AU7953598A - Screening for phosphatidylinositol related-kinase inhibitors - Google Patents

Screening for phosphatidylinositol related-kinase inhibitors Download PDF

Info

Publication number
AU7953598A
AU7953598A AU79535/98A AU7953598A AU7953598A AU 7953598 A AU7953598 A AU 7953598A AU 79535/98 A AU79535/98 A AU 79535/98A AU 7953598 A AU7953598 A AU 7953598A AU 7953598 A AU7953598 A AU 7953598A
Authority
AU
Australia
Prior art keywords
cells
wortmannin
kinase
mtor
phas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU79535/98A
Other languages
English (en)
Inventor
Robert T. Abraham
Jann N. Sarkaria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Original Assignee
Mayo Foundation for Medical Education and Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research filed Critical Mayo Foundation for Medical Education and Research
Publication of AU7953598A publication Critical patent/AU7953598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU79535/98A 1997-06-06 1998-06-05 Screening for phosphatidylinositol related-kinase inhibitors Abandoned AU7953598A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4886997P 1997-06-06 1997-06-06
US60048869 1997-06-06
PCT/US1998/011420 WO1998055602A1 (fr) 1997-06-06 1998-06-05 Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol

Publications (1)

Publication Number Publication Date
AU7953598A true AU7953598A (en) 1998-12-21

Family

ID=21956893

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79535/98A Abandoned AU7953598A (en) 1997-06-06 1998-06-05 Screening for phosphatidylinositol related-kinase inhibitors

Country Status (4)

Country Link
EP (1) EP0990028A4 (fr)
AU (1) AU7953598A (fr)
CA (1) CA2292540A1 (fr)
WO (1) WO1998055602A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714971D0 (en) 1997-07-16 1997-09-24 Cancer Res Campaign Tech Assays,therapeutic methods and means
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
JP4079581B2 (ja) * 2000-08-11 2008-04-23 ユニ・チャーム株式会社 使い捨て着用物品
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
KR20060066722A (ko) 2003-08-13 2006-06-16 쿠도스 파마슈티칼스 리미티드 아미노피론 및 atm억제제로서의 이의 용도
US20070238731A1 (en) 2004-09-20 2007-10-11 Kudos Pharmaceuticals Limited Dna-Pk Inhibitors
CN101115747A (zh) 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
WO2009047567A1 (fr) * 2007-10-10 2009-04-16 University Of Sheffield Essai pour identifier des agents qui inhibent les voies atr et/ou dna-pk
WO2015057461A2 (fr) 2013-10-18 2015-04-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps se liant spécifiquement à l'ataxie télangiectasie mutée et la kinase phosphorylée liée à rad3 à la position 1989, et leur utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466716A (en) * 1990-12-31 1995-11-14 The Biomembrane Institute Liposomal trimethylsphingosine
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation

Also Published As

Publication number Publication date
WO1998055602A1 (fr) 1998-12-10
WO1998055602A9 (fr) 1999-04-08
EP0990028A1 (fr) 2000-04-05
EP0990028A4 (fr) 2000-09-27
CA2292540A1 (fr) 1998-12-10

Similar Documents

Publication Publication Date Title
US5352660A (en) Method for assaying for a substance that affects a SH2-phosphorylated ligand regulatory system
Reuther et al. Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family
Gould et al. Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity
Behrend et al. Interaction of casein kinase 1 delta (CK1δ) with post-Golgi structures, microtubules and the spindle apparatus
Millward et al. Calcium regulation of Ndr protein kinase mediated by S100 calcium‐binding proteins
DerMardirossian et al. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase
Diekmann et al. Rac GTPase interacts with GAPs and target proteins through multiple effector sites.
Anderson et al. Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo.
She et al. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.
Weber et al. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase
US7160692B2 (en) ATM kinase compositions and methods
Auvinen et al. Ornithine decarboxylase-and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS
Pietromonaco et al. Association of 14-3-3 proteins with centrosomes
Price et al. Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide.
AU7953598A (en) Screening for phosphatidylinositol related-kinase inhibitors
Moyers et al. The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to β-adrenergic agonists in cells overexpressing c-src
Ulrich et al. Specific TrkA survival signals interfere with different apoptotic pathways
Cha et al. Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies
US6383734B1 (en) Method to determine inhibition of PAK3 activation of Raf-1
US7087392B2 (en) Antiproliferative SgK reagents and methods
Reilly et al. A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction
Frick et al. Insulin-mimetic signalling of synthetic phosphoinositolglycans in isolated rat adipocytes
Dai et al. Constitutively and autonomously active protein kinase C associated with 14‐3‐3 ζ in the rodent brain
Roche et al. The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes
Lewis et al. Ca2+/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted