimiento del endotelio vascular 2. |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
| US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| EP1117428B1 (fr) * | 1998-10-08 | 2003-09-24 | Children's Hospital | Compositions et leur utilisation pour inhiber l'angiogenese |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| CA2435411A1 (fr) * | 1999-06-25 | 2001-01-04 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Procede permettant d'induire une angiogenese au moyen de micro-organes |
| NZ518077A (en) | 2000-08-04 | 2003-11-28 | Human Genome Sciences Inc | Biologically active fragments, analogues and derivatives of VEGF-2 for the treatment of peripheral artery diseases such as critical limb ischemia and coronary disease |
| US6793918B2 (en) * | 2000-11-01 | 2004-09-21 | Ludwig Institute For Cancer Research | In vivo stimulation of angiogenic activity |
| US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
| EP2228389B1 (fr) | 2001-04-13 | 2015-07-08 | Human Genome Sciences, Inc. | Anticorps contre facteur de croissance endothéliale vasculaire 2 |
| US20080075750A1 (en) * | 2001-05-11 | 2008-03-27 | The Nemours Foundation | Methods for producing three-dimensional tissue-engineered cardiac constructs and uses regarding same |
| CN1684706A (zh) * | 2002-07-23 | 2005-10-19 | 路德维格癌症研究所 | 活化或抑制vegf－d和vegf－c的方法和组合物 |
| AU2005218570A1 (en) * | 2004-03-02 | 2005-09-15 | Ludwig Institute For Cancer Research | Method for inhibiting tumor formation and growth |
| KR101449587B1 (ko) | 2006-09-14 | 2014-10-10 | 메드제닉스 메디칼 이스라엘 리미티드 | 장기 지속형 약물 제형 |
| JP2013532152A (ja) | 2010-06-15 | 2013-08-15 | メドジェニクス・メディカル・イスラエル・リミテッド | 長期持続性の医薬製剤 |
| CN114996996B (zh) * | 2022-05-19 | 2024-05-17 | 电子科技大学 | 一种基于相场模型的3d毛细血管生长方法 |
| CN117695378A (zh) * | 2023-12-11 | 2024-03-15 | 湛江中心人民医院 | 载药系统及其制备方法与应用 |
Family Cites Families (1)
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| US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
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1998
- 1998-08-14 JP JP2000509282A patent/JP2001514867A/ja active Pending
- 1998-08-14 AU AU89056/98A patent/AU8905698A/en not_active Abandoned
- 1998-08-14 WO PCT/US1998/016816 patent/WO1999008522A1/fr not_active Application Discontinuation
- 1998-08-14 CA CA002300964A patent/CA2300964A1/fr not_active Abandoned
- 1998-08-14 KR KR1020007001491A patent/KR20010022887A/ko not_active Application Discontinuation
- 1998-08-14 EP EP98940875A patent/EP1011328A4/fr not_active Withdrawn
- 1998-08-14 CN CN98810009A patent/CN1275050A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001514867A (ja) | 2001-09-18 |
| CN1275050A (zh) | 2000-11-29 |
| AU8905698A (en) | 1999-03-08 |
| WO1999008522A1 (fr) | 1999-02-25 |
| EP1011328A1 (fr) | 2000-06-28 |
| EP1011328A4 (fr) | 2001-05-16 |
| KR20010022887A (ko) | 2001-03-26 |
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| FZDE | Discontinued |