CA2299345A1 - Multi parameter scanner - Google Patents
Multi parameter scanner Download PDFInfo
- Publication number
- CA2299345A1 CA2299345A1 CA002299345A CA2299345A CA2299345A1 CA 2299345 A1 CA2299345 A1 CA 2299345A1 CA 002299345 A CA002299345 A CA 002299345A CA 2299345 A CA2299345 A CA 2299345A CA 2299345 A1 CA2299345 A1 CA 2299345A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- scanner
- radiation
- wavelength
- coupled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000001514 detection method Methods 0.000 claims abstract description 52
- 230000005284 excitation Effects 0.000 claims abstract description 31
- 230000003287 optical effect Effects 0.000 claims abstract description 27
- 239000000523 sample Substances 0.000 claims description 120
- 239000000835 fiber Substances 0.000 claims description 71
- 230000005855 radiation Effects 0.000 claims description 45
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 42
- 238000013519 translation Methods 0.000 claims description 34
- 230000008878 coupling Effects 0.000 claims description 16
- 238000010168 coupling process Methods 0.000 claims description 16
- 238000005859 coupling reaction Methods 0.000 claims description 16
- 239000013307 optical fiber Substances 0.000 claims description 14
- 239000000499 gel Substances 0.000 claims description 9
- 238000012544 monitoring process Methods 0.000 claims description 4
- 238000005457 optimization Methods 0.000 claims description 4
- 238000003491 array Methods 0.000 claims description 3
- 238000012163 sequencing technique Methods 0.000 claims description 3
- 238000009396 hybridization Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000011546 protein dye Substances 0.000 claims description 2
- 238000005286 illumination Methods 0.000 claims 11
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 17
- 102000004190 Enzymes Human genes 0.000 abstract description 5
- 108090000790 Enzymes Proteins 0.000 abstract description 5
- 238000012546 transfer Methods 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 238000004476 mid-IR spectroscopy Methods 0.000 abstract description 2
- 239000000975 dye Substances 0.000 description 8
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 6
- 239000007850 fluorescent dye Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 230000009977 dual effect Effects 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- -1 Bodipy Chemical compound 0.000 description 3
- 229910052786 argon Inorganic materials 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 238000001917 fluorescence detection Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- MZZINWWGSYUHGU-UHFFFAOYSA-J ToTo-1 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3S2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2S1 MZZINWWGSYUHGU-UHFFFAOYSA-J 0.000 description 2
- GRRMZXFOOGQMFA-UHFFFAOYSA-J YoYo-1 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3O2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2O1 GRRMZXFOOGQMFA-UHFFFAOYSA-J 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 239000005350 fused silica glass Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229910052743 krypton Inorganic materials 0.000 description 2
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- VOFUROIFQGPCGE-UHFFFAOYSA-N nile red Chemical compound C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=O)C2=C1 VOFUROIFQGPCGE-UHFFFAOYSA-N 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- VGIRNWJSIRVFRT-UHFFFAOYSA-N 2',7'-difluorofluorescein Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(F)C(=O)C=C2OC2=CC(O)=C(F)C=C21 VGIRNWJSIRVFRT-UHFFFAOYSA-N 0.000 description 1
- WORLWSFCGZCFSW-UHFFFAOYSA-N 6-[2-[3-(3-ethyl-1,3-benzoxazol-2-ylidene)prop-1-enyl]-1,3-benzoxazol-3-ium-3-yl]hexanoate Chemical compound O1C2=CC=CC=C2[N+](CCCCCC([O-])=O)=C1\C=C\C=C1/N(CC)C2=CC=CC=C2O1 WORLWSFCGZCFSW-UHFFFAOYSA-N 0.000 description 1
- DJFNQJJTTPMBIL-UHFFFAOYSA-N 7-nitrobenzoxadiazole-6-aminohexanoic acid Chemical compound OC(=O)CCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C12 DJFNQJJTTPMBIL-UHFFFAOYSA-N 0.000 description 1
- 230000007023 DNA restriction-modification system Effects 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- GYPIAQJSRPTNTI-UHFFFAOYSA-J PoPo-3 Chemical compound [I-].[I-].[I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=CC=C1C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN2C=CC(=CC=CC3=[N+](C4=CC=CC=C4O3)C)C=C2)C=C1 GYPIAQJSRPTNTI-UHFFFAOYSA-J 0.000 description 1
- CGNLCCVKSWNSDG-UHFFFAOYSA-N SYBR Green I Chemical compound CN(C)CCCN(CCC)C1=CC(C=C2N(C3=CC=CC=C3S2)C)=C2C=CC=CC2=[N+]1C1=CC=CC=C1 CGNLCCVKSWNSDG-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- GTSMOYLSFUBTMV-UHFFFAOYSA-N ethidium homodimer Chemical compound [H+].[H+].[Cl-].[Cl-].[Cl-].[Cl-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2C(C)=[N+]1CCCNCCNCCC[N+](C1=CC(N)=CC=C1C1=CC=C(N)C=C11)=C1C1=CC=CC=C1 GTSMOYLSFUBTMV-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- XJENLUNLXRJLEZ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=C(C)C(N(CC)CC)=CC2=[O+]C=2C=C(N(CC)CC)C(C)=CC=2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O XJENLUNLXRJLEZ-UHFFFAOYSA-M 0.000 description 1
- DLBFLQKQABVKGT-UHFFFAOYSA-L lucifer yellow dye Chemical compound [Li+].[Li+].[O-]S(=O)(=O)C1=CC(C(N(C(=O)NN)C2=O)=O)=C3C2=CC(S([O-])(=O)=O)=CC3=C1N DLBFLQKQABVKGT-UHFFFAOYSA-L 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
- JGVWCANSWKRBCS-UHFFFAOYSA-N tetramethylrhodamine thiocyanate Chemical compound [Cl-].C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=C(SC#N)C=C1C(O)=O JGVWCANSWKRBCS-UHFFFAOYSA-N 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B42/00—Obtaining records using waves other than optical waves; Visualisation of such records by using optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6471—Special filters, filter wheel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/024—Modular construction
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5556797P | 1997-08-13 | 1997-08-13 | |
| US60/055,567 | 1997-08-13 | ||
| US09/001,254 | 1997-12-30 | ||
| US09/001,254 US6043506A (en) | 1997-08-13 | 1997-12-30 | Multi parameter scanner |
| PCT/US1998/016680 WO1999009455A1 (en) | 1997-08-13 | 1998-08-11 | Multi parameter scanner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2299345A1 true CA2299345A1 (en) | 1999-02-25 |
Family
ID=26668772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002299345A Abandoned CA2299345A1 (en) | 1997-08-13 | 1998-08-11 | Multi parameter scanner |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6043506A (enExample) |
| EP (1) | EP1004056A4 (enExample) |
| JP (2) | JP2001516036A (enExample) |
| CA (1) | CA2299345A1 (enExample) |
| WO (1) | WO1999009455A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6597450B1 (en) * | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays |
| JPH1198372A (ja) * | 1997-09-18 | 1999-04-09 | Olympus Optical Co Ltd | 色調整方法 |
