CA2289837A1 - Procede et appareil d'administration ciblee de medicament a un patient, mettant en oeuvre une imagerie par resonance magnetique - Google Patents

Procede et appareil d'administration ciblee de medicament a un patient, mettant en oeuvre une imagerie par resonance magnetique Download PDF

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Publication number
CA2289837A1
CA2289837A1 CA002289837A CA2289837A CA2289837A1 CA 2289837 A1 CA2289837 A1 CA 2289837A1 CA 002289837 A CA002289837 A CA 002289837A CA 2289837 A CA2289837 A CA 2289837A CA 2289837 A1 CA2289837 A1 CA 2289837A1
Authority
CA
Canada
Prior art keywords
tissue
delivery device
area
volume
change
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002289837A
Other languages
English (en)
Inventor
Michael E. Moseley
John Kucharczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/856,894 external-priority patent/US6061587A/en
Priority claimed from US08/857,043 external-priority patent/US6026316A/en
Application filed by Individual filed Critical Individual
Publication of CA2289837A1 publication Critical patent/CA2289837A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0034—Multi-lumen catheters with stationary elements characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/004—Multi-lumen catheters with stationary elements characterized by lumina being arranged circumferentially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M2025/0073—Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Signal Processing (AREA)
  • Anesthesiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention se rapporte à un appareil et à un procédé d'administration ciblée de médicament à un patient au moyen de l'imagerie par résonance magnétique (IRM). Cet appareil et ce procédé servent à l'administration de médicament à tous types de tissu vivant et font appel à l'imagerie par résonance magnétique pour suivre la trace du médicament administré et estimer la vitesse d'administration du médicament. Un dispositif d'administration de médicament par résonance magnétique visible, positionné au niveau d'un site cible (par exemple, en vue d'une administration intracrânienne) administre au tissu (par exemple, au tissu cérébral) une solution médicamenteuse diagnostique ou thérapeutique. La cinétique de distribution spatiale de l'agent médicamenteux injecté ou infusé fait l'objet d'une surveillance quantitative, non invasive, par IRM à diffusion directionnelle de protons dans l'eau permettant d'évaluer l'efficacité de l'administration du médicament au niveau de l'emplacement cible.
CA002289837A 1997-05-15 1998-05-15 Procede et appareil d'administration ciblee de medicament a un patient, mettant en oeuvre une imagerie par resonance magnetique Abandoned CA2289837A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/856,894 1997-05-15
US08/857,043 1997-05-15
US08/856,894 US6061587A (en) 1997-05-15 1997-05-15 Method and apparatus for use with MR imaging
US08/857,043 US6026316A (en) 1997-05-15 1997-05-15 Method and apparatus for use with MR imaging
PCT/US1998/009942 WO1998052064A1 (fr) 1997-05-15 1998-05-15 Procede et appareil d'administration ciblee de medicament a un patient, mettant en oeuvre une imagerie par resonance magnetique

Publications (1)

Publication Number Publication Date
CA2289837A1 true CA2289837A1 (fr) 1998-11-19

Family

ID=27127382

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002289837A Abandoned CA2289837A1 (fr) 1997-05-15 1998-05-15 Procede et appareil d'administration ciblee de medicament a un patient, mettant en oeuvre une imagerie par resonance magnetique

Country Status (5)

