CA2292540A1 - Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol - Google Patents

Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol Download PDF

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Publication number
CA2292540A1
CA2292540A1 CA002292540A CA2292540A CA2292540A1 CA 2292540 A1 CA2292540 A1 CA 2292540A1 CA 002292540 A CA002292540 A CA 002292540A CA 2292540 A CA2292540 A CA 2292540A CA 2292540 A1 CA2292540 A1 CA 2292540A1
Authority
CA
Canada
Prior art keywords
cells
wortmannin
kinase
mtor
phas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002292540A
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English (en)
Inventor
Jann N. Sarkaria
Robert T. Abraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2292540A1 publication Critical patent/CA2292540A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention concerne un procédé permettant d'identifier un composé qui inhibe l'activité de phosphorylation d'un polypeptide de kinase apparenté au phosphoinositide 3-kinase; ainsi que des anticorps présentant une affinité de liaison spécifique pour un conjugué comprenant du wortmannin.
CA002292540A 1997-06-06 1998-06-05 Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol Abandoned CA2292540A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4886997P 1997-06-06 1997-06-06
US60/048,869 1997-06-06
PCT/US1998/011420 WO1998055602A1 (fr) 1997-06-06 1998-06-05 Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol

Publications (1)

Publication Number Publication Date
CA2292540A1 true CA2292540A1 (fr) 1998-12-10

Family

ID=21956893

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002292540A Abandoned CA2292540A1 (fr) 1997-06-06 1998-06-05 Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol

Country Status (4)

Country Link
EP (1) EP0990028A4 (fr)
AU (1) AU7953598A (fr)
CA (1) CA2292540A1 (fr)
WO (1) WO1998055602A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714971D0 (en) 1997-07-16 1997-09-24 Cancer Res Campaign Tech Assays,therapeutic methods and means
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
JP4079581B2 (ja) * 2000-08-11 2008-04-23 ユニ・チャーム株式会社 使い捨て着用物品
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
GB2420781B (en) 2003-08-13 2008-07-09 Kudos Pharm Ltd Aminopyrones and their use as ATM inhibitors
BRPI0515498A (pt) 2004-09-20 2008-07-29 Kudos Pharm Ltd inibidores de dna-pk
WO2006085067A1 (fr) 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Inhibiteurs d’atm
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
WO2009047567A1 (fr) * 2007-10-10 2009-04-16 University Of Sheffield Essai pour identifier des agents qui inhibent les voies atr et/ou dna-pk
WO2015057461A2 (fr) 2013-10-18 2015-04-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps se liant spécifiquement à l'ataxie télangiectasie mutée et la kinase phosphorylée liée à rad3 à la position 1989, et leur utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466716A (en) * 1990-12-31 1995-11-14 The Biomembrane Institute Liposomal trimethylsphingosine
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation

Also Published As

Publication number Publication date
WO1998055602A1 (fr) 1998-12-10
AU7953598A (en) 1998-12-21
EP0990028A4 (fr) 2000-09-27
EP0990028A1 (fr) 2000-04-05
WO1998055602A9 (fr) 1999-04-08

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Legal Events

Date Code Title Description
FZDE Discontinued