| JP3333449B2 (ja) * | 1998-04-30 | 2002-10-15 | 富士写真フイルム株式会社 | 画像読み取り装置 |
| US6528801B1 (en) * | 1998-11-04 | 2003-03-04 | The Research Foundation Of State University Of New York | Method and apparatus for detecting radiation |
| US6320196B1 (en) * | 1999-01-28 | 2001-11-20 | Agilent Technologies, Inc. | Multichannel high dynamic range scanner |
| US20050279949A1 (en) | 1999-05-17 | 2005-12-22 | Applera Corporation | Temperature control for light-emitting diode stabilization |
| US6518068B1 (en) * | 1999-07-21 | 2003-02-11 | Tropix, Inc. | Luminescence detection workstation |
| US6411373B1 (en) | 1999-10-08 | 2002-06-25 | Instrumentation Metrics, Inc. | Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis |
| US6448089B1 (en) * | 1999-10-12 | 2002-09-10 | Aurora Biosciences Corporation | Multiwell scanner and scanning method |
| US6586257B1 (en) * | 1999-10-12 | 2003-07-01 | Vertex Pharmaceuticals Incorporated | Multiwell scanner and scanning method |
| US6814933B2 (en) * | 2000-09-19 | 2004-11-09 | Aurora Biosciences Corporation | Multiwell scanner and scanning method |
| US6775567B2 (en) * | 2000-02-25 | 2004-08-10 | Xenogen Corporation | Imaging apparatus |
| US6563581B1 (en) * | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
| US6495812B1 (en) | 2000-08-02 | 2002-12-17 | Li-Cor, Inc. | Apparatus and method for analyzing an object of interest having a pivotably movable source and detector |
| JP4282251B2 (ja) * | 2000-08-02 | 2009-06-17 | 富士フイルム株式会社 | 生化学解析用ユニットおよびそれを用いた生化学解析方法 |
| JP3903102B2 (ja) * | 2000-08-18 | 2007-04-11 | 富士フイルム株式会社 | 画像情報読取装置 |
| KR100371560B1 (ko) * | 2000-12-14 | 2003-02-07 | 주식회사 디지탈바이오테크놀러지 | 유전자 판독기 |
| DE60105968T2 (de) * | 2001-03-28 | 2005-10-13 | Agilent Technologies Inc., A Delaware Corp., Palo Alto | Verbesserte Vorrichtung und Verfahren für Extinktionsbestimmungen |
| US20040130704A1 (en) * | 2001-04-05 | 2004-07-08 | Josef Beller | Optical property determination using differences in signal responses to applied modulated laser signals |
| US7348587B2 (en) * | 2001-06-28 | 2008-03-25 | Fujifilm Corporation | Method for producing biochemical analysis data and apparatus used therefor |
| US6995841B2 (en) * | 2001-08-28 | 2006-02-07 | Rice University | Pulsed-multiline excitation for color-blind fluorescence detection |
| US6750457B2 (en) * | 2001-08-29 | 2004-06-15 | Becton Dickinson And Company | System for high throughput analysis |
| GB0128587D0 (en) * | 2001-11-29 | 2002-01-23 | Amersham Pharm Biotech Uk Ltd | Dynamic range |
| US7474398B2 (en) * | 2002-02-22 | 2009-01-06 | Xenogen Corporation | Illumination system for an imaging apparatus with low profile output device |
| US7474399B2 (en) * | 2002-02-22 | 2009-01-06 | Xenogen Corporation | Dual illumination system for an imaging apparatus and method |
| US6922246B2 (en) * | 2002-02-22 | 2005-07-26 | Xenogen Corporation | Bottom fluorescence illumination assembly for an imaging apparatus |
| KR100482821B1 (ko) * | 2002-03-22 | 2005-04-14 | (주) 엠아이알 | 형광 이미지 저장 스크린 판독장치 및 방법 |
| US7061616B2 (en) * | 2002-03-28 | 2006-06-13 | Samsung Electronics Co., Ltd. | Optical transceiver and method for image density measurement |
| US20040072274A1 (en) * | 2002-05-09 | 2004-04-15 | Lebrun Stewart J. | System and method for visualization and digital analysis of protein and other macromolecule microarrays |
| ES2543587T3 (es) * | 2002-05-17 | 2015-08-20 | Life Technologies Corporation | Instrumento óptico que incluye una fuente de excitación |
| US20040027659A1 (en) * | 2002-08-08 | 2004-02-12 | Messerschmidt Robert G. | Sample holder |
| CA2446368C (en) * | 2002-10-29 | 2014-10-14 | Bayer Healthcare Llc | Diffuse reflectance readhead |
| US20040095615A1 (en) * | 2002-11-14 | 2004-05-20 | Chung-Hua Tsai | Biological scanner with two dimensional scanning operation |
| JP2006507503A (ja) * | 2002-11-21 | 2006-03-02 | シーデックス， インコーポレイテッド | 紫外蛍光を使用して、分子種を検出し、検査し、分類するための方法および装置 |
| US6934030B2 (en) * | 2002-12-18 | 2005-08-23 | The Research Foundation Of State University Of New York | Method and apparatus for detecting radiation |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| EP1634059A1 (en) * | 2003-06-03 | 2006-03-15 | Bayer HealthCare LLC | Verification device and method for optical inspection machine |
| DE10325735B4 (de) * | 2003-06-06 | 2006-06-29 | Robert Bosch Gmbh | Vorrichtung und Verfahren zur Analyse einer Materialbibliothek |
| ES2244296B1 (es) * | 2003-10-03 | 2007-02-01 | Signe, S.A. | Sistema de medicion de fosforo y procedimiento asociado. |
| US7295316B2 (en) * | 2004-01-14 | 2007-11-13 | Applera Corporation | Fluorescent detector with automatic changing filters |
| JP4170947B2 (ja) * | 2004-04-09 | 2008-10-22 | 株式会社日立ハイテクノロジーズ | 生体試料成分検出法及びその装置 |
| EP1742040A4 (en) * | 2004-04-30 | 2011-08-17 | Prec System Science Co Ltd | OPTICAL INFORMATION READER |
| DE102004022263A1 (de) * | 2004-05-06 | 2005-12-15 | Clondiag Chip Technologies Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
| EP1610091A1 (de) * | 2004-06-23 | 2005-12-28 | Leica Geosystems AG | Scannersystem und Verfahren zur Erfassung von Oberflächen |
| US20060237664A1 (en) * | 2005-04-25 | 2006-10-26 | Polestar Technologies, Inc. | Feedback control system |
| US8552401B2 (en) * | 2005-04-25 | 2013-10-08 | Polestar Technologies, Inc. | Optical chemical sensor feedback control system |
| AU2006259569A1 (en) * | 2005-06-13 | 2006-12-28 | Stratagene California | System and method for fluorescence excitation and detection having distinct optical paths |
| US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
| US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
| JP2007147584A (ja) * | 2005-10-28 | 2007-06-14 | Fujifilm Corp | 放射線画像変換パネルおよび放射線画像取得システム |
| US20070098594A1 (en) * | 2005-11-03 | 2007-05-03 | Roche Molecular Systems, Inc. | Analytical multi-spectral optical detection system |
| US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
| US20070178480A1 (en) * | 2006-01-31 | 2007-08-02 | Corson John F | Extended dynamic range reading of chemical arrays |
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1997
- 1997-12-30 US US09/001,254 patent/US6043506A/en not_active Expired - Lifetime
-
1998
- 1998-08-11 JP JP2000510061A patent/JP2001516036A/ja not_active Withdrawn
- 1998-08-11 EP EP98939349A patent/EP1004056A4/en not_active Withdrawn
- 1998-08-11 CA CA002299345A patent/CA2299345A1/en not_active Abandoned
- 1998-08-11 WO PCT/US1998/016680 patent/WO1999009455A1/en not_active Ceased
-
2004
- 2004-06-07 JP JP2004168607A patent/JP2004264312A/ja active Pending
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|---|---|
| JP2004264312A (ja) | 2004-09-24 |
| JP2001516036A (ja) | 2001-09-25 |
| WO1999009455A1 (en) | 1999-02-25 |
| US6043506A (en) | 2000-03-28 |
| EP1004056A1 (en) | 2000-05-31 |
| EP1004056A4 (en) | 2001-08-16 |
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