Country Link
EP (1) EP0981761A1 (fr)
JP (1) JP2001525703A (fr)
AU (1) AU7388398A (fr)
CA (1) CA2289837A1 (fr)
WO (1) WO1998052064A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11298043B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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US6537232B1 (en) * 1997-05-15 2003-03-25 Regents Of The University Of Minnesota Intracranial pressure monitoring device and method for use in MR-guided drug delivery
US6479481B1 (en) * 1999-06-04 2002-11-12 Ed. Geistlich Soehne Ag Fur Chemische Industrie Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS)
SE9902695L (sv) * 1999-07-14 2001-01-15 Cma Microdialysis Ab Förbättrad sond
ATE484757T1 (de) 2000-02-01 2010-10-15 Surgivision Inc Transseptale nadelantenne für ein mr- bildgebungsgerät
AU2001247806A1 (en) * 2000-03-24 2001-10-08 Surgi-Vision Endoluminal mri probe
FR2823092B1 (fr) 2001-04-10 2004-03-05 Eurorad 2 6 Dispositif per-operatoire pour la localisation de tissus marques et procede utilisant un tel dispositif
GB0110392D0 (en) * 2001-04-27 2001-06-20 Oxford Instr Plc Method and apparatus for magnetic resonance imaging
US8862203B2 (en) * 2003-03-27 2014-10-14 Boston Scientific Scimed Inc. Medical device with temperature modulator for use in magnetic resonance imaging
WO2007064739A2 (fr) 2005-11-29 2007-06-07 Surgi-Vision, Inc. Systèmes de mise en place de dérivation et/ou de localisation guidés par irm et procédés, dispositifs et programmes informatiques associés
WO2008100930A2 (fr) 2007-02-13 2008-08-21 Cornell University Appareil, procédé et application d'administration améliorée par convection
US8175677B2 (en) 2007-06-07 2012-05-08 MRI Interventions, Inc. MRI-guided medical interventional systems and methods
CA2700531A1 (fr) 2007-09-24 2009-04-02 Surgivision, Inc. Plaques compatibles avec l'irm et leur proceder d'utilisation
US8548569B2 (en) 2007-09-24 2013-10-01 MRI Interventions, Inc. Head fixation assemblies for medical procedures
WO2009042130A2 (fr) 2007-09-24 2009-04-02 Surgivision, Inc. Systèmes et procédés d'intervention médicaux guidés par irm
US8099150B2 (en) 2007-09-24 2012-01-17 MRI Interventions, Inc. MRI-compatible head fixation frame with cooperating head coil apparatus
US8315689B2 (en) 2007-09-24 2012-11-20 MRI Interventions, Inc. MRI surgical systems for real-time visualizations using MRI image data and predefined data of surgical tools
WO2009047490A2 (fr) * 2007-10-08 2009-04-16 Renishaw Plc Cathéter
US8340743B2 (en) 2007-11-21 2012-12-25 MRI Interventions, Inc. Methods, systems and computer program products for positioning a guidance apparatus relative to a patient
CA2739173A1 (fr) * 2008-10-08 2010-04-15 Renishaw (Ireland) Limited Catheter
CA3050475C (fr) 2011-08-01 2021-09-14 Alcyone Lifesciences, Inc. Dispositifs microfluidiques d'administration de medicament
KR101820534B1 (ko) 2011-10-07 2018-01-22 서강대학교산학협력단 약물 전달 속도를 정량화하는 방법, 이에 의한 ｍｒｉ 장치
US9192446B2 (en) 2012-09-05 2015-11-24 MRI Interventions, Inc. Trajectory guide frame for MRI-guided surgeries
EP2934627B1 (fr) 2012-12-18 2021-04-07 Alcyone Lifesciences, Inc. Appareils et procédés permettant d'éviter un reflux dans un système de distribution
EP3010574B1 (fr) 2013-06-17 2019-12-18 Alcyone Lifesciences, Inc. Dispositifs de protection d'embouts de cathéters et fixations stéréotactiques pour microcathéters
WO2015017609A2 (fr) 2013-07-31 2015-02-05 Alcyone Lifesciences, Inc. Systèmes et procédés d'administration de médicament, de traitement et de surveillance
US10806396B2 (en) 2015-01-26 2020-10-20 Alcyone Lifesciences, Inc. Drug delivery methods with tracer
WO2017120167A1 (fr) 2016-01-04 2017-07-13 Alcyone Lifesciences, Inc. Procédés et dispositifs de traitement d'un accident vasculaire cérébral
US10905497B2 (en) 2017-04-21 2021-02-02 Clearpoint Neuro, Inc. Surgical navigation systems

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US3640269A (en) * 1969-10-24 1972-02-08 Jose M R Delgado Fluid-conducting instrument insertable in living organisms
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FI80585C (fi) * 1988-11-11 1990-07-10 Instrumentarium Oy Arrangemang foer undersoekning av ett objekt.
DE4310993A1 (de) * 1993-04-03 1994-10-06 Philips Patentverwaltung MR-Abbildungsverfahren und Anordnung zur Durchführung des Verfahrens
US5470307A (en) * 1994-03-16 1995-11-28 Lindall; Arnold W. Catheter system for controllably releasing a therapeutic agent at a remote tissue site
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11298043B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11298041B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system

Also Published As

Publication number Publication date
WO1998052064A1 (fr) 1998-11-19
JP2001525703A (ja) 2001-12-11
AU7388398A (en) 1998-12-08
EP0981761A1 (fr) 2000-03-01

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Legal Events

Date Code Title Description
FZDE Discontinued