CA2298682A1 - Acides mercapto-acyl-amines utilises comme inhibiteurs des metallo-beta lactamases - Google Patents

Acides mercapto-acyl-amines utilises comme inhibiteurs des metallo-beta lactamases Download PDF

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Publication number
CA2298682A1
CA2298682A1 CA002298682A CA2298682A CA2298682A1 CA 2298682 A1 CA2298682 A1 CA 2298682A1 CA 002298682 A CA002298682 A CA 002298682A CA 2298682 A CA2298682 A CA 2298682A CA 2298682 A1 CA2298682 A1 CA 2298682A1
Authority
CA
Canada
Prior art keywords
alkyl
phenyl
compound according
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002298682A
Other languages
English (en)
Inventor
Desmond John Best
John Hargreaves Bateson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9716221.8A external-priority patent/GB9716221D0/en
Priority claimed from GBGB9716224.2A external-priority patent/GB9716224D0/en
Application filed by Individual filed Critical Individual
Publication of CA2298682A1 publication Critical patent/CA2298682A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des dérivés d'acides aminés représentés par la formule (I) et présentant des propriétés inhibitrices dirigéescontre les métallo-.beta.-lactamases, propriétés qui sont utiles dans le traitement des infections chez l'animal. Dans la formule (I), R¿4?S-C(R¿5?R¿6?)-C(=CHR¿3?)-CON(R¿2?)-CH(R¿1?)-CO¿2?R, les variables sont telles que définies dans la revendication 1.
CA002298682A 1997-07-31 1998-07-21 Acides mercapto-acyl-amines utilises comme inhibiteurs des metallo-beta lactamases Abandoned CA2298682A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9716224.2 1997-07-31
GB9716221.8 1997-07-31
GBGB9716221.8A GB9716221D0 (en) 1997-07-31 1997-07-31 Compounds
GBGB9716224.2A GB9716224D0 (en) 1997-07-31 1997-07-31 Compounds
PCT/EP1998/004974 WO1999006365A1 (fr) 1997-07-31 1998-07-21 Acides mercapto-acyl-amines utilises comme inhibiteurs des metallo-beta lactamases

Publications (1)

Publication Number Publication Date
CA2298682A1 true CA2298682A1 (fr) 1999-02-11

Family

ID=26311979

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002298682A Abandoned CA2298682A1 (fr) 1997-07-31 1998-07-21 Acides mercapto-acyl-amines utilises comme inhibiteurs des metallo-beta lactamases

Country Status (4)

Country Link
EP (1) EP1000024A1 (fr)
JP (1) JP2001512099A (fr)
CA (1) CA2298682A1 (fr)
WO (1) WO1999006365A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075143A1 (fr) * 1999-06-03 2000-12-14 Eisai Co., Ltd. Cristaux de derives de carbapenem et preparations pharmaceutiques pour injection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy

Also Published As

Publication number Publication date
JP2001512099A (ja) 2001-08-21
EP1000024A1 (fr) 2000-05-17
WO1999006365A1 (fr) 1999-02-11

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FZDE Dead