CA2294704A1 - Proteine se fixant a la proteine trail - Google Patents

Proteine se fixant a la proteine trail Download PDF

Info

Publication number
CA2294704A1
CA2294704A1 CA002294704A CA2294704A CA2294704A1 CA 2294704 A1 CA2294704 A1 CA 2294704A1 CA 002294704 A CA002294704 A CA 002294704A CA 2294704 A CA2294704 A CA 2294704A CA 2294704 A1 CA2294704 A1 CA 2294704A1
Authority
CA
Canada
Prior art keywords
trail
polypeptide
dna
seq
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002294704A
Other languages
English (en)
Inventor
Henning Walczak
Craig A. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2294704A1 publication Critical patent/CA2294704A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention se rapporte à une protéine appelée TRAIL-BP qui se fixe à la protéine appelée TRAIL (ligand inducteur d'apoptose apparenté au facteur de nécrose tumorale). Cette protéine TRAIL-BP trouve une application dans la purification de la protéine TRAIL ou dans l'inhibition des activités de cette protéine. Des séquences d'ADN isolées codant la protéine TRAIL-BP, ainsi que des vecteurs d'expression contenant ces séquences d'ADN, et des cellules hôtes transformées par de tels vecteurs d'expression recombinés font également l'objet de cette invention. Des anticorps immunoréactifs avec la protéine TRAIL-BP sont également présentés.
CA002294704A 1997-06-26 1998-06-25 Proteine se fixant a la proteine trail Abandoned CA2294704A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88352997A 1997-06-26 1997-06-26
US08/883,529 1997-06-26
PCT/US1998/013491 WO1999000423A1 (fr) 1997-06-26 1998-06-25 Proteine se fixant a la proteine trail

Publications (1)

Publication Number Publication Date
CA2294704A1 true CA2294704A1 (fr) 1999-01-07

Family

ID=25382755

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002294704A Abandoned CA2294704A1 (fr) 1997-06-26 1998-06-25 Proteine se fixant a la proteine trail

Country Status (7)

Country Link
EP (1) EP1001990A4 (fr)
JP (1) JP2002507127A (fr)
AU (1) AU756759B2 (fr)
CA (1) CA2294704A1 (fr)
IL (1) IL133602A0 (fr)
NZ (1) NZ501831A (fr)
WO (1) WO1999000423A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455040B1 (en) 1997-01-14 2002-09-24 Human Genome Sciences, Inc. Tumor necrosis factor receptor 5
WO1998030693A2 (fr) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Recepteur 5 du facteur de necrose tumorale
US6313269B1 (en) * 1997-03-14 2001-11-06 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
PT970213E (pt) 1997-03-17 2007-04-30 Human Genome Sciences Inc Receptor 5 contendo um domínio de morte
CA2374674A1 (fr) * 1999-05-20 2000-11-30 Human Genome Sciences, Inc. Recepteur 5 du facteur de necrose tumorale
KR100436089B1 (ko) * 2000-07-06 2004-06-14 설대우 분비성 재조합 트라이머형의 트레일 단백질 생산을 위한 디엔에이 카세트, 테트라사이클린/독시사이클린-유도성아데노-관련 바이러스 벡터, 이 둘의 조합, 및 이들을이용한 유전자 치료
WO2002097033A2 (fr) 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Anticorps se liant de maniere immunospecifique a des recepteurs de trail
PT1446733E (pt) * 2001-10-13 2009-09-28 Asterion Ltd Polipéptidos contendo glicosilfosfatidilinositol
BRPI0507233B8 (pt) 2004-03-11 2021-05-25 Genentech Inc processo para a produção de um polipeptídeo heterólogo em e. coli
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
JP7281795B2 (ja) 2016-04-07 2023-05-26 ザ・ジョンズ・ホプキンス・ユニバーシティー 膵炎および疼痛をデス受容体アゴニストで処置するための組成物および方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030693A2 (fr) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Recepteur 5 du facteur de necrose tumorale
CA2221687A1 (fr) * 1997-02-05 1998-08-05 Smithkline Beecham Corporation Recepteurs relies a la necrose des tumeurs, tr5
JP2002508663A (ja) * 1997-06-18 2002-03-19 ジェネンテク，インコーポレイテッド Ａｐｏ−２ＤｃＲ

Also Published As

Publication number Publication date
EP1001990A4 (fr) 2001-12-19
IL133602A0 (en) 2001-04-30
WO1999000423A1 (fr) 1999-01-07
JP2002507127A (ja) 2002-03-05
AU8175898A (en) 1999-01-19
EP1001990A1 (fr) 2000-05-24
NZ501831A (en) 2001-09-28
AU756759B2 (en) 2003-01-23

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Legal Events

Date Code Title Description
FZDE Discontinued