CA2291647A1 - Antagonistes de la gonadoliberine - Google Patents
Antagonistes de la gonadoliberine Download PDFInfo
- Publication number
- CA2291647A1 CA2291647A1 CA002291647A CA2291647A CA2291647A1 CA 2291647 A1 CA2291647 A1 CA 2291647A1 CA 002291647 A CA002291647 A CA 002291647A CA 2291647 A CA2291647 A CA 2291647A CA 2291647 A1 CA2291647 A1 CA 2291647A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- alkyl
- aryl
- compound
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention porte sur des composés de formule (I) et leurs sels pharmacocompatibles servant d'antagonistes de l'hormone GnRH et utiles à ce titre dans le traitement d'états liés aux hormones sexuelles chez l'homme et chez la femme.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4874397P | 1997-06-05 | 1997-06-05 | |
US4863597P | 1997-06-05 | 1997-06-05 | |
US60/048,743 | 1997-06-05 | ||
US60/048,635 | 1997-06-05 | ||
GBGB9716865.2A GB9716865D0 (en) | 1997-08-08 | 1997-08-08 | Antagonists of gonadotrophin releasing hormone |
GB9716865.2 | 1997-08-08 | ||
GBGB9719391.6A GB9719391D0 (en) | 1997-09-11 | 1997-09-11 | Antagonists of gonadotropin releasing hormone |
GB9719391.6 | 1997-09-11 | ||
PCT/US1998/011072 WO1998055479A1 (fr) | 1997-06-05 | 1998-06-01 | Antagonistes de la gonadoliberine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2291647A1 true CA2291647A1 (fr) | 1998-12-10 |
Family
ID=27451687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002291647A Abandoned CA2291647A1 (fr) | 1997-06-05 | 1998-06-01 | Antagonistes de la gonadoliberine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0986557A4 (fr) |
JP (1) | JP2002502422A (fr) |
AU (1) | AU729663B2 (fr) |
CA (1) | CA2291647A1 (fr) |
WO (1) | WO1998055479A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346534B1 (en) | 1998-09-23 | 2002-02-12 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US6537998B1 (en) | 1999-10-15 | 2003-03-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
JP4931314B2 (ja) | 2000-01-25 | 2012-05-16 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 性腺刺激ホルモン放出ホルモンレセプタアンタゴニストおよびそれに関連した方法 |
JP2002080397A (ja) * | 2000-07-05 | 2002-03-19 | Takeda Chem Ind Ltd | 性ホルモン依存性疾患の治療用医薬製剤 |
GB0022670D0 (en) | 2000-09-15 | 2000-11-01 | Astrazeneca Ab | Molecules |
SE0100566D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
SE0101692D0 (sv) | 2001-05-14 | 2001-05-14 | Astrazeneca Ab | Compounds |
AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
MXPA04000986A (es) | 2001-08-02 | 2005-02-17 | Neurocrine Biosciences Inc | 1,2,3-triazin-3,5-dionas sustituidas como antagonistas del receptor de hormona de liberacion de gonadotropina (gnrh). |
EP1411941A2 (fr) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Antagonistes du recepteur de l'hormone liberant la gonadotropine et procedes associes |
EP1412363A1 (fr) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Antagonistes du recepteur de l'hormone liberatrice de la gonadotropine |
JP2005505525A (ja) | 2001-08-02 | 2005-02-24 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法 |
TW200407127A (en) | 2002-08-21 | 2004-05-16 | Astrazeneca Ab | Chemical compounds |
ATE363481T1 (de) | 2002-08-21 | 2007-06-15 | Astrazeneca Ab | Pyrazolderivate als gnrh-inhibitoren |
WO2004018479A1 (fr) | 2002-08-21 | 2004-03-04 | Astrazeneca Ab | Composes de thieno-pyrrole utilises comme antagonistes de l'hormone de liberation de gonadotrophine |
TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
GB0219472D0 (en) | 2002-08-21 | 2002-10-02 | Astrazeneca Ab | Chemical compounds |
CN100376246C (zh) | 2003-07-07 | 2008-03-26 | 纽罗克里生物科学有限公司 | 作为促性激素释放激素受体拮抗剂的嘧啶-2,4-二酮衍生物 |
WO2005007633A1 (fr) | 2003-07-07 | 2005-01-27 | Neurocrine Biosciences, Inc. | Antagonistes des recepteurs des hormones liberant des gonadotropines et procedes connexes |
CN100424078C (zh) | 2003-07-07 | 2008-10-08 | 纽罗克里生物科学有限公司 | 作为促性激素释放激素受体拮抗剂的嘧啶-2,4-二酮衍生物 |
DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
EP1943226A2 (fr) | 2005-10-13 | 2008-07-16 | Smithkline Beecham Corporation | Nouveaux composes heterocycliques |
EP2095818A1 (fr) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration |
TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
WO2012175514A1 (fr) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Dérivés de pyridinone et compositions pharmaceutiques les contenant |
EP3185881B1 (fr) | 2014-08-26 | 2022-03-09 | Betanien Hospital | Méthodes, agents et compositions pour le traitement d'états inflammatoires |
KR20210125471A (ko) | 2018-10-05 | 2021-10-18 | 안나푸르나 바이오, 인코포레이티드 | Apj 수용체 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
IL124459A0 (en) * | 1995-12-14 | 1998-12-06 | Merck & Co Inc | Antagonists of gonadotropin releasing hormone |
SK77598A3 (en) * | 1995-12-14 | 1999-01-11 | Merck & Co Inc | Nonpeptide derivatives, pharmaceutical composition containing them and their use |
-
1998
- 1998-06-01 AU AU76056/98A patent/AU729663B2/en not_active Ceased
- 1998-06-01 CA CA002291647A patent/CA2291647A1/fr not_active Abandoned
- 1998-06-01 JP JP50263399A patent/JP2002502422A/ja active Pending
- 1998-06-01 EP EP98923865A patent/EP0986557A4/fr not_active Withdrawn
- 1998-06-01 WO PCT/US1998/011072 patent/WO1998055479A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO1998055479A1 (fr) | 1998-12-10 |
EP0986557A1 (fr) | 2000-03-22 |
EP0986557A4 (fr) | 2001-03-14 |
AU7605698A (en) | 1998-12-21 |
JP2002502422A (ja) | 2002-01-22 |
AU729663B2 (en) | 2001-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |