CA2289837A1 - Method and apparatus for targeted drug delivery into a living patient using magnetic resonance imaging - Google Patents
Method and apparatus for targeted drug delivery into a living patient using magnetic resonance imaging Download PDFInfo
- Publication number
- CA2289837A1 CA2289837A1 CA002289837A CA2289837A CA2289837A1 CA 2289837 A1 CA2289837 A1 CA 2289837A1 CA 002289837 A CA002289837 A CA 002289837A CA 2289837 A CA2289837 A CA 2289837A CA 2289837 A1 CA2289837 A1 CA 2289837A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- delivery device
- area
- volume
- change
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0034—Multi-lumen catheters with stationary elements characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/004—Multi-lumen catheters with stationary elements characterized by lumina being arranged circumferentially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M2025/0073—Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0693—Brain, cerebrum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Signal Processing (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/857,043 US6026316A (en) | 1997-05-15 | 1997-05-15 | Method and apparatus for use with MR imaging |
US08/856,894 | 1997-05-15 | ||
US08/856,894 US6061587A (en) | 1997-05-15 | 1997-05-15 | Method and apparatus for use with MR imaging |
US08/857,043 | 1997-05-15 | ||
PCT/US1998/009942 WO1998052064A1 (en) | 1997-05-15 | 1998-05-15 | Method and apparatus for targeted drug delivery into a living patient using magnetic resonance imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2289837A1 true CA2289837A1 (en) | 1998-11-19 |
Family
ID=27127382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002289837A Abandoned CA2289837A1 (en) | 1997-05-15 | 1998-05-15 | Method and apparatus for targeted drug delivery into a living patient using magnetic resonance imaging |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0981761A1 (ja) |
JP (1) | JP2001525703A (ja) |
AU (1) | AU7388398A (ja) |
CA (1) | CA2289837A1 (ja) |
WO (1) | WO1998052064A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11298041B2 (en) | 2016-08-30 | 2022-04-12 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
US11497576B2 (en) | 2017-07-17 | 2022-11-15 | Voyager Therapeutics, Inc. | Trajectory array guide system |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6537232B1 (en) * | 1997-05-15 | 2003-03-25 | Regents Of The University Of Minnesota | Intracranial pressure monitoring device and method for use in MR-guided drug delivery |
US6479481B1 (en) * | 1999-06-04 | 2002-11-12 | Ed. Geistlich Soehne Ag Fur Chemische Industrie | Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS) |
SE9902695L (sv) * | 1999-07-14 | 2001-01-15 | Cma Microdialysis Ab | Förbättrad sond |
CA2398967A1 (en) | 2000-02-01 | 2001-08-09 | Albert C. Lardo | Magnetic resonance imaging transseptal needle antenna |
CA2404352A1 (en) * | 2000-03-24 | 2001-10-04 | Ergin Atalar | Endoluminal mri probe |
FR2823092B1 (fr) | 2001-04-10 | 2004-03-05 | Eurorad 2 6 | Dispositif per-operatoire pour la localisation de tissus marques et procede utilisant un tel dispositif |
GB0110392D0 (en) * | 2001-04-27 | 2001-06-20 | Oxford Instr Plc | Method and apparatus for magnetic resonance imaging |
US8862203B2 (en) * | 2003-03-27 | 2014-10-14 | Boston Scientific Scimed Inc. | Medical device with temperature modulator for use in magnetic resonance imaging |
EP2305109A1 (en) | 2005-11-29 | 2011-04-06 | Surgi-Vision, Inc. | MRI-guided localization and/or lead placement systems, related methods, devices and computer program products |
US8790317B2 (en) | 2007-02-13 | 2014-07-29 | Cornell University | Convection enhanced delivery apparatus, method, and application |
US8175677B2 (en) | 2007-06-07 | 2012-05-08 | MRI Interventions, Inc. | MRI-guided medical interventional systems and methods |
US8548569B2 (en) | 2007-09-24 | 2013-10-01 | MRI Interventions, Inc. | Head fixation assemblies for medical procedures |
WO2009042155A2 (en) | 2007-09-24 | 2009-04-02 | Surgivision, Inc. | Mri-compatible patches and methods for using the same |
US8099150B2 (en) | 2007-09-24 | 2012-01-17 | MRI Interventions, Inc. | MRI-compatible head fixation frame with cooperating head coil apparatus |
US8315689B2 (en) | 2007-09-24 | 2012-11-20 | MRI Interventions, Inc. | MRI surgical systems for real-time visualizations using MRI image data and predefined data of surgical tools |
CA2700523A1 (en) | 2007-09-24 | 2009-04-02 | Surgivision, Inc. | Mri-guided medical interventional systems and methods |
EP2211973A2 (en) * | 2007-10-08 | 2010-08-04 | Renishaw (Ireland) Limited | Catheter |
US8340743B2 (en) | 2007-11-21 | 2012-12-25 | MRI Interventions, Inc. | Methods, systems and computer program products for positioning a guidance apparatus relative to a patient |
EP2344232A2 (en) * | 2008-10-08 | 2011-07-20 | Renishaw (Ireland) Limited | Rigid ceramic catheter |
US20130035660A1 (en) | 2011-08-01 | 2013-02-07 | Alcyone Lifesciences, Inc. | Multidirectional microfluidic drug delivery devices with conformable balloons |
KR101820534B1 (ko) | 2011-10-07 | 2018-01-22 | 서강대학교산학협력단 | 약물 전달 속도를 정량화하는 방법, 이에 의한 mri 장치 |
US9192446B2 (en) | 2012-09-05 | 2015-11-24 | MRI Interventions, Inc. | Trajectory guide frame for MRI-guided surgeries |
WO2014100157A1 (en) | 2012-12-18 | 2014-06-26 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
WO2014204954A1 (en) | 2013-06-17 | 2014-12-24 | Alcyone Lifesciences, Inc. | Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters |
WO2015017609A2 (en) | 2013-07-31 | 2015-02-05 | Alcyone Lifesciences, Inc. | Systems and methods for drug delivery, treatment, and monitoring |
US10806396B2 (en) | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
WO2017120167A1 (en) | 2016-01-04 | 2017-07-13 | Alcyone Lifesciences, Inc. | Methods and devices for treating stroke |
US10905497B2 (en) | 2017-04-21 | 2021-02-02 | Clearpoint Neuro, Inc. | Surgical navigation systems |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3640269A (en) * | 1969-10-24 | 1972-02-08 | Jose M R Delgado | Fluid-conducting instrument insertable in living organisms |
SE434214B (sv) * | 1982-12-01 | 1984-07-16 | Carl Urban Ungerstedt | Dialysprob, avsedd for inforing i biologiska vevnader |
GB8600665D0 (en) * | 1986-01-13 | 1986-02-19 | Longmore D B | Surgical catheters |
US5154179A (en) * | 1987-07-02 | 1992-10-13 | Medical Magnetics, Inc. | Device construction and method facilitating magnetic resonance imaging of foreign objects in a body |
FI80585C (fi) * | 1988-11-11 | 1990-07-10 | Instrumentarium Oy | Arrangemang foer undersoekning av ett objekt. |
DE4310993A1 (de) * | 1993-04-03 | 1994-10-06 | Philips Patentverwaltung | MR-Abbildungsverfahren und Anordnung zur Durchführung des Verfahrens |
US5470307A (en) * | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
US5419325A (en) * | 1994-06-23 | 1995-05-30 | General Electric Company | Magnetic resonance (MR) angiography using a faraday catheter |
-
1998
- 1998-05-15 CA CA002289837A patent/CA2289837A1/en not_active Abandoned
- 1998-05-15 AU AU73883/98A patent/AU7388398A/en not_active Abandoned
- 1998-05-15 WO PCT/US1998/009942 patent/WO1998052064A1/en not_active Application Discontinuation
- 1998-05-15 EP EP98921222A patent/EP0981761A1/en not_active Withdrawn
- 1998-05-15 JP JP54956798A patent/JP2001525703A/ja active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11298041B2 (en) | 2016-08-30 | 2022-04-12 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
US11298043B2 (en) | 2016-08-30 | 2022-04-12 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
US11497576B2 (en) | 2017-07-17 | 2022-11-15 | Voyager Therapeutics, Inc. | Trajectory array guide system |
Also Published As
Publication number | Publication date |
---|---|
AU7388398A (en) | 1998-12-08 |
EP0981761A1 (en) | 2000-03-01 |
JP2001525703A (ja) | 2001-12-11 |
WO1998052064A1 (en) | 1998-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |